Makarewich Lab

Publications

Kamradt, ML; Makarewich, CA. Mitochondrial microproteins: critical regulators of protein import, energy production, stress response pathways, and programmed cell death. American Journal of Physiology: Cell Physiology. 2023; 325:C807-C816.

Hassel, KR; Brito-Estrada, O; Makarewich, CA. Microproteins: Overlooked regulators of physiology and disease. iScience. 2023; 26:106781.

Brito-Estrada, O; Hassel, KR; Makarewich, CA. An Integrated Approach for Microprotein Identification and Sequence Analysis. Jove-Journal of Visualized Experiments. 2022; 2022.

Makarewich, CA; Munir, AZ; Bezprozvannaya, S; Gibson, AM; Kim, SY; Martin-Sandoval, MS; Mathews, TP; Szweda, LI; Bassel-Duby, R; Olson, EN. The cardiac-enriched microprotein mitolamban regulates mitochondrial respiratory complex assembly and function in mice. Proceedings of the National Academy of Sciences of USA. 2022; 119:e2120476119.

Makarewich, CA; Bezprozvannaya, S; Gibson, AM; Bassel-Duby, R; Olson, EN. Gene Therapy With the DWORF Micropeptide Attenuates Cardiomyopathy in Mice. Circulation Research. 2020; 127:1340-1342.

Singh, DR; Dalton, MP; Cho, EE; Pribadi, MP; Zak, TJ; Seflova, J; Makarewich, CA; Olson, EN; Robia, SL. Newly Discovered Micropeptide Regulators of SERCA Form Oligomers but Bind to the Pump as Monomers. Journal of Molecular Biology. 2019; 431:4429-4443.

Makarewich, CA; Munir, AZ; Schiattarella, GG; Bezprozvannaya, S; Raguimova, ON; Cho, EE; Vidal, AH; Robia, SL; Bassel-Duby, R; Olson, EN. The DWORF micropeptide enhances contractility and prevents heart failure in a mouse model of dilated cardiomyopathy. eLife. 2018; 7:e38319.

Makarewich, CA; Baskin, KK; Munir, AZ; Bezprozvannaya, S; Sharma, G; Khemtong, C; Shah, AM; McAnally, JR; Malloy, CR; Szweda, LI; et al. MOXI Is a Mitochondrial Micropeptide That Enhances Fatty Acid β-Oxidation. Cell Reports. 2018; 23:3701-3709.

Makarewich, CA; Olson, EN. Mining for Micropeptides. Trends in Cell Biology. 2017; 27:685-696.

Anderson, DM; Makarewich, CA; Anderson, KM; Shelton, JM; Bezprozvannaya, S; Bassel-Duby, R; Olson, EN. Widespread control of calcium signaling by a family of SERCA-inhibiting micropeptides. Science Signaling. 2016; 9:ra119.

Nelson, BR; Makarewich, CA; Anderson, DM; Winders, BR; Troupes, CD; Wu, F; Reese, AL; McAnally, JR; Chen, X; Kavalali, ET; et al. A peptide encoded by a transcript annotated as long noncoding RNA enhances SERCA activity in muscle. Science. 2016; 351:271-275.

Stege, NM; Eijgenraam, TR; Oliveira Nunes Teixeira, V; Feringa, AM; Schouten, EM; Kuster, DW D; Van Der Velden, J; Wolters, AH G; Giepmans, BN G; Makarewich, CA; et al. DWORF Extends Life Span in a PLN-R14del Cardiomyopathy Mouse Model by Reducing Abnormal Sarcoplasmic Reticulum Clusters. Circulation Research. 2023; 133:1006-1021.

Kamradt, ML; Makarewich, CA. Mitochondrial microproteins: critical regulators of protein import, energy production, stress response pathways, and programmed cell death. American Journal of Physiology: Cell Physiology. 2023; 325:C807-C816.

Hassel, KR; Brito-Estrada, O; Makarewich, CA. Microproteins: Overlooked regulators of physiology and disease. iScience. 2023; 26:106781.

Morales, ED; Yue, Y; Watkins, TB; Han, J; Pan, X; Gibson, AM; Hu, B; Brito-Estrada, O; Yao, G; Makarewich, CA; et al. Dwarf Open Reading Frame (DWORF) Gene Therapy Ameliorated Duchenne Muscular Dystrophy Cardiomyopathy in Aged mdx Mice. Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease. 2023; 12:e027480.

Jebessa, ZH; Schnieder, A; Dewenter, M; Berlin, M; Makarewich, C; Olson, EN; Freichel, M; Backs, J; Busch, M; Most, P. S100A1 & STRIT1 redundantly governs responsiveness of the heart to hemodynamic stress via modulation of SERCA2A activity. Journal of Molecular and Cellular Cardiology. 2022; 173:164.

Brito-Estrada, O; Hassel, KR; Makarewich, CA. An Integrated Approach for Microprotein Identification and Sequence Analysis. Jove-Journal of Visualized Experiments. 2022; 2022.

Makarewich, CA; Thum, T. Exercise-Induced Long Noncoding RNAs As New Players in Cardiac Hypertrophy. Circulation. 2022; 145:1234-1237.

Makarewich, CA; Munir, AZ; Bezprozvannaya, S; Gibson, AM; Kim, SY; Martin-Sandoval, MS; Mathews, TP; Szweda, LI; Bassel-Duby, R; Olson, EN. The cardiac-enriched microprotein mitolamban regulates mitochondrial respiratory complex assembly and function in mice. Proceedings of the National Academy of Sciences of USA. 2022; 119:e2120476119.

Makarewich, CA; Bezprozvannaya, S; Gibson, AM; Bassel-Duby, R; Olson, EN. Gene Therapy With the DWORF Micropeptide Attenuates Cardiomyopathy in Mice. Circulation Research. 2020; 127:1340-1342.

Makarewich, CA. The hidden world of membrane microproteins. Experimental Cell Research. 2020; 388:111853.

Singh, DR; Dalton, MP; Cho, EE; Pribadi, MP; Zak, TJ; Seflova, J; Makarewich, CA; Olson, EN; Robia, SL. Newly Discovered Micropeptide Regulators of SERCA Form Oligomers but Bind to the Pump as Monomers. Journal of Molecular Biology. 2019; 431:4429-4443.

Makarewich, CA; Munir, AZ; Schiattarella, GG; Bezprozvannaya, S; Raguimova, ON; Cho, EE; Vidal, AH; Robia, SL; Bassel-Duby, R; Olson, EN. The DWORF micropeptide enhances contractility and prevents heart failure in a mouse model of dilated cardiomyopathy. eLife. 2018; 7:e38319.

Makarewich, CA; Baskin, KK; Munir, AZ; Bezprozvannaya, S; Sharma, G; Khemtong, C; Shah, AM; McAnally, JR; Malloy, CR; Szweda, LI; et al. MOXI Is a Mitochondrial Micropeptide That Enhances Fatty Acid β-Oxidation. Cell Reports. 2018; 23:3701-3709.