Makarewich Lab

Publications

Hassel, KR; Gibson, AM; Šeflová, J; Cho, EE; Blair, NS; Van Raamsdonk, CD; Anderson, DM; Robia, SL; Makarewich, CA. Another-regulin regulates cardiomyocyte calcium handling via integration of neuroendocrine signaling with SERCA2a activity. Journal of Molecular and Cellular Cardiology. 2024; 197:45-58.

Kamradt, ML; Makarewich, CA. Mitochondrial microproteins: critical regulators of protein import, energy production, stress response pathways, and programmed cell death. American Journal of Physiology: Cell Physiology. 2023; 325:C807-C816.

Hassel, KR; Brito-Estrada, O; Makarewich, CA. Microproteins: Overlooked regulators of physiology and disease. iScience. 2023; 26:106781.

Brito-Estrada, O; Hassel, KR; Makarewich, CA. An Integrated Approach for Microprotein Identification and Sequence Analysis. Jove-Journal of Visualized Experiments. 2022; 2022.

Makarewich, CA; Munir, AZ; Bezprozvannaya, S; Gibson, AM; Kim, SY; Martin-Sandoval, MS; Mathews, TP; Szweda, LI; Bassel-Duby, R; Olson, EN. The cardiac-enriched microprotein mitolamban regulates mitochondrial respiratory complex assembly and function in mice. Proceedings of the National Academy of Sciences of USA. 2022; 119:e2120476119.

Makarewich, CA; Bezprozvannaya, S; Gibson, AM; Bassel-Duby, R; Olson, EN. Gene Therapy With the DWORF Micropeptide Attenuates Cardiomyopathy in Mice. Circulation Research. 2020; 127:1340-1342.

Singh, DR; Dalton, MP; Cho, EE; Pribadi, MP; Zak, TJ; Seflova, J; Makarewich, CA; Olson, EN; Robia, SL. Newly Discovered Micropeptide Regulators of SERCA Form Oligomers but Bind to the Pump as Monomers. Journal of Molecular Biology. 2019; 431:4429-4443.

Makarewich, CA; Munir, AZ; Schiattarella, GG; Bezprozvannaya, S; Raguimova, ON; Cho, EE; Vidal, AH; Robia, SL; Bassel-Duby, R; Olson, EN. The DWORF micropeptide enhances contractility and prevents heart failure in a mouse model of dilated cardiomyopathy. eLife. 2018; 7:e38319.

Makarewich, CA; Baskin, KK; Munir, AZ; Bezprozvannaya, S; Sharma, G; Khemtong, C; Shah, AM; McAnally, JR; Malloy, CR; Szweda, LI; Bassel-Duby, R; Olson, EN. MOXI Is a Mitochondrial Micropeptide That Enhances Fatty Acid β-Oxidation. Cell Reports. 2018; 23:3701-3709.

Makarewich, CA; Olson, EN. Mining for Micropeptides. Trends in Cell Biology. 2017; 27:685-696.

Anderson, DM; Makarewich, CA; Anderson, KM; Shelton, JM; Bezprozvannaya, S; Bassel-Duby, R; Olson, EN. Widespread control of calcium signaling by a family of SERCA-inhibiting micropeptides. Science Signaling. 2016; 9:ra119.

Nelson, BR; Makarewich, CA; Anderson, DM; Winders, BR; Troupes, CD; Wu, F; Reese, AL; McAnally, JR; Chen, X; Kavalali, ET; Cannon, SC; Houser, SR; Bassel-Duby, R; Olson, EN. A peptide encoded by a transcript annotated as long noncoding RNA enhances SERCA activity in muscle. Science. 2016; 351:271-275.

Coughlin, TM; Makarewich, CA. Emerging roles for microproteins as critical regulators of endoplasmic reticulum function and cellular homeostasis. Seminars in Cell and Developmental Biology. 2025; 170:103608.

Cleary, SR; Teng, AC T; Kongmeneck, AD; Fang, X; Phillips, TA; Cho, EE; Smith, RA; Karkut, P; Makarewich, CA; Kekenes-Huskey, PM; Gramolini, AO; Robia, SL. Dilated cardiomyopathy variant R14del increases phospholamban pentamer stability, blunting dynamic regulation of calcium. The Journal of biological chemistry. 2025; 301:108118.

Li, Z; Gu, M; Zaparte, A; Fu, X; Mahen, K; Mrdjen, M; Li, XS; Yang, Z; Ma, J; Thoudam, T; Brown, JM; Lefer, DJ; Welsh, DA; Sharp, TE. Alcohol-induced gut microbial reorganization and associated overproduction of phenylacetylglutamine promotes cardiovascular disease. Nature Communications. 2024; 15:10788.

Hassel, KR; Gibson, AM; Šeflová, J; Cho, EE; Blair, NS; Van Raamsdonk, CD; Anderson, DM; Robia, SL; Makarewich, CA. Another-regulin regulates cardiomyocyte calcium handling via integration of neuroendocrine signaling with SERCA2a activity. Journal of Molecular and Cellular Cardiology. 2024; 197:45-58.

Stege, NM; de Boer, RA; Makarewich, CA; van der Meer, P; Silljé, HH W. Reassessing the Mechanisms of PLN-R14del Cardiomyopathy: From Calcium Dysregulation to S/ER Malformation. JACC: Basic to Translational Science. 2024; 9:1041-1052.

Rabolli, CP; Naarmann-De Vries, IS; Makarewich, CA; Baskin, KK; Dieterich, C; Accornero, F. Nanopore Detection of METTL3-Dependent m6A-Modified mRNA Reveals a New Mechanism Regulating Cardiomyocyte Mitochondrial Metabolism. Circulation. 2024; 149:1319-1322.

Kamradt, ML; Makarewich, CA. CHKB-DT: A Long Noncoding RNA Critical for Cardiovascular Health. Circulation Research. 2024; 134:442-444.

Stege, NM; Eijgenraam, TR; Oliveira Nunes Teixeira, V; Feringa, AM; Schouten, EM; Kuster, DW D; Van Der Velden, J; Wolters, AH G; Giepmans, BN G; Makarewich, CA; Bassel-Duby, R; Olson, EN; De Boer, RA; Silljé, HH W. DWORF Extends Life Span in a PLN-R14del Cardiomyopathy Mouse Model by Reducing Abnormal Sarcoplasmic Reticulum Clusters. Circulation Research. 2023; 133:1006-1021.

Kamradt, ML; Makarewich, CA. Mitochondrial microproteins: critical regulators of protein import, energy production, stress response pathways, and programmed cell death. American Journal of Physiology: Cell Physiology. 2023; 325:C807-C816.

Hassel, KR; Brito-Estrada, O; Makarewich, CA. Microproteins: Overlooked regulators of physiology and disease. iScience. 2023; 26:106781.

Morales, ED; Yue, Y; Watkins, TB; Han, J; Pan, X; Gibson, AM; Hu, B; Brito-Estrada, O; Yao, G; Makarewich, CA; Babu, GJ; Duan, D. Dwarf Open Reading Frame (DWORF) Gene Therapy Ameliorated Duchenne Muscular Dystrophy Cardiomyopathy in Aged mdx Mice. Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease. 2023; 12:e027480.

Brito-Estrada, O; Hassel, KR; Makarewich, CA. An Integrated Approach for Microprotein Identification and Sequence Analysis. Jove-Journal of Visualized Experiments. 2022; 2022.

Makarewich, CA; Thum, T. Exercise-Induced Long Noncoding RNAs As New Players in Cardiac Hypertrophy. Circulation. 2022; 145:1234-1237.

Makarewich, CA; Munir, AZ; Bezprozvannaya, S; Gibson, AM; Kim, SY; Martin-Sandoval, MS; Mathews, TP; Szweda, LI; Bassel-Duby, R; Olson, EN. The cardiac-enriched microprotein mitolamban regulates mitochondrial respiratory complex assembly and function in mice. Proceedings of the National Academy of Sciences of USA. 2022; 119:e2120476119.

Makarewich, CA; Bezprozvannaya, S; Gibson, AM; Bassel-Duby, R; Olson, EN. Gene Therapy With the DWORF Micropeptide Attenuates Cardiomyopathy in Mice. Circulation Research. 2020; 127:1340-1342.