Molkentin Lab

Vanhoutte, D; Schips, TG; Vo, A; Grimes, KM; Baldwin, TA; Brody, MJ; Accornero, F; Sargent, MA; Molkentin, JD. Thbs1 induces lethal cardiac atrophy through PERK-ATF4 regulated autophagy. Nature Communications. 2021; 12.

Vagnozzi, RJ; Kasam, RK; Sargent, MA; Molkentin, JD. Cardiac Cell Therapy Fails to Rejuvenate the Chronically Scarred Rodent Heart. Circulation. 2021; 144:328-331.

Davis, G; York, AJ; Bacon, WC; Lin, SC; McNeal, MM; Yarawsky, AE; Maciag, JJ; Miller, JL C; Locker, KC S; Bailey, M; et al. Seroprevalence of SARS-CoV-2 infection in Cincinnati Ohio USA from August to December 2020. PLoS ONE. 2021; 16.

Huo, J; Lu, S; Kwong, JQ; Bround, MJ; Grimes, KM; Sargent, MA; Brown, ME; Davis, ME; Bers, DM; Molkentin, JD. MCUb Induction Protects the Heart From Postischemic Remodeling. Circulation Research. 2020; 127:379-390.

Vagnozzi, RJ; Sargent, MA; Molkentin, JD. Cardiac Cell Therapy Rejuvenates the Infarcted Rodent Heart via Direct Injection but Not by Vascular Infusion. Circulation. 2020; 141:1037-1039.

Vagnozzi, RJ; Maillet, M; Sargent, MA; Khalil, H; Johansen, AK Z; Schwanekamp, JA; York, AJ; Huang, V; Nahrendorf, M; Sadayappan, S; et al. An acute immune response underlies the benefit of cardiac stem cell therapy. Nature. 2020; 577:405-409.

Schips, TG; Vanhoutte, D; Vo, A; Correll, RN; Brody, MJ; Khalil, H; Karch, J; Tjondrokoesoemo, A; Sargent, MA; Maillet, M; et al. Thrombospondin-3 augments injury-induced cardiomyopathy by intracellular integrin inhibition and sarcolemmal instability. Nature Communications. 2019; 10.

Karch, J; Bround, MJ; Khalil, H; Sargent, MA; Latchman, N; Terada, N; Peixoto, PM; Molkentin, JD. Inhibition of mitochondrial permeability transition by deletion of the ANT family and CypD. Science advances. 2019; 5.

Khalil, H; Kanisicak, O; Vagnozzi, RJ; Johansen, AK; Maliken, BD; Prasad, V; Boyer, JG; Brody, MJ; Schips, T; Kilian, KK; et al. Cell-specific ablation of Hsp47 defines the collagen-producing cells in the injured heart. JCI insight. 2019; 4.

Vagnozzi, RJ; Sargent, MA; Lin, SJ; Palpant, NJ; Murry, CE; Molkentin, JD. Genetic Lineage Tracing of Sca-1+ Cells Reveals Endothelial but Not Myogenic Contribution to the Murine Heart. Circulation. 2018; 138:2931-2939.

Fu, X; Khalil, H; Kanisicak, O; Boyer, JG; Vagnozzi, RJ; Maliken, BD; Sargent, MA; Prasad, V; Valiente-Alandi, I; Blaxall, BC; et al. Specialized fibroblast differentiated states underlie scar formation in the infarcted mouse heart. Journal of Clinical Investigation. 2018; 128:2127-2143.

Correll, RN; Makarewich, CA; Zhang, H; Zhang, C; Sargent, MA; York, AJ; Berretta, RM; Chen, X; Houser, SR; Molkentin, JD. Caveolae-localized L-type Ca2+ channels do not contribute to function or hypertrophic signalling in the mouse heart. Cardiovascular Research. 2017; 113:749-759.

Davis, J; Davis, LC; Correll, RN; Makarewich, CA; Schwanekamp, JA; Moussavi-Harami, F; Wang, D; York, AJ; Wu, H; Houser, SR; et al. A Tension-Based Model Distinguishes Hypertrophic versus Dilated Cardiomyopathy. Cell. 2016; 165:1147-1159.

Tjondrokoesoemo, A; Schips, TG; Sargent, MA; Vanhoutte, D; Kanisicak, O; Prasad, V; Lin, SJ; Maillet, M; Molkentin, JD. Cathepsin S Contributes to the Pathogenesis of Muscular Dystrophy in Mice. Journal of Biological Chemistry. 2016; 291:9920-9928.

van Berlo, JH; Kanisicak, O; Maillet, M; Vagnozzi, RJ; Karch, J; Lin, SJ; Middleton, RC; Marban, E; Molkentin, JD. c-kit+ cells minimally contribute cardiomyocytes to the heart. Nature. 2014; 509:337-341.

Zampese, E; Wokosin, DL; Gonzalez-Rodriguez, P; Guzman, JN; Tkatch, T; Kondapalli, J; Surmeier, WC; D’Alessandro, KB; De Stefani, D; Rizzuto, R; et al. Ca2+ channels couple spiking to mitochondrial metabolism in substantia nigra dopaminergic neurons. Science advances. 2022; 8.

Wintzinger, M; Panta, M; Miz, K; Prabakaran, AD; Durumutla, HB; Sargent, M; Peek, CB; Bass, J; Molkentin, JD; Quattrocelli, M. Impact of circadian time of dosing on cardiomyocyte-autonomous effects of glucocorticoids. Molecular Metabolism. 2022; 62.

Prasad, V; Molkentin, JD. At the Brink of Human Therapy to Generate New Myocytes in the Adult Injured Heart. Circulation. 2022; 145:1356-1358.

Bowers, SL K; Meng, Q; Molkentin, JD. Fibroblasts orchestrate cellular crosstalk in the heart through the ECM. 2022; 1:312-321.

Vanhoutte, D; Schips, TG; Vo, A; Grimes, KM; Baldwin, TA; Brody, MJ; Accornero, F; Sargent, MA; Molkentin, JD. Thbs1 induces lethal cardiac atrophy through PERK-ATF4 regulated autophagy. Nature Communications. 2021; 12.

Sun, F; Wang, G; Pradhan, A; Xu, K; Gomez-Arroyo, J; Zhang, Y; Kalin, GT; Deng, Z; Vagnozzi, RJ; He, H; et al. Nanoparticle Delivery of STAT3 Alleviates Pulmonary Hypertension in a Mouse Model of Alveolar Capillary Dysplasia. Circulation. 2021; 144:539-555.

Vagnozzi, RJ; Kasam, RK; Sargent, MA; Molkentin, JD. Cardiac Cell Therapy Fails to Rejuvenate the Chronically Scarred Rodent Heart. Circulation. 2021; 144:328-331.

Davis, G; York, AJ; Bacon, WC; Lin, SC; McNeal, MM; Yarawsky, AE; Maciag, JJ; Miller, JL C; Locker, KC S; Bailey, M; et al. Seroprevalence of SARS-CoV-2 infection in Cincinnati Ohio USA from August to December 2020. PLoS ONE. 2021; 16.

Fischesser, DM; Meyer, EC; Sargent, M; Molkentin, JD. Refined CLARITY-Based Tissue Clearing for Three-Dimensional Fibroblast Organization in Healthy and Injured Mouse Hearts. Journal of Visualized Experiments. 2021.

Vagnozzi, RJ; Molkentin, JD. Resident macrophages keep mitochondria running in the heart. Cell Research. 2020; 30:1057-1058.

Huo, J; Lu, S; Kwong, JQ; Bround, MJ; Grimes, KM; Sargent, MA; Brown, ME; Davis, ME; Bers, DM; Molkentin, JD. MCUb Induction Protects the Heart From Postischemic Remodeling. Circulation Research. 2020; 127:379-390.

Bround, MJ; Bers, DM; Molkentin, JD. A 20/20 view of ANT function in mitochondrial biology and necrotic cell death. Journal of Molecular and Cellular Cardiology. 2020; 144:A3-A13.

Vagnozzi, RJ; Sargent, MA; Molkentin, JD. Cardiac Cell Therapy Rejuvenates the Infarcted Rodent Heart via Direct Injection but Not by Vascular Infusion. Circulation. 2020; 141:1037-1039.

Vagnozzi, RJ; Maillet, M; Sargent, MA; Khalil, H; Johansen, AK Z; Schwanekamp, JA; York, AJ; Huang, V; Nahrendorf, M; Sadayappan, S; et al. An acute immune response underlies the benefit of cardiac stem cell therapy. Nature. 2020; 577:405-409.

Schips, TG; Vanhoutte, D; Vo, A; Correll, RN; Brody, MJ; Khalil, H; Karch, J; Tjondrokoesoemo, A; Sargent, MA; Maillet, M; et al. Thrombospondin-3 augments injury-induced cardiomyopathy by intracellular integrin inhibition and sarcolemmal instability. Nature Communications. 2019; 10.

Correll, RN; Grimes, KM; Prasad, V; Lynch, JM; Khalil, H; Molkentin, JD. Overlapping and differential functions of ATF6α versus ATF6β in the mouse heart. Scientific Reports. 2019; 9.

Vagnozzi, RJ; Johansen, AK Z; Molkentin, JD. CARdiac Immunotherapy: T Cells Engineered to Treat the Fibrotic Heart. Molecular Therapy. 2019; 27:1869-1871.

Johansen, AK Z; Molkentin, JD. Hippo signaling does it again: arbitrating cardiac fibroblast identity and activation. Genes and Development. 2019; 33:1457-1459.

Karch, J; Bround, MJ; Khalil, H; Sargent, MA; Latchman, N; Terada, N; Peixoto, PM; Molkentin, JD. Inhibition of mitochondrial permeability transition by deletion of the ANT family and CypD. Science advances. 2019; 5.

Khalil, H; Kanisicak, O; Vagnozzi, RJ; Johansen, AK; Maliken, BD; Prasad, V; Boyer, JG; Brody, MJ; Schips, T; Kilian, KK; et al. Cell-specific ablation of Hsp47 defines the collagen-producing cells in the injured heart. JCI insight. 2019; 4.

Brody, MJ; Vanhoutte, D; Bakshi, CV; Liu, R; Correll, RN; Sargent, MA; Molkentin, JD. Disruption of valosin-containing protein activity causes cardiomyopathy and reveals pleiotropic functions in cardiac homeostasis. Journal of Biological Chemistry. 2019; 294:8918-8929.

Boyer, JG; Prasad, V; Song, T; Lee, D; Fu, X; Grimes, KM; Sargent, MA; Sadayappan, S; Molkentin, JD. ERK1/2 signaling induces skeletal muscle slow fiber-type switching and reduces muscular dystrophy disease severity. JCI insight. 2019; 5.

Vagnozzi, RJ; Sargent, MA; Lin, SJ; Palpant, NJ; Murry, CE; Molkentin, JD. Genetic Lineage Tracing of Sca-1+ Cells Reveals Endothelial but Not Myogenic Contribution to the Murine Heart. Circulation. 2018; 138:2931-2939.

Kwong, JQ; Huo, J; Bround, MJ; Boyer, JG; Schwanekamp, JA; Ghazal, N; Maxwell, JT; Jang, YC; Khuchua, Z; Shi, K; et al. The mitochondrial calcium uniporter underlies metabolic fuel preference in skeletal muscle. JCI insight. 2018; 3.

Maliken, BD; Kanisicak, O; Karch, J; Khalil, H; Fu, X; Boyer, JG; Prasad, V; Zheng, Y; Molkentin, JD. Gata4-Dependent Differentiation of c-Kit+-Derived Endothelial Cells Underlies Artefactual Cardiomyocyte Regeneration in the Heart. Circulation. 2018; 138:1012-1024.

Maliken, BD; Molkentin, JD. Undeniable Evidence That the Adult Mammalian Heart Lacks an Endogenous Regenerative Stem Cell. Circulation. 2018; 138:806-808.

Brody, MJ; Vanhoutte, D; Schips, TG; Boyer, JG; Bakshi, CV; Sargent, MA; York, AJ; Molkentin, JD. Defective Flux of Thrombospondin-4 through the Secretory Pathway Impairs Cardiomyocyte Membrane Stability and Causes Cardiomyopathy. Molecular and Cellular Biology. 2018; 38.

Vagnozzi, RJ; Molkentin, JD; Houser, SR. New Myocyte Formation in the Adult Heart: Endogenous Sources and Therapeutic Implications. Circulation Research. 2018; 123:159-176.

Karch, J; Molkentin, JD. Identity of the elusive mitochondrial permeability transition pore: What it might be, what it was, and what it still could be?. 2018; 3:57-62.

Fu, X; Khalil, H; Kanisicak, O; Boyer, JG; Vagnozzi, RJ; Maliken, BD; Sargent, MA; Prasad, V; Valiente-Alandi, I; Blaxall, BC; et al. Specialized fibroblast differentiated states underlie scar formation in the infarcted mouse heart. Journal of Clinical Investigation. 2018; 128:2127-2143.

van Berlo, JH; Kanisicak, O; Maillet, M; Vagnozzi, RJ; Karch, J; Lin, SJ; Middleton, RC; Marban, E; Molkentin, JD. van Berlo et al. reply. Nature. 2018; 555.