Molkentin Lab

Huo, J; Lu, S; Kwong, JQ; Bround, MJ; Grimes, KM; Sargent, MA; Brown, ME; Davis, ME; Bers, DM; Molkentin, JD. MCUb induction protects the heart from postischemic remodeling. Circulation Research. 2020; 127:379-390.

Vagnozzi, RJ; Sargent, MA; Molkentin, JD. Cardiac Cell Therapy Rejuvenates the Infarcted Rodent Heart via Direct Injection but Not by Vascular Infusion. Circulation. 2020; 141:1037-1039.

Vagnozzi, RJ; Maillet, M; Sargent, MA; Khalil, H; Johansen, AK Z; Schwanekamp, JA; York, AJ; Huang, V; Nahrendorf, M; Sadayappan, S; et al. An acute immune response underlies the benefit of cardiac stem cell therapy. Nature. 2020; 577:405-409.

Schips, TG; Vanhoutte, D; Vo, A; Correll, RN; Brody, MJ; Khalil, H; Karch, J; Tjondrokoesoemo, A; Sargent, MA; Maillet, M; et al. Thrombospondin-3 augments injury-induced cardiomyopathy by intracellular integrin inhibition and sarcolemmal instability. Nature Communications. 2019; 10.

Correll, RN; Grimes, KM; Prasad, V; Lynch, JM; Khalil, H; Molkentin, JD. Overlapping and differential functions of ATF6 alpha versus ATF6 beta in the mouse heart. Scientific Reports. 2019; 9.

Karch, J; Bround, MJ; Khalil, H; Sargent, MA; Latchman, N; Terada, N; Peixoto, PM; Molkentin, JD. Inhibition of mitochondrial permeability transition by deletion of the ANT family and CypD. Science Advances. 2019; 5:eaaw4597-eaaw4597.

Khalil, H; Kanisicak, O; Vagnozzi, RJ; Johansen, AK; Maliken, BD; Prasad, V; Boyer, JG; Brody, MJ; Schips, T; Kilian, KK; et al. Cell-specific ablation of Hsp47 defines the collagen-producing cells in the injured heart. JCI insight. 2019; 4.

Brody, MJ; Vanhoutte, D; Bakshi, CV; Liu, R; Correll, RN; Sargent, MA; Molkentin, JD. Disruption of valosin-containing protein activity causes cardiomyopathy and reveals pleiotropic functions in cardiac homeostasis. The Journal of biological chemistry. 2019; 294:8918-8929.

Boyer, JG; Prasad, V; Song, T; Lee, D; Fu, X; Grimes, KM; Sargent, MA; Sadayappan, S; Molkentin, JD. ERK1/2 signaling induces skeletal muscle slow fiber-type switching and reduces muscular dystrophy disease severity. JCI insight. 2019; 5.

Vagnozzi, RJ; Sargent, MA; Lin, SJ; Palpant, NJ; Murry, CE; Molkentin, JD. Genetic Lineage Tracing of Sca-1(+) Cells Reveals Endothelial but Not Myogenic Contribution to the Murine Heart. Circulation. 2018; 138:2931-2939.

Kwong, JQ; Huo, J; Bround, MJ; Boyer, JG; Schwanekamp, JA; Ghazal, N; Maxwell, JT; Jang, YC; Khuchua, Z; Shi, K; et al. The mitochondrial calcium uniporter underlies metabolic fuel preference in skeletal muscle. JCI insight. 2018; 3.

Maliken, BD; Kanisicak, O; Karch, J; Khalil, H; Fu, X; Boyer, JG; Prasad, V; Zheng, Y; Molkentin, JD. Gata4-Dependent Differentiation of c-Kit(+)-Derived Endothelial Cells Underlies Artefactual Cardiomyocyte Regeneration in the Heart. Circulation. 2018; 138:1012-1024.

Fu, X; Khalil, H; Kanisicak, O; Boyer, JG; Vagnozzi, RJ; Maliken, BD; Sargent, MA; Prasad, V; Valiente-Alandi, I; Blaxall, BC; et al. Specialized fibroblast differentiated states underlie scar formation in the infarcted mouse heart. Journal of Clinical Investigation. 2018; 128:2127-2143.

Accornero, F; Schips, TG; Petrosino, JM; Gu, S; Kanisicak, O; van Berlo, JH; Molkentin, JD. BEX1 is an RNA-dependent mediator of cardiomyopathy. Nature Communications. 2017; 8.

Karch, J; Schips, TG; Maliken, BD; Brody, MJ; Sargent, MA; Kanisciak, O; Molkentin, JD. Autophagic cell death is dependent on lysosomal membrane permeability through Bax and Bak. eLife. 2017; 6.

Khalil, H; Kanisicak, O; Prasad, V; Correll, RN; Fu, X; Schips, T; Vagnozzi, RJ; Liu, R; Huynh, T; Lee, S; et al. Fibroblast-specific TGF-beta-Smad2/3 signaling underlies cardiac fibrosis. Journal of Clinical Investigation. 2017; 127:3770-3783.

Molkentin, JD; Bugg, D; Ghearing, N; Dorn, LE; Kim, P; Sargent, MA; Gunaje, J; Otsu, K; Davis, J. Fibroblast-Specific Genetic Manipulation of p38 Mitogen-Activated Protein Kinase In Vivo Reveals Its Central Regulatory Role in Fibrosis. Circulation. 2017; 136:549-561.

Tallquist, MD; Molkentin, JD. Redefining the identity of cardiac fibroblasts. Nature Reviews Cardiology. 2017; 14:484-491.

Correll, RN; Makarewich, CA; Zhang, H; Zhang, C; Sargent, MA; York, AJ; Berretta, RM; Chen, X; Houser, SR; Molkentin, JD. Caveolae-localized L-type Ca2+ channels do not contribute to function or hypertrophic signalling in themouse heart. Cardiovascular Research. 2017; 113:749-759.

Cai, C; Molkentin, JD. The Elusive Progenitor Cell in Cardiac Regeneration Slip Slidin' Away. Circulation Research. 2017; 120:400-406.

Liu, R; Molkentin, JD. Regulation of cardiac hypertrophy and remodeling through the dual-specificity MAPK phosphatases (DUSPs). Journal of Molecular and Cellular Cardiology. 2016; 101:44-49.

Liu, R; Khalil, H; Lin, SJ; Sargent, MA; York, AJ; Molkentin, JD. Nemo-Like Kinase (NLK) Is a Pathological Signaling Effector in the Mouse Heart. PLoS ONE. 2016; 11:e0164897-e0164897.

Vanhoutte, D; Schips, TG; Kwong, JQ; Davis, J; Tjondrokoesoemo, A; Brody, MJ; Sargent, MA; Kanisicak, O; Yi, H; Gao, QQ; et al. Thrombospondin expression in myofibers stabilizes muscle membranes. eLife. 2016; 5.

Liu, R; van Berlo, JH; York, AJ; Vagnozzi, RJ; Maillet, M; Molkentin, JD. DUSP8 Regulates Cardiac Ventricular Remodeling by Altering ERK1/2 Signaling. Circulation Research. 2016; 119:249-260.

Davis, J; Davis, LC; Correll, RN; Makarewich, CA; Schwanekamp, JA; Moussavi-Harami, F; Wang, D; York, AJ; Wu, H; Houser, SR; et al. A Tension-Based Model Distinguishes Hypertrophic versus Dilated Cardiomyopathy. Cell. 2016; 165:1147-1159.

Tjondrokoesoemo, A; Schips, TG; Sargent, MA; Vanhoutte, D; Kanisicak, O; Prasad, V; Lin, SJ; Maillet, M; Molkentin, JD. Cathepsin S Contributes to the Pathogenesis of Muscular Dystrophy in Mice. The Journal of biological chemistry. 2016; 291:9920-9928.

Tjondrokoesoemo, A; Schips, T; Kanisicak, O; Sargent, MA; Molkentin, JD. Genetic overexpression of Serpina3n attenuates muscular dystrophy in mice. Human Molecular Genetics. 2016; 25:1192-1202.

van Berlo, JH; Molkentin, JD. Most of the Dust Has Settled cKit(+) Progenitor Cells Are an Irrelevant Source of Cardiac Myocytes In Vivo. Circulation Research. 2016; 118:17-19.

Brody, MJ; Schips, TG; Vanhoutte, D; Kanisicak, O; Karch, J; Maliken, BD; Blair, NS; Sargent, MA; Prasad, V; Molkentin, JD. Dissection of Thrombospondin-4 Domains Involved in Intracellular Adaptive Endoplasmic Reticulum Stress-Responsive Signaling. Molecular and Cellular Biology. 2016; 36:MCB.00607-15.

Schwanekamp, JA; Lorts, A; Vagnozzi, RJ; Vanhoutte, D; Molkentin, JD. Deletion of Periostin Protects Against Atherosclerosis in Mice by Altering Inflammation and Extracellular Matrix Remodeling. Arteriosclerosis, Thrombosis, and Vascular Biology. 2016; 36:60-68.

Correll, RN; Goonasekera, SA; van Berlo, JH; Burr, AR; Accornero, F; Zhang, H; Makarewich, CA; York, AJ; Sargent, MA; Chen, X; et al. STIM1 elevation in the heart results in aberrant Ca2+ handling and cardiomyopathy. Journal of Molecular and Cellular Cardiology. 2015; 87:38-47.

Liu, R; Correll, RN; Davis, J; Vagnozzi, RJ; York, AJ; Sargent, MA; Nairn, AC; Molkentin, JD. Cardiac-specific deletion of protein phosphatase 1 beta promotes increased myofilament protein phosphorylation and contractile alterations. Journal of Molecular and Cellular Cardiology. 2015; 87:204-213.

Burr, AR; Molkentin, JD. Genetic evidence in the mouse solidifies the calcium hypothesis of myofiber death in muscular dystrophy. Cell Death and Differentiation. 2015; 22:1402-1412.

Kwong, JQ; Lu, X; Correll, RN; Schwanekamp, JA; Vagnozzi, RJ; Sargent, MA; York, AJ; Zhang, J; Bers, DM; Molkentin, JD. The Mitochondrial Calcium Uniporter Selectively Matches Metabolic Output to Acute Contractile Stress in the Heart. Cell Reports. 2015; 12:15-22.

Accornero, F; van Berlo, JH; Correll, RN; Elrod, JW; Sargent, MA; York, A; Rabinowitz, JE; Leask, A; Molkentin, JD. Genetic Analysis of Connective Tissue Growth Factor as an Effector of Transforming Growth Factor beta Signaling and Cardiac Remodeling. Molecular and Cellular Biology. 2015; 35:2154-2164.

Weinberger, T; Esfandyari, D; Messerer, D; Percin, G; Schleifer, C; Thaler, R; Liu, L; Stremmel, C; Schneider, V; Vagnozzi, RJ; et al. Ontogeny of arterial macrophages defines their functions in homeostasis and inflammation. Nature Communications. 2020; 11.

Vagnozzi, RJ; Molkentin, JD. Resident macrophages keep mitochondria running in the heart. Cell Research. 2020; 30:1057-1058.

Schriever, SC; Kabra, DG; Pfuhlmann, K; Baumann, P; Baumgart, EV; Nagler, J; Seebacher, F; Harrison, L; Irmler, M; Kullmann, S; et al. Type 2 diabetes risk gene Dusp8 regulates hypothalamic Jnk signaling and insulin sensitivity. Journal of Clinical Investigation. 2020; 130:6093-6108.

Huo, J; Lu, S; Kwong, JQ; Bround, MJ; Grimes, KM; Sargent, MA; Brown, ME; Davis, ME; Bers, DM; Molkentin, JD. MCUb induction protects the heart from postischemic remodeling. Circulation Research. 2020; 127:379-390.

Bround, MJ; Bers, DM; Molkentin, JD. A 20/20 view of ANT function in mitochondrial biology and necrotic cell death. Journal of Molecular and Cellular Cardiology. 2020; 144:A3-A13.

Vagnozzi, RJ; Sargent, MA; Molkentin, JD. Cardiac Cell Therapy Rejuvenates the Infarcted Rodent Heart via Direct Injection but Not by Vascular Infusion. Circulation. 2020; 141:1037-1039.

Vagnozzi, RJ; Maillet, M; Sargent, MA; Khalil, H; Johansen, AK Z; Schwanekamp, JA; York, AJ; Huang, V; Nahrendorf, M; Sadayappan, S; et al. An acute immune response underlies the benefit of cardiac stem cell therapy. Nature. 2020; 577:405-409.

Schips, TG; Vanhoutte, D; Vo, A; Correll, RN; Brody, MJ; Khalil, H; Karch, J; Tjondrokoesoemo, A; Sargent, MA; Maillet, M; et al. Thrombospondin-3 augments injury-induced cardiomyopathy by intracellular integrin inhibition and sarcolemmal instability. Nature Communications. 2019; 10.

Correll, RN; Grimes, KM; Prasad, V; Lynch, JM; Khalil, H; Molkentin, JD. Overlapping and differential functions of ATF6 alpha versus ATF6 beta in the mouse heart. Scientific Reports. 2019; 9.

Vagnozzi, RJ; Johansen, AK Z; Molkentin, JD. CARdiac Immunotherapy: T Cells Engineered to Treat the Fibrotic Heart. Molecular Therapy. 2019; 27:1869-1871.

Johansen, AK Z; Molkentin, JD. Hippo signaling does it again: arbitrating cardiac fibroblast identity and activation. Genes and Development. 2019; 33:1457-1459.

Karch, J; Bround, MJ; Khalil, H; Sargent, MA; Latchman, N; Terada, N; Peixoto, PM; Molkentin, JD. Inhibition of mitochondrial permeability transition by deletion of the ANT family and CypD. Science Advances. 2019; 5:eaaw4597-eaaw4597.

Khalil, H; Kanisicak, O; Vagnozzi, RJ; Johansen, AK; Maliken, BD; Prasad, V; Boyer, JG; Brody, MJ; Schips, T; Kilian, KK; et al. Cell-specific ablation of Hsp47 defines the collagen-producing cells in the injured heart. JCI insight. 2019; 4.

Brody, MJ; Vanhoutte, D; Bakshi, CV; Liu, R; Correll, RN; Sargent, MA; Molkentin, JD. Disruption of valosin-containing protein activity causes cardiomyopathy and reveals pleiotropic functions in cardiac homeostasis. The Journal of biological chemistry. 2019; 294:8918-8929.

Boyer, JG; Prasad, V; Song, T; Lee, D; Fu, X; Grimes, KM; Sargent, MA; Sadayappan, S; Molkentin, JD. ERK1/2 signaling induces skeletal muscle slow fiber-type switching and reduces muscular dystrophy disease severity. JCI insight. 2019; 5.

Vagnozzi, RJ; Sargent, MA; Lin, SJ; Palpant, NJ; Murry, CE; Molkentin, JD. Genetic Lineage Tracing of Sca-1(+) Cells Reveals Endothelial but Not Myogenic Contribution to the Murine Heart. Circulation. 2018; 138:2931-2939.

Kwong, JQ; Huo, J; Bround, MJ; Boyer, JG; Schwanekamp, JA; Ghazal, N; Maxwell, JT; Jang, YC; Khuchua, Z; Shi, K; et al. The mitochondrial calcium uniporter underlies metabolic fuel preference in skeletal muscle. JCI insight. 2018; 3.

Maliken, BD; Kanisicak, O; Karch, J; Khalil, H; Fu, X; Boyer, JG; Prasad, V; Zheng, Y; Molkentin, JD. Gata4-Dependent Differentiation of c-Kit(+)-Derived Endothelial Cells Underlies Artefactual Cardiomyocyte Regeneration in the Heart. Circulation. 2018; 138:1012-1024.

Maliken, BD; Molkentin, JD. Undeniable Evidence That the Adult Mammalian Heart Lacks an Endogenous Regenerative Stem Cell. Circulation. 2018; 138:806-808.

Brody, MJ; Vanhoutte, D; Schips, TG; Boyer, JG; Bakshi, CV; Sargent, MA; York, AJ; Molkentin, JD. Defective Flux of Thrombospondin-4 through the Secretory Pathway Impairs Cardiomyocyte Membrane Stability and Causes Cardiomyopathy. Molecular and Cellular Biology. 2018; 38.

Vagnozzi, RJ; Molkentin, JD; Houser, SR. New Myocyte Formation in the Adult Heart: Endogenous Sources and Therapeutic Implications. Circulation Research. 2018; 123:159-176.

Karch, J; Molkentin, JD. Identity of the elusive mitochondrial permeability transition pore: what it might be, what it was, and what it still could be. 2018; 3:57-62.

Fu, X; Khalil, H; Kanisicak, O; Boyer, JG; Vagnozzi, RJ; Maliken, BD; Sargent, MA; Prasad, V; Valiente-Alandi, I; Blaxall, BC; et al. Specialized fibroblast differentiated states underlie scar formation in the infarcted mouse heart. Journal of Clinical Investigation. 2018; 128:2127-2143.

van Berlo, JH; Kanisicak, O; Maillet, M; Vagnozzi, RJ; Karch, J; Lin, SJ; Middleton, RC; Marban, E; Molkentin, JD. Kit(cre) knock-in mice fail to fate-map cardiac stem cells reply. Nature. 2018; 555:E18-E5.

Correll, RN; Lynch, JM; Schips, TG; Prasad, V; York, AJ; Sargent, MA; Brochet, DX P; Ma, J; Molkentin, JD. Mitsugumin 29 regulates t-tubule architecture in the failing heart. Scientific Reports. 2017; 7.

Accornero, F; Schips, TG; Petrosino, JM; Gu, S; Kanisicak, O; van Berlo, JH; Molkentin, JD. BEX1 is an RNA-dependent mediator of cardiomyopathy. Nature Communications. 2017; 8.

Karch, J; Schips, TG; Maliken, BD; Brody, MJ; Sargent, MA; Kanisciak, O; Molkentin, JD. Autophagic cell death is dependent on lysosomal membrane permeability through Bax and Bak. eLife. 2017; 6.

Kanisicak, O; Vagnozzi, RJ; Molkentin, JD. Identity Crisis for Regenerative Cardiac cKit(+) Cells. Circulation Research. 2017; 121:1130-1132.

Khalil, H; Maillet, M; Molkentin, JD. Spatial Gene Profiling in the Ischemic Heart Fibroblasts Put on Their SOX. Circulation. 2017; 136:1410-1411.

Khalil, H; Kanisicak, O; Prasad, V; Correll, RN; Fu, X; Schips, T; Vagnozzi, RJ; Liu, R; Huynh, T; Lee, S; et al. Fibroblast-specific TGF-beta-Smad2/3 signaling underlies cardiac fibrosis. Journal of Clinical Investigation. 2017; 127:3770-3783.

Molkentin, JD; Bugg, D; Ghearing, N; Dorn, LE; Kim, P; Sargent, MA; Gunaje, J; Otsu, K; Davis, J. Fibroblast-Specific Genetic Manipulation of p38 Mitogen-Activated Protein Kinase In Vivo Reveals Its Central Regulatory Role in Fibrosis. Circulation. 2017; 136:549-561.

Tallquist, MD; Molkentin, JD. Redefining the identity of cardiac fibroblasts. Nature Reviews Cardiology. 2017; 14:484-491.

Schwanekamp, JA; Lorts, A; Sargent, MA; York, AJ; Grimes, KM; Fischesser, DM; Gokey, JJ; Whitsett, JA; Conway, SJ; Molkentin, JD. TGFBI functions similar to periostin but is uniquely dispensable during cardiac injury. PLoS ONE. 2017; 12:e0181945-e0181945.

Correll, RN; Makarewich, CA; Zhang, H; Zhang, C; Sargent, MA; York, AJ; Berretta, RM; Chen, X; Houser, SR; Molkentin, JD. Caveolae-localized L-type Ca2+ channels do not contribute to function or hypertrophic signalling in themouse heart. Cardiovascular Research. 2017; 113:749-759.

Luongo, TS; Lambert, JP; Gross, P; Nwokedi, M; Lombardi, AA; Shanmughapriya, S; Carpenter, AC; Kolmetzky, D; Gao, E; van Berlo, JH; et al. The mitochondrial Na+/Ca2+ exchanger is essential for Ca2+ homeostasis and viability. Nature. 2017; 545:93-97.

Cai, C; Molkentin, JD. The Elusive Progenitor Cell in Cardiac Regeneration Slip Slidin' Away. Circulation Research. 2017; 120:400-406.

Kanisicak, O; Molkentin, JD. Applying Modern Transcriptomics to Interrogate the Human Cardiac Fibroblast. JACC: Basic to Translational Science. 2016; 1:603-605.

Liu, R; Molkentin, JD. Regulation of cardiac hypertrophy and remodeling through the dual-specificity MAPK phosphatases (DUSPs). Journal of Molecular and Cellular Cardiology. 2016; 101:44-49.

Kanisicak, O; Khalil, H; Ivey, MJ; Karch, J; Maliken, BD; Correll, RN; Brody, MJ; Lin, SJ; Aronow, BJ; Tallquist, MD; et al. Genetic lineage tracing defines myofibroblast origin and function in the injured heart. Nature Communications. 2016; 7.

Liu, R; Khalil, H; Lin, SJ; Sargent, MA; York, AJ; Molkentin, JD. Nemo-Like Kinase (NLK) Is a Pathological Signaling Effector in the Mouse Heart. PLoS ONE. 2016; 11:e0164897-e0164897.

Vanhoutte, D; Schips, TG; Kwong, JQ; Davis, J; Tjondrokoesoemo, A; Brody, MJ; Sargent, MA; Kanisicak, O; Yi, H; Gao, QQ; et al. Thrombospondin expression in myofibers stabilizes muscle membranes. eLife. 2016; 5.

Liu, R; van Berlo, JH; York, AJ; Vagnozzi, RJ; Maillet, M; Molkentin, JD. DUSP8 Regulates Cardiac Ventricular Remodeling by Altering ERK1/2 Signaling. Circulation Research. 2016; 119:249-260.

Davis, J; Davis, LC; Correll, RN; Makarewich, CA; Schwanekamp, JA; Moussavi-Harami, F; Wang, D; York, AJ; Wu, H; Houser, SR; et al. A Tension-Based Model Distinguishes Hypertrophic versus Dilated Cardiomyopathy. Cell. 2016; 165:1147-1159.

Tjondrokoesoemo, A; Schips, TG; Sargent, MA; Vanhoutte, D; Kanisicak, O; Prasad, V; Lin, SJ; Maillet, M; Molkentin, JD. Cathepsin S Contributes to the Pathogenesis of Muscular Dystrophy in Mice. The Journal of biological chemistry. 2016; 291:9920-9928.

Tjondrokoesoemo, A; Schips, T; Kanisicak, O; Sargent, MA; Molkentin, JD. Genetic overexpression of Serpina3n attenuates muscular dystrophy in mice. Human Molecular Genetics. 2016; 25:1192-1202.

van Berlo, JH; Molkentin, JD. Most of the Dust Has Settled cKit(+) Progenitor Cells Are an Irrelevant Source of Cardiac Myocytes In Vivo. Circulation Research. 2016; 118:17-19.

Brody, MJ; Schips, TG; Vanhoutte, D; Kanisicak, O; Karch, J; Maliken, BD; Blair, NS; Sargent, MA; Prasad, V; Molkentin, JD. Dissection of Thrombospondin-4 Domains Involved in Intracellular Adaptive Endoplasmic Reticulum Stress-Responsive Signaling. Molecular and Cellular Biology. 2016; 36:MCB.00607-15.

Schwanekamp, JA; Lorts, A; Vagnozzi, RJ; Vanhoutte, D; Molkentin, JD. Deletion of Periostin Protects Against Atherosclerosis in Mice by Altering Inflammation and Extracellular Matrix Remodeling. Arteriosclerosis, Thrombosis, and Vascular Biology. 2016; 36:60-68.