Molkentin Lab

Publications

Kuwabara, Y; York, AJ; Lin, SC; Sargent, MA; Grimes, KM; Pirruccello, JP; Molkentin, JD. A human FLII gene variant alters sarcomeric actin thin filament length and predisposes to cardiomyopathy. Proceedings of the National Academy of Sciences of USA. 2023; 120:e2213696120.

Florens, N; Kasam, RK; Rudman-Melnick, V; Lin, SC; Prasad, V; Molkentin, JD. Interleukin-33 Mediates Cardiomyopathy After Acute Kidney Injury by Signaling to Cardiomyocytes. Circulation. 2023; 147:746-758.

Boyer, JG; Huo, J; Han, S; Havens, JR; Prasad, V; Lin, BL; Kass, DA; Song, T; Sadayappan, S; Khairallah, RJ; et al. Depletion of skeletal muscle satellite cells attenuates pathology in muscular dystrophy. Nature Communications. 2022; 13:2940.

Vanhoutte, D; Schips, TG; Vo, A; Grimes, KM; Baldwin, TA; Brody, MJ; Accornero, F; Sargent, MA; Molkentin, JD. Thbs1 induces lethal cardiac atrophy through PERK-ATF4 regulated autophagy. Nature Communications. 2021; 12:3928.

Vagnozzi, RJ; Kasam, RK; Sargent, MA; Molkentin, JD. Cardiac Cell Therapy Fails to Rejuvenate the Chronically Scarred Rodent Heart. Circulation. 2021; 144:328-331.

Davis, G; York, AJ; Bacon, WC; Lin, SC; McNeal, MM; Yarawsky, AE; Maciag, JJ; Miller, JL C; Locker, KC S; Bailey, M; et al. Seroprevalence of SARS-CoV-2 infection in Cincinnati Ohio USA from August to December 2020. Editor, Kumar B. PloS one. 2021; 16:e0254667.

Huo, J; Lu, S; Kwong, JQ; Bround, MJ; Grimes, KM; Sargent, MA; Brown, ME; Davis, ME; Bers, DM; Molkentin, JD. MCUb Induction Protects the Heart From Postischemic Remodeling. Circulation Research. 2020; 127:379-390.

Vagnozzi, RJ; Sargent, MA; Molkentin, JD. Cardiac Cell Therapy Rejuvenates the Infarcted Rodent Heart via Direct Injection but Not by Vascular Infusion. Circulation. 2020; 141:1037-1039.

Vagnozzi, RJ; Maillet, M; Sargent, MA; Khalil, H; Johansen, AK Z; Schwanekamp, JA; York, AJ; Huang, V; Nahrendorf, M; Sadayappan, S; et al. An acute immune response underlies the benefit of cardiac stem cell therapy. Nature. 2020; 577:405-409.

Schips, TG; Vanhoutte, D; Vo, A; Correll, RN; Brody, MJ; Khalil, H; Karch, J; Tjondrokoesoemo, A; Sargent, MA; Maillet, M; et al. Thrombospondin-3 augments injury-induced cardiomyopathy by intracellular integrin inhibition and sarcolemmal instability. Nature Communications. 2019; 10:76.

Karch, J; Bround, MJ; Khalil, H; Sargent, MA; Latchman, N; Terada, N; Peixoto, PM; Molkentin, JD. Inhibition of mitochondrial permeability transition by deletion of the ANT family and CypD. Science Advances. 2019; 5:eaaw4597.

Bowers, SL K; Meng, Q; Kuwabara, Y; Huo, J; Minerath, R; York, AJ; Sargent, MA; Prasad, V; Saviola, AJ; Galindo, DC; et al. Col1a2-Deleted Mice Have Defective Type I Collagen and Secondary Reactive Cardiac Fibrosis with Altered Hypertrophic Dynamics. Cells. 2023; 12:2174.

Bround, MJ; Havens, JR; York, AJ; Sargent, MA; Karch, J; Molkentin, JD. ANT-dependent MPTP underlies necrotic myofiber death in muscular dystrophy. Science Advances. 2023; 9:eadi2767.

Kuwabara, Y; York, AJ; Lin, SC; Sargent, MA; Grimes, KM; Pirruccello, JP; Molkentin, JD. A human FLII gene variant alters sarcomeric actin thin filament length and predisposes to cardiomyopathy. Proceedings of the National Academy of Sciences of USA. 2023; 120:e2213696120.

Florens, N; Kasam, RK; Rudman-Melnick, V; Lin, SC; Prasad, V; Molkentin, JD. Interleukin-33 Mediates Cardiomyopathy After Acute Kidney Injury by Signaling to Cardiomyocytes. Circulation. 2023; 147:746-758.

Grimes, KM; Prasad, V; Huo, J; Kuwabara, Y; Vanhoutte, D; Baldwin, TA; Bowers, SL K; Johansen, AK Z; Sargent, MA; Lin, SC J; et al. Rpl3l gene deletion in mice reduces heart weight over time. Frontiers in Physiology. 2023; 14:1054169.

Yan, R; Cigliola, V; Oonk, KA; Petrover, Z; DeLuca, S; Wolfson, DW; Vekstein, A; Mendiola, MA; Devlin, G; Bishawi, M; et al. An enhancer-based gene-therapy strategy for spatiotemporal control of cargoes during tissue repair. Cell Stem Cell. 2023; 30:96-111.e6.

Wintzinger, M; Miz, K; York, A; Demonbreun, AR; Molkentin, JD; McNally, EM; Quattrocelli, M. Effects of Glucocorticoids in Murine Models of Duchenne and Limb-Girdle Muscular Dystrophy. Methods in molecular biology (Clifton, N.J.). 2023; 2587:467-478.

Boyer, JG; Huo, J; Han, S; Havens, JR; Prasad, V; Lin, BL; Kass, DA; Song, T; Sadayappan, S; Khairallah, RJ; et al. Depletion of skeletal muscle satellite cells attenuates pathology in muscular dystrophy. Nature Communications. 2022; 13:2940.

Li, Y; Li, C; Liu, Q; Wang, L; Bao, AX; Jung, JP; Dodlapati, S; Sun, J; Gao, P; Zhang, X; et al. Loss of Acta2 in cardiac fibroblasts does not prevent the myofibroblast differentiation or affect the cardiac repair after myocardial infarction. Journal of Molecular and Cellular Cardiology. 2022; 171:117-132.

Molkentin, JD; Leinwand, LA. Remembering Jeff Robbins: The Father of Cardiac Transgenesis. JACC: Basic to Translational Science. 2022; 7:1063-1065.

Zampese, E; Wokosin, DL; Gonzalez-Rodriguez, P; Guzman, JN; Tkatch, T; Kondapalli, J; Surmeier, WC; D’Alessandro, KB; De Stefani, D; Rizzuto, R; et al. Ca2+ channels couple spiking to mitochondrial metabolism in substantia nigra dopaminergic neurons. Science Advances. 2022; 8:eabp8701.

Prasad, V; Molkentin, JD. At the Brink of Human Therapy to Generate New Myocytes in the Adult Injured Heart. Circulation. 2022; 145:1356-1358.

Bowers, SL K; Meng, Q; Molkentin, JD. Fibroblasts orchestrate cellular crosstalk in the heart through the ECM. 2022; 1:312-321.

Vanhoutte, D; Schips, TG; Vo, A; Grimes, KM; Baldwin, TA; Brody, MJ; Accornero, F; Sargent, MA; Molkentin, JD. Thbs1 induces lethal cardiac atrophy through PERK-ATF4 regulated autophagy. Nature Communications. 2021; 12:3928.

Sun, F; Wang, G; Pradhan, A; Xu, K; Gomez-Arroyo, J; Zhang, Y; Kalin, GT; Deng, Z; Vagnozzi, RJ; He, H; et al. Nanoparticle Delivery of STAT3 Alleviates Pulmonary Hypertension in a Mouse Model of Alveolar Capillary Dysplasia. Circulation. 2021; 144:539-555.

Vagnozzi, RJ; Kasam, RK; Sargent, MA; Molkentin, JD. Cardiac Cell Therapy Fails to Rejuvenate the Chronically Scarred Rodent Heart. Circulation. 2021; 144:328-331.

Davis, G; York, AJ; Bacon, WC; Lin, SC; McNeal, MM; Yarawsky, AE; Maciag, JJ; Miller, JL C; Locker, KC S; Bailey, M; et al. Seroprevalence of SARS-CoV-2 infection in Cincinnati Ohio USA from August to December 2020. Editor, Kumar B. PloS one. 2021; 16:e0254667.

Fischesser, DM; Meyer, EC; Sargent, M; Molkentin, JD. Refined CLARITY-Based Tissue Clearing for Three-Dimensional Fibroblast Organization in Healthy and Injured Mouse Hearts. Jove-Journal of Visualized Experiments. 2021; 2021.

Vagnozzi, RJ; Molkentin, JD. Resident macrophages keep mitochondria running in the heart. Cell Research. 2020; 30:1057-1058.

Huo, J; Lu, S; Kwong, JQ; Bround, MJ; Grimes, KM; Sargent, MA; Brown, ME; Davis, ME; Bers, DM; Molkentin, JD. MCUb Induction Protects the Heart From Postischemic Remodeling. Circulation Research. 2020; 127:379-390.

Bround, MJ; Bers, DM; Molkentin, JD. A 20/20 view of ANT function in mitochondrial biology and necrotic cell death. Journal of Molecular and Cellular Cardiology. 2020; 144:A3-A13.

Vagnozzi, RJ; Sargent, MA; Molkentin, JD. Cardiac Cell Therapy Rejuvenates the Infarcted Rodent Heart via Direct Injection but Not by Vascular Infusion. Circulation. 2020; 141:1037-1039.

Vagnozzi, RJ; Maillet, M; Sargent, MA; Khalil, H; Johansen, AK Z; Schwanekamp, JA; York, AJ; Huang, V; Nahrendorf, M; Sadayappan, S; et al. An acute immune response underlies the benefit of cardiac stem cell therapy. Nature. 2020; 577:405-409.

Schips, TG; Vanhoutte, D; Vo, A; Correll, RN; Brody, MJ; Khalil, H; Karch, J; Tjondrokoesoemo, A; Sargent, MA; Maillet, M; et al. Thrombospondin-3 augments injury-induced cardiomyopathy by intracellular integrin inhibition and sarcolemmal instability. Nature Communications. 2019; 10:76.

Correll, RN; Grimes, KM; Prasad, V; Lynch, JM; Khalil, H; Molkentin, JD. Overlapping and differential functions of ATF6α versus ATF6β in the mouse heart. Scientific Reports. 2019; 9:2059.

Vagnozzi, RJ; Johansen, AK Z; Molkentin, JD. CARdiac Immunotherapy: T Cells Engineered to Treat the Fibrotic Heart. Molecular Therapy. 2019; 27:1869-1871.

Johansen, AK Z; Molkentin, JD. Hippo signaling does it again: arbitrating cardiac fibroblast identity and activation. Genes and Development. 2019; 33:1457-1459.

Karch, J; Bround, MJ; Khalil, H; Sargent, MA; Latchman, N; Terada, N; Peixoto, PM; Molkentin, JD. Inhibition of mitochondrial permeability transition by deletion of the ANT family and CypD. Science Advances. 2019; 5:eaaw4597.

Khalil, H; Kanisicak, O; Vagnozzi, RJ; Johansen, AK; Maliken, BD; Prasad, V; Boyer, JG; Brody, MJ; Schips, T; Kilian, KK; et al. Cell-specific ablation of Hsp47 defines the collagen-producing cells in the injured heart. JCI insight. 2019; 4:e128722.

Brody, MJ; Vanhoutte, D; Bakshi, CV; Liu, R; Correll, RN; Sargent, MA; Molkentin, JD. Disruption of valosin-containing protein activity causes cardiomyopathy and reveals pleiotropic functions in cardiac homeostasis. The Journal of biological chemistry. 2019; 294:8918-8929.

Boyer, JG; Prasad, V; Song, T; Lee, D; Fu, X; Grimes, KM; Sargent, MA; Sadayappan, S; Molkentin, JD. ERK1/2 signaling induces skeletal muscle slow fiber-type switching and reduces muscular dystrophy disease severity. JCI insight. 2019; 5:e127356.