Molkentin Lab
Publications

Publications

Johansen, AKZ; Kasam, RK; Vagnozzi, RJ; Lin, S-CJ; Gomez-Arroyo, J; Shittu, A; Bowers, SLK; Kuwabara, Y; Grimes, KM; Warrick, K; Sargent, MA; Baldwin, TA; Quaggin, SE; Barski, A; Molkentin, JD. Transcription Factor 21 Regulates Cardiac Myofibroblast Formation and Fibrosis. Circulation Research. 2025; 136(1):44-58.

Vanhoutte, D; Schips, TG; Minerath, RA; Huo, J; Kavuri, NSS; Prasad, V; Lin, S-C; Bround, MJ; Sargent, MA; Adams, CM; Molkentin, JD. Thbs1 regulates skeletal muscle mass in a TGFβ-Smad2/3-ATF4-dependent manner. Cell reports. 2024; 43(5):114149.

Bround, MJ; Abay, E; Huo, J; Havens, JR; York, AJ; Bers, DM; Molkentin, JD. MCU-independent Ca2+ uptake mediates mitochondrial Ca2+ overload and necrotic cell death in a mouse model of Duchenne muscular dystrophy. Scientific Reports. 2024; 14(1):6751.

Huo, J; Prasad, V; Grimes, KM; Vanhoutte, D; Blair, NS; Lin, S-C; Bround, MJ; Bers, DM; Molkentin, JD. MCUb is an inducible regulator of calcium-dependent mitochondrial metabolism and substrate utilization in muscle. Cell reports. 2023; 42(11):113465.

Bround, MJ; Havens, JR; York, AJ; Sargent, MA; Karch, J; Molkentin, JD. ANT-dependent MPTP underlies necrotic myofiber death in muscular dystrophy. Science Advances. 2023; 9(34):eadi2767.

Kuwabara, Y; York, AJ; Lin, S-C; Sargent, MA; Grimes, KM; Pirruccello, JP; Molkentin, JD. A human FLII gene variant alters sarcomeric actin thin filament length and predisposes to cardiomyopathy. Proceedings of the National Academy of Sciences of the United States of America. 2023; 120(19):e2213696120.

Florens, N; Kasam, RK; Rudman-Melnick, V; Lin, S-C; Prasad, V; Molkentin, JD. Interleukin-33 Mediates Cardiomyopathy After Acute Kidney Injury by Signaling to Cardiomyocytes. Circulation. 2023; 147(9):746-758.

Boyer, JG; Huo, J; Han, S; Havens, JR; Prasad, V; Lin, BL; Kass, DA; Song, T; Sadayappan, S; Khairallah, RJ; Ward, CW; Molkentin, JD. Depletion of skeletal muscle satellite cells attenuates pathology in muscular dystrophy. Nature Communications. 2022; 13(1):2940.

Vagnozzi, RJ; Kasam, RK; Sargent, MA; Molkentin, JD. Cardiac Cell Therapy Fails to Rejuvenate the Chronically Scarred Rodent Heart. Circulation. 2021; 144(4):328-331.

Vanhoutte, D; Schips, TG; Vo, A; Grimes, KM; Baldwin, TA; Brody, MJ; Accornero, F; Sargent, MA; Molkentin, JD. Thbs1 induces lethal cardiac atrophy through PERK-ATF4 regulated autophagy. Nature Communications. 2021; 12(1):3928.

Fischesser, DM; Meyer, EC; Sargent, M; Molkentin, JD. Refined CLARITY-Based Tissue Clearing for Three-Dimensional Fibroblast Organization in Healthy and Injured Mouse Hearts. Journal of Visualized Experiments. 2021; 171.

Davis, G; York, AJ; Bacon, WC; Lin, S-C; Mcneal, MM; Yarawsky, AE; Maciag, JJ; Miller, JLC; Locker, KCS; Bailey, M; Jordan, MB; Herr, AB; Hildeman, DA; Molkentin, JD. Seroprevalence of SARS-CoV-2 infection in Cincinnati Ohio USA from August to December 2020. PLoS ONE. 2021; 16(7):e0254667.

Huo, J; Lu, S; Kwong, JQ; Bround, MJ; Grimes, KM; Sargent, MA; Brown, ME; Davis, ME; Bers, DM; Molkentin, JD. MCUb Induction Protects the Heart From Postischemic Remodeling. Circulation Research. 2020; 127(3):379-390.

Vagnozzi, RJ; Sargent, MA; Molkentin, JD. Cardiac Cell Therapy Rejuvenates the Infarcted Rodent Heart via Direct Injection but Not by Vascular Infusion. Circulation. 2020; 141(12):1037-1039.

Vagnozzi, RJ; Maillet, M; Sargent, MA; Khalil, H; Johansen, AKZ; Schwanekamp, JA; York, AJ; Huang, V; Nahrendorf, M; Sadayappan, S; Molkentin, JD. An acute immune response underlies the benefit of cardiac stem cell therapy. Nature. 2020; 577(7790):405-409.

Khalil, H; Kanisicak, O; Vagnozzi, RJ; Johansen, AK; Maliken, BD; Prasad, V; Boyer, JG; Brody, MJ; Schips, T; Kilian, KK; Correll, RN; Kawasaki, K; Nagata, K; Molkentin, JD. Cell-specific ablation of Hsp47 defines the collagen-producing cells in the injured heart. JCI Insight. 2019; 4(15):e128722.

Karch, J; Bround, MJ; Khalil, H; Sargent, MA; Latchman, N; Terada, N; Peixoto, PM; Molkentin, JD. Inhibition of mitochondrial permeability transition by deletion of the ANT family and CypD. Science Advances. 2019; 5(8):eaaw4597.

Schips, TG; Vanhoutte, D; Vo, A; Correll, RN; Brody, MJ; Khalil, H; Karch, J; Tjondrokoesoemo, A; Sargent, MA; Maillet, M; Ross, RS; Molkentin, JD. Thrombospondin-3 augments injury-induced cardiomyopathy by intracellular integrin inhibition and sarcolemmal instability. Nature Communications. 2019; 10(1):76.

Warrick, KA; Molkentin, JD; Pasare, C. Immune checkpoint blockade induces de novo CD8 T cell priming and innate inflammation leading to myocarditis 3714. Journal of Immunology. 2025; 214(Supplement_1).

Brito-Estrada, O; Kuwabara, Y; Gibson, AM; Hassel, KR; Kamradt, ML; Verry, JP; Blair, NS; Bround, MJ; Huo, J; Molkentin, JD; Makarewich, CA. DWORF Gene Therapy Improves Cardiac Calcium Handling and Mitochondrial Function. Circulation Research. 2025; 137(8):1072-1088.

Mia, S; Siokatas, G; Sidiropoulou, R; Hoffman, M; Fragkiadakis, K; Markopoulou, E; Elesawy, MI; Roy, R; Blair, S; Kuwabara, Y; Schilling, JD; Molkentin, JD; Marketou, M; Drosatos, K. Hepato-cardiac interorgan communication controls cardiac hypertrophy via combined endocrine-autocrine FGF21 signaling. Cell Reports Medicine. 2025; 6(6):102125.

Johansen, AKZ; Kasam, RK; Vagnozzi, RJ; Lin, S-CJ; Gomez-Arroyo, J; Shittu, A; Bowers, SLK; Kuwabara, Y; Grimes, KM; Warrick, K; Sargent, MA; Baldwin, TA; Quaggin, SE; Barski, A; Molkentin, JD. Transcription Factor 21 Regulates Cardiac Myofibroblast Formation and Fibrosis. Circulation Research. 2025; 136(1):44-58.

Patel, P; Mendoza, A; Ramirez, D; Robichaux, D; Molkentin, JD; Karch, J. The adenine nucleotide translocase family underlies cardiac ischemia-reperfusion injury through the mitochondrial permeability pore independently of cyclophilin D. Science Advances. 2024; 10(50):eadp7444.

Huo, J; Molkentin, JD. MICU1 and MICU2, two peas in a pod or entirely different fruits? Cell Calcium. 2024; 124:102959.

Tang, X; Wei, W; Sun, Y; Weaver, TE; Nakayasu, ES; Clair, G; Snowball, JM; Na, C-L; Apsley, KS; Martin, EP; Molkentin, JD; Gower, WA; Lin, X; Whitsett, JA. EMC3 regulates trafficking and pulmonary toxicity of the SFTPCI73T mutation associated with interstitial lung disease. Journal of Clinical Investigation. 2024; 134(23).

Huo, J; Molkentin, JD. MCU genetically altered mice suggest how mitochondrial Ca2+ regulates metabolism. Trends in Endocrinology and Metabolism. 2024; 35(10):918-928.

Meng, Q; Yang, B; Qiao, Y; Wu, Y; Chen, J; Lin, X; Molkentin, JD. Genetic and Pharmacologic Inhibition of JAK1/2 Antagonizes Cardiac Fibrosis. Circulation. 2024; 150(11):899-901.

Vanhoutte, D; Schips, TG; Minerath, RA; Huo, J; Kavuri, NSS; Prasad, V; Lin, S-C; Bround, MJ; Sargent, MA; Adams, CM; Molkentin, JD. Thbs1 regulates skeletal muscle mass in a TGFβ-Smad2/3-ATF4-dependent manner. Cell reports. 2024; 43(5):114149.

Bround, MJ; Abay, E; Huo, J; Havens, JR; York, AJ; Bers, DM; Molkentin, JD. MCU-independent Ca2+ uptake mediates mitochondrial Ca2+ overload and necrotic cell death in a mouse model of Duchenne muscular dystrophy. Scientific Reports. 2024; 14(1):6751.

Grimes, KM; Maillet, M; Swoboda, CO; Bowers, SLK; Millay, DP; Molkentin, JD. MEK1-ERK1/2 signaling regulates the cardiomyocyte non-sarcomeric actin cytoskeletal network. American Journal of Physiology. Heart and Circulatory Physiology. 2024; 326(1):H180-H189.

Baldwin, TA; Teuber, JP; Kuwabara, Y; Subramani, A; Lin, S-CJ; Kanisicak, O; Vagnozzi, RJ; Zhang, W; Brody, MJ; Molkentin, JD. Palmitoylation-dependent regulation of cardiomyocyte Rac1 signaling activity and minor effects on cardiac hypertrophy. Journal of Biological Chemistry. 2023; 299(12):105426.

Huo, J; Prasad, V; Grimes, KM; Vanhoutte, D; Blair, NS; Lin, S-C; Bround, MJ; Bers, DM; Molkentin, JD. MCUb is an inducible regulator of calcium-dependent mitochondrial metabolism and substrate utilization in muscle. Cell reports. 2023; 42(11):113465.

Bowers, SLK; Meng, Q; Kuwabara, Y; Huo, J; Minerath, R; York, AJ; Sargent, MA; Prasad, V; Saviola, AJ; Galindo, DC; Hansen, KC; Vagnozzi, RJ; Yutzey, KE; Molkentin, JD. Col1a2-Deleted Mice Have Defective Type I Collagen and Secondary Reactive Cardiac Fibrosis with Altered Hypertrophic Dynamics. Cells. 2023; 12(17).

Bround, MJ; Havens, JR; York, AJ; Sargent, MA; Karch, J; Molkentin, JD. ANT-dependent MPTP underlies necrotic myofiber death in muscular dystrophy. Science Advances. 2023; 9(34):eadi2767.

Kuwabara, Y; York, AJ; Lin, S-C; Sargent, MA; Grimes, KM; Pirruccello, JP; Molkentin, JD. A human FLII gene variant alters sarcomeric actin thin filament length and predisposes to cardiomyopathy. Proceedings of the National Academy of Sciences of the United States of America. 2023; 120(19):e2213696120.

Florens, N; Kasam, RK; Rudman-Melnick, V; Lin, S-C; Prasad, V; Molkentin, JD. Interleukin-33 Mediates Cardiomyopathy After Acute Kidney Injury by Signaling to Cardiomyocytes. Circulation. 2023; 147(9):746-758.

Yan, R; Cigliola, V; Oonk, KA; Petrover, Z; Deluca, S; Wolfson, DW; Vekstein, A; Mendiola, MA; Devlin, G; Bishawi, M; Molkentin, JD; Bursac, N; Black, BL; Poss, KD. An enhancer-based gene-therapy strategy for spatiotemporal control of cargoes during tissue repair. Cell Stem Cell. 2023; 30(1):96-111.e6.

Wintzinger, M; Miz, K; York, A; Demonbreun, AR; Molkentin, JD; Mcnally, EM; Quattrocelli, M. Effects of Glucocorticoids in Murine Models of Duchenne and Limb-Girdle Muscular Dystrophy. Methods in Molecular Biology. 2023; 2587:467-478.

Grimes, KM; Prasad, V; Huo, J; Kuwabara, Y; Vanhoutte, D; Baldwin, TA; Bowers, SLK; Johansen, AKZ; Sargent, MA; Lin, S-CJ; Molkentin, JD. Rpl3l gene deletion in mice reduces heart weight over time. Frontiers in Physiology. 2023; 14:1054169.

Li, Y; Li, C; Liu, Q; Wang, L; Bao, AX; Jung, JP; Dodlapati, S; Sun, J; Gao, P; Zhang, X; Francis, J; Molkentin, JD; Fu, X. Loss of Acta2 in cardiac fibroblasts does not prevent the myofibroblast differentiation or affect the cardiac repair after myocardial infarction. Journal of Molecular and Cellular Cardiology. 2022; 171:117-132.

Molkentin, JD; Leinwand, LA. Remembering Jeff Robbins: The Father of Cardiac Transgenesis. JACC: Basic to Translational Science. 2022; 7(10):1063-1065.

Zampese, E; Wokosin, DL; Gonzalez-Rodriguez, P; Guzman, JN; Tkatch, T; Kondapalli, J; Surmeier, WC; D'alessandro, KB; De Stefani, D; Rizzuto, R; Iino, M; Molkentin, JD; Chandel, NS; Schumacker, PT; Surmeier, DJ. Ca2+ channels couple spiking to mitochondrial metabolism in substantia nigra dopaminergic neurons. Science Advances. 2022; 8(39):eabp8701.

Boyer, JG; Huo, J; Han, S; Havens, JR; Prasad, V; Lin, BL; Kass, DA; Song, T; Sadayappan, S; Khairallah, RJ; Ward, CW; Molkentin, JD. Depletion of skeletal muscle satellite cells attenuates pathology in muscular dystrophy. Nature Communications. 2022; 13(1):2940.

Prasad, V; Molkentin, JD. At the Brink of Human Therapy to Generate New Myocytes in the Adult Injured Heart. Circulation. 2022; 145(17):1356-1358.

Bowers, SLK; Meng, Q; Molkentin, JD. Fibroblasts orchestrate cellular crosstalk in the heart through the ECM. Nature Cardiovascular Research. 2022; 1(4):312-321.

Sun, F; Wang, G; Pradhan, A; Xu, K; Gomez-Arroyo, J; Zhang, Y; Kalin, GT; Deng, Z; Vagnozzi, RJ; He, H; Woods, JC; Kalin, TV; Molkentin, JD; Kalinichenko, VV. Nanoparticle Delivery of STAT3 Alleviates Pulmonary Hypertension in a Mouse Model of Alveolar Capillary Dysplasia. Circulation. 2021; 144(7):539-555.

Vagnozzi, RJ; Kasam, RK; Sargent, MA; Molkentin, JD. Cardiac Cell Therapy Fails to Rejuvenate the Chronically Scarred Rodent Heart. Circulation. 2021; 144(4):328-331.

Vanhoutte, D; Schips, TG; Vo, A; Grimes, KM; Baldwin, TA; Brody, MJ; Accornero, F; Sargent, MA; Molkentin, JD. Thbs1 induces lethal cardiac atrophy through PERK-ATF4 regulated autophagy. Nature Communications. 2021; 12(1):3928.

Fischesser, DM; Meyer, EC; Sargent, M; Molkentin, JD. Refined CLARITY-Based Tissue Clearing for Three-Dimensional Fibroblast Organization in Healthy and Injured Mouse Hearts. Journal of Visualized Experiments. 2021; 171.

Fischesser, DM; Meyer, EC; Sargent, M; Molkentin, JD. Refined CLARITY-Based Tissue Clearing for Three-Dimensional Fibroblast Organization in Healthy and Injured Mouse Hearts. Journal of Visualized Experiments. 2021; 171.

Davis, G; York, AJ; Bacon, WC; Lin, S-C; Mcneal, MM; Yarawsky, AE; Maciag, JJ; Miller, JLC; Locker, KCS; Bailey, M; Jordan, MB; Herr, AB; Hildeman, DA; Molkentin, JD. Seroprevalence of SARS-CoV-2 infection in Cincinnati Ohio USA from August to December 2020. PLoS ONE. 2021; 16(7):e0254667.

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