Steimle Lab

Publications

Xie, B; Steimle, J; Deshmukh, V; Liu, L; Tsai, C-R; Heallen, TR; Paltzer, W; Morikawa, Y; Meng, F; Wang, J; Martin, JF. TEAD-independent mechanisms of YAP function in cardiomyocyte cell cycle reentry. Life Science Alliance. 2026; 9(4).

Tsai, C-R; Liu, L; Zhao, Y; Kim, JH; Czarnewski, P; Li, RG; Meng, F; Zheng, M; Steimle, J; Zhao, X; Wang, J; Samee, MAH; Li, X; Martin, JF. YAP-Induced Glycolysis Drives Fibroinflammation and Disrupts Fibroblast Fidelity. Circulation Research. 2025; 137(12):1443-1458.

Van Der Maarel, LE; Mungroo, MR; Mulleners, OJ; Rivaud, MR; Verkerk, AO; Van Duijvenboden, K; Tiel Groenestege, FHT; Steimle, JD; Fokkert, L; De Gier-De Vries, C; Jensen, B; Boink, GJJ; Devalla, HD; Christoffels, VM. PITX2 dosage-dependent changes in pacemaker cell state underlie sinus node dysfunction and atrial arrhythmias. Nature Communications. 2025; 16(1):11197.

Meng, F; Steimle, JD; Straight, E; Li, RG; Morikawa, Y; Iqbal, Z; Xie, B; Wang, J; Paltzer, WG; Zhao, Y; Karch, JM; Pautler, RG; Li, X; Martin, JF. Gene therapy CM-YAPon protects the mouse heart from myocardial infarction. Nature Cardiovascular Research. 2025; 4(12):1616-1626.

Meng, F; Kim, JH; Tsai, C-R; Steimle, JD; Wang, J; Shi, Y; Li, RG; Xie, B; Deshmukh, V; Liu, S; Li, X; Martin, JF. SARS-CoV-2 NSP13 interacts with TEAD to suppress Hippo-YAP signaling. eLife. 2025; 13.

Meng, F; Kim, JH; Tsai, C-R; Steimle, JD; Wang, J; Shi, Y; Li, RG; Xie, B; Deshmukh, V; Liu, S; Li, X; Martin, JF. SARS-CoV-2 NSP13 interacts with TEAD to suppress Hippo-YAP signaling. eLife. 2025; 13.

Liu, S; Deshmukh, V; Meng, F; Wang, Y; Morikawa, Y; Steimle, JD; Li, RG; Wang, J; Martin, JF. Microtubules Sequester Acetylated YAP in the Cytoplasm and Inhibit Heart Regeneration. Circulation. 2025; 151(1):59-75.

Steimle, JD; Zhao, Y; Meng, F; Taylor, ME; Turaga, D; Adachi, I; Li, X; Martin, JF. Single-nuclei transcriptomics reveals TBX5-dependent targets in a patient with Holt-Oram syndrome. Journal of Clinical Investigation. 2024; 135(2).

Broman, MT; Nadadur, RD; Perez-Cervantes, C; Burnicka-Turek, O; Lazarevic, S; Gams, A; Laforest, B; Steimle, JD; Iddir, S; Wang, Z; Weber, CR; Mcnally, EM; Svensson, EC; Moskowitz, IP. A Genomic Link From Heart Failure to Atrial Fibrillation Risk: FOG2 Modulates a TBX5/GATA4-Dependent Atrial Gene Regulatory Network. Circulation. 2024; 149(15):1205-1230.

Long, H; Steimle, JD; Grisanti Canozo, FJ; Kim, JH; Li, X; Morikawa, Y; Park, M; Turaga, D; Adachi, I; Wythe, JD; Samee, MAH; Martin, JF. Endothelial cells adopt a pro-reparative immune responsive signature during cardiac injury. Life Science Alliance. 2024; 7(2).

Steimle, JD; Martin, JF. Sweet and sour story of maternal diabetes and birth defects. Nature Cardiovascular Research. 2023; 2(12):1107-1108.

Liu, S; Deshmukh, V; Meng, F; Wang, Y; Morikawa, Y; Steimle, J; Li, RG; Wang, J; Martin, JF. Abstract P2006: Cardiac Cytoskeleton Sequesters Acetylated Yap In The Cytoplasm To Inhibit Cardiomyocyte Renewal After Myocardial Infarction. Circulation Research. 2023; 133(Suppl_1).

Steimle, JD; Kim, C; Rowton, M; Nadadur, RD; Wang, Z; Stocker, M; Hoffmann, AD; Hanson, E; Kweon, J; Sinha, T; Choi, K; Black, BL; Cunningham, JM; Moskowitz, IP; Ikegami, K. ETV2 primes hematoendothelial gene enhancers prior to hematoendothelial fate commitment. Cell reports. 2023; 42(6):112665.

Bersell, KR; Yang, T; Mosley, JD; Glazer, AM; Hale, AT; Kryshtal, DO; Kim, K; Steimle, JD; Brown, JD; Salem, J-E; York, JD; Wang, TJ; Knollmann, BC; Roden, DM. Transcriptional Dysregulation Underlies Both Monogenic Arrhythmia Syndrome and Common Modifiers of Cardiac Repolarization. Circulation. 2023; 147(10):824-840.

Steimle, JD; Martin, JF. Regrowing the heart, one TREE at a time. Cell Stem Cell. 2023; 30(1):1-2.

Rowton, M; Perez-Cervantes, C; Hur, S; Jacobs-Li, J; Lu, E; Deng, N; Guzzetta, A; Hoffmann, AD; Stocker, M; Steimle, JD; Basu, A; Ikegami, K; Pott, S; Moskowitz, IP. Hedgehog signaling activates a mammalian heterochronic gene regulatory network controlling differentiation timing across lineages. Developmental Cell. 2022; 57(18):2181-2203.e9.

Martínez Traverso, IM; Steimle, JD; Zhao, X; Wang, J; Martin, JF. LATS1/2 control TGFB-directed epithelial-to-mesenchymal transition in the murine dorsal cranial neuroepithelium through YAP regulation. Development. 2022; 149(18).

Steimle, JD; Grisanti Canozo, FJ; Park, M; Kadow, ZA; Samee, MAH; Martin, JF. Decoding the PITX2-controlled genetic network in atrial fibrillation. JCI Insight. 2022; 7(11).