Yutzey Lab

Kim, AJ; Xu, N; Umeyama, K; Hulin, A; Ponny, SR; Vagnozzi, RJ; Green, EA; Hanson, P; McManus, BM; Nagashima, H; et al. Deficiency of Circulating Monocytes Ameliorates the Progression of Myxomatous Valve Degeneration in Marfan Syndrome. Circulation. 2020; 141:132-146.

Agnew, EJ; Velayutham, N; Ortiz, GM; Alfieri, CM; Hortells, L; Moore, V; Riggs, KW; Baker, RS; Gibson, AM; Ponny, SR; et al. Scar Formation with Decreased Cardiac Function Following Ischemia/Reperfusion Injury in 1 Month Old Swine. Journal of Cardiovascular Development and Disease. 2019; 7.

Gomez-Stallons, MV; Tretter, JT; Hassel, K; Gonzalez-Ramos, O; Amofa, D; Ollberding, NJ; Mazur, W; Choo, JK; Smith, JM; Kereiakes, DJ; et al. Calcification and extracellular matrix dysregulation in human postmortem and surgical aortic valves. Heart. 2019; 105:1616-1621.

Velayutham, N; Agnew, EJ; Yutzey, KE. Postnatal Cardiac Development and Regenerative Potential in Large Mammals. Pediatric Cardiology. 2019; 40:1345-1358.

Hortells, L; Johansen, AK Z; Yutzey, KE. Cardiac Fibroblasts and the Extracellular Matrix in Regenerative and Nonregenerative Hearts. Journal of Cardiovascular Development and Disease. 2019; 6.

Hulin, A; Hortells, L; Gomez-Stallons, MV; O'Donnell, A; Chetal, K; Adam, M; Lancellotti, P; Oury, C; Potter, SS; Salomonis, N; et al. Maturation of heart valve cell populations during postnatal remodeling. Development (Cambridge). 2019; 146.

Kim, AJ; Alfieri, CM; Yutzey, KE. Endothelial Cell Lineage Analysis Does Not Provide Evidence for EMT in Adult Valve Homeostasis and Disease. Anatomical Record - Part A Discoveries in Molecular, Cellular, and Evolutionary Biology. 2019; 302:125-135.

Hulin, A; Anstine, LJ; Kim, AJ; Potter, SJ; DeFalco, T; Lincoln, J; Yutzey, KE. Macrophage Transitions in Heart Valve Development and Myxomatous Valve Disease. Arteriosclerosis, Thrombosis, and Vascular Biology. 2018; 38:636-644.

Xiang, F; Fang, M; Yutzey, KE. Loss of β-catenin in resident cardiac fibroblasts attenuates fibrosis induced by pressure overload in mice. Nature Communications. 2017; 8.

Hulin, A; Moore, V; James, JM; Yutzey, KE. Loss of Axin2 results in impaired heart valve maturation and subsequent myxomatous valve disease. Cardiovascular Research. 2017; 113:40-51.

Gomez-Stallons, MV; Wirrig-Schwendeman, EE; Hassel, KR; Conway, SJ; Yutzey, KE. Bone Morphogenetic Protein Signaling Is Required for Aortic Valve Calcification. Arteriosclerosis, Thrombosis, and Vascular Biology. 2016; 36:1398-1405.

Xiang, F; Guo, M; Yutzey, KE. Overexpression of Tbx20 in Adult Cardiomyocytes Promotes Proliferation and Improves Cardiac Function After Myocardial Infarction. Circulation. 2016; 133:1081-1092.

Fang, M; Alfieri, CM; Hulin, A; Conway, SJ; Yutzey, KE. Loss of β-catenin promotes chondrogenic differentiation of aortic valve interstitial cells. Arteriosclerosis, Thrombosis, and Vascular Biology. 2014; 34:2601-2608.

Braitsch, CM; Kanisicak, O; van Berlo, JH; Molkentin, JD; Yutzey, KE. Differential expression of embryonic epicardial progenitor markers and localization of cardiac fibrosis in adult ischemic injury and hypertensive heart disease. Journal of Molecular and Cellular Cardiology. 2013; 65:108-119.

Padula, SL; Velayutham, N; Yutzey, KE. Transcriptional Regulation of Postnatal Cardiomyocyte Maturation and Regeneration. International Journal of Molecular Sciences. 2021; 22.

Kim, AJ; Xu, N; Yutzey, KE. Macrophage lineages in heart valve development and disease. Cardiovascular Research. 2021; 117:663-673.

Velayutham, N; Alfieri, CM; Agnew, EJ; Riggs, KW; Baker, RS; Ponny, SR; Zafar, F; Yutzey, KE. Cardiomyocyte cell cycling, maturation, and growth by multinucleation in postnatal swine. Journal of Molecular and Cellular Cardiology. 2020; 146:95-108.

Hortells, L; Valiente-Alandi, I; Thomas, ZM; Agnew, EJ; Schnell, DJ; York, AJ; Vagnozzi, RJ; Meyer, EC; Molkentin, JD; Yutzey, KE. A specialized population of Periostin-expressing cardiac fibroblasts contributes to postnatal cardiomyocyte maturation and innervation. Proceedings of the National Academy of Sciences of the United States of America. 2020; 117:21469-21479.

O'Donnell, A; Yutzey, KE. Mechanisms of heart valve development and disease. Development (Cambridge). 2020; 147.

Gomez-Stallons, MV; Hassel, K; Yutzey, KE. Developmental Pathways and Aortic Valve Calcification. Cardiovascular Calcification and Bone Mineralization. 2020.

O'Donnell, A; Yutzey, KE. To EndoMT or Not to EndoMT: Zebrafish Heart Valve Development. Circulation Research. 2020; 126:985-987.

Xu, N; Gulick, J; Osinska, H; Yu, Y; McLendon, PM; Shay-Winkler, K; Robbins, J; Yutzey, KE. Ube2v1 Positively Regulates Protein Aggregation by Modulating Ubiquitin Proteasome System Performance Partially Through K63 Ubiquitination. Circulation Research. 2020; 126:907-922.

Yutzey, KE. Cytokinesis, Beta-Blockers, and Congenital Heart Disease. New England Journal of Medicine. 2020; 382:291-293.

Kim, AJ; Xu, N; Umeyama, K; Hulin, A; Ponny, SR; Vagnozzi, RJ; Green, EA; Hanson, P; McManus, BM; Nagashima, H; et al. Deficiency of Circulating Monocytes Ameliorates the Progression of Myxomatous Valve Degeneration in Marfan Syndrome. Circulation. 2020; 141:132-146.

Agnew, EJ; Velayutham, N; Ortiz, GM; Alfieri, CM; Hortells, L; Moore, V; Riggs, KW; Baker, RS; Gibson, AM; Ponny, SR; et al. Scar Formation with Decreased Cardiac Function Following Ischemia/Reperfusion Injury in 1 Month Old Swine. Journal of Cardiovascular Development and Disease. 2019; 7.

Gomez-Stallons, MV; Tretter, JT; Hassel, K; Gonzalez-Ramos, O; Amofa, D; Ollberding, NJ; Mazur, W; Choo, JK; Smith, JM; Kereiakes, DJ; et al. Calcification and extracellular matrix dysregulation in human postmortem and surgical aortic valves. Heart. 2019; 105:1616-1621.

Velayutham, N; Agnew, EJ; Yutzey, KE. Postnatal Cardiac Development and Regenerative Potential in Large Mammals. Pediatric Cardiology. 2019; 40:1345-1358.

Hortells, L; Johansen, AK Z; Yutzey, KE. Cardiac Fibroblasts and the Extracellular Matrix in Regenerative and Nonregenerative Hearts. Journal of Cardiovascular Development and Disease. 2019; 6.

Hortells, L; Valiente, I; Velayutham, N; Yutzey, KE. Abstract 521: Cardiac Fibroblasts are Activated During Postnatal Extracellular Matrix Remodeling. Circulation Research. 2019; 125.

Velayutham, N; Alfieri, CM; Agnew, EJ; Riggs, KW; Baker, RS; Zafar, F; Yutzey, KE. Abstract 423: Cardiomyocyte Maturation and Multinucleation in Postnatal Swine. Circulation Research. 2019; 125.

Agnew, EJ; Velayutham, N; Moore, V; Alsaied, T; Baker, RS; Riggs, KW; Zafar, F; Yutzey, KE. Abstract 131: Cardiomyocyte Renewal and Cardiac Outcomes Following Injury in Young Swine. Circulation Research. 2019; 125.

Hulin, A; Hortells, L; Gomez-Stallons, MV; O'Donnell, A; Chetal, K; Adam, M; Lancellotti, P; Oury, C; Potter, SS; Salomonis, N; et al. Maturation of heart valve cell populations during postnatal remodeling. Development (Cambridge). 2019; 146.

Kim, AJ; Alfieri, CM; Yutzey, KE. Endothelial Cell Lineage Analysis Does Not Provide Evidence for EMT in Adult Valve Homeostasis and Disease. Anatomical Record - Part A Discoveries in Molecular, Cellular, and Evolutionary Biology. 2019; 302:125-135.

Ustiyan, V; Bolte, C; Zhang, Y; Han, L; Xu, Y; Yutzey, KE; Zorn, AM; Kalin, TV; Shannon, JM; Kalinichenko, VV. FOXF1 transcription factor promotes lung morphogenesis by inducing cellular proliferation in fetal lung mesenchyme. Developmental Biology. 2018; 443:50-63.

Hulin, A; Anstine, LJ; Kim, AJ; Potter, SJ; DeFalco, T; Lincoln, J; Yutzey, KE. Macrophage Transitions in Heart Valve Development and Myxomatous Valve Disease. Arteriosclerosis, Thrombosis, and Vascular Biology. 2018; 38:636-644.

Amofa, D; Hulin, A; Nakada, Y; Sadek, HA; Yutzey, KE. Hypoxia promotes primitive glycosaminoglycan-rich extracellular matrix composition in developing heart valves. American Journal of Physiology - Heart and Circulatory Physiology. 2017; 313:H1143-H1154.

Xiang, F; Fang, M; Yutzey, KE. Loss of β-catenin in resident cardiac fibroblasts attenuates fibrosis induced by pressure overload in mice. Nature Communications. 2017; 8.

Wang, Y; Wu, B; Farrar, E; Lui, W; Lu, P; Zhang, D; Alfieri, CM; Mao, K; Chu, M; Yang, D; et al. Notch-Tnf signalling is required for development and homeostasis of arterial valves. European Heart Journal. 2017; 38:675-686.

Yutzey, KE. Cardiomyocyte Proliferation: Teaching an Old Dogma New Tricks. Circulation Research. 2017; 120:627-629.

Wu, B; Wang, Y; Xiao, F; Butcher, JT; Yutzey, KE; Zhou, B. Developmental Mechanisms of Aortic Valve Malformation and Disease. Annual Review of Physiology. 2017; 79:21-41.

Hulin, A; Moore, V; James, JM; Yutzey, KE. Loss of Axin2 results in impaired heart valve maturation and subsequent myxomatous valve disease. Cardiovascular Research. 2017; 113:40-51.