Vorhees / Williams Lab

Publications

Vorhees, CV; Williams, MT. Cincinnati water maze: A review of the development, methods, and evidence as a test of egocentric learning and memory. Neurotoxicology and Teratology. 2016; 57:1-19.

Williams, MT; Braun, AA; Amos-Kroohs, RM; II, MJ P; Lindquist, DM; Mangano, FT; Vorhees, CV; Yuan, W. Kaolin-induced ventriculomegaly at weaning produces long-term learning, memory, and motor deficits in rats. International Journal of Developmental Neuroscience. 2014; 35:7-15.

Braun, AA; Graham, DL; Schaefer, TL; Vorhees, CV; Williams, MT. Dorsal striatal dopamine depletion impairs both allocentric and egocentric navigation in rats. Neurobiology of Learning and Memory. 2012; 97:402-408.

Grace, CE; Schaefer, TL; Gudelsky, GA; Williams, MT; Vorhees, CV. Neonatal methamphetamine-induced corticosterone release in rats is inhibited by adrenal autotransplantation without altering the effect of the drug on hippocampal serotonin. Neurotoxicology and Teratology. 2010; 32:356-361.

Williams, MT; Schaefer, TL; Furay, AR; Ehrman, LA; Vorhees, CV. Ontogeny of the adrenal response to (+)-methamphetamine in neonatal rats: the effect of prior drug exposure. Stress. 2006; 9:153-163.

Vorhees, CV; Williams, MT. Morris water maze: procedures for assessing spatial and related forms of learning and memory. Nature Protocols. 2006; 1:848-858.

WILLIAMS, MT; HENNESSY, MB; DAVIS, HN. CRF administered to pregnant rats alters offspring behavior and morphology. Pharmacology Biochemistry and Behavior. 1995; 52:161-167.

Zoubovsky, SP; Williams, MT; Hoseus, S; Tumukuntala, S; Riesenberg, A; Schulkin, J; Vorhees, CV; Campbell, K; Lim, HW; Muglia, LJ. Neurobehavioral abnormalities following prenatal psychosocial stress are differentially modulated by maternal environment. Translational Psychiatry. 2022; 12.

Pitzer, EM; Sugimoto, C; Regan, SL; Gudelsky, GA; Williams, MT; Vorhees, CV. Developmental deltamethrin: Sex-specific hippocampal effects in Sprague Dawley rats. 2022; 3.

Upton, BA; Nayak, G; Schweinzger, I; D’souza, SP; Vorhees, CV; Williams, MT; Earl, BR; Lang, RA. Comprehensive Behavioral Analysis of Opsin 3 (Encephalopsin)-Deficient Mice Identifies Role in Modulation of Acoustic Startle Reflex. eNeuro. 2022; 9.

Williams, MT; Sugimoto, C; Regan, SL; Pitzer, EM; Fritz, AL; Sertorio, M; Mascia, AE; Vatner, RE; Perentesis, JP; Vorhees, CV. Cognitive and behavioral effects of whole brain conventional or high dose rate (FLASH) proton irradiation in a neonatal Sprague Dawley rat model. PLoS ONE. 2022; 17.

Regan, SL; Sugimoto, C; Dawson, HE; Williams, MT; Vorhees, CV. Latrophilin-3 heterozygous versus homozygous mutations in Sprague Dawley rats: Effects on egocentric and allocentric memory and locomotor activity. Genes, Brain and Behavior. 2022; 21.

Zoubovsky, SP; Williams, MT; Hoseus, S; Tumukuntala, S; Riesenberg, A; Schulkin, J; Vorhees, CV; Campbell, K; Lim, H; Muglia, LJ. Neurobehavioral abnormalities following prenatal psychosocial stress are differentially modulated by maternal environment. Translational Psychiatry. 2022; 12.

Regan, SL; Williams, MT; Vorhees, CV. Review of rodent models of attention deficit hyperactivity disorder. Neuroscience and Biobehavioral Reviews. 2022; 132:621-637.

Sable, HJ K; Lester, DB; Potter, JL; Nolen, HG; Cruthird, DM; Estes, LM; Johnson, AD; Regan, SL; Williams, MT; Vorhees, CV. An assessment of executive function in two different rat models of attention-deficit hyperactivity disorder: Spontaneously hypertensive versus Lphn3 knockout rats. Genes, Brain and Behavior. 2021; 20.

Vorhees, CV; Vatner, RE; Williams, MT. Review of Conventional and High Dose Rate Brain Radiation (FLASH): Neurobehavioural, Neurocognitive and Assessment Issues in Rodent Models. Comparative Haematology International. 2021; 33:e482-e491.

Regan, SL; Pitzer, EM; Hufgard, JR; Sugimoto, C; Williams, MT; Vorhees, CV. A novel role for the ADHD risk gene latrophilin-3 in learning and memory in Lphn3 knockout rats. Neurobiology of Disease. 2021; 158.

Pitzer, EM; Williams, MT; Vorhees, CV. Effects of pyrethroids on brain development and behavior: Deltamethrin. Neurotoxicology and Teratology. 2021; 87.

Vorhees, CV; Williams, MT. Issues in the design, analysis, and application of rodent developmental neurotoxicology studies. Neurotoxicology and Teratology. 2021; 87.

Regan, SL; Williams, MT; Vorhees, CV. Latrophilin-3 disruption: Effects on brain and behavior. Neuroscience and Biobehavioral Reviews. 2021; 127:619-629.

Regan, SL; Sugimoto, C; Fritz, AL; Vorhees, CV; Williams, MT. Effects of Permethrin or Deltamethrin Exposure in Adult Sprague Dawley Rats on Acoustic and Light Prepulse Inhibition of Acoustic or Tactile Startle. Neurotoxicity Research. 2021; 39:543-555.

Schaefer, TL; Ashworth, AA; Tiwari, D; Tomasek, MP; Parkins, EV; White, AR; Snider, A; Davenport, MH; Grainger, LM; Becker, RA; et al. GABAA Alpha 2,3 Modulation Improves Select Phenotypes in a Mouse Model of Fragile X Syndrome. Frontiers in Psychiatry. 2021; 12.

Sprowles, JL N; Vorhees, CV; Williams, MT. Impact of preweaning stress on long-term neurobehavioral outcomes in Sprague-Dawley rats: Differential effects of barren cage rearing, pup isolation, and the combination. Neurotoxicology and Teratology. 2021; 84.

Vorhees, CV; Williams, MT; Hawkey, AB; Levin, ED. Translating Neurobehavioral Toxicity Across Species From Zebrafish to Rats to Humans: Implications for Risk Assessment. Frontiers in Toxicology. 2021; 3.

Williams, MT; Sugimoto, C; Regan, SL; Pitzer, EM; Fritz, AL; Mascia, AE; Sertorio, M; Vatner, RE; Perentesis, JP; Vorhees, CV. Whole brain proton irradiation in adult Sprague Dawley rats produces dose dependent and non-dependent cognitive, behavioral, and dopaminergic effects. Scientific Reports. 2020; 10.

Zoubovsky, SP; Hoseus, S; Tumukuntala, S; Schulkin, JO; Williams, MT; Vorhees, CV; Muglia, LJ. Chronic psychosocial stress during pregnancy affects maternal behavior and neuroendocrine function and modulates hypothalamic CRH and nuclear steroid receptor expression. Translational Psychiatry. 2020; 10.

Tiwari, D; Schaefer, TL; Schroeder-Carter, LM; Krzeski, JC; Bunk, AT; Parkins, EV; Snider, A; Danzer, R; Williams, MT; Vorhees, CV; et al. The potassium channel Kv4.2 regulates dendritic spine morphology, electroencephalographic characteristics and seizure susceptibility in mice. Neurodegeneration : a journal for neurodegenerative disorders, neuroprotection, and neuroregeneration. 2020; 334.

Kwan, LY; Eaton, DL; Andersen, SL; Dow-Edwards, D; Levin, ED; Talpos, J; Vorhees, CV; Li, AA. This is your teen brain on drugs: In search of biological factors unique to dependence toxicity in adolescence. Neurotoxicology and Teratology. 2020; 81.

Regan, SL; Cryan, MT; Williams, MT; Vorhees, CV; Ross, AE. Enhanced Transient Striatal Dopamine Release and Reuptake in Lphn3 Knockout Rats. ACS Chemical Neuroscience. 2020; 11:1171-1177.

Vorhees, CV; Williams, MT. Litter effects: Comments on Golub and Sobin's "Statistical modeling of litter as a random effect in mixed models to manage "intralitter likeness " ". Neurotoxicology and Teratology. 2020; 77.

Yermakov, LM; Griggs, RB; Drouet, DE; Sugimoto, C; Williams, MT; Vorhees, CV; Susuki, K. Impairment of cognitive flexibility in type 2 diabetic db/db mice. Behavioural Brain Research. 2019; 371.

Regan, SL; Hufgard, JR; Pitzer, EM; Sugimoto, C; Hu, Y; Williams, MT; Vorhees, CV. Knockout of latrophilin-3 in Sprague-Dawley rats causes hyperactivity, hyper-reactivity, under-response to amphetamine, and disrupted dopamine markers. Neurobiology of Disease. 2019; 130.

Kyser, TL; Dourson, AJ; McGuire, JL; Hemmerle, AM; Williams, MT; Seroogy, KB. Characterization of Motor and Non-Motor Behavioral Alterations in the Dj-1 (PARK7) Knockout Rat. Journal of Molecular Neuroscience. 2019; 69:298-311.

Balczon, R; Pittet, J; Wagener, BM; Moser, SA; Voth, S; Vorhees, CV; Williams, MT; Bridges, JP; Alvarez, DF; Koloteva, A; et al. Infection-induced endothelial amyloids impair memory. FASEB Journal. 2019; 33:10300-10314.

Jablonski, SA; Williams, MT; Vorhees, CV. Learning and Memory Effects of Neonatal Methamphetamine Exposure in Sprague-Dawley Rats: Test of the Role of Dopamine Receptors D1 in Mediating the Long-Term Effects. Developmental Neuroscience. 2019; 41:44-55.

Gutierrez, A; Regan, SL; Hoover, CS; Williams, MT; Vorhees, CV. Effects of intrastriatal dopamine D1 or D2 antagonists on methamphetamine-induced egocentric and allocentric learning and memory deficits in Sprague-Dawley rats. Psychopharmacology. 2019; 236:2243-2258.

Pitzer, EM; Sugimoto, C; Gudelsky, GA; Adams, CL H; Williams, MT; Vorhees, CV. Deltamethrin Exposure Daily From Postnatal Day 3-20 in Sprague-Dawley Rats Causes Long-term Cognitive and Behavioral Deficits. Toxicological Sciences. 2019; 169:511-523.

Mann, EA; Sugimoto, C; Williams, MT; Vorhees, CV. Mouse knockout of guanylyl cyclase C: Recognition memory deficits in the absence of activity changes. Genes, Brain and Behavior. 2019; 18.

Bailey, RA; Gutierrez, A; Kyser, TL; Hemmerle, AM; Hufgard, JR; Seroogy, KB; Vorhees, CV; Williams, MT. Effects of Preweaning Manganese in Combination with Adult Striatal Dopamine Lesions on Monoamines, BDNF, TrkB, and Cognitive Function in Sprague-Dawley Rats. Neurotoxicity Research. 2019; 35:606-620.

Hufgard, JR; Sprowles, JL N; Pitzer, EM; Koch, SE; Jiang, M; Wang, Q; Zhang, X; Biesiada, J; Rubinstein, J; Puga, A; et al. Prenatal exposure to PCBs in Cyp1a2 knock-out mice interferes with F1 fertility, impairs long-term potentiation, reduces acoustic startle and impairs conditioned freezing contextual memory with minimal transgenerational effects. Journal of Applied Toxicology. 2019; 39:603-621.

Williams, MT; Gutierrez, A; Vorhees, CV. Effects of Acute Deltamethrin Exposure in Adult and Developing Sprague Dawley Rats on Acoustic Startle Response in Relation to Deltamethrin Brain and Plasma Concentrations. Toxicological Sciences. 2019; 168:61-69.

Amos-Kroohs, RM; Usach, V; Pinero, G; Vorhees, CV; Martinez Vivot, R; Soto, PA; Williams, MT; Setton-Avruj, P. Metal bashing: iron deficiency and manganese overexposure impact on peripheral nerves. Journal of Toxicology and Environmental Health - Part A: Current Issues. 2019; 82:99-112.

Cynober, L; Fernstrom, JD; Koletzko, B; Rietjens, IM C M; Roberts, A; Tennant, DR; Tome, D; Vorhees, CV. Introduction and Summary of the 2018 Dietary Glutamate Workshop. Annals of Nutrition and Metabolism. 2018; 73 Suppl 5:1-4.

Vorhees, CV. A Test of Dietary Monosodium Glutamate Developmental Neurotoxicity in Rats: A Reappraisal. Annals of Nutrition and Metabolism. 2018; 73 Suppl 5:36-42.

Williams, MT; Gutierrez, A; Vorhees, CV. Effects of Acute Exposure of Permethrin in Adult and Developing Sprague-Dawley Rats on Acoustic Startle Response and Brain and Plasma Concentrations. Toxicological Sciences. 2018; 165:361-371.

Vorhees, CV; Sprowles, JN; Regan, SL; Williams, MT. A better approach to in vivo developmental neurotoxicity assessment: Alignment of rodent testing with effects seen in children after neurotoxic exposures. Toxicology and Applied Pharmacology. 2018; 354:176-190.

Udobi, KC; Kokenge, AN; Hautman, ER; Ullio, G; Coene, J; Williams, MT; Vorhees, CV; Mabondzo, A; Skelton, MR. Cognitive deficits and increases in creatine precursors in a brain-specific knockout of the creatine transporter gene Slc6a8. Genes, Brain and Behavior. 2018; 17.

Sprowles, JL N; Amos-Kroohs, RM; Braun, AA; Sugimoto, C; Vorhees, CV; Williams, MT. Developmental manganese, lead, and barren cage exposure have adverse long-term neurocognitive, behavioral and monoamine effects in Sprague-Dawley rats. Neurotoxicology and Teratology. 2018; 67:50-64.

Gutierrez, A; Williams, MT; Vorhees, CV. A Single High Dose of Methamphetamine Reduces Monoamines and Impairs Egocentric and Allocentric Learning and Memory in Adult Male Rats. Neurotoxicity Research. 2018; 33:671-680.