Vorhees / Williams Lab

Publications

Williams, MT; Gutierrez, A; Vorhees, CV. Effects of Acute Deltamethrin Exposure in Adult and Developing Sprague Dawley Rats on Acoustic Startle Response in Relation to Deltamethrin Brain and Plasma Concentrations. Toxicological Sciences (Elsevier). 2019; 168:61-69.

Vorhees, CV; Williams, MT. Cincinnati water maze: A review of the development, methods, and evidence as a test of egocentric learning and memory. Neurotoxicology and Teratology. 2016; 57:1-19.

Williams, MT; Braun, AA; Amos-Kroohs, RM; II, MJ P; Lindquist, DM; Mangano, FT; Vorhees, CV; Yuan, W. Kaolin-induced ventriculomegaly at weaning produces long-term learning, memory, and motor deficits in rats. International Journal of Developmental Neuroscience. 2014; 35:7-15.

Braun, AA; Graham, DL; Schaefer, TL; Vorhees, CV; Williams, MT. Dorsal striatal dopamine depletion impairs both allocentric and egocentric navigation in rats. Neurobiology of Learning and Memory. 2012; 97:402-408.

Grace, CE; Schaefer, TL; Gudelsky, GA; Williams, MT; Vorhees, CV. Neonatal methamphetamine-induced corticosterone release in rats is inhibited by adrenal autotransplantation without altering the effect of the drug on hippocampal serotonin. Neurotoxicology and Teratology. 2010; 32:356-361.

Williams, MT; Schaefer, TL; Furay, AR; Ehrman, LA; Vorhees, CV. Ontogeny of the adrenal response to (+)-methamphetamine in neonatal rats: the effect of prior drug exposure. Stress: The International Journal on the Biology of Stress (Informa). 2006; 9:153-163.

Vorhees, CV; Williams, MT. Morris water maze: procedures for assessing spatial and related forms of learning and memory. Nature Protocols. 2006; 1:848-858.

Williams, MT; Brown, RW; Vorhees, CV. Neonatal methamphetamine administration induces region-specific long-term neuronal morphological changes in the rat hippocampus, nucleus accumbens and parietal cortex. European Journal of Neuroscience. 2004; 19:3165-3170.

WILLIAMS, MT; HENNESSY, MB; DAVIS, HN. CRF administered to pregnant rats alters offspring behavior and morphology. Pharmacology, Biochemistry and Behavior. 1995; 52:161-167.

Brewer, LM; Patel, J; Andrasik, F; Sable, JJ; Williams, MT; Vorhees, CV; Sable, HJ K. Auditory Event-Related Potentials in Two Rat Models of Attention-Deficit Hyperactivity Disorder: Evidence of Automatic Attention Deficits in Spontaneously Hypertensive Rats but Not in Latrophilin-3 Knockout Rats. Genes. 2025; 16:672.

Raje, KR; Williams, MT; Vorhees, CV. Comparison of Sprague Dawley with Long Evans rats on a battery of widely used neurobehavioral tests. Physiology and Behavior. 2025; 294:114860.

Vorhees, C; Fritz, A; Gollaway, B; Williams, M. Gene x environment interaction between heterozygous deletion of the ADHD risk gene latrophilin-3 (Lphn3) and developmental deltamethrin exposure in Sprague Dawley rats. Neurotoxicology and Teratology. 2025; 109:107492.

Vorhees, CV; Fritz, AL; Gollaway, BM; Williams, MT. Gene × environment interaction between heterozygous deletion of the ADHD risk gene latrophilin-3 (adgrl3) and developmental deltamethrin exposure in Sprague Dawley rats. Neurotoxicology and Teratology. 2025; 108:107435.

Sable, HJ K; Paige, NB; Nalan, PA; Pace, RL; Hicks, CB; Regan, SL; Williams, MT; Vorhees, CV; Lester, DB. Phasic dopamine release in two different rat models of attention-deficit/hyperactivity disorder: Spontaneously hypertensive rats (SHR) versus Lphn3 knockout rats. Neuroscience. 2025; 567:150-162.

Vorhees, CV; Amos-Kroohs, RM; Williams, MT. Long-term effects of Preweaning environmental impoverishment on neurobehavioral and neurocognitive outcomes in Sprague Dawley rats: An early environmental stress model. Neurotoxicology and Teratology. 2024; 103:107356.

Vorhees, CV; Sugimoto, C; Regan, SL; Pitzer, EM; Fritz, AL; Gollaway, BM; Sertorio, M; Mascia, AE; Vatner, RE; Parentesis, JP; Williams, MT. 3174: Effects of whole brain conventional or FLASH proton irradiation in Sprague Dawley rats. Radiotherapy and Oncology. 2024; 194:s5308-s5310.

Sugimoto, C; Perna, MK; Regan, SL; Tepe, EA; Liou, R; Fritz, AL; Williams, MT; Vorhees, CV; Skelton, MR. A Gad2 specific Slc6a8 deletion recapitulates the contextual and cued freezing deficits seen in Slc6a8-/y mice. Brain Research. 2024; 1825:148690.

Vorhees, CV; Williams, MT. Tests for learning and memory in rodent regulatory studies. Current Research in Toxicology. 2024; 6:100151.

Vorhees, C; Fritz, A; Gollaway, B; Williams, M. Interaction of latrophilin-3, an ADHD risk gene, and deltamethrin in Sprague Dawley rats on learning and memory. Neurotoxicology and Teratology. 2023; 98:107271.

Bromley, R; Graz, MB; Bluett-Duncan, M; Chambers, C; Damkier, P; Dietrich, K; Dolk, H; Grant, K; Mattson, S; Meador, K; Yates, L; Ystrom, E; Supraja, TA; Adams, J. Expert consensus on neurodevelopmental outcomes in pregnancy pharmacovigilance studies. Neurotoxicology and Teratology. 2023; 98:107203.

Williams, M; Sugimoto, C; Regan, S; Pitzer, E; Fritz, A; Sertorio, M; Mascia, A; Vatner, R; Perentesis, J; Vorhees, C. Cognitive and behavioral effects of whole brain conventional or high dose rate (FLASH) proton irradiation in a neonatal Sprague Dawley rat model. Neurotoxicology and Teratology. 2023; 98:107276.

Vorhees, CV. Concern over differences between experimental design and data analyses in Jones et al. Proceedings of the National Academy of Sciences of USA. 2023; 120:e2302944120.

Bromley, RL; Bickle Graz, M; Bluett-Duncan, M; Chambers, C; Damkier, P; Dietrich, K; Dolk, H; Grant, K; Mattson, S; Meador, KJ; Yates, L; Ystrom, E; Supraja, TA; Adams, J. Expert consensus on neurodevelopmental outcomes in pregnancy pharmacovigilance studies. Frontiers in Pharmacology. 2023; 14:1094698.

Carbajal, MS; Bounmy, AJ C; Harrison, OB; Nolen, HG; Regan, SL; Williams, MT; Vorhees, CV; Sable, HJ K. Impulsive choice in two different rat models of ADHD-Spontaneously hypertensive and Lphn3 knockout rats. Frontiers in Neuroscience. 2023; 17:1094218.

Zoubovsky, SP; Williams, MT; Hoseus, S; Tumukuntala, S; Riesenberg, A; Schulkin, J; Vorhees, CV; Campbell, K; Lim, HW; Muglia, LJ. Neurobehavioral abnormalities following prenatal psychosocial stress are differentially modulated by maternal environment. Translational Psychiatry. 2022; 12.

Williams, MT; Sugimoto, C; Regan, SL; Pitzer, EM; Fritz, AL; Sertorio, M; Mascia, AE; Vatner, RE; Perentesis, JP; Vorhees, CV. Cognitive and behavioral effects of whole brain conventional or high dose rate (FLASH) proton irradiation in a neonatal Sprague Dawley rat model. Editor, Lee J. PloS one. 2022; 17:e0274007.

Upton, BA; Nayak, G; Schweinzger, I; D’souza, SP; Vorhees, CV; Williams, MT; Earl, BR; Lang, RA. Comprehensive Behavioral Analysis of Opsin 3 (Encephalopsin)-Deficient Mice Identifies Role in Modulation of Acoustic Startle Reflex. eNeuro. 2022; 9:ENEURO.0202-ENEU22.2022.

Regan, SL; Sugimoto, C; Dawson, HE; Williams, MT; Vorhees, CV. Latrophilin-3 heterozygous versus homozygous mutations in Sprague Dawley rats: Effects on egocentric and allocentric memory and locomotor activity. Genes, Brain and Behavior. 2022; 21:e12817.

Zoubovsky, SP; Williams, MT; Hoseus, S; Tumukuntala, S; Riesenberg, A; Schulkin, J; Vorhees, CV; Campbell, K; Lim, H; Muglia, LJ. Neurobehavioral abnormalities following prenatal psychosocial stress are differentially modulated by maternal environment. Translational Psychiatry. 2022; 12:22.

Zoubovsky, SP; Williams, MT; Hoseus, S; Tumukuntala, S; Riesenberg, A; Schulkin, J; Vorhees, CV; Campbell, K; Lim, H; Muglia, LJ. Neurobehavioral abnormalities following prenatal psychosocial stress are differentially modulated by maternal environment. Translational Psychiatry. 2022; 12.

Regan, SL; Williams, MT; Vorhees, CV. Review of rodent models of attention deficit hyperactivity disorder. Neuroscience and Biobehavioral Reviews. 2022; 132:621-637.

Pitzer, EM; Sugimoto, C; Regan, SL; Gudelsky, GA; Williams, MT; Vorhees, CV. Developmental deltamethrin: Sex-specific hippocampal effects in Sprague Dawley rats. Current Research in Toxicology. 2022; 3:100093.

Atanasova, NA; Williams, MT; Vorhees, CV. Science in Practice in Neuroscience. The Tools of Neuroscience Experiment. : Taylor & Francis; Taylor & Francis; 2021.

Sable, HJ K; Lester, DB; Potter, JL; Nolen, HG; Cruthird, DM; Estes, LM; Johnson, AD; Regan, SL; Williams, MT; Vorhees, CV. An assessment of executive function in two different rat models of attention-deficit hyperactivity disorder: Spontaneously hypertensive versus Lphn3 knockout rats. Genes, Brain and Behavior. 2021; 20:e12767.

Vorhees, CV; Vatner, RE; Williams, MT. Review of Conventional and High Dose Rate Brain Radiation (FLASH): Neurobehavioural, Neurocognitive and Assessment Issues in Rodent Models. Comparative Haematology International. 2021; 33:e482-e491.

Regan, SL; Pitzer, EM; Hufgard, JR; Sugimoto, C; Williams, MT; Vorhees, CV. A novel role for the ADHD risk gene latrophilin-3 in learning and memory in Lphn3 knockout rats. Neurobiology of Disease. 2021; 158:105456.

Vorhees, CV; Williams, MT. Issues in the design, analysis, and application of rodent developmental neurotoxicology studies. Neurotoxicology and Teratology. 2021; 87:107018.

Pitzer, EM; Williams, MT; Vorhees, CV. Effects of pyrethroids on brain development and behavior: Deltamethrin. Neurotoxicology and Teratology. 2021; 87:106983.

Regan, SL; Williams, MT; Vorhees, CV. Latrophilin-3 disruption: Effects on brain and behavior. Neuroscience and Biobehavioral Reviews. 2021; 127:619-629.

Regan, SL; Sugimoto, C; Fritz, AL; Vorhees, CV; Williams, MT. Effects of Permethrin or Deltamethrin Exposure in Adult Sprague Dawley Rats on Acoustic and Light Prepulse Inhibition of Acoustic or Tactile Startle. Neurotoxicity Research. 2021; 39:543-555.

Schaefer, TL; Ashworth, AA; Tiwari, D; Tomasek, MP; Parkins, EV; White, AR; Snider, A; Davenport, MH; Grainger, LM; Becker, RA; Gibson, JR; Huber, KM; Gross, C; Erickson, CA. GABAA Alpha 2,3 Modulation Improves Select Phenotypes in a Mouse Model of Fragile X Syndrome. Frontiers in Psychiatry. 2021; 12:678090.

Sprowles, JL N; Vorhees, CV; Williams, MT. Impact of preweaning stress on long-term neurobehavioral outcomes in Sprague-Dawley rats: Differential effects of barren cage rearing, pup isolation, and the combination. Neurotoxicology and Teratology. 2021; 84:106956.

Vorhees, CV; Williams, MT; Hawkey, AB; Levin, ED. Translating Neurobehavioral Toxicity Across Species From Zebrafish to Rats to Humans: Implications for Risk Assessment. Frontiers in Toxicology. 2021; 3:629229.