Vorhees-Williams Lab

Hautman, E.R., Kokenge, A.N., Udobi, K.C.,, Williams, M.T., Vorhees, C.V., and Skelton, M.R. Female mice heterozygous for creatine transporter deficiency show moderate cognitive deficits. J. Inherited. Metab. Dis., 37, 63-68.  PMID:23716276 (Jan). 2014. 

Williams, M.T., Braun, A.A., Amos-Kroohs, R., McAllister, J.P., Lindquist, D.M., Mangano, F.T., Vorhees, C.V., Yuan, W. Kaolin-induced ventriculomegaly at weaning produces long-term learning, memory and motor deficits in rats. Int. J. Dev. Neurosci., 35, 7-15.  PMID:24594360 (June). 2014. 

Vorhees, C.V. and Williams, M.T. Assessing spatial learning and memory in rodents. Inst. Lab. Animal Res. J., 55, 310-332. PMID:25225309. (Sept). 2014. 

Vorhees, C.V. and Williams, M.T. Value of water mazes for assessing spatial and egocentric learning and memory in rodent basic research and regulatory studies. Neurotoxicol. Teratol., 45, 75-90. PMID:25116937 (Sept/Oct). 2014. 

Lin, E., Miles, L., Hughes, E.A., McCann, J.C., Vorhees, C.V., McAuliffe, J.J., and Loepke, A.W. Combination of mild hypothermia and sevoflurane afford long-term protection in a modified neonatal mouse model of cerebral hypoxia-ischemia.  Anesthes. Analges., 119,1158-73.  PMID:24878681. (Nov). 2014. 

 Vorhees, C.V., Graham, D. L., Braun, A. A., Schaefer, T. L., Skelton, M. R., Richtand, N.M., Williams, M.T. (in press).  Prenatal immune challenge in rats: Effects of polyinosinic-polycytidylic acid on spatial learning, prepulse inhibition, conditioned fear, and responses to MK-801 and amphetamine. Neurotoxicology &Teratology. 2014.

Braun, A. A., Amos-Kroohs, R.M., Gutierrez, A., Lundgren, K.H., Seroogy K.B., Skelton, M. R., Vorhees, C.V., Williams, M. T. (in press).  Dopamine depletion in either the dorsomedial or dorsolateral striatum impairs egocentric Cincinnati water maze performance while sparing allocentric Morris water maze learning. Neurobiology of Learning and Memory. 2014. 

Vorhees, C.V., Graham, D. L., Amos-Kroohs, R.M., Braun, A.A., Grace, C. E., Schaefer, T. L., Skelton, M. R., Erikson, K.M., Aschner, M., Williams, M. T.  Effects of developmental manganese, stress, and the combination of both on monoamines, growth, and corticosterone. Toxicology Reports. 2014.  

Williams, M. T., Skelton, M. R., Longacre, I.D., Huggins, K.N., Maple, A.M., Vorhees, C. V., Brown, R.W. Neuronal reorganization of the nucleus accumbens, dentate gyrus, and entorhinal cortex in adult rats neonatally exposed to (±)-3,4-methylenedioxymethamphetamine.  Toxicology Reports 1: 699-706. 2014. 

Amos-Kroohs, R.M., Williams, M.T., Braun, A.A., Graham, D.L., Webb, C.L., Birtles, T.S., Greene, R.M., Vorhees, C.V., and Pisano, M.M.   Neurobehavioral phenotype of C57BL/6J mice prenatally and neonatally exposed to cigarette smoke. Neurotoxicol. Teratol., 35, 34-45. (1-2/13). 2013. 

Schaefer, T.L., Grace, C.E., Braun, A.A., Amos-Kroohs, R.M., Graham, D.L., Skelton, M.R., Williams, M.T, and Vorhees, C.V.  Cognitive impairments from developmental exposure to serotonergic drugs: citalopram or MDMA. Int. J. Neuropsychopharmacol., 16, 1383-94. (7/13). 2013. 

Sun, Y., Zamzow, M., Ran, H., Zhang, W., Quinn, B., Barnes, S., Witte, D.P., Setchell, K.D.R., Williams, M.T., Vorhees, C.V., and Grabowski, G.A.  Tissue-specific effects of saposin A and saposin B on glycosphingolipid degradation in mutant mice. Hum. Mol. Genet., 22, 2435-2450. (6/13). 2013. 

Mayes, D.A., Rizvi, T.A., Titus-Mitchell, H., Oberst, R., Ciraolo, G.M., Vorhees, C.V., Robinson, A.P., Miller, S.D., Cancelas, J.A., Stemmer-Rachamimov, A.O., and Ratner, N. Nf1 loss and Ras hyperactivation in oligodendrocytes induce NOS-driven defects in myelin and vasculature. Cell Reports, 4, 1197-1212. PMID:24035394. (Sept). 2013. 

Ehrman, L.A., Mu, X., Waclaw, R.R., Yoshida, Y., Vorhees, C.V., Klein, W.H., and Campbell, K. The LIM homeobox gene Isl1 is required for the correct development of the striatonigral pathway in the mouse. PNAS, 110, E4026-4035. PMID:24082127. (Oct). 2013. 

Grace, C.E., Schaefer, T.L., Herring, N.R., Williams, M.T, and Vorhees, C.V.  Effects of neonatal methamphetamine treatment on adult stress-induced corticosterone release in rats. Neurotoxicol. Teratol., 34, 136-142. 2012.

Graham, D.L., Herring, N.R., Schaefer, T.L., Holland, K.D., Vorhees, C.V., and Williams, M.T.  Electroencephalographic and electroconvulsive effects of binge exposures to methamphetamine, 5-methoxydiisopropyltryptamine, and MDMA in rats. Open Neuropsychopharmacol. J., 5, 1-8. 2012. 

Hemmerle, A.M., Dickerson, J.W., Herring, N.R., Schaefer, T.L., Vorhees, C.V., Williams, M.T., and Seroogy, K.B.  (±)3,4-Methylenedioxymethamphetamine (ecstasy) treatment modulates expression of neurotrophins and their receptors in multiple regions of the adult rat brain.  J. Comp. Neurol., 520, 2459-2474. 2012. 

Schaefer, T.L., Grace, C.E., Skelton, M.R., Graham, D.L., Gudelsky, G.A., Vorhees, C.V., and Williams, M.T. Neonatal citalopram pretreatment inhibits the 5-HT depleting effects of MDMA exposure in rats. ACS Chem. Neurosci., 3(1), 12-21. 2012. 

Chen, Y, Curran, C.P., Nebert, D.W., Patel, K.V., Williams, M.T., and Vorhees, C.V.  Effects of vitamin C deficiency during postnatal development on adult behavior: functional behavioral phenotype of Gulo(-/-) mice. Genes Brain Behav., 11, 269-277. 2012. 

Braun, A.A., Graham, D.L., Schaefer, T.L., Vorhees, C.V., and Williams, M.T. Dorsal striatal dopamine depletion impairs both allocentric and egocentric navigation in rats. Neurobiol. Learn. Mem., 97(4), 402-408. 2012. 

Skelton, M.R., Graham, D.L., Schaefer, T.L., Grace, C.E., Braun, A.A., Burns, L.A., Amos-Kroohs, R.M., Williams, M.T., and Vorhees, C.V. Distinct periods of developmental sensitive to the effects 3,4-(±)-methylenedioxymethamphetamine (MDMA) on behaviour and monoamines in rats. Int. J. Neuropsychopharmacol., 15, 811-824. 2012. 

Chen, Y., Curran, C.P., Nebert, D.W., Patel, K.V., Williams, M.T., and Vorhees, C.V. Effect of chronic glutathione deficiency on the behavioral phenotype of Gclm(-/-) knockout mice. Neurotoxicol. Teratol., 34, 450-457. 2012. 

Schaefer, T.L., Braun, A.A., Amos-Kroohs, R.M., Williams, M.T., Ostertag, E., and Vorhees, C.V. A new model of Pde4d deficiency: Genetic knock-down of PDE4D enzyme in rats produces an antidepressant phenotype without spatial cognitive effects. Genes Brain Behav., 11(5), 614-622. 2012. 

Vorhees,  C.V., Graham, D.L., Braun, A.A., Schaefer, T.L., Skelton, M.R., Richtand, N.M., and Williams, M.T. Prenatal immune challenge in rats: Altered responses to dopaminergic and glutamatergic agents, prepulse inhibition of acoustic startle, and reduced route-based learning as a function of maternal body weight gain after prenatal exposure to Poly IC.  Synapse, 66(8), 725-737. 2012. 

Graham, D.L., Amos-Kroohs, R.M., Braun, A.A., Grace, C.E., Schaefer, T.L., Skelton, M.R., Vorhees, C.V., and Williams, M.T. Neonatal (+)-methamphetamine exposure in rats alters adult locomotor responses to dopamine D1 and D2 agonists and to a glutamate NMDA receptor antagonist, but not to serotonin agonists.  Int. J. Neuropsychopharmacol., 16, 377-391. 2012. 

Braun AA, Skelton MR, Vorhees CV, Williams MT. Comparison of the elevated plus and elevated zero mazes in treated and untreated male Sprague-Dawley rats: effects of anxiolytic and anxiogenic agents. Pharmacol. Biochem. Behav. 97, 406-415. 2010. 

Curran CP, Vorhees CV, Williams MT, Genter MB, Miller ML, Nebert DW. In utero and lactational exposure to complex mixture of polychlorinated biphenyls: toxicity in pups dependent on the Cyp1a2 and Ahr genotypes. Toxicol. Sci. 119, 189-208. 2010. 

Graham DL, Grace CE, Braun AA, Schaefer TL, Skelton MR, Tang PH, Vorhees CV, Williams MT. Effects of developmental stress and lead (Pb) on corticosterone after chronic and acute stress, brain monoamines, and blood Pb levels. Int. J. Dev. Neurosci. 29, 45-55. 2010. 

Skelton MR, Schaefer TL, Graham DL, Degrauw TJ, Clark JF, Williams MT, Vorhees CV. Creatine transporter (CrT; Slc6a8) knockout mice as a model of human CrT deficiency.PLoS One, 6(1) 1-10 (e16187). 2011.

Vorhees CV, He E, Skelton MR, Graham DL, Schaefer TL, Grace CE, Braun AA, Amos-Kroohs R, Williams MT. Comparison of (+)-methamphetamine, (±)-methylenedioxymethamphetamine (MDMA), (+)-amphetamine and (±)-fenfluramine in rats on egocentric learning in the Cincinnati water maze. Synapse, 65, 368-378. 2011.

Schaefer TL, Lingrel JB, Moseley AE, Vorhees CV, Williams MT. Targeted mutations in the Na,K-ATPase alpha 2 isoform confer ouabain resistance and result in abnormal behavior in mice. Synapse, 65, 520-531. 2010.

Braun AA, Herring NR, Schaefer TL, Hemmerle AM, Dickerson JW, Seroogy KB, Vorhees CV, Williams MT. Neurotoxic (+)-methamphetamine treatment increases brain-derived neurotrophic factor and tropomyosin receptor kinase B expression in multiple brain regions. Neuroscience, 184, 164-71. 2011. 

Curran CP, Nebert DW, Genter MB, Patel KV, Schaefer TL, Skelton MR, Williams MT, Vorhees CV. In utero and lactational exposure to PCBs in mice: Adult offspring show altered learning and memory dependent on Cyp1a2 and Ahr genotypes. Environ. Hlth. Pers., (ePub head of print PMID:21571617). 2011. 

Grace CE, Schaefer TL, Herring NR, Williams MT, Vorhees CV. Effects of neonatal methamphetamine treatment on adult stress-induced corticosterone release in rats. Neurotoxicol. Teratology (in press). 2011. 

Graham DL, Herring NR, Schaefer TL, Holland KD, Vorhees CV, Williams MT. Electroencephalographic abnormalities and seizures following exposure to binge doses of methamphetamine or 5-methoxydiisopropyltryptamine but not MDMA. 2010. 

Amos-Kroohs RM, Williams MT, Vorhees CV. Neonatal methylphenidate exposure in rats: Effects on spatial learning and memory in the Morris water maze. Neurosci. Lett. (in press). 2011. 

Skelton MR, Graham DL, Schaefer TL, Grace CE, Braun AA, Burns LA, Williams MT, Vorhees CV. Sensitive periods of neonatal 3,4-(±)-methylenedioxymethamphetamine (MDMA) treatment on later behavior in rats. Int. J. Neuropsychopharmacol. (in press). 2011.

Herring NR, Gudelsky GA, Vorhees CV, Williams MT. (+)-Methamphetamine-induced monoamine reductions and impaired egocentric learning in adrenalectomized rats is independent of hyperthermia. Synapse 64, 773-785. 2010. 

Schaefer TL, Grace CE, Gudelsky GA, Vorhees CV, Williams MT. Effects on plasma corticosterone levels and brain serotonin from interference with methamphetamine-induced corticosterone release in neonatal rats. Stress 13, 469-480. 2010. 

*Sun Y, Ran H, Zamzow M, Kitatani K, Skelton MR, Williams MT, Vorhees CV, Witte DP, Hannum YA, Grabowski GA. Specific saposin C deficiency: CNS impairment and acid beta-glucosidase effects in the mouse. Human Mol. Genet. 19, 634-647. 2010. 

*Graham DL, Herring NR, Schaefer TL, Vorhees CV, Williams MT. Glucose and corticosterone changes in developing and adult rats following exposure to (±)-3,4-methylendioxymethamphetamine or 5-methoxydiisopropyltryptamine. Neurotoxicol. Teratol. 32, 152-157. 2010. 

*Sun Y, Liou B, Ran H, Skelton MR, Williams MT, Vorhees CV, Kitatani K, Hannun YA, Witte DP, Xu YH, Grabowski GA. Neuronopathic Gaucher disease in the mouse: Viable combined selective saposin C deficiency and mutant glucocerebrosidase (V394L) mice with glucosylsphingosine and glucosylceramide accumulation and progressive neurological deficits. Human Mol. Genet. 19, 1088-1097. 2010. 

*Grace CE, Schaefer TL, Herring NR, Graham DL, Skelton MR, Gudelsky GA, Williams MT, Vorhees CV. Effect of a neurotoxic dose regimen of (+)-methamphetamine on behavior, plasma corticosterone, and brain monoamines in adult C57BL/6 mice. Neurotoxicol. Teratol. 32, 346-355. 2010. 

*Grace CE, Schaefer TL, Gudelsky GA, Williams MT, Vorhees CV. Neonatal methamphetamine-induced corticosterone release in rats is inhibited by adrenal autotransplantation without altering the effect of the drug on hippocampal serotonin. Neurotoxicol. Teratol. 32, 356-361. 2010. 

*Grace CE, Schaefer TL, Graham DL, Skelton MR, Williams MT, Vorhees CV. Effects of inhibiting neonatal methamphetamine-induced corticosterone release in rats by adrenal autotransplantation on later learning, memory, and plasma corticosterone levels. Int. J. Dev. Neurosci. 28, 331-342. 2010. 

*Zhu H, Mingler MK, McBride ML, Murphy AJ, Valenzuela DM, Yancopoulos GD, Williams MT, Vorhees* CV, Rothenberg* ME. (*coequal senior authors) Abnormal response to stress and impaired NPS-induced hyperlocomotion, anxiolytic effect and corticosterone increase in mice lacking NPSR1. Psychoneuroendocrinology. 35, 1119-1132. 2010. 

Loepke AW, Istaphanous GK, Miles L, Hughes EH, McCann JC, Kurth CD, Williams MT, Vorhees CV, Danzer SC. The effects of neonatal isoflurane exposure in mice on brain cell viability, adult behavior, learning, and memory. Anes. Analges. 108, 90-104. 2009. 

Vorhees CV, Johnson HL, Burns LN, Williams MT. Developmental treatment with the dopamine D2/3 agonist quinpirole selectively impairs spatial learning in the Morris water maze. Neurotoxicol. Teratol. 31, 1-10. 2009. 

Vorhees CV, Skelton MR, Grace CR, Schaefer TL, Graham DL, Braun AA, Williams MT. Effects of (+)-methamphetamine on path integration and spatial learning, but not locomotor activity or acoustic startle, align with the stress hyporesponsive period in rats. Int. J. Dev. Neurosci. 27, 289-298. 2009. 

Vorhees CV, Schaefer TL, Skelton MR, Grace CE, Herring NR, Williams MT. ±3,4-Methylenedioxymethamphetamine (MDMA) dose-dependently impairs spatial learning in the Morris water maze after exposure of rats to different five-day intervals from birth to postnatal day 20. Dev. Neurosci. 31, 107-120. 2009. 

Skelton MR, Schaefer TL, Herring NR, Grace CE, Vorhees CV, Williams MT. Comparison of the developmental effects of 5-methoxy-N,N-diisopropyltryptamine (Foxy) to (±)-3,4-methylenedioxymethamphetamine (ecstasy) in rats. Psychopharmacology. 204, 287-297. 2009. 

McAuliffe JJ, Loepke AW, Miles L, Joseph B, Hughes E, Vorhees CV. Desflurane, isoflurane, and sevoflurane provide limited neuroprotection against neonatal hypoxia-ischemia in a delayed-preconditioning paradigm. Anesthesiology. 111, 533-546. 2009. 

Schaefer TL, Vorhees CV, Williams MT. Mouse plasmacytoma-expressed transcript 1 knock out induced 5-HT disruption results in a lack of cognitive deficits and an anxiety phenotype complicated by hypoactivity and defensiveness. Neuroscience. 164, 1431-1443. 2009.

Grace CE, Schaefer TL, Herring NR, Skelton MR, McCrea AE, Vorhees CV, Williams MT. (+)-Methamphetamine increases corticosterone in plasma and BDNF in brain more than forced swim or isolation in neonatal rats. Synapse. 62, 110-121. 2008. 

Pan D, Sciascia A 2nd, Vorhees CV, Williams MT. Progression of multiple behavioral deficits with various ages of onset in a murine model of Hurler syndrome. Brain Res. 1188, 241-253. 2008. 

McAuliffe JJ, Joseph B, Hughes E, Miles L, Vorhees CV. Metallothionein I,II deficient mice do not exhibit significantly worse long-term behavioral outcomes following neonatal hypoxia-ischemia: MT I,II deficient mice have inherent behavioral impairments.  Brain Res. 1190, 175-185. 2008. 

Schaefer TL, Skelton MR, Herring NR, Gudelsky GA, Vorhees CV, Williams MT. Short- and long-term effects of (+)-methamphetamine or (±)-3,4-methylenedioxymethamphetamine on monoamine and corticosterone levels in the neonatal rats following multiple days of treatment. J. Neurochem. 104, 1674-1685. 2008. 

Skelton MR, Williams MT, Vorhees CV. Developmental effects of 3,4-methylenedioxymethamphetamine: A review. Behav. Pharmacol. 19, 91-111. 2008. 

Herring NR, Schaefer TL, Tang PH, Skelton MR, Lucot JP, Gudelsky GA, Vorhees CV, Williams MT. Comparison of time-dependent effects of (+)-methamphetamine or forced swim on monoamines, corticosterone, glucose, creatine, and creatinine in rats. BMC Neurosci. 9, 49. 2008. 

Vorhees CV, Herring NR, Schaefer TL, Grace CE, Skelton MR, Johnson HL, Williams MT. Effects of neonatal (+)-methamphetamine on path integration and spatial learning in rats: Effects of dose and rearing conditions. Int. J. Dev. Neurosci. 26, 599-610. 2008. 

Sun Y, Witte DP, Ran H, Zamzow M, Barnes S, Cheng H, Han X, Williams MT, Skelton MR, Vorhees CV, Grabowski GA. Neurological deficits and glycosphingolipid accumulation in Saposin B deficient mice. Human Mol. Genet. 17, 2345-2356. 2008. 

Sun Y, Jia L, Williams MT, Zamzow M, Ran H, Quinn B, Aronow BJ, Vorhees CV, Witte DP, Grabowski GA. Temporal gene expression profiling reveals CEBPD as a candidate regulator of brain disease in prosaposin deficient mice. BMC Neurosci. 9, 76. 2008. 

Herring NR, Schaefer TL, Gudelsky GA, Vorhees CV, Williams MT. Effect of (+)-Methamphetamine on path integration learning, novel object recognition, and neurotoxicity in rats. Psychopharmacology. 199, 637-650. 2008. 

Skelton MR, Able JA, Grace CE, Herring NR, Schaefer TL, Gudelsky GA, Vorhees CV, Williams MT. (±)-3,4-Methylenedioxymethamphetamine treatment in adult rats impairs path integration learning: a comparison of single vs once per week treatment for 5 weeks. Neuropharmacology. 55, 1121-1130. 2008.

Moseley AE, Williams MT, Schaefer TL, Bohanan CS, Neumann JC, Behbehani MM, Vorhees CV, Lingrel JB. Deficiency in Na,K-ATPase alpha isoform genes alters spatial learning, motor activity and anxiety in mice. J. Neurosci. 27(3), 616-626. 2007. 

Williams MT, Herring NR, Schaefer TL, Skelton MR, Campbell NG, Lipton JW, McCrea AE, Vorhees CV. Alterations in body temperature, corticosterone, and behavior following the administration of 5-methoxy-diisopropyltryptamine (‘Foxy’) to adult rats: a new drug of abuse. Neuropsychopharmacology. 32, 1404-1420. 2007. 

Able JA, Gudelsky GA, Vorhees CV, Williams MT. 3,4-Methylenedioxymethamphetamine in adult rats produces deficits in path integration and spatial reference memory. Biol. Psychiatr. 59, 1219-1226. 2006. 

Vorhees CV, Williams MT. Morris water maze: Procedures for assessing spatial and related forms of learning and memory. Nature Protocols. 1(2), 848-858. 2006. 

Schaefer TL, Ehrman LA, Gudelsky GA, Vorhees CV, Williams MT. Comparison of monoamine and corticosterone levels 24 h following +methamphetamine, ±3,4-methylenedioxymethamphetamine, cocaine, ±fenfluramine or ±methylphenidate administration in the neonatal rat. J. Neurochem. 98, 1369-1378. 2006. 

Ehrman LA, Williams MT, Schaefer TL, Gudelsky GA, Reed TM, Fienberg AA, Greengard P, Vorhees CV. Phosphodiesterase 1B differentially modulates the effects of methamphetamine on locomotor activity and spatial learning through a DARPP32-dependent pathway: evidence from PDE1B-DARPP32 double-knockout mice. Genes Brain Behav. 5, 540-551. 2006.