Cincinnati water maze: A review of the development, methods, and evidence as a test of egocentric learning and memory. Neurotoxicology and Teratology. 2016; 57:1-19.
.Kaolin-induced ventriculomegaly at weaning produces long-term learning, memory, and motor deficits in rats. International Journal of Developmental Neuroscience. 2014; 35:7-15.
.Dorsal striatal dopamine depletion impairs both allocentric and egocentric navigation in rats. Neurobiology of Learning and Memory. 2012; 97:402-408.
.Neonatal methamphetamine-induced corticosterone release in rats is inhibited by adrenal autotransplantation without altering the effect of the drug on hippocampal serotonin. Neurotoxicology and Teratology. 2010; 32:356-361.
.Ontogeny of the adrenal response to (+)-methamphetamine in neonatal rats: the effect of prior drug exposure. Stress. 2006; 9:153-163.
.Morris water maze: procedures for assessing spatial and related forms of learning and memory. Nature Protocols. 2006; 1:848-858.
.CRF administered to pregnant rats alters offspring behavior and morphology. Pharmacology Biochemistry and Behavior. 1995; 52:161-167.
.2022; 12.
. Neurobehavioral abnormalities following prenatal psychosocial stress are differentially modulated by maternal environment. Translational Psychiatry.Developmental deltamethrin: Sex-specific hippocampal effects in Sprague Dawley rats. 2022; 3.
.Comprehensive Behavioral Analysis of Opsin 3 (Encephalopsin)-Deficient Mice Identifies Role in Modulation of Acoustic Startle Reflex. eNeuro. 2022; 9.
.Cognitive and behavioral effects of whole brain conventional or high dose rate (FLASH) proton irradiation in a neonatal Sprague Dawley rat model. PLoS ONE. 2022; 17.
.Latrophilin-3 heterozygous versus homozygous mutations in Sprague Dawley rats: Effects on egocentric and allocentric memory and locomotor activity. Genes, Brain and Behavior. 2022; 21.
.Neurobehavioral abnormalities following prenatal psychosocial stress are differentially modulated by maternal environment. Translational Psychiatry. 2022; 12.
.Review of rodent models of attention deficit hyperactivity disorder. Neuroscience and Biobehavioral Reviews. 2022; 132:621-637.
.An assessment of executive function in two different rat models of attention-deficit hyperactivity disorder: Spontaneously hypertensive versus Lphn3 knockout rats. Genes, Brain and Behavior. 2021; 20.
.Review of Conventional and High Dose Rate Brain Radiation (FLASH): Neurobehavioural, Neurocognitive and Assessment Issues in Rodent Models. Comparative Haematology International. 2021; 33:e482-e491.
.A novel role for the ADHD risk gene latrophilin-3 in learning and memory in Lphn3 knockout rats. Neurobiology of Disease. 2021; 158.
.Effects of pyrethroids on brain development and behavior: Deltamethrin. Neurotoxicology and Teratology. 2021; 87.
.Issues in the design, analysis, and application of rodent developmental neurotoxicology studies. Neurotoxicology and Teratology. 2021; 87.
.Latrophilin-3 disruption: Effects on brain and behavior. Neuroscience and Biobehavioral Reviews. 2021; 127:619-629.
.Effects of Permethrin or Deltamethrin Exposure in Adult Sprague Dawley Rats on Acoustic and Light Prepulse Inhibition of Acoustic or Tactile Startle. Neurotoxicity Research. 2021; 39:543-555.
.GABAA Alpha 2,3 Modulation Improves Select Phenotypes in a Mouse Model of Fragile X Syndrome. Frontiers in Psychiatry. 2021; 12.
.Impact of preweaning stress on long-term neurobehavioral outcomes in Sprague-Dawley rats: Differential effects of barren cage rearing, pup isolation, and the combination. Neurotoxicology and Teratology. 2021; 84.
.Translating Neurobehavioral Toxicity Across Species From Zebrafish to Rats to Humans: Implications for Risk Assessment. Frontiers in Toxicology. 2021; 3.
.Whole brain proton irradiation in adult Sprague Dawley rats produces dose dependent and non-dependent cognitive, behavioral, and dopaminergic effects. Scientific Reports. 2020; 10.
.Chronic psychosocial stress during pregnancy affects maternal behavior and neuroendocrine function and modulates hypothalamic CRH and nuclear steroid receptor expression. Translational Psychiatry. 2020; 10.
.The potassium channel Kv4.2 regulates dendritic spine morphology, electroencephalographic characteristics and seizure susceptibility in mice. Neurodegeneration : a journal for neurodegenerative disorders, neuroprotection, and neuroregeneration. 2020; 334.
.This is your teen brain on drugs: In search of biological factors unique to dependence toxicity in adolescence. Neurotoxicology and Teratology. 2020; 81.
.Enhanced Transient Striatal Dopamine Release and Reuptake in Lphn3 Knockout Rats. ACS Chemical Neuroscience. 2020; 11:1171-1177.
.Litter effects: Comments on Golub and Sobin's "Statistical modeling of litter as a random effect in mixed models to manage "intralitter likeness " ". Neurotoxicology and Teratology. 2020; 77.
.Impairment of cognitive flexibility in type 2 diabetic db/db mice. Behavioural Brain Research. 2019; 371.
.Knockout of latrophilin-3 in Sprague-Dawley rats causes hyperactivity, hyper-reactivity, under-response to amphetamine, and disrupted dopamine markers. Neurobiology of Disease. 2019; 130.
.Characterization of Motor and Non-Motor Behavioral Alterations in the Dj-1 (PARK7) Knockout Rat. Journal of Molecular Neuroscience. 2019; 69:298-311.
.Infection-induced endothelial amyloids impair memory. FASEB Journal. 2019; 33:10300-10314.
.Learning and Memory Effects of Neonatal Methamphetamine Exposure in Sprague-Dawley Rats: Test of the Role of Dopamine Receptors D1 in Mediating the Long-Term Effects. Developmental Neuroscience. 2019; 41:44-55.
.Effects of intrastriatal dopamine D1 or D2 antagonists on methamphetamine-induced egocentric and allocentric learning and memory deficits in Sprague-Dawley rats. Psychopharmacology. 2019; 236:2243-2258.
.Deltamethrin Exposure Daily From Postnatal Day 3-20 in Sprague-Dawley Rats Causes Long-term Cognitive and Behavioral Deficits. Toxicological Sciences. 2019; 169:511-523.
.Mouse knockout of guanylyl cyclase C: Recognition memory deficits in the absence of activity changes. Genes, Brain and Behavior. 2019; 18.
.Effects of Preweaning Manganese in Combination with Adult Striatal Dopamine Lesions on Monoamines, BDNF, TrkB, and Cognitive Function in Sprague-Dawley Rats. Neurotoxicity Research. 2019; 35:606-620.
.Prenatal exposure to PCBs in Cyp1a2 knock-out mice interferes with F1 fertility, impairs long-term potentiation, reduces acoustic startle and impairs conditioned freezing contextual memory with minimal transgenerational effects. Journal of Applied Toxicology. 2019; 39:603-621.
.Effects of Acute Deltamethrin Exposure in Adult and Developing Sprague Dawley Rats on Acoustic Startle Response in Relation to Deltamethrin Brain and Plasma Concentrations. Toxicological Sciences. 2019; 168:61-69.
.Metal bashing: iron deficiency and manganese overexposure impact on peripheral nerves. Journal of Toxicology and Environmental Health - Part A: Current Issues. 2019; 82:99-112.
.Introduction and Summary of the 2018 Dietary Glutamate Workshop. Annals of Nutrition and Metabolism. 2018; 73 Suppl 5:1-4.
.A Test of Dietary Monosodium Glutamate Developmental Neurotoxicity in Rats: A Reappraisal. Annals of Nutrition and Metabolism. 2018; 73 Suppl 5:36-42.
.Effects of Acute Exposure of Permethrin in Adult and Developing Sprague-Dawley Rats on Acoustic Startle Response and Brain and Plasma Concentrations. Toxicological Sciences. 2018; 165:361-371.
.A better approach to in vivo developmental neurotoxicity assessment: Alignment of rodent testing with effects seen in children after neurotoxic exposures. Toxicology and Applied Pharmacology. 2018; 354:176-190.
.Cognitive deficits and increases in creatine precursors in a brain-specific knockout of the creatine transporter gene Slc6a8. Genes, Brain and Behavior. 2018; 17.
.Developmental manganese, lead, and barren cage exposure have adverse long-term neurocognitive, behavioral and monoamine effects in Sprague-Dawley rats. Neurotoxicology and Teratology. 2018; 67:50-64.
.A Single High Dose of Methamphetamine Reduces Monoamines and Impairs Egocentric and Allocentric Learning and Memory in Adult Male Rats. Neurotoxicity Research. 2018; 33:671-680.
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Charles V. Vorhees, PhD
Division of Neurology
Phone: 513-636-8622
Email: charles.vorhees@cchmc.org
Michael T. Williams, PhD
Division of Neurology
Phone: 513-636-4222
Email: michael.williams@cchmc.org