The Crone Lab investigates how neural circuits that control breathing are altered by disease and injury. A variety of approaches are used to study the control of breathing in transgenic mice at the level of the whole animal (plethysmography, electromyography), neural circuit (synaptic tracing, 3D imaging, chemogenetics) and individual molecules (RNA sequencing).
We are working to develop new approaches to repair or enhance the function of respiratory circuits to improve breathing in patients with spinal cord injury, epilepsy, and neuromuscular diseases such as amyotrophic lateral sclerosis (ALS), spinal muscular atrophy (SMA) and muscular dystrophy.
Our lab is also actively involved in the Neuromuscular Development Group. Our collaborations aim to accelerate research in the development and diseases of the neuromuscular system.