Perentesis Lab

Publications

Schuemann, J; Rothwell, B; Mascia, A; Fan, Y; Loo, BW; Yock, T; Liu, KX; Perentesis, J; Haas-Kogan, DA. The potential and risks of FLASH radiotherapy in pediatric patients. Neuro-Oncology Pediatrics. 2025.

Crisler, K; Norris, R; Ketterl, T; Perentesis, J; Mcgrady, M. Social support and barriers to medication adherence among adolescents and young adults with leukemia and lymphoma. Blood. 2025; 146(Supplement 1):2706.

Almohtasib, J; Indelicato, DJ; Paulino, AC; Mihalcik, S; Lee, J; Ermoian, R; Chang, JH-C; Kwok, Y; Perentesis, J; Perkins, SM; Hill-Kayser, C; Zeina, W; Laack, NN; Yock, TI; Gargollo, PC. Assessing Acute and Long-Term Toxicities of Proton Radiation Therapy in Pediatric Pelvic Tumors: Findings From the Pediatric Proton Consortium Registry. Pediatric Blood and Cancer. 2025; 72(10):e31811.

Krisch, JM; Ermoian, RP; Indelicato, DJ; Lee, JY; Perentesis, JP; Perkins, SM; Laack, NN; Chang, JH; Macewan, IJ; Wolden, SL; Wang, D; Yock, TI; Aridgides, PD. Outcomes following radiation therapy for embryonal tumor with multilayered rosettes (ETMR): results from the Pediatric Proton/Photon Consortium Registry (PPCR). Journal of Neuro-Oncology. 2025; 174(2):369-380.

Cha, E; Mihalcik, SA; Indelicato, DJ; Laack, NN; Ermoian, RP; Mangona, VS; Perkins, SM; Wolden, SL; Lee, JY; Perentesis, JP; Eaton, BR; Le, HV; Paulino, AC; Yock, TI. Outcomes of Patients with Intracranial Germinoma Enrolled on the Pediatric Proton Photon Consortium Registry. International Journal of Radiation Oncology Biology Physics. 2025; 123(1):e144-e145.

Nguyen, P; Indelicato, DJ; Esterman, A; Paulino, AC; Ermoian, RP; Laack, NN; Perkins, SM; Mangona, V; Mihalcik, S; Lee, J; Perentesis, JP; Macewan, I; Le, H; Yock, TI. Acute Toxicities of Proton Craniospinal Irradiation in Pediatric Medulloblastoma: A Pediatric Proton/Photon Consortium Registry (PPCR) Study. International Journal of Particle Therapy. 2025; 16:100747.

Sarangdhar, M; Snyder, J; O'brien, E; Vancauwenbergh, B; Basu, M; Pressey, J; Perentesis, J. Abstract 3155: High-throughput drug repositioning identifies dinaciclib as a potent osteosarcoma inhibitor. Cancer Research. 2025; 85(8_Supplement_1):3155-3155.

Williams, MT; Regan, SL; Fritz, AL; Gollaway, BM; Mascia, AE; Vatner, RE; Perentesis, JP; Vorhees, CV. Effects of whole brain proton irradiation at conventional or ultra-high dose rate (FLASH), in adult male Sprague Dawley rats. Scientific Reports. 2025; 15(1):10602.

Garrett, MC; Carnwath, T; Albano, R; Zhuang, Y; Behrmann, CA; Pemberton, M; Barakat, F; Lober, R; Hoeprich, M; Paravati, A; Perentesis, J; Nasser, R; Medvedovic, M; Plas, DR. CPI203, a BET inhibitor, down-regulates a consistent set of DNA synthesis genes across a wide array of glioblastoma lines. PLoS ONE. 2025; 20(5):e0306846.

Sarangdhar, M; O'brien, E; Vancauwenbergh, B; Basu, M; Snyder, J; Leuenberger, G; Perentesis, JP. High-Throughput Drug Repurposing Identifies SN-38 As a Potent Inhibitor of AML with Synergistic Effects in Combination with PARP and BCL-2 Inhibitors for Treating KMT2A-Rearranged Leukemias. Blood. 2024; 144(Supplement 1):2203.

Culver-Cochran, AE; Hassan, A; Hueneman, K; Choi, K; Ma, A; Vancauwenbergh, B; O'brien, E; Wunderlich, M; Perentesis, JP; Starczynowski, DT. Chemotherapy resistance in acute myeloid leukemia is mediated by A20 suppression of spontaneous necroptosis. Nature Communications. 2024; 15(1):9189.

Knapp, J; Ermoian, RP; Indelicato, DJ; Lee, JY; Perentesis, JP; Perkins, SM; Laack, NN; Chang, J; Macewan, I; Wolden, SL; Wang, D; Aridgides, PD; Yock, TI. Outcomes Following Radiation Therapy (RT) for Embryonal Tumor with Multilayered Rosettes (ETMR): Results from the Pediatric Proton/Photon Consortium Registry (PPCR) International Journal of Radiation Oncology Biology Physics. 2024; 120(2):e697.

Leblanc, FR; Breese, EH; Burns, KC; Chang, EK; Jones, LM; Lee, L; Mizukawa, B; Norris, RE; O'brien, MM; Phillips, CL; Perentesis, JP; Rubinstein, J; Pommert, L. Clinical outcomes of hypomethylating agents and venetoclax in newly diagnosed unfit and relapsed/refractory paediatric, adolescent and young adult acute myeloid leukaemia patients. British Journal of Haematology. 2024; 205(3):1055-1066.

Loo, BW; Verginadis, II; Sørensen, BS; Mascia, AE; Perentesis, JP; Koong, AC; Schüler, E; Rankin, EB; Maxim, PG; Limoli, CL; Vozenin, M-C. Navigating the Critical Translational Questions for Implementing FLASH in the Clinic. Seminars in Radiation Oncology. 2024; 34(3):351-364.

Doig, M; Kwok, Y; Lee, J; Macewan, I; Mangona, V; Laack, N; Wolden, S; Perentesis, J; Allison, K; Galloto, S; Gorayski, P; Le, H; Bezak, E; Yock, T. O114 / #164 DOSE TO ORGANS AT RISK IMPACTS HEALTH-RELATED QUALITY OF LIFE OUTCOMES FOR CHILDREN WITH BRAIN TUMORS. International Journal of Particle Therapy. 2024; 12:100227.

Daugherty, EC; Zhang, Y; Xiao, Z; Mascia, AE; Sertorio, M; Woo, J; Mccann, C; Russell, KJ; Sharma, RA; Khuntia, D; Bradley, JD; Simone, CB; Breneman, JC; Perentesis, JP. FLASH radiotherapy for the treatment of symptomatic bone metastases in the thorax (FAST-02): protocol for a prospective study of a novel radiotherapy approach. Radiation Oncology. 2024; 19(1):34.

Mascia, A; Mccauley, S; Speth, J; Nunez, SA; Boivin, G; Vilalta, M; Sharma, RA; Perentesis, JP; Sertorio, M. Impact of Multiple Beams on the FLASH Effect in Soft Tissue and Skin in Mice. International Journal of Radiation Oncology Biology Physics. 2024; 118(1):253-261.

Correia, D; Indelicato, DJ; Paulino, AC; Ermoian, R; Mihalcik, S; Perkins, SM; Hill-Kayser, C; Mangona, VS; Lee, J; Chang, JH-C; Bajaj, BVM; Allison, KW; Perry, A; Yock, TI. Evolution of Proton Radiation Therapy Brainstem Constraints on the Pediatric Proton/Photon Consortium Registry. Practical Radiation Oncology. 2024; 14(6):e507-e514.

Shukla, S; Saha, T; Rama, N; Acharya, A; Le, T; Bian, F; Donovan, J; Tan, LA; Vatner, R; Kalinichenko, V; Mascia, A; Perentesis, JP; Kalin, TV. Ultra-high dose-rate proton FLASH improves tumor control. Radiotherapy and Oncology. 2023; 186:109741.

Garrett, MC; Albano, R; Carnwath, T; Elahi, L; Behrmann, CA; Pemberton, M; Woo, D; O'brien, E; Vancauwenbergh, B; Perentesis, J; Roskin, K; Kornblum, H; Plas, DR; Lu, QR. HDAC1 and HDAC6 are essential for driving growth in IDH1 mutant glioma. Scientific Reports. 2023; 13(1):12433.

Williams, M; Sugimoto, C; Regan, S; Pitzer, E; Fritz, A; Sertorio, M; Mascia, A; Vatner, R; Perentesis, J; Vorhees, C. Cognitive and behavioral effects of whole brain conventional or high dose rate (FLASH) proton irradiation in a neonatal Sprague Dawley rat model. Neurotoxicology and Teratology. 2023; 98:107276.

Bender, JD; Rubinstein, JD; Mizukawa, B; Perentesis, JP; Pommert, L. Use of gemcitabine, oxaliplatin, and anti-CD20 therapy in children and adolescents with non-Hodgkin lymphoma unfit for intensive therapy. Pediatric Blood and Cancer. 2023; 70(4):e30214.

Roehrig, A; Indelicato, DJ; Paulino, AC; Ermoian, R; Hartsell, W; Perentesis, J; Hill-Kayser, C; Lee, JY; Laack, NN; Mangona, V; Gallotto, S; Bajaj, BVM; Aridgides, PD; Yock, TI. Radiotherapy for Atypical Teratoid/Rhabdoid Tumor (ATRT) on the Pediatric Proton/Photon Consortium Registry (PPCR). Journal of Neuro-Oncology. 2023; 162(2):353-362.

Mcgrady, ME; Ketterl, TG; Norris, RE; Perentesis, JP; Pettee, D; Mara, CA; Breen, G; Pai, ALH. Barriers to medication adherence among adolescents and young adults with cancer. Pediatric Blood and Cancer. 2023; 70(3):e30186.

Wyatt, KD; Noyd, DH; Wood, NM; Phillips, CA; Miller, TP; Rubin, EM; Winestone, LE; Waanders, AJ; Perentesis, JP; Aplenc, R. Data standards in pediatric oncology: Past, present, and future. Pediatric Blood and Cancer. 2023; 70(2):e30128.

Daugherty, EC; Mascia, A; Zhang, Y; Lee, E; Xiao, Z; Sertorio, M; Woo, J; Mccann, C; Russell, K; Levine, L; Bradley, J; Simone, CB; Perentesis, J; Breneman, J. FLASH Radiotherapy for the Treatment of Symptomatic Bone Metastases (FAST-01): Protocol for the First Prospective Feasibility Study. JMIR Research Protocols. 2023; 12:e41812.

Mascia, AE; Daugherty, EC; Zhang, Y; Lee, E; Xiao, Z; Sertorio, M; Woo, J; Backus, LR; Mcdonald, JM; Mccann, C; Bradley, JD; Simone, CB; Perentesis, JP; Breneman, JC. Proton FLASH Radiotherapy for the Treatment of Symptomatic Bone Metastases: The FAST-01 Nonrandomized Trial. JAMA Oncology. 2023; 9(1):62-69.

Lawell, MP; Paulino, AC; Indelicato, DJ; Hill-Kayser, C; Perkins, S; Perentesis, J; Bajaj, B; Yock, TI. Neurocognitive outcomes in pediatric brain tumor survivors treated with proton radiotherapy: a study from the Pediatric Proton/Photon Consortium Registry (PPCR) International Journal of Radiation Oncology Biology Physics. 2022; 114(5):1074.

Sarangdhar, MM; O'brien, E; Vancauwenbergh, B; Alexander, J; Theile, C; Basu, M; Sarangdhar, M; Seibel, W; Perentesis, JP. High Throughput Pre-Clinical Models to Determine a Synergistic Molar Ratio of 5-Azacitidine to Venetoclax and Uncover Resistance Mechanisms to 5-Azacitidine and Venetoclax Combination Therapy in Acute Myeloid Leukemia. Blood. 2022; 140(Supplement 1):10693-10694.

Fobare, S; Orwick, S; Kohlschmidt, J; Sesterhenn, T; Mrózek, K; Wronowski, B; Johnstone, M; Carroll, AJ; Stone, RM; Wang, ES; Perentesis, JP; Eisfeld, A-K; Hertlein, E; Byrd, JC. Identification of PTPN11 mutations As Early Events in the Development of Acute Myeloid Leukemia. Blood. 2022; 140(Supplement 1):743-744.

Daugherty, EC; Mascia, AE; Sertorio, MGB; Zhang, Y; Lee, E; Xiao, Z; Speth, J; Woo, J; Mccann, C; Russell, K; Levine, L; Sharma, R; Khuntia, D; Perentesis, JP; Breneman, JC. FAST-01: Results of the First-in-Human Study of Proton FLASH Radiotherapy. International Journal of Radiation Oncology Biology Physics. 2022; 114(3):s4.

Power-Hays, A; Dandoy, CE; Lorts, A; Perentesis, JP; Unaka, N; Ware, RE; Mcgann, PT. US News & World Report and quality metrics: Inclusion of sickle cell disease is a matter of equity. Pediatric Blood and Cancer. 2022; 69(8):e29679.

Barreyro, L; Sampson, AM; Ishikawa, C; Hueneman, KM; Choi, K; Pujato, MA; Chutipongtanate, S; Wyder, M; Haffey, WD; O'brien, E; Greis, KD; Nurmemmedov, E; Seibel, WL; Starczynowski, DT. Blocking UBE2N abrogates oncogenic immune signaling in acute myeloid leukemia. Science Translational Medicine. 2022; 14(635):eabb7695.

Hegde, S; Gasilina, A; Wunderlich, M; Lin, Y; Buchholzer, M; Krumbach, OHF; Akbarzadeh, M; Ahmadian, MR; Seibel, W; Zheng, Y; Perentesis, JP; Mizukawa, BE; Vinnedge, LP; Cancelas, JA; Nassar, NN. Inhibition of the RacGEF VAV3 by the small molecule IODVA1 impedes RAC signaling and overcomes resistance to tyrosine kinase inhibition in acute lymphoblastic leukemia. Leukemia. 2022; 36(3):637-647.

Niederkorn, M; Ishikawa, C; M Hueneman, K; Bartram, J; Stepanchick, E; R Bennett, J; E Culver-Cochran, A; Bolanos, LC; Uible, E; Choi, K; Wunderlich, M; Perentesis, JP; M Chlon, T; Filippi, M-D; Starczynowski, DT. The deubiquitinase USP15 modulates cellular redox and is a therapeutic target in acute myeloid leukemia. Leukemia. 2022; 36(2):438-451.

Wunderlich, M; Chen, J; Sexton, C; Manning, N; Byerly, L; O’Brien, E; Perentesis, JP; Mulloy, JC; Mizukawa, B. PDX models of relapsed pediatric AML preserve global gene expression patterns and reveal therapeutic targets. bioRxiv. 2022; 2022.01.31.478534.

Cunningham, S; Mccauley, S; Speth, J; Abel, E; Sharma, R; Perentesis, J; Wells, S; Mascia, A; Sertorio, M. O086 FLASH Mechanisms Track (Oral Presentations) FLASH PROTON PENCIL BEAM SCANNING IRRADIATION USING A CLINICAL GANTRY DIMINISHES RADIATION INDUCED SKIN AND SOFT TISSUE TOXICITY IN MICE. Physica Medica. 2022; 94:s47-s48.

Williams, MT; Sugimoto, C; Regan, SL; Pitzer, EM; Fritz, AL; Sertorio, M; Mascia, AE; Vatner, RE; Perentesis, JP; Vorhees, CV. Cognitive and behavioral effects of whole brain conventional or high dose rate (FLASH) proton irradiation in a neonatal Sprague Dawley rat model. PLoS ONE. 2022; 17(9):e0274007.