The goal of our research is to identify molecular mechanisms of temperature sensation using the fly brain as a model. We will elucidate how temperature stimuli are relayed and represented in the brain and will uncover the temperature-responsive neural circuits using genetic, behavioral and physiological approaches.
Tang X, Roessingh S, Hayley SE, Chu ML, Tanaka KL, Werner W, Stanewsky R, Hamada FN. The role of PDF neurons in setting the preferred temperature before dawn in Drosophila. eLife. 2017 May 2;6.
Hamada FN, Rosenzweig M, Kang K, Pulver S, Ghezzi A, Jegla T, Garrity PA.
An internal thermal sensor controlling temperature preference in Drosophila
. Nature. 454(7201):217-20. 2008.
Hamada FN, Namekawa SH, Ishii S, Iwabata K, Nara T, Koshiyama A, Yamaguchi T, Ishizaki T, Sakaguchi K, Sawado T. Proliferating cell nuclear antigen (PCNA) interacts with a meiosis-specific RecA homologues, Lim15/Dmc1, but does not stimulate its strand transfer activity. Biochem Biophys Res Commun. 352(4):836-42. 2007.
Hamada FN, Park PJ, Gordadze PR, Kuroda MI. Global regulation of X chromosomal genes by the MSL complex in Drosophila melanogaster. Genes & Development.19(19):2289-94. 2005.
Fumika Hamada, PhD
Assistant ProfessorUC Department of Pediatrics
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