Translational and Clinical Pharmacology

Publications

Ailabouni, A; Prasad, B. Organic cation transporters 2: Structure, regulation, functions, and clinical implications. Drug metabolism and disposition: the biological fate of chemicals. 2025; 53:100044.

Ailabouni, AS; Singh, DK; Thakur, A; Boone, EC; Gaedigk, A; Paine, MF; Prasad, B. Quantitative Contributions of Hepatic and Renal Organic Cation Transporters to the Clinical Pharmacokinetic Cimetidine-Metformin Interaction. Clinical Pharmacology and Therapeutics. 2025; 118:343-354.

Ailabouni, AS; Vijaywargi, G; Subash, S; Singh, DK; Gaborik, Z; Prasad, B. Is N1-Methylnicotinamide a Good Organic Cation Transporter 2 (OCT2) Biomarker?. Metabolites. 2025; 15:80.

Bachhav, N; Prasad, B. Development of human glucuronide atlas and its application for identifying endogenous UGT substrates by a novel metabolomic-based DMET biomarker discovery (MDBD) approach. Drug Metabolism and Pharmacokinetics. 2025; 61:101301.

Bachhav, N; Subash, S; Ahire, D; Singh, DK; Prasad, B. Inter-individual variability, differential tissue abundance, and sub-cellular localization of human aldo-keto reductases (AKRs) and hydroxy-steroid dehydrogenases (HSDs). Biochemical Pharmacology. 2025; 239:117044.

Bartel, C; Mizuno, T; Irie, K; Samuels, A; Lynch, K; Jackson, K; Hyams, J; Boyle, B; Saeed, S; Kurowski, J; Noe, J; Chun, K; Yang, J; Denson, L; Minar, P. AN EVALUATION OF ENDOSCOPIC HEALING IN PEDIATRIC CROHN’S DISEASE USING MULTIPLE ENDOSCOPIC SCORING METHODS IDENTIFIES SIMILARITIES IN BLOOD AND STOOL BIOMARKERS. Gastroenterology. 2025; 168:s84-s85.

Bartel, C; Mizuno, T; Irie, K; Samuels, A; Lynch, K; Jackson, K; Hyams, J; Boyle, B; Saeed, S; Kurowski, J; Noe, J; Chun, K; Yang, J; Denson, L; Minar, P. AN EVALUATION OF ENDOSCOPIC HEALING IN PEDIATRIC CROHN’S DISEASE USING MULTIPLE ENDOSCOPIC SCORING METHODS IDENTIFIES SIMILARITIES IN BLOOD AND STOOL BIOMARKERS. Inflammatory Bowel Diseases. 2025; 31:s59-s60.

Davydov, DR; Ponraj, K; Davydova, N; Singh, DK; Prasad, B. A new naphthalene-based fluorogenic substrate for cytochrome P450 4A11. The Biochemical journal. 2025; 482:839-857.

Gaither, KA; Thakur, A; Singh, DK; Hart, KD; Kis, E; Gáborik, Z; Clarke, J; Prasad, B. Confounding Effect of Phenol Red on OAT- and OATP-Mediated Transporter Assays: Implications for Accuracy and Translatability of In Vitro Data (Abstract ID: 168143). The Journal of pharmacology and experimental therapeutics. 2025; 392:101704.

Gaither, KA; Yue, G; Singh, DK; Trudeau, J; Ponraj, K; Davydova, NY; Lazarus, P; Davydov, DR; Prasad, B. Effects of Chronic Alcohol Intake on the Composition of the Ensemble of Drug-Metabolizing Enzymes and Transporters in the Human Liver. Journal of Xenobiotics. 2025; 15:20.

Gu, W; Langlois, AW R; Giratallah, H; Claw, KG; Prasad, B; Thummel, KE; Tyndale, RF. Extending Investigations of miR-126-5p on the Regulation of CYP2A6, the Major Nicotine-Inactivating Enzyme. Pharmacology Research and Perspectives. 2025; 13:e70149.

Kim, C; Molina, R; Lee, M; Garay-Alvarez, A; Yang, J; Qian, Y; Birhanu, BT; Hesek, D; Hermoso, JA; Chang, M; Mobashery, S. Reactions of SleC, Its Structure and Inhibition in Mitigation of Spore Germination in Clostridioides difficile. Journal of the American Chemical Society. 2025; 147:5060-5070.

Lapehn, S; Nair, S; Firsick, EJ; MacDonald, J; Thoreson, C; Litch, JA; Bush, NR; Kadam, L; Girard, S; Myatt, L; Prasad, B; Sathyanarayana, S; Paquette, AG. A transcriptomic comparison of in vitro models of the human placenta. Placenta. 2025; 159:52-61.

Li, Y; Yabut, J; Zhang, Z; Fauty, S; Houle, R; Miller, H; Zhang, NR; Shin, MK; Rosahl, TW; Zhou, HH; Prasad, B; Unadkat, JD; Chu, X. Characterization of organic anion transporting polypeptide (OATP)1B1 and OATP1B3 humanized rat as a translational model to study the pharmacokinetics of OATP1B substrate drugs. Drug metabolism and disposition: the biological fate of chemicals. 2025; 53:100101.

Marsh, R; Khoury, R; Mizuno, K; Hosawi, A; Cottrell, C; Nguyen, E; Landon, B; Chandra, S; Jordan, M; Kumar, A; Bleesing, J; Davies, S; Moore, C; Mehta, P. Precision Alemtuzumab Dosing Results in Day 0 Target Range Achievement in 80% of IEI Patients and Minimizes Risks of GVHD, Clinically Significant Mixed Chimerism, and Secondary Graft Failure. 2025; 1.

Masuda, S; Lemaitre, F; Barten, MJ; Bergan, S; Shipkova, M; van Gelder, T; Vinks, S; Wieland, E; Bornemann-Kolatzki, K; Brunet, M; Venkataramanan, R; Walson, P; Woillard, JB; Langman, LJ. Everolimus Personalized Therapy: Second Consensus Report by the International Association of Therapeutic Drug Monitoring and Clinical Toxicology. Therapeutic Drug Monitoring. 2025; 47:4-31.

Mehta, PA; Nelson, A; Loveless, S; Lane, A; Fukuda, T; Teusink-Cross, A; Elder, D; Lagory, D; Miller, E; Cancelas, JA; Edwards, S; Chihanga, T; Wells, SI; Davies, SM. Phase 1 study of quercetin, a natural antioxidant for children and young adults with Fanconi anemia. Blood Advances. 2025; 9:1927-1939.

Mizuno, K; Teusink-Cross, A; Sabulski, DA; Davies, SM; Jodele, S. Unraveling the Challenges of Non-Responders to the Eculizumab Treatment with High-Risk Hematopoietic Stem Cell Transplant-Associated Thrombotic Microangiopathy (TA-TMA). Transplantation and Cellular Therapy. 2025; 31:s542-s543.

Morales Junior, R; Hambrick, HR; Mizuno, T; Pavia, KE; Paice, KM; Tang, P; Schuler, E; Krallman, KA; Johnson, L; Collins, M; Gibson, A; Curry, C; Kaplan, J; Goldstein, S; Tang Girdwood, S. Population Pharmacokinetics of Cefepime in Critically Ill Children and Young Adults: Model Development and External Validation for Monte Carlo Simulations and Model-Informed Precision Dosing. Clinical Pharmacokinetics. 2025; 64:553-564.

Naji-Talakar, S; Singh, DK; Paine, M; Prasad, B. Diclofenac Glucuronidation and Oxidation Are Inhibited by Curcumin Standard and Supplements (Abstract ID: 167709). The Journal of pharmacology and experimental therapeutics. 2025; 392:101701.

Negi, CK; Gadara, D; Bajard, L; Spáčil, Z; Blaha, L. 2-Ethylhexyl Diphenyl Phosphate Affects Steroidogenesis and Lipidome Profile in Human Adrenal (H295R) Cells. Chemical Research in Toxicology. 2025; 38:733-744.

Nguyen, VT; Birhanu, BT; Miguel-Ruano, V; Kim, C; Batuecas, M; Yang, J; El-Araby, AM; Jiménez-Faraco, E; Schroeder, VA; Alba, A; Fisher, JF; Hermoso, JA; Chang, M; Mobashery, S. Restoring susceptibility to β-lactam antibiotics in methicillin-resistant Staphylococcus aureus. Nature Chemical Biology. 2025; 21:482-489.

Panipinto, PM; Yue, GE; Prasad, B; Ahmed, S. Pentagalloyl glucose inhibits monosodium urate-induced inflammation and NLRP3 inflammasome formation via TAK1. American Journal of Physiology: Cell Physiology. 2025; 329:C500-C512.

Pavia, K; Girdwood, ST; Paice, K; Dong, M; Mizuno, T; Tang, P; Mangeot, C; Vinks, AA; Kaplan, J. Acute kidney injury is associated with abnormal cefepime exposure among critically ill children and young adults. Pediatric Nephrology. 2025; 40:513-521.

Power-Hays, A; Namazzi, R; Dong, M; Kazinga, C; Kato, C; Aliwuya, S; McElhinney, K; Conroy, AL; Lane, A; John, C; Vinks, AA; Latham, T; Opoka, RO; Ware, RE. The feasibility of pharmacokinetic-based dosing of hydroxyurea for children with sickle cell anaemia in Uganda: Baseline results of the alternative dosing and prevention of transfusions trial. British Journal of Clinical Pharmacology. 2025; 91:1865-1872.

Power-Hays, A; Namazzi, R; Dong, M; Kazinga, C; Kato, C; Aliwuya, S; McElhinney, K; Conroy, AL; Lane, A; John, C; Vinks, AA; Latham, T; Opoka, RO; Ware, RE. The feasibility of pharmacokinetic-based dosing of hydroxyurea for children with sickle cell anaemia in Uganda: Baseline results of the alternative dosing and prevention of transfusions trial. British Journal of Clinical Pharmacology. 2025; 91:1865-1872.

Prasad, B. Integrating intestinal physiology and drug metabolism, disposition, and interactions through PBPK modeling. Drug Metabolism and Pharmacokinetics. 2025; 61:101072.

Pyatt, A; McGowan, M; Tanaka, R; Miyagawa, B; Mizuno, T; Shields, AR; Christianson, A; West-Thielke, P; Leone, JP; Woodle, ES; Kaufman, D; Wiseman, A; Matas, AJ; Vinks, AA; Alloway, RR. Belatacept Pharmacokinetic Analysis of Belatacept Early Steroid Withdrawal Trial (BEST) to Clinical Outcomes and Compared With Reported BENEFIT and BENEFIT-EXT Pharmacokinetic Analysis. Clinical Transplantation. 2025; 39:e70172.

Samuels, A; Irie, K; Mizuno, T; Reifenberg, J; Punt, N; Vinks, AA; Minar, P. Integrating early response biomarkers in pharmacokinetic models: A novel method to individualize the initial infliximab dose in patients with Crohn's disease. Clinical and Translational Science. 2025; 18:e70086.

Saponjac, VT; Sun, R; Zheng, Z; Chen, J; Srinual, S; Prasad, B; Singh, DK; Hu, M; Singh, R. Influence of locally bioavailable herbal components on the regulation of gut homoeostatis via expression of intestinal drug metabolizing enzymes and transporters in irinotecan-induced intestinal injury model. Drug Metabolism and Pharmacokinetics. 2025; 61:101335.

Shaffer, G; Prasad, B. Investigation of Interindividual Variability of Drug Metabolizing Kinases in Human Hepatocytes: Influence of Age, Sex, and Race (Abstract ID: 161579). The Journal of pharmacology and experimental therapeutics. 2025; 392:101673.

Singh, D; Ahire, D; Jones, R; Ma, B; Yu, T; Murray, B; Smith, B; Zientek, M; Heyward, S; Prasad, B. The ontogeny and inter-individual variability of hydrolytic drug-metabolizing enzymes in human liver. Drug Metabolism and Pharmacokinetics. 2025; 61:101127.

Subash, S; Ahire, D; Jones, R; Ma, B; Tian, Y; Murray, B; Stresser, D; Taub, M; Prasad, B. Protein abundance of hydrolytic drug metabolizing enzymes in different tissues and across species. Drug Metabolism and Pharmacokinetics. 2025; 61:101350.

Tan, WR; Irie, K; Mcintire, C; Torres, JL; Jones, R; Gibson, A; Mizuno, T; Girdwood, ST. Model-informed dose optimization for prophylactic piperacillin-tazobactam in perioperative pediatric critically ill patients. Editor, Doernberg S. Antimicrobial Agents and Chemotherapy. 2025; 69:e0122724.

Tanaka, R; Irie, K; Mizuno, T. Physiologically Based Pharmacokinetic Modeling of Antibiotics in Children: Perspectives on Model-Informed Precision Dosing. Antibiotics. 2025; 14:541.

Thakur, A; Singh, DK; Lynch, KD; Kis, E; Gáborik, Z; Clarke, JD; Paine, MF; Prasad, B. Identification and validation of selective endogenous substrates of organic anion transporter 1 (OAT1) versus OAT3 using metabolomics and in-vitro mechanistic studies. Drug Metabolism and Pharmacokinetics. 2025; 61:101454.

Thakur, A; Subash, S; Ahire, D; Prasad, B. Characterization of age-dependent abundance of drug transporter proteins and conjugating enzymes in human hepatocytes: Implication for pediatric drug dosing. Drug Metabolism and Pharmacokinetics. 2025; 61:101453.

Thomas, C; Thomas, CA; Kim, C; El-Araby, AM; Birhanu, BT; Mobashery, S; Chang, M. 392 Adjuvants for the potentiation of the activity of β-lactam antibiotics against methicillin-resistant Staphylococcus aureus. Journal of Clinical and Translational Science. 2025; 9:121.

Venkatachalapathy, P; Singh, DK; Thakur, A; Prasad, B. Identification of Potential Endogenous Substrates of Cytochrome P450 Enzymes Using an Optimized Metabolomics-Based Approach (Abstract ID: 161986). The Journal of pharmacology and experimental therapeutics. 2025; 392:101676.

Vijaywargi, G; Ailabouni, AS; Neogi, AG; Halpin, KL; Paine, M; Prasad, B. Identification of Potential Pre-Dose Endogenous Metabolic Features Associated with Metformin Plasma Exposure in Healthy Adults and Pediatric Patients (Abstract ID: 167055). The Journal of pharmacology and experimental therapeutics. 2025; 392:101700.

Yang, J; Qian, Y; Kim, C; Birhanu, BT; Cal y Mayor-Luna, C; Ding, D; Yu, X; Schroeder, VA; Mobashery, S; Chang, M. Targeting SleC and CspB in the Inhibition of Spore Germination in Clostridioides difficile. Journal of Medicinal Chemistry. 2025; 68:9357-9370.

Zhao, J; Zhao, X; Mizuno, T; Irie, K; Devarajan, P; Brunner, HI; Setchell, KD R. Volumetric Absorptive Microsampling Combined with Mass Spectrometry to Support Pharmacokinetically-Guided Precision Dosing of Mycophenolate Mofetil in Pediatric Lupus Nephritis Patients. The journal of applied laboratory medicine. 2025; 10:806-819.