Translational and Clinical Pharmacology

Publications

Ailabouni, A; Prasad, B. Organic cation transporters 2: Structure, regulation, functions, and clinical implications. Drug metabolism and disposition: the biological fate of chemicals. 2025; 53:100044.

Ailabouni, AS; Vijaywargi, G; Subash, S; Singh, DK; Gaborik, Z; Prasad, B. Is N1-Methylnicotinamide a Good Organic Cation Transporter 2 (OCT2) Biomarker?. Metabolites. 2025; 15:80.

Bartel, C; Mizuno, T; Irie, K; Samuels, A; Lynch, K; Jackson, K; Hyams, J; Boyle, B; Saeed, S; Kurowski, J; Noe, J; Chun, K; Yang, J; Denson, L; Minar, P. AN EVALUATION OF ENDOSCOPIC HEALING IN PEDIATRIC CROHN’S DISEASE USING MULTIPLE ENDOSCOPIC SCORING METHODS IDENTIFIES SIMILARITIES IN BLOOD AND STOOL BIOMARKERS. Gastroenterology. 2025; 168:s84-s85.

Bartel, C; Mizuno, T; Irie, K; Samuels, A; Lynch, K; Jackson, K; Hyams, J; Boyle, B; Saeed, S; Kurowski, J; Noe, J; Chun, K; Yang, J; Denson, L; Minar, P. AN EVALUATION OF ENDOSCOPIC HEALING IN PEDIATRIC CROHN’S DISEASE USING MULTIPLE ENDOSCOPIC SCORING METHODS IDENTIFIES SIMILARITIES IN BLOOD AND STOOL BIOMARKERS. Inflammatory Bowel Diseases. 2025; 31:s59-s60.

Gaither, KA; Thakur, A; Singh, DK; Hart, KD; Kis, E; Gáborik, Z; Clarke, J; Prasad, B. Confounding Effect of Phenol Red on OAT- and OATP-Mediated Transporter Assays: Implications for Accuracy and Translatability of In Vitro Data (Abstract ID: 168143). The Journal of pharmacology and experimental therapeutics. 2025; 392:101704.

Gaither, KA; Yue, G; Singh, DK; Trudeau, J; Ponraj, K; Davydova, NY; Lazarus, P; Davydov, DR; Prasad, B. Effects of Chronic Alcohol Intake on the Composition of the Ensemble of Drug-Metabolizing Enzymes and Transporters in the Human Liver. Journal of Xenobiotics. 2025; 15:20.

Kim, C; Molina, R; Lee, M; Garay-Alvarez, A; Yang, J; Qian, Y; Birhanu, BT; Hesek, D; Hermoso, JA; Chang, M; Mobashery, S. Reactions of SleC, Its Structure and Inhibition in Mitigation of Spore Germination in Clostridioides difficile. Journal of the American Chemical Society. 2025; 147:5060-5070.

Lapehn, S; Nair, S; Firsick, EJ; MacDonald, J; Thoreson, C; Litch, JA; Bush, NR; Kadam, L; Girard, S; Myatt, L; Prasad, B; Sathyanarayana, S; Paquette, AG. A transcriptomic comparison of in vitro models of the human placenta. Placenta. 2025; 159:52-61.

Marsh, R; Khoury, R; Mizuno, K; Hosawi, A; Cottrell, C; Nguyen, E; Landon, B; Chandra, S; Jordan, M; Kumar, A; Bleesing, J; Davies, S; Moore, C; Mehta, P. Precision Alemtuzumab Dosing Results in Day 0 Target Range Achievement in 80% of IEI Patients and Minimizes Risks of GVHD, Clinically Significant Mixed Chimerism, and Secondary Graft Failure. 2025; 1.

Masuda, S; Lemaitre, F; Barten, MJ; Bergan, S; Shipkova, M; van Gelder, T; Vinks, S; Wieland, E; Bornemann-Kolatzki, K; Brunet, M; Venkataramanan, R; Walson, P; Woillard, JB; Langman, LJ. Everolimus Personalized Therapy: Second Consensus Report by the International Association of Therapeutic Drug Monitoring and Clinical Toxicology. Therapeutic Drug Monitoring. 2025; 47:4-31.

Mehta, PA; Nelson, A; Loveless, S; Lane, A; Fukuda, T; Teusink-Cross, A; Elder, D; Lagory, D; Miller, E; Cancelas, JA; Edwards, S; Chihanga, T; Wells, SI; Davies, SM. Phase 1 study of quercetin, a natural antioxidant for children and young adults with Fanconi anemia. Blood Advances. 2025; 9:1927-1939.

Mizuno, K; Teusink-Cross, A; Sabulski, DA; Davies, SM; Jodele, S. Unraveling the Challenges of Non-Responders to the Eculizumab Treatment with High-Risk Hematopoietic Stem Cell Transplant-Associated Thrombotic Microangiopathy (TA-TMA). Transplantation and Cellular Therapy. 2025; 31:s542-s543.

Morales Junior, R; Hambrick, HR; Mizuno, T; Pavia, KE; Paice, KM; Tang, P; Schuler, E; Krallman, KA; Johnson, L; Collins, M; Gibson, A; Curry, C; Kaplan, J; Goldstein, S; Tang Girdwood, S. Population Pharmacokinetics of Cefepime in Critically Ill Children and Young Adults: Model Development and External Validation for Monte Carlo Simulations and Model-Informed Precision Dosing. Clinical Pharmacokinetics. 2025; 64:553-564.

Naji-Talakar, S; Singh, DK; Paine, M; Prasad, B. Diclofenac Glucuronidation and Oxidation Are Inhibited by Curcumin Standard and Supplements (Abstract ID: 167709). The Journal of pharmacology and experimental therapeutics. 2025; 392:101701.

Negi, CK; Gadara, D; Bajard, L; Spáčil, Z; Blaha, L. 2-Ethylhexyl Diphenyl Phosphate Affects Steroidogenesis and Lipidome Profile in Human Adrenal (H295R) Cells. Chemical Research in Toxicology. 2025; 38:733-744.

Nguyen, VT; Birhanu, BT; Miguel-Ruano, V; Kim, C; Batuecas, M; Yang, J; El-Araby, AM; Jiménez-Faraco, E; Schroeder, VA; Alba, A; Fisher, JF; Hermoso, JA; Chang, M; Mobashery, S. Restoring susceptibility to β-lactam antibiotics in methicillin-resistant Staphylococcus aureus. Nature Chemical Biology. 2025; 21:482-489.

Pavia, K; Girdwood, ST; Paice, K; Dong, M; Mizuno, T; Tang, P; Mangeot, C; Vinks, AA; Kaplan, J. Acute kidney injury is associated with abnormal cefepime exposure among critically ill children and young adults. Pediatric Nephrology. 2025; 40:513-521.

Samuels, A; Irie, K; Mizuno, T; Reifenberg, J; Punt, N; Vinks, AA; Minar, P. Integrating early response biomarkers in pharmacokinetic models: A novel method to individualize the initial infliximab dose in patients with Crohn's disease. Clinical and Translational Science. 2025; 18:e70086.

Shaffer, G; Prasad, B. Investigation of Interindividual Variability of Drug Metabolizing Kinases in Human Hepatocytes: Influence of Age, Sex, and Race (Abstract ID: 161579). The Journal of pharmacology and experimental therapeutics. 2025; 392:101673.

Tan, WR; Irie, K; Mcintire, C; Torres, JL; Jones, R; Gibson, A; Mizuno, T; Girdwood, ST. Model-informed dose optimization for prophylactic piperacillin-tazobactam in perioperative pediatric critically ill patients. Editor, Doernberg S. Antimicrobial Agents and Chemotherapy. 2025; 69:e0122724.

Thomas, C; Thomas, CA; Kim, C; El-Araby, AM; Birhanu, BT; Mobashery, S; Chang, M. 392 Adjuvants for the potentiation of the activity of β-lactam antibiotics against methicillin-resistant Staphylococcus aureus. Journal of Clinical and Translational Science. 2025; 9:121.

Venkatachalapathy, P; Singh, DK; Thakur, A; Prasad, B. Identification of Potential Endogenous Substrates of Cytochrome P450 Enzymes Using an Optimized Metabolomics-Based Approach (Abstract ID: 161986). The Journal of pharmacology and experimental therapeutics. 2025; 392:101676.

Vijaywargi, G; Ailabouni, AS; Neogi, AG; Halpin, KL; Paine, M; Prasad, B. Identification of Potential Pre-Dose Endogenous Metabolic Features Associated with Metformin Plasma Exposure in Healthy Adults and Pediatric Patients (Abstract ID: 167055). The Journal of pharmacology and experimental therapeutics. 2025; 392:101700.

Yang, J; Qian, Y; Kim, C; Birhanu, BT; Cal y Mayor-Luna, C; Ding, D; Yu, X; Schroeder, VA; Mobashery, S; Chang, M. Targeting SleC and CspB in the Inhibition of Spore Germination in Clostridioides difficile. Journal of Medicinal Chemistry. 2025; 68:9357-9370.