Translational and Clinical Pharmacology

Publications

Ailabouni, AS; Singh, DK; Thakur, A; Boone, EC; Gaedigk, A; Paine, MF; Prasad, B. Quantitative Contributions of Hepatic and Renal Organic Cation Transporters to the Clinical Pharmacokinetic Cimetidine-Metformin Interaction. Clinical Pharmacology and Therapeutics. 2025; 118(2):343-354.

Ailabouni, A; Prasad, B. Organic cation transporters 2: Structure, regulation, functions, and clinical implications. Drug Metabolism And Disposition. 2025; 53(3):100044.

Ailabouni, AS; Vijaywargi, G; Subash, S; Singh, DK; Gaborik, Z; Prasad, B. Is N1-Methylnicotinamide a Good Organic Cation Transporter 2 (OCT2) Biomarker? Metabolites. 2025; 15(2).

Bachhav, N; Subash, S; Ahire, D; Singh, DK; Prasad, B. Inter-individual variability, differential tissue abundance, and sub-cellular localization of human aldo-keto reductases (AKRs) and hydroxy-steroid dehydrogenases (HSDs). Biochemical Pharmacology. 2025; 239:117044.

Bachhav, N; Singh, DK; Shaffer, G; Amory, JK; Prasad, B. Curcumin enhances the oral bioavailability of testosterone by inhibiting its intestinal metabolism. Drug Metabolism And Disposition. 2025; 53(9):100144.

Bachhav, N; Prasad, B. Development of human glucuronide atlas and its application for identifying endogenous UGT substrates by a novel metabolomic-based DMET biomarker discovery (MDBD) approach. Drug Metabolism and Pharmacokinetics. 2025; 61:101301.

Baker, BH; Kruger, L; Prasad, B; Macdonald, JW; Bammler, TK; Konwar, C; Kobor, MS; Bush, NR; Lewinn, KZ; Zhao, Q; Paquette, AG; Sathyanarayana, S. Placental proteomic signatures of preterm birth, gestational age, and birthweight. BMC Pregnancy and Childbirth. 2025; 26(1):50.

Bartel, C; Mizuno, T; Irie, K; Samuels, A; Lynch, K; Jackson, K; Hyams, J; Boyle, B; Saeed, S; Kurowski, J; Noe, J; Chun, K; Yang, J; Denson, L; Minar, P. AN EVALUATION OF ENDOSCOPIC HEALING IN PEDIATRIC CROHN’S DISEASE USING MULTIPLE ENDOSCOPIC SCORING METHODS IDENTIFIES SIMILARITIES IN BLOOD AND STOOL BIOMARKERS. Inflammatory Bowel Diseases. 2025; 31(Supplement_1):s59-s60.

Bartel, C; Mizuno, T; Irie, K; Samuels, A; Lynch, K; Jackson, K; Hyams, J; Boyle, B; Saeed, S; Kurowski, J; Noe, J; Chun, K; Yang, J; Denson, L; Minar, P. AN EVALUATION OF ENDOSCOPIC HEALING IN PEDIATRIC CROHN’S DISEASE USING MULTIPLE ENDOSCOPIC SCORING METHODS IDENTIFIES SIMILARITIES IN BLOOD AND STOOL BIOMARKERS. Gastroenterology. 2025; 168(3):s84-s85.

Burlo, F; Pastore, S; Stocco, G; Zuanna, PD; Curci, D; Mizuno, T; Irie, K; Taddio, A; Tommasini, A. Give weekly adalimumab a chance before discontinuing it: a retrospective clinical and pharmacokinetic analysis in pediatric rheumatology. Arthritis Research & Therapy. 2025; 27(1):230.

Davydov, DR; Ponraj, K; Davydova, N; Singh, DK; Prasad, B. A new naphthalene-based fluorogenic substrate for cytochrome P450 4A11. Biochemical Journal. 2025; 482(12):839-857.

Dixon, DL; Buckley, LF; Aljadeed, R; Baker, WL; Barreto, JN; Greer, SC; Kang, AY; Laizure, SC; Leino, AD; Maclaren, R; Moore, D; Nahata, MC; Ng, TMH; Nguyen, E. The Clinical Pharmacist as Principal Investigator—2026. JACCP Journal of the American College of Clinical Pharmacy. 2025; 8(12):1362-1367.

Gaither, KA; Thakur, A; Singh, DK; Hart, KD; Kis, E; Gáborik, Z; Clarke, J; Prasad, B. Confounding Effect of Phenol Red on OAT- and OATP-Mediated Transporter Assays: Implications for Accuracy and Translatability of In Vitro Data (Abstract ID: 168143) Journal of Pharmacology and Experimental Therapeutics. 2025; 392(3):101704.

Gaither, KA; Yue, G; Singh, DK; Trudeau, J; Ponraj, K; Davydova, NY; Lazarus, P; Davydov, DR; Prasad, B. Effects of Chronic Alcohol Intake on the Composition of the Ensemble of Drug-Metabolizing Enzymes and Transporters in the Human Liver. Journal of Xenobiotics. 2025; 15(1).

Gooden, F; Meier, BD; Shaffer, GD; Gibson, K; Toren, P; Punt, NC; Subash, S; Singh, DK; Prasad, B; Ramsey, LB; Taylor, ZL. Pharmacogenetic hSLCO1B1*14-Guided Dosing of Methotrexate in Transgenic Arthritic Mice Normalizes Exposure and Response. Clinical and Translational Science. 2026; 19(1):e70449.

Granados, JC; Cheung, KWK; Prasad, B. Editorial: Diverse functions of drug transporters. Frontiers in Pharmacology. 2025; 16:1697775.

Gu, W; Langlois, AWR; Giratallah, H; Claw, KG; Prasad, B; Thummel, KE; Tyndale, RF. Extending Investigations of miR-126-5p on the Regulation of CYP2A6, the Major Nicotine-Inactivating Enzyme. Pharmacology Research & Perspectives. 2025; 13(4):e70149.

Irie, K; Minar, P; Reifenberg, J; Boyle, BM; Noe, JD; Hyams, JS; Mizuno, T. Machine Learning Modeling for Predicting Infliximab Pharmacokinetics in Pediatric and Young Adult Patients With Crohn Disease: Leveraging Ensemble Modeling With Synthetic and Real-World Data. Therapeutic Drug Monitoring. 2026; 48(1):98-104.

Irie, K; Minar, P; Reifenberg, J; Boyle, BM; Noe, JD; Hyams, JS; Mizuno, T. Model-Informed Deep Q-Networks to Guide Infliximab Dosing in Pediatric Crohn's Disease. Clinical Pharmacology and Therapeutics. 2026; 119(2):555-563.

Irie, K; Minar, P; Reifenberg, J; Boyle, BM; Noe, JD; Hyams, JS; Mizuno, T. Hybrid Population Pharmacokinetic-Machine Learning Modeling to Predict Infliximab Pharmacokinetics in Pediatric and Young Adult Patients with Crohn's Disease. Clinical Pharmacokinetics. 2025; 64(11):1669-1679.

Johnson, LSM; Leino, AD; Haver, DB. Public communication and perception of xenotransplantation. Current Opinion in Organ Transplantation. 2026; 31(1):33-40.

Katsube, Y; Umemura, K; Urabe, Y; Ono, M; Katada, Y; Hira, D; Ohsumi, A; Nakajima, D; Tsuda, M; Nakagawa, S; Mizuno, T; Nagao, M; Date, H; Terada, T. NUDT15 Genetic Polymorphism as a Risk Factor for Early Neutropenia During Valganciclovir Prophylaxis in Lung Transplant Patients. Transplant Infectious Disease. 2025; 27(6):e70108.

Lapehn, S; Nair, S; Firsick, EJ; Macdonald, J; Thoreson, C; Litch, JA; Bush, NR; Kadam, L; Girard, S; Myatt, L; Prasad, B; Sathyanarayana, S; Paquette, AG. A transcriptomic comparison of in vitro models of the human placenta. Placenta. 2025; 159:52-61.

Li, Y; Yabut, J; Zhang, Z; Fauty, S; Houle, R; Miller, H; Zhang, NR; Shin, MK; Rosahl, TW; Zhou, HH; Prasad, B; Unadkat, JD; Chu, X. Characterization of organic anion transporting polypeptide (OATP)1B1 and OATP1B3 humanized rat as a translational model to study the pharmacokinetics of OATP1B substrate drugs. Drug Metabolism And Disposition. 2025; 53(7):100101.

Marsh, R; Khoury, R; Mizuno, K; Hosawi, A; Cottrell, C; Nguyen, E; Landon, B; Chandra, S; Jordan, M; Kumar, A; Bleesing, J; Davies, S; Moore, C; Mehta, P. Precision Alemtuzumab Dosing Results in Day 0 Target Range Achievement in 80% of IEI Patients and Minimizes Risks of GVHD, Clinically Significant Mixed Chimerism, and Secondary Graft Failure. Journal of Human Immunity. 2025; 1(CIS2025).

Masuda, S; Lemaitre, F; Barten, MJ; Bergan, S; Shipkova, M; Van Gelder, T; Vinks, S; Wieland, E; Bornemann-Kolatzki, K; Brunet, M; Venkataramanan, R; Walson, P; Woillard, J-B; Langman, LJ. Everolimus Personalized Therapy: Second Consensus Report by the International Association of Therapeutic Drug Monitoring and Clinical Toxicology. Therapeutic Drug Monitoring. 2025; 47(1):4-31.

Mehta, PA; Nelson, A; Loveless, S; Lane, A; Fukuda, T; Teusink-Cross, A; Elder, D; Lagory, D; Miller, E; Cancelas, JA; Edwards, S; Chihanga, T; Wells, SI; Davies, SM. Phase 1 study of quercetin, a natural antioxidant for children and young adults with Fanconi anemia. Blood advances. 2025; 9(8):1927-1939.

Mizuno, K; Teusink-Cross, A; Sabulski, A; Davies, SM; Jodele, S. Unraveling the Challenges of Non-Responders to the Eculizumab Treatment with High-Risk Hematopoietic Stem Cell Transplant-Associated Thrombotic Microangiopathy (TA-TMA) Transplantation and Cellular Therapy. 2025; 31(2):s542-s543.

Morales Junior, R; Mizuno, T; Tan, WR; Irie, K; Tang Girdwood, S. From PICU to NICU: Extrapolating Meropenem Exposure From Pediatric to Neonatal Intensive Care Patients. Journal of Clinical Pharmacology. 2026; 66(1):e70097.

Morales Junior, R; Hambrick, HR; Mizuno, T; Pavia, KE; Paice, KM; Tang, P; Schuler, E; Krallman, KA; Johnson, L; Collins, M; Gibson, A; Curry, C; Kaplan, J; Goldstein, S; Tang Girdwood, S. Population Pharmacokinetics of Cefepime in Critically Ill Children and Young Adults: Model Development and External Validation for Monte Carlo Simulations and Model-Informed Precision Dosing. Clinical Pharmacokinetics. 2025; 64(4):553-564.

Naji-Talakar, S; Singh, DK; Paine, M; Prasad, B. Diclofenac Glucuronidation and Oxidation Are Inhibited by Curcumin Standard and Supplements (Abstract ID: 167709) Journal of Pharmacology and Experimental Therapeutics. 2025; 392(3):101701.

Ogawa-Iio, A; Takeuchi, K; Shigemi, K; Genoveso, MJ; Niitsu, H; Koh, I; Ota, Y; Yamane, K; Hinoi, T; Osaka, N; Goyama, S; Yasuda, T; Senda, T; Sasaki, AT. IMPDH and GTP Metabolism in Cancer: Mechanisms, Regulation, and Translational Scope. Cancer Science. 2025; 116(12):3250-3265.

Panipinto, PM; Yue, GE; Prasad, B; Ahmed, S. Pentagalloyl glucose inhibits monosodium urate-induced inflammation and NLRP3 inflammasome formation via TAK1. American Journal of Physiology - Cell Physiology. 2025; 329(2):C500-C512.

Pavia, K; Girdwood, ST; Paice, K; Dong, M; Mizuno, T; Tang, P; Mangeot, C; Vinks, AA; Kaplan, J. Acute kidney injury is associated with abnormal cefepime exposure among critically ill children and young adults. Pediatric Nephrology. 2025; 40(2):513-521.

Power-Hays, A; Namazzi, R; Dong, M; Kazinga, C; Kato, C; Aliwuya, S; Mcelhinney, K; Conroy, AL; Lane, A; John, C; Vinks, AA; Latham, T; Opoka, RO; Ware, RE. The feasibility of pharmacokinetic-based dosing of hydroxyurea for children with sickle cell anaemia in Uganda: Baseline results of the alternative dosing and prevention of transfusions trial. British Journal of Clinical Pharmacology. 2025; 91(6):1865-1872.

Power-Hays, A; Namazzi, R; Dong, M; Kazinga, C; Kato, C; Aliwuya, S; Mcelhinney, K; Conroy, AL; Lane, A; John, C; Vinks, AA; Latham, T; Opoka, RO; Ware, RE. The feasibility of pharmacokinetic-based dosing of hydroxyurea for children with sickle cell anaemia in Uganda: Baseline results of the alternative dosing and prevention of transfusions trial. British Journal of Clinical Pharmacology. 2025; 91(6):1865-1872.

Prasad, B. Promise of Quantitative Proteomics in the Qualification of New Approach Methodologies. Clinical Pharmacology and Therapeutics. 2025; 118(6):1273-1275.

Prasad, B. Integrating intestinal physiology and drug metabolism, disposition, and interactions through PBPK modeling. Drug Metabolism and Pharmacokinetics. 2025; 61:101072.

Pyatt, A; Mcgowan, M; Tanaka, R; Miyagawa, B; Mizuno, T; Shields, AR; Christianson, A; West-Thielke, P; Leone, JP; Woodle, ES; Kaufman, D; Wiseman, A; Matas, AJ; Vinks, AA; Alloway, RR. Belatacept Pharmacokinetic Analysis of Belatacept Early Steroid Withdrawal Trial (BEST) to Clinical Outcomes and Compared With Reported BENEFIT and BENEFIT-EXT Pharmacokinetic Analysis. Clinical Transplantation. 2025; 39(8):e70172.

Ritter, DM; Schneider, K; Ezeakudo, N; Krueger, DA; Mizuno, T; Knilans, TK; Franz, DN. Maternal Sirolimus Treatment Reverses Cardiac Rhabdomyoma-Induced Hydrops Fetalis in a Twin Gestation With Tuberous Sclerosis Complex. American Journal of Medical Genetics, Part A. 2025; 197(11):e64175.

Samuels, A; Irie, K; Mizuno, T; Reifenberg, J; Punt, N; Vinks, AA; Minar, P. Integrating early response biomarkers in pharmacokinetic models: A novel method to individualize the initial infliximab dose in patients with Crohn's disease. Clinical and Translational Science. 2025; 18(2):e70086.

Saponjac, VT; Sun, R; Zheng, Z; Chen, J; Srinual, S; Prasad, B; Singh, DK; Hu, M; Singh, R. Influence of locally bioavailable herbal components on the regulation of gut homoeostatis via expression of intestinal drug metabolizing enzymes and transporters in irinotecan-induced intestinal injury model. Drug Metabolism and Pharmacokinetics. 2025; 61:101335.

Sawada, K; Khandelwal, P; Davies, SM; Crooker, A; Mizuno, T; Asai, A. Pharmacokinetic Monitoring of JAK Inhibitor and Tacrolimus for Safe and Effective Management of Graft-Versus-Host Disease After Pediatric Liver Transplantation. Pediatric Transplantation. 2025; 29(7):e70187.

Shaffer, G; Prasad, B. Investigation of Interindividual Variability of Drug Metabolizing Kinases in Human Hepatocytes: Influence of Age, Sex, and Race (Abstract ID: 161579) Journal of Pharmacology and Experimental Therapeutics. 2025; 392(3):101673.

Singh, DK; Ahire, D; Jones, RS; Kikuchi, R; Ma, B; Tian, Y; Wang, T; Zubair, F; Heyward, S; Khojasteh, SC; Stresser, DM; Taub, M; Zientek, M; Prasad, B. Protein Abundance of Clinically Relevant Drug-Metabolizing Hydrolases in Human Liver and Intestine by Targeted versus Global Proteomics Approaches: A Comparative Study. Journal of Proteome Research. 2025; 24(11):5683-5695.

Singh, D; Ahire, D; Jones, R; Ma, B; Yu, T; Murray, B; Smith, B; Zientek, M; Heyward, S; Prasad, B. The ontogeny and inter-individual variability of hydrolytic drug-metabolizing enzymes in human liver. Drug Metabolism and Pharmacokinetics. 2025; 61:101127.

Subash, S; Singh, DK; Khojasteh, SC; Murray, BP; Zientek, MA; Jones, RS; Kulkarni, P; Smith, BJ; Prasad, B. Confounding Effect of Hepatic Carboxylesterase 1 (CES1) Variability on Clopidogrel Oxidation. Molecular Pharmaceutics. 2025; 22(12):7359-7370.

Subash, S; Ahire, D; Jones, R; Ma, B; Tian, Y; Murray, B; Stresser, D; Taub, M; Prasad, B. Protein abundance of hydrolytic drug metabolizing enzymes in different tissues and across species. Drug Metabolism and Pharmacokinetics. 2025; 61:101350.

Tan, WR; Irie, K; Mcintire, C; Torres, JL; Jones, R; Gibson, A; Mizuno, T; Tang Girdwood, S. Model-informed dose optimization for prophylactic piperacillin-tazobactam in perioperative pediatric critically ill patients. Antimicrobial Agents and Chemotherapy. 2025; 69(3):e0122724.

Tanaka, R; Irie, K; Mizuno, T. Physiologically Based Pharmacokinetic Modeling of Antibiotics in Children: Perspectives on Model-Informed Precision Dosing. Antibiotics. 2025; 14(6).

Tang Girdwood, S; Morales Junior, R; Schuler, E; Tang, P; Diseroad, E; Misch, C; Engle, B; Mccall, S; Murphy, ME; Taylor, ZL; Mizuno, T; Vinks, AA; Kaplan, J. Building a Beta-Lactam Model-Informed Precision Dosing Service in a Quaternary Care Children's Hospital. Clinical and Translational Science. 2025; 18(12):e70438.

Thakur, A; Singh, DK; Hart, KD; Kis, E; Gáborik, Z; Denton, TT; Clarke, JD; Paine, MF; Prasad, B. From Discovery to Translation: Endogenous Substrates of OAT1 and OAT3 as Clinical Biomarkers for Renal Secretory Function. Clinical Pharmacology and Therapeutics. 2025; 118(3):693-704.

Thakur, A; Subash, S; Ahire, D; Prasad, B. Characterization of age-dependent abundance of drug transporter proteins and conjugating enzymes in human hepatocytes: Implication for pediatric drug dosing. Drug Metabolism and Pharmacokinetics. 2025; 61:101453.

Thakur, A; Singh, DK; Lynch, KD; Kis, E; Gáborik, Z; Clarke, JD; Paine, MF; Prasad, B. Identification and validation of selective endogenous substrates of organic anion transporter 1 (OAT1) versus OAT3 using metabolomics and in-vitro mechanistic studies. Drug Metabolism and Pharmacokinetics. 2025; 61:101454.

Umemura, K; Katsube, Y; Tsuchido, Y; Katada, Y; Hira, D; Kawata, M; Saigo, M; Tsuda, M; Nakagawa, S; Hattori, EY; Arakawa, Y; Date, H; Nagao, M; Terada, T. Efficient Penetration of Terbinafine into Brain Abscesses in a Lung Transplant Recipient with Scedosporiosis: A Short Communication. Therapeutic Drug Monitoring. 2026; 48(1):134-139.

Venkatachalapathy, P; Singh, DK; Thakur, A; Prasad, B. Identification of Potential Endogenous Substrates of Cytochrome P450 Enzymes Using an Optimized Metabolomics-Based Approach (Abstract ID: 161986) Journal of Pharmacology and Experimental Therapeutics. 2025; 392(3):101676.

Vijaywargi, G; Ailabouni, AS; Neogi, AG; Halpin, KL; Paine, M; Prasad, B. Identification of Potential Pre-Dose Endogenous Metabolic Features Associated with Metformin Plasma Exposure in Healthy Adults and Pediatric Patients (Abstract ID: 167055) Journal of Pharmacology and Experimental Therapeutics. 2025; 392(3):101700.

Webster, A; Mizuno, K; Luebbering, N; Davies, SM; Jodele, S; Sabulski, A. Interferon-induced cell senescence as a novel mechanism of eculizumab resistance in transplant associated thrombotic microangiopathy. Blood. 2025; 146(Supplement 1):509.

Zhao, J; Zhao, X; Mizuno, T; Irie, K; Devarajan, P; Brunner, HI; Setchell, KDR. Volumetric Absorptive Microsampling Combined with Mass Spectrometry to Support Pharmacokinetically-Guided Precision Dosing of Mycophenolate Mofetil in Pediatric Lupus Nephritis Patients. Journal of Applied Laboratory Medicine. 2025; 10(4):806-819.