Brugmann Lab

Chang CF, Chang YT, Millington G, Brugmann SA. Craniofacial Ciliopathies Reveal Specific Requirements for GLI Proteins during Development of the Facial Midline. PLoS Genetics. 2016 Nov 1;12(11):e1006351.

Chang YT, Chaturvedi P, Schock EN, Brugmann SA. Understanding Mechanisms of GLI-Mediated Transcription during Craniofacial Development and Disease Using the Ciliopathic Mutant, talpid2. Front Physiol. 2016 Oct 17;7:468. PMID:27799912

Schock EN, Chang CF, Youngworth IA, Davey MG, Delany ME, Brugmann SA. Utilizing the chicken as an animal model for human craniofacial ciliopathies. Dev Biol. 2016 July 15;415(2):326-37. PMID:26597494

Romick-Rosendale LE, Hoskins EE, Privette Vinnedge LM, Foglesong GD, Brusadelli MG, Potter SS, Komurov K, Brugmann SA, Lambert PF, Kimple RJ, Virts EL, Hanenberg H, Gillison ML, Wells SI. Defects in the Fanconi Anemia Pathway in Head and Neck Cancer Cells Stimulate Tumor Cell Invasion through DNA-PK and Rac1 Signaling. Clin Cancer Res. 2016 Apr 15;22(8):2062-73.

Schock EN, Chang CF, Struve JN, Chang YT, Chang J, Delany ME, Brugmann SA. Using the avian mutant talpid2 as a disease model for understanding the oral-facial phenotypes of Oral-facial-digital syndrome. Dis Model Mech. 2015 Aug 1:8(8):855-56.

Saal HM, Prows CA, Guerreiro I, Donlin M, Knudson L, Sund KL, Chang CF, Brugmann SA, Stottmann RW. A mutation in FRIZZLED2 impairs Wnt signaling and causes autosomal dominant omodysplasia. Hum Mol Genet. 2015  Jun 15;24(12):3399-409.

Chang CF, Schock EN, Attia AC, Stottmann RW, Brugmann SA. The Ciliary Baton: Orchestrating Neural Crest Cell Development. Curr Top Dev Biol. 2015;111:97-134.

Chang CF, Schock EN, O'Hare EA, Dodgson J, Cheng HH, Muir WM, Edelmann RE, Delany ME, Brugmann SA. The cellular and molecular etiology of the craniofacial defects in the avian ciliopathic mutant, talpid² . Development. 2014 Aug; 141(15):3003-12.

Brugmann SA, Wells JM. Building additional complexity to in vitro derived intestinal tissues. Stem Cell Res Ther.  2013; 4 Suppl 1:S1.

Liu H, Lan Y, Xu J, Chang CF, Brugmann SA, Jiang R. Odd-skipped related-1 controls neural crest chondrogenesis during tongue development . Proc Natl Acad Sci U S A. 2013 Nov 12; 110(46):18555-60.

Powder KE, Ku YC, Brugmann SA, Veile RA, Renaud NA, Helms JA, Lovett M. A Cross-Species Analysis of MicroRNAs in the Developing Avian Face. PLoS ONE. 2012;7(4):e35111.

Chang ALS, Atzmon G, Bergman A, Brugmann S, Atwood SX, Chang HY, Barzilai N. Identification of Genes Promoting Skin Youthfulness by Genome-Wide Association Study. J Invest Dermatol. 2014 Mar; 134(3):651-7.

Rada-Iglesias A, Bajpai R, Prescott S, Brugmann SA, Swigut T, Wysocka J. Epigenomic annotation of enhancer elements predicts transcriptional regulators of human neural crest. Cell Stem Cell. 2012 Nov 2;11(5):633-48.

Lenton K, James AW, Manu A, Brugmann SA, Birker D, Nelson ER, Leucht P, Helms JA, Longaker MT. Indian hedgehog positively regulates calvarial ossification and modulates bone morphogenetic protein signaling. Genesis. 2011 Oct;49(10):784-96.

Levi B, James AW, Nelson ER, Brugmann SA, Sorkin M, Manu A, Longaker MT. Role of Indian hedgehog signaling in palatal osteogenesis. Plast Reconstr Surg. 2011 Mar;127(3):1182-90.

Zaghloul NA, Brugmann SA. The emerging face of primary cilia. Genesis. 2011 Apr;49(4):231-46.

Rada-Iglesias A, Bajpai R, Swigut T, Brugmann SA, Flynn RA, Wysocka J. A unique chromatin signature uncovers early developmental enhancers in humans. Nature. 2011 Feb 10;470(7333):279-83.

Cordero DR, Brugmann S, Chu Y, Bajpai R, Jame M, Helms JA. Cranial neural crest cells on the move: Their roles in craniofacial development. Am J Med Genet A. 2011 Feb;155A(2):270-9.

Levi B, Brugmann S, Longaker MT. Discussion: Hes1 is required for the development of craniofacial structures derived from ectomesenchymal neural crest cells. J Craniofac Surg. 2010 Sep;21(5):1450-1.

Brugmann SA, Cordero DR, Helms JA. Craniofacial ciliopathies: A new classification for craniofacial disorders. Am J Med Genet Part A. 2010 Dec;152A(12):2995-3006.

Brugmann SA, Allen NC, James AW, Mekonnen Z, Madan E, Helms JA. A primary cilia-dependent etiology for midline facial disorders. Hum Mol Genet. 2010 Apr 15;19(8):1577-92.

Brugmann SA*, Powder KE*, Young NM, Goodnough LH, Hahn SM, James AW, Helms JA, Lovett M. Comparative gene expression analysis of avian embryonic facial structures reveals new candidates for human craniofacial disorders. Hum Mol Genet. 2010 Mar 1;19(5):920-30.

Anderson CT, Castillo AB, Brugmann SA, Helms JA, Jacobs CR, Sterns T. Primary Cilia: Cellular Sensors for the Skeleton. Anat Rec (Hoboken). 2008 Sep;291(9):1074-8.

Schlosser G, Awtry T, Brugmann SA, Jensen ED, Neilson K, Ruan G, Stammler A, Voelker D, Yan B, Zhang C, Klymkowsky MW, Moody SA. Eya1 and Six1 promote neurogenesis in the cranial placodes in a SoxB1-dependent fashion. Dev Biol. 2008 Aug 1; 320(1):199-214.

Helms JA, Brugmann SA. The origins of species-specific facial morphology: The proof is in the pigeon. Integr Comp Biol. 2007 Sep; 47(3):338-42.

Brugmann SA, Goodnough LH, Gregorieff A, Leucht P, ten Berge D, Fuerer C, Clevers H, Nusse R, Helms JA. Wnt signaling mediates regional specification in the vertebrate face. Development. 2007 Sep; 134(18):3283-95.

Brugmann SA, Kim J, Helms JA. Looking different: towards an understanding diversity in facial form. Am J Med Genet A. 2006 Dec 1; 140(23):2521-9.

Brugmann SA, Tapadia MD, Helms JA. The Molecular Origins of Species-Specific Facial Pattern. Curr Top Dev Biol. 2006; 73:1-42.

Brugmann SA, Moody SA. (2005). Induction and specification of the vertebrate ectodermal placodes: precursors of the cranial sensory organs. Biol Cell. 2005 May; 97(5):303-19. (Cover)

Brugmann SA, Pandur PD, Kenyon KL, Pignoni F, Moody SA. Six1 promotes a placodal fate within the lateral neurogenic ectoderm by functioning as both a transcriptional activator and repressor. Development. 2004 Dec; 131(23):5871-81.

C.F. Chang, E.N. Schock, D.A. Billmire and S.A. Brugmann. ^“Craniofacial syndromes: etiology, impact and treatment” Principles of Developmental Genetics, 2nd Edition . Ed. Sally A. Moody. Elsevier, New York. 2014. 654-671.

M. Jame, S.A. Brugmann and J.A. Helms. “Embryology of the craniofacial complex” Plastic Surgery 3^rd Edition Vol. 3 Head & Neck . Ed. Joe Losee. Elsevier, New York. 2012.

S.A. Brugmann, R.R. Amasha, D.M. Gupta, J.A. Helms. “Craniofacial Patterning and Dysmorphologies” Craniofacial Growth and Development . Ed. Jeremy J. Mao and Hyun-duck Nah. Iowa State University Press. 2009. 320.

J. A. Helms, S.A. Brugmann, and D.R. Cordero. “Shh and Other Genes and the Holoprosencephaly Malformation Sequence” Inborn Errors of Development Second Edition . Ed. Charles J. Epstein, Robert P. Erickson, and Anthony Wynshaw-Boris. Oxford University Press, London. 2008. 291-300.

S.A. Brugmann and J.A. Helms. "Craniofacial formation and congenital defects" Principles of Developmental Genetics . Ed. Sally A. Moody. Elsevier, New York. 2007. 656-679.