Brugmann Lab
Brugmann Lab

Research Interests

The role of primary cilia during craniofacial development

Research in the Brugmann lab focuses on understanding the molecular, cellular and genetic factors that guide neural crest cell (NCC) development into craniofacial tissues. Specifically, we seek apply what we learn about NCC development to direct NCCs to differentiate into skeletal tissues that can be used to surgically repair craniofacial malformations. To achieve this goal, we aim to identify how primary cilia function during normal facial development and employ the cilia to direct NCC differentiation.

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Figure 1 - Lateral view of an embryonic mouse head with histological staining for NCC derived cartilage (blue) and bone (red).
Figure 1- Lateral view of an embryonic mouse head with histological staining for NCC derived cartilage (blue) and bone (red).
Figure 2 - Transmission electron microscopy of a primary cilium. The axoneme (purple dotted lines), basal bodies (light green dotted lines), and ciliary pocket (black dotted lines) are all highlighted.
Figure 2 - Transmission electron microscopy of a primary cilium. The axoneme (purple dotted lines), basal bodies (light green dotted lines), and ciliary pocket (black dotted lines) are all highlighted.
Ciliary transcriptome searchable database
Figure 3 - Ciliary transcriptome searchable database detailing tissue-specific ciliome heterogeneity.
Learn more about ciliome gene expression.

Current Projects

Follow the links below to read more about our lab's current projects.
Primary cilia in patterning the facial midline image.
The role of primary cilia in patterning the facial midline.
The role of primary cilia during glossal development image.
The role of primary cilia during glossal development.
Using the avian model talpid2 to study human craniofacial ciliopathies image.
Using the avian model talpid2 to study human craniofacial ciliopathies.
Scanning electron microscopy of primary cilia extending from the ventral neuroectoderm. Primary cilia are pseudo colored for emphasis.
Cilia interpreting and processing molecular signals.
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