Research Interests

The role of primary cilia during craniofacial development

Research in the Brugmann lab focuses on understanding the molecular, cellular and genetic factors that guide neural crest cell (NCC) development into craniofacial tissues. Specifically, we seek apply what we learn about NCC development to direct NCCs to differentiate into skeletal tissues that can be used to surgically repair craniofacial malformations. To achieve this goal, we aim to identify how primary cilia function during normal facial development and employ the cilia to direct NCC differentiation.





Figure 1 -  Scanning electron microscopy of primary cilia extending from the ventral neuroectoderm. Primary cilia are pseudo colored for emphasis.
 Figure 2 - Transmission electron microscopy of a primary cilium. The axoneme (purple dotted lines), basal bodies (light green dotted lines), and ciliary pocket (black dotted lines) are all highlighted.
 Figure 1 - Lateral view of an embryonic mouse head with histological staining for NCC derived cartilage (blue) and bone (red).
 Figure 2 - Transmission electron microscopy of a primary cilium. The axoneme (purple dotted lines), basal bodies (light green dotted lines), and ciliary pocket (black dotted lines) are all highlighted.

Current Projects

Follow the links below to read more about our lab's current projects.