Brugmann Lab
GLI Protein Function in the Developing Mandible

Determine if ciliary processing is necessary for GLI to interact with co-regulators

Primary cilia are necessary for the generation of GLI activators and repressors. Furthermore, GLI activators and repressors work together with co-regulator proteins to modulate target gene expression. Our current work examines how ciliary processing affects GLI interactions with co-factors and determines if these interactions are necessary for patterning facial prominences.
Myosin immunostaining on an e13.5 murine tongue.
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Loss of the ciliary protein Kif3a on cranial neural crest cells results in aglossial. Dorsal view of the developing tongue in control and ciliopathic (Kif3a cKO) embryos. Tongue is outlined in dotted white line in control. Lack of tongue is denoted by white asterisk in the mutant.
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GLI activator and repressor activity have differential requirements in the NCCs of the developing mandibular prominence.
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