Plastic Surgery
Lan Lab

Lan Research Lab

Craniofacial malformations, including cleft palate, are among the most common birth defects in humans. Although mutations for several cleft palate syndromes have been identified, the causes for most cleft palate cases are still unknown. To better understand the causes and pathogenic mechanisms of cleft palate and other craniofacial malformations, our lab uses a combination of mouse genetics, genome editing, and modern cell and developmental biology approaches to unravel the molecular mechanisms of craniofacial and palate development.

Publications

Xu, J; Iyyanar, PP R; Lan, Y; Jiang, R. Sonic hedgehog signaling in craniofacial development. Differentiation; Research in Biological Diversity. 2023; 133:60-76.

Xu, J; Liu, H; Lan, Y; Jiang, R. The transcription factors Foxf1 and Foxf2 integrate the SHH, HGF and TGFβ signaling pathways to drive tongue organogenesis. Development (Cambridge). 2022; 149:dev200667.

Lee, JM; Qin, C; Chai, OH; Lan, Y; Jiang, R; Kwon, HJ E. MSX1 Drives Tooth Morphogenesis Through Controlling Wnt Signaling Activity. Critical reviews in oral biology and medicine : an official publication of the American Association of Oral Biologists. 2022; 101:832-839.

Iyyanar, PP R; Wu, Z; Lan, Y; Hu, YC; Jiang, R. Alx1 Deficient Mice Recapitulate Craniofacial Phenotype and Reveal Developmental Basis of ALX1-Related Frontonasal Dysplasia. Frontiers in Cell and Developmental Biology. 2022; 10:777887.

Lan, Y; Jiang, R. Mouse models in palate development and orofacial cleft research: Understanding the crucial role and regulation of epithelial integrity in facial and palate morphogenesis. Current Topics in Developmental Biology. 2022; 148:13-50.

Liu, H; Xu, J; Lan, Y; Lim, HW; Jiang, R. The Scleraxis Transcription Factor Directly Regulates Multiple Distinct Molecular and Cellular Processes During Early Tendon Cell Differentiation. Frontiers in Cell and Developmental Biology. 2021; 9:654397.

Xu, J; Liu, H; Lan, Y; Jiang, R. Cis-Repression of Foxq1 Expression Affects Foxf2-Mediated Gene Expression in Palate Development. Frontiers in Cell and Developmental Biology. 2021; 9:665109.

Yue, M; Lan, Y; Liu, H; Wu, Z; Imamura, T; Jiang, R. Tissue-specific analysis of Fgf18 gene function in palate development. Developmental Dynamics. 2021; 250:562-573.

Li, C; Liu, H; Hu, Y; Lan, Y; Jiang, R. Generation and characterization of Six2 conditional mice. Genesis: the Journal of Genetics and Development. 2020; 58:e23365.

Xu, J; Liu, H; Lan, Y; Park, JS; Jiang, R. Genome-wide Identification of Foxf2 Target Genes in Palate Development. Critical reviews in oral biology and medicine : an official publication of the American Association of Oral Biologists. 2020; 99:463-471.

Lan, Y; Qin, C; Jiang, R. Requirement of Hyaluronan Synthase-2 in Craniofacial and Palate Development. Critical reviews in oral biology and medicine : an official publication of the American Association of Oral Biologists. 2019; 98:1367-1375.

Liu, Z; Li, C; Xu, J; Lan, Y; Liu, H; Li, X; Maire, P; Wang, X; Jiang, R. Crucial and Overlapping Roles of Six1 and Six2 in Craniofacial Development. Critical reviews in oral biology and medicine : an official publication of the American Association of Oral Biologists. 2019; 98:572-579.

Xu, J; Liu, H; Lan, Y; Adam, M; Clouthier, DE; Potter, S; Jiang, R. Hedgehog signaling patterns the oral-aboral axis of the mandibular arch. eLife. 2019; 8:e40315.

Open Positions

Candidates interested in mammalian craniofacial development research are encouraged to contact Yu Lan, PhD, (yu.lan@cchmc.org) to discuss opportunities.

Contact Us

Yu Lan, PhD
Associate Professor
UC Department of Surgery

Email: yu.lan@cchmc.org
Office Phone: 513-803-7842
Lab Phone: 513-803-5160
Fax Number: 513-636-4317

Dennis Hawkins 
Financial Analyst
Mailing Address:
3333 Burnet Ave
MLC 7007
Cincinnati, OH 45229
Email: dennis.hawkins@cchmc.org
Phone: 513-803-4193