Plastic Surgery

Craniofacial development

Visit the Brugmann Lab.

Biography

Samantha A. Brugmann, PhD, is an assistant professor of pediatrics in the Divisions of Plastic Surgery and Developmental Biology within the University of Cincinnati College of Medicine. She received her BS in cell and molecular biology from Tulane University in New Orleans, LA. She then obtained her PhD in genetics from George Washington University in Washington, DC where she studied cranial sensory placode development in Xenopus laevis. She performed her postdoctoral fellowship at Stanford University where her research focused on craniofacial development. While at Stanford she received a Ruth L. Kirschstein National Research Service Awards for Individual Postdoctoral Fellows (F32), a Pediatric Research Fund-Child Health Research Program Grant and a NIH Pathway to Independence Award (K99/R00). She joined Cincinnati Children’s Hospital Medical Center in January 2011 to study craniofacial development and disease.

BS: Tulane University, New Orleans, LA.

PhD: George Washington University, Washington DC.

Fellowship: Stanford University, Stanford, CA.

Chang CF, Schock EN, Attia A, Stottmann RW, Brugmann SA. The ciliary baton: orchestrating neural crest development. Current Topics in Developmental Biology. In press.

Brugmann SA, Wells JM. Building additional complexity to in vitro-derived intestinal tissues. Stem Cell Res Ther. 2013;4 Suppl 1:S1.

Liu H, Lan Y, Xu , Chang CF, Brugmann SA, Jiang R. Odd-skipped related-1 controls neural crest chondrogenesis during tongue development. Proc Natl Acad Sci U S A. 2013 Nov 12;110(46):18555-60.

Chang CF, Schock EN, O’Hare EA, Dodgson J, Cheng HH, Muir WM, Edelmann RE, Delany ME, Brugmann SA. The cellular and molecular etiology of the craniofacial defects in the avian ciliopathic mutant, talpid2. Development. 2014 Aug;141(15):3003-12.

Rada-Iglesias A, Bajpai R, Prescott S, Brugmann SA, Swigut T, Wysocka J. Epigenomic annotation of enhancers predicts transcriptional regulators of human neural crest. Cell Stem Cell. 2012 Nov 2;11(5):633-48.

Lenton K, James AW, Manu A, Brugmann SA, Birker D, Nelson ER, Leucht P, Helms JA, Longaker MT. Indian hedgehog positively regulates calvarial ossification and modulates bone morphogenetic protein signaling. Genesis. 2011 Oct;49(10):784-96.

Powder KE, Ku YC, Brugmann SA, Veile RA, Renaud NA, Helms JA, Lovett M. A cross-species analysis of microRNAs in the developing avian face. PLoS One. 2012;7(4):e35111.

Haithem M. Elhadi Babiker, MD, DMD, FAAP Staff Surgeon, Division of Plastic Surgery

Haithem M. Elhadi Babiker, MD, DMD, FAAP, works in the upper airway center to develop protocols for management of pediatric sleep apnea syndrome. His other interests include reconstruction of critical mandibular defects using stem cells and cadaveric bone.

513-636-7181 haithem.elhadi@cchmc.org

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Haithem M. Elhadi Babiker, MD, DMD, FAAP

Staff Surgeon, Division of Plastic Surgery

Academic Affiliations

Assistant Professor, UC Department of Surgery

Phone 513-636-7181

Email haithem.elhadi@cchmc.org

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Clinical & Research Interests

Clinical

Pediatric obstructive sleep apnea syndrome; complex upper airway problems; Treacher Collins Syndrome

Research

Craniofacial biology

Biography

Dr. Elhadi Babiker, MD, DMD, holds a double degree in medicine and dentistry. In addition, he is trained in both plastic surgery and in oral and maxillofacial surgery. He has completed fellowship training in craniofacial surgery. This training places him among an elite group of surgeons in the USA and around the world.

He currently serves as the director of the Treacher Collins Program.

MD: Kasturba Medical College, Manipal, India.

Residency: University of Cincinnati Plastic Surgery, General Surgery and Oral Maxillofacial Surgery, Cincinnati, OH.

Fellowship: Pediatric and Craniofacial Plastic Surgery, Cincinnati Children’s Hospital Medical Center, Cincinnati, OH.

DMD: University of Pennsylvania, Philadelphia, PA.

Pan BS, Elhadi H, Billmire DA. Maxillofacial Trauma. In Wheeler DS, Wong HR, Shanley TP, Editors: Pediatric Critical Medicine. Basic science and clinical evidence. 2nd Edition.

Vu A, Elhadi H, Patel P, Schwentker A, Yakuboff K. Pediatric Thoracic Outlet Syndrome: A case series and literature review. J Hand Surg. 2014 Mar;39(3):484-487.

Patel P, Elhadi H, Kitzmiller J, Billmire D, Yakuboff K. Complications of Tissue Expanders in the Pediatric Burn Patients: A 10 year follow up review. Ann Plast Surg. 2014 Feb;72(2):150-4.

Elhadi H, Reddy LV. Nasal Fractures. In Fonseca, Marciani and Turvey Editors: Oral And Maxillofacial Surgery. Saunders. 2009. 2nd Edition.

Reddy LV, Elhadi H. Maxillary Advancement by Distraction Osteogenesis. Atlas Oral Maxillofac Surg Clin North Am. 2008 Sep;16(2):237-47.

McIntosh JE, Campbell JH, Aguirre A, Reddy LV, Elhadi H. Expansile Mass of the Maxilla. J Oral Maxillofac Surg. 2008 June 6; 66:1253-58.

Elhadi H, Reddy LV. Maxillofacial Trauma. In Wheeler DS, Wong HR, Shanley TP, Editors: Pediatric Critical Care Medicine. Basic science and clinical evidence. Springer-Verlag. 2007. 1st Edition.

Ronald R. Hathaway, DDS, MS, MS Director, Craniofacial and Surgical Orthodontics, Division of Plastic Surgery

Ronald R. Hathaway, DDS, MS, MS, has research interests in craniofacial morphology, clinical outcomes for craniofacial treatment protocols and evidence based practices. He is a co-investigator for the Americleft Project, an inter-center North American cohort study for evaluating cleft palate outcomes and identifying best practices. He serves as an editorial consultant and reviewer for journals in his discipline.

513-636-4141 ronald.hathaway@cchmc.org

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Ronald R. Hathaway, DDS, MS, MS

Director, Craniofacial and Surgical Orthodontics, Division of Plastic Surgery

Academic Affiliations

Professor, UC Department of Surgery

UC Department of Pediatrics

Phone 513-636-4141

Email ronald.hathaway@cchmc.org

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Clinical & Research Interests

Clinical

Craniofacial orthodontics; orthognathic surgery

Research

Outcome studies

Biography

Ron Hathaway, DDS, MS, MS, is the 2015 president of the American Cleft Palate-Craniofacial Association. He has been involved in the diagnosis and treatment of children with craniofacial anomalies since 1979. He has been in private practice, but has spent most of his professional career in academics, clinical teaching and patient care associated with multi-disciplinary craniofacial teams at university hospitals.

He has been a faculty member in Orthodontics (Baylor College of Dentistry and Indiana University School of Dentistry), Oral and Maxillofacial Surgery (University of Texas Southwestern Medical School) and Pediatric Plastic Surgery (Indiana University School of Medicine). He has served as the chief and director of Craniofacial Anomalies/Orthodontics in these appointments for 25 years. His teaching career includes courses given in craniofacial growth and development to over 2000 dental and medical students. He taught treatment planning for orthognathic surgery to residents in plastic surgery, oral and maxillofacial surgery and orthodontics for approximately two decades and has mentored 22 craniofacial fellowship doctors, many who currently direct similar programs as a result of their training.

Dr. Hathaway served as the founder and medical director of the Craniofacial Center at Peyton Manning Children’s Hospital from 2006 to 2013 in Indianapolis, Indiana. Dr. Hathaway has been an active member of the American Cleft-Craniofacial Association since 1979 and has held all of the executive leadership offices of the association and has chaired or served as a member of 10 national committees.

His research interests are listed above; however, his greatest satisfaction is to be “in the everyday trenches” with children who have facial differences and interacting with colleagues to improve the care for these children through adopting best practices.

BA: University of Notre Dame, Notre Dame, IN, 1977.

MS: Vanderbilt University, Nashville, TN, 1979.

DDS: University of Iowa,Iowa City, IA, 1984.

Residency: Cleveland Metropolitan General Hospital, Cleveland, OH, 1985.

Residency: University of Detroit-Mercy, Detroit, MI, 1987.

MS: University or Detroit-Mercy, Detroit, MI, 1987.

Fellowship: Craniofacial and Surgical Orthodontics, University of Texas Southwestern Medical School, Dallas, TX, 1988.

Hathaway RR, Long Jr. RE. Early cleft management and the case against NAM: In search of evidence. AJO-DO. 2014 Feb.

Hathaway RR, Long Jr. RE, Mercado AM, Daskalogiannakis J, Russell KA, Semb G, Shaw WC. Use of a standardized outcome measure of dental arch relationships (GOSLON) to allow international, inter-study comparisons. Transactions manuscript of the 12th International Congress on Cleft Lip/Cleft Palate and Related Craniofacial Anomalies. 2013.

Mercado A, Russell K, Hathaway R, Daskalogiannakis J, Sadek H, Long RE Jr, Cohen M, Semb G, Shaw W. The Americleft Study: An Inter-Center Study of Treatment Outcomes for Patients with Unilateral Cleft Lip and Palate. Part 5. Summary and Conclusions. Cleft Palate Craniofac J. 2011;48(3)265-70.

Mercado A, Russell K, Hathaway R, Daskalogiannakis J, Sadek H, Long RE Jr, Cohen M, Semb G, Shaw W. The Americleft Study: An Inter-Center Study of Treatment Outcomes for Patients with Unilateral Cleft Lip and Palate. Part 4. Nasolabial Esthetics. Cleft Palate Craniofac J. 2011;48(3)259-64.

Hathaway RR, Long Jr. RE, Daskalogiannakis J, Mercado A, Russell K, Long RE Jr, Cohen M, Semb G, Shaw W. The Americleft Study: An Inter-Center Study of Treatment Outcomes for Patients with Unilateral Cleft Lip and Palate. Part 2. Dental Arch Relationships. Cleft Palate Craniofac J. 2011;48(3)244-51.

Daskalogiannakis J, Mercado A, Russell K, Hathaway R, Dugas G, Long RE Jr, Cohen M, Semb G, Shaw W. The Americleft Study: An Inter-Center Study of Treatment Outcomes for Patients with Unilateral Cleft Lip and Palate. Part 3. Analysis of Craniofacial Form. Cleft Palate Craniofac J. 2011;48(3) 252-58.

Long RE Jr, Daskalogiannakis J, Mercado A, Russell K, Cohen M, Semb G, Shaw W. The Americleft Study: An Inter-Center Study of Treatment Outcomes for Patients with Unilateral Cleft Lip and Palate. Part 1. Principles and Study Design. Cleft Palate Craniofac J. 2011;48(3)239-43.

Hathaway RR, Havlik RJ. Cat’s cradle: A rigid fixation system for distraction osteogenesis in Le Fort III patients. The Journal of Craniofacial Surgery. 2004.

Hathaway RR. DC stimulation of the coronal suture in rabbits. The Journal of Craniofacial Surgery. 197;8:221-229.

Rulang Jiang, PhD Member, Division of Developmental Biology

Rulang Jiang, PhD, is a developmental biologist directing research programs in craniofacial biology. His lab generates and uses mutant mouse models to investigate the genetic and developmental basis of craniofacial birth defects, including cleft lip, cleft palate, tooth defects, and other craniofacial deformities. His lab also studies development of joints, including long bone joints in the limb and the temporomandibular joint of the jaw.

Visit the Jiang Lab.

513-636-3212 rulang.jiang@cchmc.org

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Rulang Jiang, PhD

Member, Division of Developmental Biology

Academic Affiliations

Professor, UC Department of Pediatrics

Phone 513-636-3212

Email rulang.jiang@cchmc.org

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BS: Nanjing Normal University, Nanjing, China, 1984.

MS: Genetics, Chinese Academy of Sciences, Beijing, China, 1987.

PhD: Wesleyan University, Middletown, CT, 1995.

Gao Y, Lan Y, Liu H, Jiang R. The zinc finger transcription factors Osr1 and Osr2 control synovial joint formation. Dev Biol. 2011 Apr;352(1):83-91.

Baek JA, Lan Y, Liu H, Maltby KM, Mishina Y, Jiang R. Bmpr1a signaling plays critical roles in palatal shelf growth and palatal bone formation. Dev Biol. 2011 Feb;350(2):520-531.

Liu W, Watson SS, Lan Y, Keene DR, Ovitt CE, Liu H, Schweitzer R, Jiang R. The atypical homeodomain transcription factor Mohawk controls tendon morphogenesis. Mol Cell Biol. 2010 Oct;30(20):4797-4807.

Lan Y, Jiang R. Sonic hedgehog signaling regulates reciprocal epithelial-mesenchymal interactions controlling palatal outgrowth. Development. 2009 Apr;136(8):1387-1396.

Zhang Z, Lan Y, Chai Y, Jiang R. Antagonistic actions of Msx1 and Osr2 pattern mammalian teeth into a single row. Science. 2009;323(5918):1232-1234.

Lan Y, Wang Q, Ovitt CE, Jiang R. A unique mouse strain expressing Cre recombinase for tissue-specific analysis of gene function in palate and kidney development. Genesis. 2007;45(10):618-624.

Jiang R, Bush JO, Lidral AC. Development of the upper lip: morphogenetic and molecular mechanisms. Dev Dyn. 2006;235(5):1152-1166.

Wang Q, Lan Y, Cho ES, Maltby KM, Jiang R. Odd-skipped related 1 (Odd1) is an essential regulator of heart and urogenital development. Dev Biol. 2005;288(2):582-594.

Lan Y, Ovitt CE, Cho ES, Maltby KM, Wang Q, Jiang R. Odd-skipped related 2 (Osr2) encodes a key intrinsic regulator of secondary palate growth and morphogenesis. Development. 2004;131(13):3207-3216.

Bush JO, Lan Y, Jiang R. The cleft lip and palate defects in the Dancer mutant mice result from gain of function of the Tbx10 gene. Proc Nat Acad Sci U S A. 2004;101(18):7022-7027.

Donna C. Jones, PhD Member, Division of Plastic Surgery

Donna C. Jones, PhD, investigates questions regarding the determinants of bone development, function and shape. In particular, she focuses on the influences of ontogeny, function and evolution on craniofacial morphology. The goal of her research is to assist clinicians treating children with craniofacial abnormalities, either congenital or acquired, through translational and laboratory-based research endeavors.

513-803-0383 donna.jones1@cchmc.org

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Donna C. Jones, PhD

Member, Division of Plastic Surgery

Academic Affiliations

Assistant Professor, UC Department of Pediatrics

UC Department of Surgery

Phone 513-803-0383

Email donna.jones1@cchmc.org

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Biography

Translational: Using shape analysis, we are characterizing quantifiable growth curves of craniofacial shape in children from three dimensional photographs. Results from this project are intended for use by clinicians during repair or reconstruction of facial features in future pediatric patients.

Bench research: Working with in vitro cells and in vivo mouse models, the lab is examining how the interaction of muscle force influences the developing shape of bone, particularly in the mandible. Using a variety of cell markers, tension sensors, and morphological investigations, this research aims to improve our understanding of the cause of developmental abnormalities of the lower jaw, to hopefully reduce the need for surgeries and long hospital stays in children affected with these disorders.

BS: State University of New York, College at Fredonia, Fredonia, NY, 1995.

MS: University of Rochester, Rochester, NY, 1998.

PhD: University of Cincinnati, Cincinnati, OH, 2004.

PostDoc: Johns Hopkins, Baltimore, MD, 2007.

Bastidas N, Runyan CM, Jones DC, Taylor JA. Anatomic study of full facial and scalp allografts without cutaneous facial scars. J Plast Surg Hand Surg. 2013 Dec;47(6):528-31.

Jones DC, German RZ. Variation in Protein and Calorie Consumption Following Protein Malnutrition in Rattus norvegicus. Animals. 2013; 3(1), 33-44.

Rapp SJ, Jones DC, Billmire D, Taylor JA. Dissection in the subgaleal and subperiosteal plane: Implications on scalp wound healing. J Plast Surg Hand Surg. 2013 Jun;47(3):168-8.

Visscher M, Burkes S, Wickett R, Hammill A, Dasgupta R, Chute C, Elluru R, Patel M, Jones DC, Azizkhan R, Adams D. Use of Multimodal Quantitative Imaging to Determine Stage and Treatment Response of Infantile Hemangiomas. ISSVA Sweden. 2012:235X-F7C6P8G9B4.

Rapp SJ, Jones DC, Gerety P, Taylor JA. Repairing Critical-Sized Rat Calvarial Defects with Progenitor Cell-Seeded Acellular Periosteum: A Novel Biomimetic Scaffold. Surgery. 2012 Oct;152(4):595-604.

Jones DC, German RZ. Catch-up and targeted growth following variable duration protein restriction: effects on bone and body mass. J Morphol. 2011 April; 272(4):485-96.

Runyan CM, Jones DC, Bove K, Simpson D, Maercks RA, Taylor JA. Porcine Allograft Mandible Revitalization Using Autologous Adipose-Derived Stem Cells, Bone Morphogenetic protein-2, and Periosteum. Plast Reconstr Surg. 2010 May;125(5):1372-82.

Jones DC, Zelditch ML, Peake PL, German RZ. The effects of muscular dystrophy on the craniofacial shape of Mus musculus. J Anat. 2007 Jun;210(6):723-30.

Yu Lan, PhD Member, Division of Plastic Surgery

Yu Lan, PhD, is interested in understanding the genetic basis and developmental mechanisms of structural birth defects. Specifically, Dr. Lan investigates the molecular pathways governing normal palate development in laboratory mice. Her ongoing investigations focus on delineating the molecular pathways involving these factors in palate development using a combination of genetic, embryological, and biochemical approaches.

Visit the Lan Lab.

513-803-7842 yu.lan@cchmc.org

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Yu Lan, PhD

Member, Division of Plastic Surgery

Academic Affiliations

Associate Professor, UC Department of Surgery

UC Department of Pediatrics

Phone 513-803-7842

Email yu.lan@cchmc.org

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Research Interests

Visit the Lan Lab.

Biography

Yu Lan, PhD, is interested in understanding the genetic basis and developmental mechanisms of structural birth defects. Specifically, Dr. Lan investigates the molecular pathways governing normal palate development in laboratory mice. Her ongoing investigations focus on delineating the molecular pathways involving these factors in palate development using a combination of genetic, embryological, and biochemical approaches.

PhD: University of Maine, Orono, ME.

Post-doc training: Wesleyan University, Middletown, CT; The Jackson Laboratory, Bar Harbor, ME.

Lan Y, Jia S, Jiang R. Molecular patterning of the mammalian dentition. Semin Cell Dev Biol. 2014 Jan-Feb;25-26: 61-70.

Liu H, Lan Y, Xu J, Chang CF, Brugmann SA, Jiang R. Odd-skipped related-1 controls neural crest chondrogenesis during tongue development. Proc Natl Acad Sci U S A. 2013 Nov 12;110(46):18555-60.

Xu J, Liu H, Park JS, Lan Y, Jiang R. Osr1 acts downstream of and interacts synergistically with Six2 to maintain nephron progenitor cells during kidney organogenesis. Development. 2014 Apr;141(7):1442-52.

Zhou H, Zou S, Lan Y, Fei W, Jiang R, Hu J. Smad7 modulates TGFbeta signaling during cranial suture development to maintain suture patency. J Bone Miner Res. 2014 Mar;29(3):716-24.

Zhou J, Gao Y, Lan Y, Jia S, Jiang R. Pax9 regulates a molecular network involving Bmp4, Fgf10, Shh signaling and the Osr2 transcription factor to control palate morphogenesis. Development. 2013 Dec;140(23):4709-18.

Lan Y, Liu H, Ovitt CE, Jiang R. Generation of Osr1 conditional mutant mice. Genesis. 2011 May;49(5):419-22.

Gao Y, Lan Y, Liu H, Jiang R. The zinc finger transcription factors Osr1 and Osr2 control synovial joint formation. Dev Biol. 2011 Apr 1;352(1):83-91.

Baek JA, Lan Y, Liu H, Maltby KM, Mishina Y, Jiang R. Bmpr1a signaling plays critical roles in palatal shelf growth and palatal bone formation. Dev Biol. 2011 Feb 15;350(2):520-31.

Chen J, Lan Y, Baek JA, Gao Y, Jiang R. Wnt/beta-catenin signaling plays an essential role in activation of odontogenic mesenchyme during early tooth development. Dev Biol. 2009 Oct 1;334(1):174–85.

Lan Y, Jiang R. Sonic hedgehog signaling regulates reciprocal epithelial-mesenchymal interactions controlling palatal outgrowth. Development. 2009 Apr;136(8):1387-96.

Brian S. Pan, MD Director, Craniofacial and Pediatric Plastic Surgery Fellowship

Brian S. Pan, MD, is a craniofacial and pediatric plastic surgeon with a clinical interest in neonatal upper airway obstruction. His basic science focus is on the modulation of hypertrophic scarring with adipose derived stem cells.

513-636-7181 brian.pan@cchmc.org

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Brian S. Pan, MD

Director, Craniofacial and Pediatric Plastic Surgery Fellowship

Member, Division of Plastic Surgery

Academic Affiliations

Assistant Professor, UC Department of Surgery

UC Department of Pediatrics

Phone 513-636-7181

Email brian.pan@cchmc.org

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BS: Biology, Creighton University, Omaha, NE, 2000.

MD: Creighton University School of Medicine, Omaha, NE, 2004.

Residency: Integrated Plastic Surgery Residency, University of Cincinnati, Cincinnati, OH, 2009; Chief Plastic Surgery Resident University of Cincinnati, Cincinnati, OH, 2010.

Fellowships: Aesthetic Surgery Visiting Fellowship, Miami, FL 2009; Craniofacial and Pediatric Plastic Surgery Visiting Fellowship The Hospital for Sick Children. Toronto, Ontario, 2011; Craniofacial and Pediatric Plastic Surgery Fellowship Cincinnati Children’s Hospital Medical Center, Cincinnati, OH, 2011.