Pushing the Boundary of Lung Regeneration: Are We There Yet?
In the Le Xu lab, we are dedicated to uncovering the cellular and molecular basis that govern lung repair and regeneration. Our ultimate goal is to translate these discoveries into strategies that enable better breathing—for adults today, and for generations to come.
Similar to stars in the sky, no cell accomplishes anything alone. Intricate networks exist and live under a set of rules. To deconvolute the functional complexity of intracellular regulatory networks and intercellular communications in both healthy and injured lungs, we deploy cutting-edge technologies including single cell multiomics, high-resolution imaging, organoid culture and lineage tracing, all blended into genetic models of both old and new..
Through close integration with clinician-scientists and translational teams at Cincinnati Children’s, we are uniquely positioned to move discoveries from bench to bedside. By bridging fundamental biology with clinical insight, we strive to transform original scientific findings into meaningful therapeutic advances for both common and rare pulmonary diseases.
