Le Xu Lab

Publications

Fang, Y; Chung, SSW; Xu, L; Xue, C; Liu, X; Jiang, D; Li, R; Korogi, Y; Yuan, K; Saqi, A; Tsukui, T; Sheppard, D; Sun, X; Que, J. RUNX2 promotes fibrosis via an alveolar-to-pathological fibroblast transition. Nature. 2025; 640(8057):221-230.

Xu, L; Tan, C; Talaba, N; Sou, A; Shen, Y; Chung, WK; Mcculley, DJ; Sun, X. Mitochondrial Lon Peptidase 1 Controls Diaphragm and Lung Development in a Context-Dependent Manner. J Respir Biol Transl Med. 2025; 2(3).

Xu, L; Tan, C; Barr, J; Talaba, N; Verheyden, J; Chin, JS; Gaboyan, S; Kasaraneni, N; Elgamal, RM; Gaulton, KJ; Shen, Y; Chung, WK; Mcculley, DJ; Sun, X. Context-dependent roles of mitochondrial LONP1 in orchestrating the balance between airway progenitor versus progeny cells. Cell Stem Cell. 2024; 31(10):1465-1483.e6.

Shepard, RM; Ghebremedhin, A; Pratumchai, I; Robinson, SR; Betts, C; Hu, J; Sasik, R; Fisch, KM; Zak, J; Chen, H; Martinot, AJ; Coussens, LM; Teijaro, JR; Varner, JA. PI3Kγ inhibition circumvents inflammation and vascular leak in SARS-CoV-2 and other infections. Science Translational Medicine. 2024; 16(754):eadi6887.

Su, Y; Xu, J; Zhu, Z; Chin, J; Xu, L; Yu, H; Nudell, V; Dash, B; Moya, EA; Ye, L; Nimmerjahn, A; Sun, X. Brainstem Dbh+ neurons control allergen-induced airway hyperreactivity. Nature. 2024; 631(8021):601-609.

Barr, J; Xu, L; Li, R; Verheyden, J; Sun, X. Airway Microfold Cells Emerge in the Post-Influenza Lung. American Journal of Respiratory Cell and Molecular Biology. 2024; 70(4):322-325.

Xu, L; Sun, X. Lung repair empowered by exogenous cells taking residence. Cell Stem Cell. 2023; 30(9):1127-1129.

Huang, T; Li, Y; Wang, W; Xu, L; Li, J; Qi, Y. Evolution of lmiRNAs and their targets from MITEs for rice adaptation. Journal of Integrative Plant Biology. 2022; 64(12):2411-2424.

Xu, J; Xu, L; Sui, P; Chen, J; Moya, EA; Hume, P; Janssen, WJ; Duran, JM; Thistlethwaite, P; Carlin, A; Crotty-Alexander, L; Deutsch, G; Young, LR; Sun, X. Excess neuropeptides in lung signal through endothelial cells to impair gas exchange. Developmental Cell. 2022; 57(7):839-853.e6.

Masso-Silva, JA; Moshensky, A; Lam, MTY; Odish, MF; Patel, A; Xu, L; Hansen, E; Trescott, S; Nguyen, C; Kim, R; Crotty, S; Coufal, NG; Meier, A; Crotty Alexander, LE. Increased Peripheral Blood Neutrophil Activation Phenotypes and Neutrophil Extracellular Trap Formation in Critically Ill Coronavirus Disease 2019 (COVID-19) Patients: A Case Series and Review of the Literature. Clinical Infectious Diseases. 2022; 74(3):479-489.

Nakayama, T; Lee, IT; Jiang, S; Matter, MS; Yan, CH; Overdevest, JB; Wu, C-T; Goltsev, Y; Shih, L-C; Liao, C-K; Patel, ZM; Tzankov, A; Nolan, GP; Nayak, JV. Determinants of SARS-CoV-2 entry and replication in airway mucosal tissue and susceptibility in smokers. Cell Reports Medicine. 2021; 2(10):100421.

Qiao, L; Xu, L; Yu, L; Wynn, J; Hernan, R; Zhou, X; Farkouh-Karoleski, C; Krishnan, US; Khlevner, J; De, A; Sun, X; Donahoe, PK; Shen, Y; Chung, WK. Rare and de novo variants in 827 congenital diaphragmatic hernia probands implicate LONP1 as candidate risk gene. American Journal of Human Genetics. 2021; 108(10):1964-1980.

Inde, Z; Croker, BA; Yapp, C; Joshi, GN; Spetz, J; Fraser, C; Qin, X; Xu, L; Deskin, B; Ghelfi, E; Park, J-A; Brownfield, D; Jia, H; Sarosiek, KA. Age-dependent regulation of SARS-CoV-2 cell entry genes and cell death programs correlates with COVID-19 severity. Science Advances. 2021; 7(34).