Brewington Lab

Publications

Miller, KA; Pion, A; Topasna, A; Ostmann, AJ; Meeker, JD; Morgan, H; Kelly, G; Brewington, J; Sharma, N; Cutting, GR; Raraigh, KS. WS13.4 Refining the CFTR genotype–function–phenotype relationship using registry and primary cell data. Journal of Cystic Fibrosis. 2026; 25:s26.

Lonetti, L; Murray, JB; Alves, J; Black, C; Morgan, H; Brewington, J; Lee, CM; Harrison, PT. EPS2.03 Allele-specific editing in primary human nasal epithelial cells with compound heterozygous genotypes. Journal of Cystic Fibrosis. 2026; 25:s39.

De Boeck, K; Burgel, P-R; Bierlaagh, M; Hill, K; Amaral, M; Birimberg-Schwartz, L; Brewington, JJ; Davies, JC; Karadag, B; Martin, U; Sharma, N; Tayor-Cousar, JL; Sermet, I; Beekman, JM. ECFS statement on theratyping and theranostics in the context of rare and ultrarare CFTR variants in people with CF. Journal of Cystic Fibrosis. 2026.

Brewington, JJ; Mall, MA; Maeda, Y. Who will win the race for the first CFTR gene replacement therapy? Molecular Therapy. 2026; 34(4):1874-1876.

Scharf, G; Davidson, CR; Ustiyan, V; Falkenberg, LG; Adavalli, A; Meeker, JD; Morgan, H; Ostmann, AJ; Hudock, KM; Brewington, JJ; Clancy, JP; Kramer, EL. TGF-β induces excessive pulmonary IL-6 secretion in cystic fibrosis via PI3K. American Journal of Physiology - Lung Cellular and Molecular Physiology. 2025; 329(4):L470-L479.

Darkwah, O; Colegate, S; Brokamp, C; Ryan, P; Manning, E; Gecili, E; Brewington, J; Kramer, E; Szczesniak, R. 710 Near-road air pollution inhibits long-term modulator effectiveness. Journal of Cystic Fibrosis. 2025; 24:s425-s426.

Dasgupta, A; Imbrogno, M; Pasula, R; Middleton, R; Baird, D; Kramer, E; Brewington, J; Morgan, H; Meeker, J; Mahajan, S; Wozniak, D; Gardner, J; Trapnell, B; Clancy, J; Hudock, K. 88 Neutrophil extracellular traps increase human bronchial epithelial iron release and promote Pseudomonas aeruginosa growth. Journal of Cystic Fibrosis. 2025; 24:s45-s46.

Brewington, J; Garter, A; Szczesniak, R. 659 Lung function decline persists among healthy children with CF taking elexacaftor/tezacaftor/ivacaftor. Journal of Cystic Fibrosis. 2025; 24:s394.

Wleklinski, M; Meeker, J; Morgan, H; Ostmann, A; Brewington, J. 314 Impact of routine pulmonary medications on modulator-rescued CFTR in cystic fibrosis cells. Journal of Cystic Fibrosis. 2025; 24:s175.

Bozkanat, KM; Wallace, C; Benscoter, D; Torres-Silva, CA; Zak, S; Burg, G; Brewington, J; Hysinger, E. Use of Bronchoscopic Cryotherapy for Recanalization and Cryoextraction in Pediatric Population: A Five-Year Single Center Experience. American Journal of Respiratory and Critical Care Medicine. 2025; 211(Supplement_1):a7710-a7710.

Kretovics, E; Schott, O; Kendall, O; Faulkner, K; Brewington, J; Benscoter, D; Pajor, NM. Aligning Expectations With Outcomes: A Prospective Study of Pediatric Bronchoscopy in the ICU Setting. American Journal of Respiratory and Critical Care Medicine. 2025; 211(Supplement_1):a2303-a2303.

Gecili, E; Brokamp, C; Asar, Ö; Andrinopoulou, E-R; Brewington, JJ; Szczesniak, RD. Spike and Slab Regression for Nonstationary Gaussian Linear Mixed Effects Modeling of Rapid Disease Progression. Environmetrics. 2025; 36(1).

Solomon, GM; Linnemann, RW; Rich, R; Streby, A; Buehler, B; Hunter, E; Vijaykumar, K; Hunt, WR; Brewington, JJ; Rab, A; Barilla, C; Suzuki, S; Davis, BR; Sorscher, EJ. Evaluation of elexacaftor-tezacaftor-ivacaftor treatment in individuals with cystic fibrosis and CFTRN1303K in the USA: a prospective, multicentre, open-label, single-arm trial. The Lancet Respiratory Medicine. 2024; 12(12):947-957.

Bdaiwi, AS; Svoboda, AM; Murdock, KE; Hendricks, A; Hossain, MM; Kramer, EL; Brewington, JJ; Willmering, MM; Woods, JC; Walkup, LL; Cleveland, ZI. Quantifying abnormal alveolar microstructure in cystic fibrosis lung disease via hyperpolarized 129Xe diffusion MRI. Journal of Cystic Fibrosis. 2024; 23(5):926-935.

Brewington, J; O'shaughnessy, R; Ostmann, A; Meeker, J; Morgan, H; Kramer, E; Hudock, K; Clancy, J. 327 Comparison of human nasal and fisher rat thyroid cell-based theratyping results. Journal of Cystic Fibrosis. 2024; 23:s173-s174.

Dasgupta, A; Imbrogno, M; Collins, M; Merlin, L; Kramer, E; Brewington, J; Morgan, H; Meeker, J; Mahajan, S; Wozniak, D; Gardner, J; Trapnell, B; Clancy, J; Hudock, K. 198 Neutrophil extracellular traps increase Pseudomonal density in human bronchial epithelia. Journal of Cystic Fibrosis. 2024; 23:s110.

Lee, J; Husami, A; Arora, K; Zhang, W; Kadri, F; Yarlagadda, S; Moon, C; Mun, KS; Zhang, K; Huang, Y; Clancy, JP; Shaikhkhalil, A; Paul, G; Naren, AP. A personalized medicine approach to optimize care for a pediatric cystic fibrosis patient with atypical clinical symptoms. Pediatric Pulmonology. 2024; 59(1):229-232.

Shipp, C; Brewington, J; Beswick, DM; Amin, R. Upper Airway Disease in Cystic Fibrosis. In: Hodson and Geddes' Cystic Fibrosis. Taylor & Francis; 2023:325-330.

Middleton, R; Collins, M; Imbrogno, M; Kramer, E; Brewington, J; Meeker, J; Morgan, H; Ostmann, A; Trapnell, B; Mahajan, S; Wozniak, D; Clancy, J; Hudock, K. 98 Neutrophil extracellular traps disrupt bronchial epithelial junctional integrity and promote infection. Journal of Cystic Fibrosis. 2023; 22:s51.

Scharf, G; Davidson, C; Morgan, H; Meeker, J; Ostmann, A; Brewington, J; Hudock, K; Clancy, J; Kramer, E. 168 Impact of TGF-β exposure on IL-6 secretion in cystic fibrosis airway epithelia. Journal of Cystic Fibrosis. 2023; 22:s89.

Salinas, DB; Ginsburg, DK; Wee, CP; Saeed, MM; Brewington, JJ. Gradual increase in sweat chloride concentration is associated with a higher risk of CRMS/CFSPID to CF reclassification. Pediatric Pulmonology. 2023; 58(4):1074-1084.

Livnat, G; Meeker, JD; Ostmann, AJ; Strecker, LM; Clancy, JP; Brewington, JJ. Phenotypic Alteration of an Established Human Airway Cell Line by Media Selection. International Journal of Molecular Sciences. 2023; 24(2).

Guimbellot, JS; Nichols, DP; Brewington, JJ. Novel Applications of Biomarkers and Personalized Medicine in Cystic Fibrosis. Clinics in Chest Medicine. 2022; 43(4):617-630.

Ostmann, A; Meeker, J; Morgan, H; O'shaughnessy, R; Brewington, J. 683 Characteristics of cystic fibrosis transmembrane conductance regulator modulator response in nasal cell models derived from patients with rare cystic fibrosis transmembrane conductance regulator variants. Journal of Cystic Fibrosis. 2022; 21:s373.

Solomon, G; Suzuki, S; Hathorne, H; Barilla, C; Wang, B; Rab, A; Manfredi, C; Joshi, D; Brewington, J; Stecenko, A; Odem-Davis, K; Davis, B; Sorscher, E; Linnemann, R. 606 Focused clinical trials of modulator response for rare cystic fibrosis genotypes. Journal of Cystic Fibrosis. 2022; 21:s336.

Collins, M; Imbrogno, M; Kramer, E; Brewington, J; Zhang, N; Sharon, P; Kopras, E; Meeker, J; Morgan, H; Ostmann, A; O'grady, S; Trapnell, B; Clancy, J; Hudock, K. 380 Neutrophil extracellular traps disrupt bronchial epithelial barrier function: Alpha-1 antitrypsin to the rescue. Journal of Cystic Fibrosis. 2022; 21:s223.

Ginsburg, D; Wee, CP; Reyes, MC; Brewington, JJ; Salinas, DB. When CFSPID becomes CF. Journal of Cystic Fibrosis. 2022; 21(1):e23-e27.

Fink-Baldauf, IM; Stuart, WD; Brewington, JJ; Guo, M; Maeda, Y. CRISPRi links COVID-19 GWAS loci to LZTFL1 and RAVER1. EBioMedicine. 2022; 75:103806.

Hudock, KM; Collins, MS; Imbrogno, MA; Kramer, EL; Brewington, JJ; Ziady, A; Zhang, N; Snowball, J; Xu, Y; Carey, BC; Gollomp, K; Mangalmurti, N; Trapnell, BC; Clancy, JP. Alpha-1 antitrypsin limits neutrophil extracellular trap disruption of airway epithelial barrier function. Frontiers in Immunology. 2022; 13:1023553.