Pulmonary Medicine

Faculty Labs

Our lab investigates how airway anatomy and motion influence airflow and breathing mechanics in airway disease by combining patient-specific MRI-based airway modeling with computational fluid dynamics, with a particular focus on conditions such as obstructive sleep apnea and tracheomalacia.

Our lab focuses on understanding respiratory diseases by studying epithelial biology—particularly in cystic fibrosis—using human-derived model systems to investigate disease mechanisms and inform treatment strategies.

Our lab investigates how environmental exposures and risk factors drive early childhood wheezing and severe asthma, while evaluating the safety and effectiveness of novel treatments and technologies to optimize asthma care across childhood.

Our lab focuses on developing gene‑editing therapies to repair the CFTR gene and treat cystic fibrosis at its genetic root, with the goal of creating broadly applicable and clinically translatable solutions for all individuals with CF, especially those not helped by current treatments.

Our lab studies the mechanisms of lung transplant rejection at single‑cell resolution using advanced sequencing technologies, with the goal of identifying new pathways and therapies to promote graft tolerance and improve long‑term transplant outcomes.

Our lab uses advanced quantitative MRI to characterize early structural and functional cardiorespiratory abnormalities in perinatal patients, with the goal of linking early-life imaging biomarkers to disease progression and personalizing care for infants born preterm or with congenital disorders.

The Hogenesch lab studies transcriptional outputs of the clock in animal models and humans.

Our lab investigates early biological and environmental drivers of cystic fibrosis lung disease—such as TGFβ signaling and inflammatory pathways—using experimental models to identify therapeutic targets and ultimately prevent or reverse early lung damage in children.

Our lab uses behavioral and social science, along with multidisciplinary collaboration, to understand how to reliably deliver the right treatment to the right child in the right way at the right time across diseases.

Our lab develops and translates advanced MRI techniques, including hyperpolarized xenon imaging, to better detect, understand, and manage regional lung disease—particularly in children and individuals with rare pulmonary conditions.

Our lab uses advanced imaging techniques and translational research to define lung structure–function relationships in diseases like cystic fibrosis and neonatal lung disorders, with the goal of improving patient outcomes through more precise diagnosis and innovative clinical approaches.