Kramer Research Lab
The Kramer Research Lab is part of the Division of Pulmonary Medicine at Cincinnati Children’s. Our lab studies early drivers of lung disease in children with cystic fibrosis (CF).
CF lung disease is characterized by infection, inflammation, and lung remodeling. These problems begin early and can cause lung damage in the first few years of life. To better understand and prevent this, we study modifiers of CF lung disease severity such as TGFβ, a cytokine associated with faster lung function decline and disease progression in people with CF. We also study environmental drivers of CF lung disease such as house dust mite particles and altered inflammatory pathways.
We use a range of techniques, including animal and cell culture models, to determine the pulmonary tissues impacted by these factors and to identify downstream pathways that may be therapeutic targets. The goal of the Kramer lab is to prevent and reverse early lung damage in children with CF.
