Kramer Lab

Publications

Chung, JJ; Oh, E; Lee, MJ; Fischer, JL; Wade, N; Woods, JC; Zemanick, ET; Churi, R; Buckingham, R; Fain, SB; Sim, MS; Goss, CH; Taylor-Cousar, JL; Beswick, DM. Sinusitis and Olfaction Improve in Young Children with Cystic Fibrosis Treated with ETI. Annals of the American Thoracic Society. 2026.

Matheson, AM; Prather, E; Willmering, MM; Mata, J; Santyr, G; Ratjen, FA; Kramer, EL; Cleveland, ZI; Woods, JC. Lung mucus burden and treatment response assessed by MRI in the post-modulator era. Journal of Cystic Fibrosis. 2026; 25(4):711-717.

Matheson, AM; Bdaiwi, AS; Willmering, MM; Difrancesco, MW; Cleveland, ZI; Santyr, GE; Ratjen, F; Kramer, EL; Szczesniak, RD; Woods, JC. Structural and Functional Pulmonary MRI to Predict Pulmonary Exacerbations in Cystic Fibrosis. Chest. 2026; 169(4):919-931.

Hussain, R; Masokano, BI; Plummer, JW; Bdaiwi, AS; Willmering, MM; Kramer, EL; Walkup, LL; Cleveland, ZI. Xenon-129 magnetic resonance imaging detects ongoing ventilation improvements in people with cystic fibrosis receiving highly effective modulator therapy. Annals of the American Thoracic Society. 2026; 23(2):303-307.

Bdaiwi, AS; Roach, DJ; West, ME; Willmering, MM; Daou, AW; Hossain, MM; Kramer, EL; Amin, R; Walkup, LL; Cleveland, ZI; Woods, JC. Longitudinal Monitoring of Lumacaftor/Ivacaftor Response in Young Children with Cystic Fibrosis Lung Disease Using 129Xe MRI. Academic Radiology. 2025; 32(10):6238-6249.

Scharf, G; Davidson, CR; Ustiyan, V; Falkenberg, LG; Adavalli, A; Meeker, JD; Morgan, H; Ostmann, AJ; Hudock, KM; Brewington, JJ; Clancy, JP; Kramer, EL. TGF-β induces excessive pulmonary IL-6 secretion in cystic fibrosis via PI3K. American Journal of Physiology - Lung Cellular and Molecular Physiology. 2025; 329(4):L470-L479.

Hussain, R; Plummer, JW; Bdaiwi, AS; Willmering, MM; Kramer, EL; Walkup, LL; Cleveland, ZI. Optimizing Xenon 129 Ventilation MRI in Cystic Fibrosis with Spiral Imaging and Flip-Angle Correction. Radiology: Cardiothoracic Imaging. 2025; 7(5):e240574.

Dasgupta, A; Imbrogno, M; Pasula, R; Middleton, R; Baird, D; Kramer, E; Brewington, J; Morgan, H; Meeker, J; Mahajan, S; Wozniak, D; Gardner, J; Trapnell, B; Clancy, J; Hudock, K. 88 Neutrophil extracellular traps increase human bronchial epithelial iron release and promote Pseudomonas aeruginosa growth. Journal of Cystic Fibrosis. 2025; 24:s45-s46.

Gecili, E; Szczesniak, R; Kramer, E. 732 A genetic algorithm-derived single index model for integrating environmental risk into longitudinal lung function prediction in cystic fibrosis. Journal of Cystic Fibrosis. 2025; 24:s437b-ss438.

Darkwah, O; Colegate, S; Brokamp, C; Ryan, P; Manning, E; Gecili, E; Brewington, J; Kramer, E; Szczesniak, R. 710 Near-road air pollution inhibits long-term modulator effectiveness. Journal of Cystic Fibrosis. 2025; 24:s425-s426.

Ansar, M; Falkenberg, L; Davidson, C; Ustiyan, V; Hudock, K; Clancy, J; Szczesniak, R; Kramer, E. 743 Effects of environmental and social epidemiological factors on cytokine response in people with cystic fibrosis. Journal of Cystic Fibrosis. 2025; 24:s447-s448.

Cheng, Y; Brokamp, C; Manning, ER; Kramer, EL; Ryan, PH; Szczesniak, RD; Gecili, E. Hypercubes to identify geomarkers of rapid cystic fibrosis lung disease progression. BMC Medical Informatics and Decision Making. 2025; 25(1):304.

Liu, CM; Fischer, JL; Zemanick, ET; Woods, JC; Markarian, KK; Fain, SB; Froh, D; Heltshe, SL; Hoffman, LR; Humphries, SM; Trout, AT; Goss, CH; Taylor-Cousar, JL; Beswick, DM. The impact of highly effective modulator therapy on sinusitis and dysosmia in young children with cystic fibrosis: a prospective study protocol. ERJ Open Research. 2025; 11(1).

Peterson, CJ; Rao, MB; Palipana, A; Manning, ER; Vancil, A; Ryan, P; Brokamp, C; Kramer, E; Szczesniak, RD; Gecili, E. Robust identification of environmental exposures and community characteristics predictive of rapid lung disease progression. Science of the Total Environment. 2024; 950:175348.

Bdaiwi, AS; Svoboda, AM; Murdock, KE; Hendricks, A; Hossain, MM; Kramer, EL; Brewington, JJ; Willmering, MM; Woods, JC; Walkup, LL; Cleveland, ZI. Quantifying abnormal alveolar microstructure in cystic fibrosis lung disease via hyperpolarized 129Xe diffusion MRI. Journal of Cystic Fibrosis. 2024; 23(5):926-935.

Brewington, J; O'shaughnessy, R; Ostmann, A; Meeker, J; Morgan, H; Kramer, E; Hudock, K; Clancy, J. 327 Comparison of human nasal and fisher rat thyroid cell-based theratyping results. Journal of Cystic Fibrosis. 2024; 23:s173-s174.

Dasgupta, A; Imbrogno, M; Collins, M; Merlin, L; Kramer, E; Brewington, J; Morgan, H; Meeker, J; Mahajan, S; Wozniak, D; Gardner, J; Trapnell, B; Clancy, J; Hudock, K. 198 Neutrophil extracellular traps increase Pseudomonal density in human bronchial epithelia. Journal of Cystic Fibrosis. 2024; 23:s110.

Collins, MS; Imbrogno, MA; Kopras, EJ; Howard, JA; Zhang, N; Kramer, EL; Hudock, KM. Heterogeneity in Neutrophil Extracellular Traps from Healthy Human Subjects. International Journal of Molecular Sciences. 2023; 25(1).

Middleton, R; Collins, M; Imbrogno, M; Kramer, E; Brewington, J; Meeker, J; Morgan, H; Ostmann, A; Trapnell, B; Mahajan, S; Wozniak, D; Clancy, J; Hudock, K. 98 Neutrophil extracellular traps disrupt bronchial epithelial junctional integrity and promote infection. Journal of Cystic Fibrosis. 2023; 22:s51.

Scharf, G; Davidson, C; Morgan, H; Meeker, J; Ostmann, A; Brewington, J; Hudock, K; Clancy, J; Kramer, E. 168 Impact of TGF-β exposure on IL-6 secretion in cystic fibrosis airway epithelia. Journal of Cystic Fibrosis. 2023; 22:s89.

Kramer, EL; Hudock, KM; Davidson, CR; Clancy, JP. CFTR dysfunction in smooth muscle drives TGFβ dependent airway hyperreactivity. Respiratory Research. 2023; 24(1):198.

Collins, M; Imbrogno, M; Kramer, E; Brewington, J; Zhang, N; Sharon, P; Kopras, E; Meeker, J; Morgan, H; Ostmann, A; O'grady, S; Trapnell, B; Clancy, J; Hudock, K. 380 Neutrophil extracellular traps disrupt bronchial epithelial barrier function: Alpha-1 antitrypsin to the rescue. Journal of Cystic Fibrosis. 2022; 21:s223.

Hudock, K; Cheng, P; Chmiel, J; Brown, C; Kramer, E; Indihar, V; Kopras, E; Aliaj, E; Hudson, J; Filigno, S. 27 Effect of SARS-CoV-2 on long-term physical and mental health symptoms in people with cystic fibrosis and their caregivers. Journal of Cystic Fibrosis. 2022; 21:s16-s17.

Hudock, KM; Collins, MS; Imbrogno, MA; Kramer, EL; Brewington, JJ; Ziady, A; Zhang, N; Snowball, J; Xu, Y; Carey, BC; Gollomp, K; Mangalmurti, N; Trapnell, BC; Clancy, JP. Alpha-1 antitrypsin limits neutrophil extracellular trap disruption of airway epithelial barrier function. Frontiers in Immunology. 2022; 13:1023553.