Kramer Lab

Publications

Cheng, Y; Brokamp, C; Manning, ER; Kramer, EL; Ryan, PH; Szczesniak, RD; Gecili, E. Hypercubes to identify geomarkers of rapid cystic fibrosis lung disease progression. BMC Medical Informatics and Decision Making. 2025; 25:304.

Darkwah, O; Colegate, S; Brokamp, C; Ryan, P; Manning, E; Gecili, E; Brewington, J; Kramer, E; Szczesniak, R. 710 Near-road air pollution inhibits long-term modulator effectiveness. Journal of Cystic Fibrosis. 2025; 24:s425-s426.

Dasgupta, A; Imbrogno, M; Pasula, R; Middleton, R; Baird, D; Kramer, E; Brewington, J; Morgan, H; Meeker, J; Mahajan, S; Wozniak, D; Gardner, J; Trapnell, B; Clancy, J; Hudock, K. 88 Neutrophil extracellular traps increase human bronchial epithelial iron release and promote Pseudomonas aeruginosa growth. Journal of Cystic Fibrosis. 2025; 24:s45-s46.

Hussain, R; Plummer, JW; Bdaiwi, AS; Willmering, MM; Kramer, EL; Walkup, LL; Cleveland, ZI. Optimizing Xenon 129 Ventilation MRI in Cystic Fibrosis with Spiral Imaging and Flip-Angle Correction. Radiology: Cardiothoracic Imaging. 2025; 7:e240574.

Scharf, G; Davidson, CR; Ustiyan, V; Falkenberg, LG; Adavalli, A; Meeker, JD; Morgan, H; Ostmann, AJ; Hudock, KM; Brewington, JJ; Clancy, JP; Kramer, EL. TGF-β induces excessive pulmonary IL-6 secretion in cystic fibrosis via PI3K. American Journal of Physiology: Lung Cellular and Molecular Physiology. 2025; 329:L470-L479.

Gecili, E; Szczesniak, R; Kramer, E. 732 A genetic algorithm-derived single index model for integrating environmental risk into longitudinal lung function prediction in cystic fibrosis. Journal of Cystic Fibrosis. 2025; 24:s437b-ss438.

Bdaiwi, AS; Roach, DJ; West, ME; Willmering, MM; Daou, AW; Hossain, MM; Kramer, EL; Amin, R; Walkup, LL; Cleveland, ZI; Woods, JC. Longitudinal Monitoring of Lumacaftor/Ivacaftor Response in Young Children with Cystic Fibrosis Lung Disease Using 129Xe MRI. Academic Radiology. 2025; 32:6238-6249.

Liu, CM; Fischer, JL; Zemanick, ET; Woods, JC; Markarian, KK; Fain, SB; Froh, D; Heltshe, SL; Hoffman, LR; Humphries, SM; Trout, AT; Goss, CH; Taylor-Cousar, JL; Beswick, DM. The impact of highly effective modulator therapy on sinusitis and dysosmia in young children with cystic fibrosis: a prospective study protocol. ERJ Open Research. 2025; 11:137-2024.

Peterson, CJ; Rao, MB; Palipana, A; Manning, ER; Vancil, A; Ryan, P; Brokamp, C; Kramer, E; Szczesniak, RD; Gecili, E. Robust identification of environmental exposures and community characteristics predictive of rapid lung disease progression. Science of the Total Environment. 2024; 950:175348.

Dasgupta, A; Imbrogno, M; Collins, M; Merlin, L; Kramer, E; Brewington, J; Morgan, H; Meeker, J; Mahajan, S; Wozniak, D; Gardner, J; Trapnell, B; Clancy, J; Hudock, K. 198 Neutrophil extracellular traps increase Pseudomonal density in human bronchial epithelia. Journal of Cystic Fibrosis. 2024; 23:s110.

Brewington, J; O'Shaughnessy, R; Ostmann, A; Meeker, J; Morgan, H; Kramer, E; Hudock, K; Clancy, J. 327 Comparison of human nasal and fisher rat thyroid cell-based theratyping results. Journal of Cystic Fibrosis. 2024; 23:s173-s174.

Bdaiwi, AS; Svoboda, AM; Murdock, KE; Hendricks, A; Hossain, MM; Kramer, EL; Brewington, JJ; Willmering, MM; Woods, JC; Walkup, LL; Cleveland, ZI. Quantifying abnormal alveolar microstructure in cystic fibrosis lung disease via hyperpolarized 129Xe diffusion MRI. Journal of Cystic Fibrosis. 2024; 23:926-935.

Collins, MS; Imbrogno, MA; Kopras, EJ; Howard, JA; Zhang, N; Kramer, EL; Hudock, KM. Heterogeneity in Neutrophil Extracellular Traps from Healthy Human Subjects. International Journal of Molecular Sciences. 2024; 25:525.

Kramer, EL; Hudock, KM; Davidson, CR; Clancy, JP. CFTR dysfunction in smooth muscle drives TGFβ dependent airway hyperreactivity. Respiratory Research. 2023; 24:198.

Scharf, G; Davidson, C; Morgan, H; Meeker, J; Ostmann, A; Brewington, J; Hudock, K; Clancy, J; Kramer, E. 168 Impact of TGF-β exposure on IL-6 secretion in cystic fibrosis airway epithelia. Journal of Cystic Fibrosis. 2023; 22:s89.

Middleton, R; Collins, M; Imbrogno, M; Kramer, E; Brewington, J; Meeker, J; Morgan, H; Ostmann, A; Trapnell, B; Mahajan, S; Wozniak, D; Clancy, J; Hudock, K. 98 Neutrophil extracellular traps disrupt bronchial epithelial junctional integrity and promote infection. Journal of Cystic Fibrosis. 2023; 22:s51.

Hudock, KM; Collins, MS; Imbrogno, MA; Kramer, EL; Brewington, JJ; Ziady, A; Zhang, N; Snowball, J; Xu, Y; Carey, BC; Gollomp, K; Mangalmurti, N; Trapnell, BC; Clancy, JP. Alpha-1 antitrypsin limits neutrophil extracellular trap disruption of airway epithelial barrier function. Frontiers in Immunology. 2023; 13:1023553.

Hudock, K; Cheng, P; Chmiel, J; Brown, C; Kramer, E; Indihar, V; Kopras, E; Aliaj, E; Hudson, J; Filigno, S. 27 Effect of SARS-CoV-2 on long-term physical and mental health symptoms in people with cystic fibrosis and their caregivers. Journal of Cystic Fibrosis. 2022; 21:s16-s17.

Collins, M; Imbrogno, M; Kramer, E; Brewington, J; Zhang, N; Sharon, P; Kopras, E; Meeker, J; Morgan, H; Ostmann, A; O'Grady, S; Trapnell, B; Clancy, J; Hudock, K. 380 Neutrophil extracellular traps disrupt bronchial epithelial barrier function: Alpha-1 antitrypsin to the rescue. Journal of Cystic Fibrosis. 2022; 21:s223.

Willmering, MM; Roach, DJ; Kramer, EL; Walkup, LL; Cleveland, ZI; Woods, JC. Sensitive structural and functional measurements and 1-year pulmonary outcomes in pediatric cystic fibrosis. Journal of Cystic Fibrosis. 2021; 20:533-539.