Higano Lab

Publications

Higano, NS; Cao, X; Guo, J; Wang, X; Kroenke, CD; Filuta, AL; Bridges, JP; Woods, JC. Fetal lung development via quantitative biomarkers from diffusion MRI and histological validation in rhesus macaques. Journal of Perinatology. 2022; 42:866-872.

Higano, NS; Thomen, RP; Quirk, JD; Huyck, HL; Hahn, AD; Fain, SB; Pryhuber, GS; Woods, JC. Alveolar Airspace Size in Healthy and Diseased Infant Lungs Measured via Hyperpolarized 3He Gas Diffusion Magnetic Resonance Imaging. Neonatology: foetal and neonatal research. 2021; 117:704-712.

Bates, AJ; Higano, NS; Hysinger, EB; Fleck, RJ; Hahn, AD; Fain, SB; Kingma, PS; Woods, JC. Quantitative Assessment of Regional Dynamic Airway Collapse in Neonates via Retrospectively Respiratory-Gated 1 H Ultrashort Echo Time MRI. Journal of Magnetic Resonance Imaging. 2019; 49:659-667.

Higano, NS; Fleck, RJ; Spielberg, DR; Walkup, LL; Hahn, AD; Thomen, RP; Merhar, SL; Kingma, PS; Tkach, JA; Fain, SB; Woods, JC. Quantification of neonatal lung parenchymal density via ultrashort echo time MRI with comparison to CT. Journal of Magnetic Resonance Imaging. 2017; 46:992-1000.

Higano, NS; Hahn, AD; Tkach, JA; Cao, X; Walkup, LL; Thomen, RP; Merhar, SL; Kingma, PS; Fain, SB; Woods, JC. Retrospective respiratory self-gating and removal of bulk motion in pulmonary UTE MRI of neonates and adults. Magnetic Resonance in Medicine. 2017; 77:1284-1295.

Dianova, E; Higano, NS; McNelis, KM; Ehrlich, SR; Liu, C; Woods, JC; Kingma, PS. Association of Early Nutrition with Bronchopulmonary Dysplasia Severity and Magnetic Resonance Imaging Lung Characteristics in Preterm Infants. Neonatology: foetal and neonatal research. 2025; 122:319-328.

Boles, C; Gunatilaka, CC; Xiao, Q; Woods, JC; Kingma, PS; Higano, NS; Bates, A. Computational Fluid Dynamics Analysis of Tracheal Pressure Difference in Neonates With Tracheoesophageal Fistulas Before and After Surgical Repair. American Journal of Respiratory and Critical Care Medicine. 2025; 211:a5119.

Stewart, NJ; Higano, NS; Wucherpfennig, L; Triphan, SM F; Simmons, A; Smith, LJ; Wielpütz, MO; Woods, JC; Wild, JM. Pulmonary MRI in Newborns and Children. Journal of Magnetic Resonance Imaging. 2025; 61:2094-2115.

Mohanakrishnan, M; Munidasa, SR; Higano, NS; Willmering, M; Hoyos Cordon, X; Bullard Elias, D; Bates, AJ; Kingma, PS; Hysinger, EB; Woods, JC. Serial MRI Evaluation of Tracheomalacia Changes in Neonates With Bronchopulmonary Dysplasia. American Journal of Respiratory and Critical Care Medicine. 2025; 211:a1284.

Munidasa, S; Higano, NS; Zinjal, R; Willmering, M; Kingma, PS; Critser, PJ; Hysinger, E; Woods, JC. Structural and Functional Cardiopulmonary Magnetic Resonance Imaging in Neonates With Bronchopulmonary Dysplasia. American Journal of Respiratory and Critical Care Medicine. 2025; 211:a1279.

Jo, S; Arroyo, R; Marks, K; Higano, NS; Bates, A; von Allenmen, D; Woods, JC; Kingma, PS. Evaluation of Magnetic Resonance Imaging (MRI) Anatomic Risk Factors to Predict Outcomes in Patients With Esophageal Atresia (EA). American Journal of Respiratory and Critical Care Medicine. 2025; 211:a2299.

Munidasa, SR; Higano, NS; Willmering, M; Bdaiwi, AS; Hoyos Cordon, X; Bullard Elias, D; Kingma, PS; Hysinger, EB; Woods, JC. Magnetic Resonance Imaging Captures the Short-Term Trajectory of Parenchymal Lung Disease in Infants With Bronchopulmonary Dysplasia. American Journal of Respiratory and Critical Care Medicine. 2025; 211:a1280.

Mukthapuram, S; Donaher, A; Higano, NS; Rowe, JA; Tkach, JA; Woods, JC; Kingma, PS. Magnetic Resonance Imaging Assessment of Pulmonary Vascularity in Preterm Infants with Bronchopulmonary Dysplasia. Neonatology: foetal and neonatal research. 2025; 122:76-83.

Zak, SM; Onge, IS; Higano, NS; Bates, AJ; Gandhi, D; Fleck, RJ; Kingma, PS; Woods, JC; Hysinger, EB. Clinical Outcomes Through Two Years for Infants With Bronchopulmonary Dysplasia and Tracheomalacia. Pediatric Pulmonology. 2025; 60:e27383.

Gunatilaka, CC; McKenzie, C; Xiao, Q; Higano, NS; Woods, JC; Bates, AJ. Effect of airway wall motion on particle deposition and delivery in the neonatal trachea. Journal of Aerosol Science. 2024; 182:106450.

von Allmen, DC; Hysinger, EB; Bates, AJ; Higano, NS; Garrison, A; Walther, A; de Alarcon, A; Woods, J; Kingma, P. Correlation of Tracheomalacia Severity With Esophageal Gap Length as Assessed by Ultrashort Echo-time MRI. Journal of Pediatric Surgery. 2024; 59:161880.

Bjorkman, KR; Miles, KG; Bellew, LE; Schneider, KA; Magness, SM; Higano, NS; Ollberding, NJ; Cordon, XH; Hirsch, RM; Hysinger, E; Woods, JC; Critser, PJ. Patent Ductus Arteriosus and Lung Magnetic Resonance Imaging Phenotype in Moderate and Severe Bronchopulmonary Dysplasia-Pulmonary Hypertension. American Journal of Respiratory and Critical Care Medicine. 2024; 210:318-328.

Higano, NS. Editorial for "Assessment of Pulmonary Ventilation Using 3D Ventilation Flow-Weighted and Ventilation-Weighted Maps From 3D Ultrashort Echo-Time (UTE) MRI ". Journal of Magnetic Resonance Imaging. 2024; 60:495-496.

Gandhi, DB; Higano, NS; Hahn, AD; Gunatilaka, CC; Torres, LA; Fain, SB; Woods, JC; Bates, AJ. Comparison of weighting algorithms to mitigate respiratory motion in free-breathing neonatal pulmonary radial UTE-MRI. Biomedical Physics and Engineering Express. 2024; 10:035030.

Gunatilaka, CC; McKenzie, C; Hysinger, EB; Xiao, Q; Higano, NS; Woods, JC; Bates, AJ. Tracheomalacia Reduces Aerosolized Drug Delivery to the Lung. Journal of Aerosol Medicine and Pulmonary Drug Delivery. 2024; 37:19-29.

Giltmier, AJ; Higano, NS; Woods, JC; Kingma, PS. Evaluation of regional lung mass and growth in neonates with bronchopulmonary dysplasia using ultrashort echo time magnetic resonance imaging. Pediatric Pulmonology. 2024; 59:55-62.

Stewart, NJ; Higano, NS; Mukthapuram, S; Willmering, MM; Loew, W; West, M; Arnsperger, A; Pratt, R; Rao, MR; Schulte, RF; Wild, JM; Woods, JC. Initial feasibility and challenges of hyperpolarized 129 Xe MRI in neonates with bronchopulmonary dysplasia. Magnetic Resonance in Medicine. 2023; 90:2420-2431.

Marks, KT; Higano, NS; Kotagal, M; Woods, JC; Kingma, PS. Magnetic Resonance Imaging-Based Evaluation of Anatomy and Outcome Prediction in Infants with Esophageal Atresia. Neonatology: foetal and neonatal research. 2023; 120:185-195.

Tkach, JA; Higano, NS; Taylor, MD; Moore, RA; Hossain, M; Huang, G; Spielberg, DR; Fain, SB; Kingma, PS; Woods, JC. Quantitative cardiopulmonary magnetic resonance imaging in neonatal congenital diaphragmatic hernia. Pediatric Radiology: roentgenology, nuclear medicine, ultrasonics, CT, MRI. 2022; 52:2306-2318.

Gunatilaka, CC; Hysinger, EB; Schuh, A; Xiao, Q; Gandhi, DB; Higano, NS; Ignatiuk, D; Hossain, MM; Fleck, RJ; Woods, JC; Bates, AJ. Predicting tracheal work of breathing in neonates based on radiological and pulmonary measurements. Journal of applied physiology (Bethesda, Md. : 1985). 2022; 133:893-901.

Higano, NS; Gandhi, DB; Xiao, Q; Gunatilaka, CC; Hysinger, EB; Fleck, RJ; Woods, JC; Bates, AJ. Virtual Bronchoscopy of Neonatal Airway Malacia via High-Resolution, Respiratory-gated Magnetic Resonance Imaging. American Journal of Respiratory and Critical Care Medicine. 2022; 206:e42-e43.

Hysinger, EB; Higano, NS; Critser, PJ; Woods, JC. Imaging in neonatal respiratory disease. Paediatric Respiratory Reviews. 2022; 43:44-52.

Zou, Q; Torres, LA; Fain, SB; Higano, NS; Bates, AJ; Jacob, M. Dynamic imaging using motion-compensated smoothness regularization on manifolds (MoCo-SToRM). Physics in Medicine and Biology. 2022; 67:144001.

Higano, NS; Cao, X; Guo, J; Wang, X; Kroenke, CD; Filuta, AL; Bridges, JP; Woods, JC. Fetal lung development via quantitative biomarkers from diffusion MRI and histological validation in rhesus macaques. Journal of Perinatology. 2022; 42:866-872.

Adaikalam, SA; Higano, NS; Hysinger, EB; Bates, AJ; Fleck, RJ; Schapiro, AH; House, MA; Nathan, AT; Ahlfeld, SK; Brady, JM; Woods, JC; Kingma, PS. Tracheostomy prediction model in neonatal bronchopulmonary dysplasia via lung and airway MRI. Pediatric Pulmonology. 2022; 57:1042-1050.

Adaikalam, SA; Higano, NS; Hysinger, EB; Bates, AJ; Fleck, RJ; Schapiro, AH; House, MA; Nathan, AT; Ahlfeld, SK; Brady, JM; Woods, JC; Kingma, PS. Cover Image, Volume 57, Number 4, April 2022. Pediatric Pulmonology. 2022; 57:ii.

Higano, NS; Bates, AJ; Gunatilaka, CC; Hysinger, EB; Critser, PJ; Hirsch, R; Woods, JC; Fleck, RJ. Bronchopulmonary dysplasia from chest radiographs to magnetic resonance imaging and computed tomography: adding value. Pediatric Radiology: roentgenology, nuclear medicine, ultrasonics, CT, MRI. 2022; 52:643-660.

Gunatilaka, CC; Hysinger, EB; Schuh, A; Gandhi, DB; Higano, NS; Xiao, Q; Hahn, AD; Fain, SB; Fleck, RJ; Woods, JC; Bates, AJ. Neonates With Tracheomalacia Generate Auto-Positive End-Expiratory Pressure via Glottis Closure. Chest. 2021; 160:2168-2177.

Trisno, SL; Higano, NS; Kechele, D; Nasr, T; Chung, W; Zorn, AM; Woods, JC; Wells, JM; Kingma, PS. Case Report: Esophageal Bronchus in a Neonate, With Image, Histological, and Molecular Analysis. Frontiers in Pediatrics. 2021; 9:707822.

Hahn, AD; Malkus, A; Kammerman, J; Higano, N; Walkup, LL; Woods, J; Fain, SB. Effects of neonatal lung abnormalities on parenchymal R2 * estimates. Journal of Magnetic Resonance Imaging. 2021; 53:1853-1861.

Gandhi, DB; Rice, A; Gunatilaka, CC; Higano, NS; Fleck, RJ; de Alarcon, A; Hart, CK; Kuo, IC; Amin, RS; Woods, JC; Hysinger, EB; Bates, AJ. Quantitative Evaluation of Subglottic Stenosis Using Ultrashort Echo Time MRI in a Rabbit Model. The Laryngoscope. 2021; 131:E1971-E1979.

Higano, NS; Ruoss, JL; Woods, JC. Modern pulmonary imaging of bronchopulmonary dysplasia. Journal of Perinatology. 2021; 41:707-717.

Yang, MM; Higano, NS; Gunatilaka, CC; Hysinger, EB; Amin, RS; Woods, JC; Bates, AJ. Subglottic Stenosis Position Affects Work of Breathing. The Laryngoscope. 2021; 131:E1220-E1226.

Higano, NS; Thomen, RP; Quirk, JD; Huyck, HL; Hahn, AD; Fain, SB; Pryhuber, GS; Woods, JC. Alveolar Airspace Size in Healthy and Diseased Infant Lungs Measured via Hyperpolarized 3He Gas Diffusion Magnetic Resonance Imaging. Neonatology: foetal and neonatal research. 2021; 117:704-712.

Bates, AJ; Higano, NS; Woods, JC. Non-Bronchoscopic Assessment of the Airways. In: Goldfarb S; Piccione J, Ed. Diagnostic and Interventional Bronchoscopy in Children. Cham: Springer Nature; 2021.