Higano Lab

Publications

Higano, NS; Cao, X; Guo, J; Wang, X; Kroenke, CD; Filuta, AL; Bridges, JP; Woods, JC. Fetal lung development via quantitative biomarkers from diffusion MRI and histological validation in rhesus macaques. Journal of Perinatology. 2022; 42:866-872.

Higano, NS; Thomen, RP; Quirk, JD; Huyck, HL; Hahn, AD; Fain, SB; Pryhuber, GS; Woods, JC. Alveolar Airspace Size in Healthy and Diseased Infant Lungs Measured via Hyperpolarized 3He Gas Diffusion Magnetic Resonance Imaging. Neonatology: foetal and neonatal research. 2021; 117:704-712.

Bates, AJ; Higano, NS; Hysinger, EB; Fleck, RJ; Hahn, AD; Fain, SB; Kingma, PS; Woods, JC. Quantitative Assessment of Regional Dynamic Airway Collapse in Neonates via Retrospectively Respiratory-Gated 1 H Ultrashort Echo Time MRI. Journal of Magnetic Resonance Imaging. 2019; 49:659-667.

Higano, NS; Fleck, RJ; Spielberg, DR; Walkup, LL; Hahn, AD; Thomen, RP; Merhar, SL; Kingma, PS; Tkach, JA; Fain, SB; et al. Quantification of neonatal lung parenchymal density via ultrashort echo time MRI with comparison to CT. Journal of Magnetic Resonance Imaging. 2017; 46:992-1000.

Higano, NS; Hahn, AD; Tkach, JA; Cao, X; Walkup, LL; Thomen, RP; Merhar, SL; Kingma, PS; Fain, SB; Woods, JC. Retrospective respiratory self-gating and removal of bulk motion in pulmonary UTE MRI of neonates and adults. Magnetic Resonance in Medicine. 2017; 77:1284-1295.

Giltmier, AJ; Higano, NS; Woods, JC; Kingma, PS. Evaluation of regional lung mass and growth in neonates with bronchopulmonary dysplasia using ultrashort echo time magnetic resonance imaging. Pediatric Pulmonology. 2024; 59:55-62.

Stewart, NJ; Higano, NS; Mukthapuram, S; Willmering, MM; Loew, W; West, M; Arnsperger, A; Pratt, R; Rao, MR; Schulte, RF; et al. Initial feasibility and challenges of hyperpolarized 129 Xe MRI in neonates with bronchopulmonary dysplasia. Magnetic Resonance in Medicine. 2023; 90:2420-2431.

Marks, KT; Higano, NS; Kotagal, M; Woods, JC; Kingma, PS. Magnetic Resonance Imaging-Based Evaluation of Anatomy and Outcome Prediction in Infants with Esophageal Atresia. Neonatology: foetal and neonatal research. 2023; 120:185-195.

Tkach, JA; Higano, NS; Taylor, MD; Moore, RA; Hossain, M; Huang, G; Spielberg, DR; Fain, SB; Kingma, PS; Woods, JC. Quantitative cardiopulmonary magnetic resonance imaging in neonatal congenital diaphragmatic hernia. Pediatric Radiology: roentgenology, nuclear medicine, ultrasonics, CT, MRI. 2022; 52:2306-2318.

Gunatilaka, CC; Hysinger, EB; Schuh, A; Xiao, Q; Gandhi, DB; Higano, NS; Ignatiuk, D; Hossain, MM; Fleck, RJ; Woods, JC; et al. Predicting tracheal work of breathing in neonates based on radiological and pulmonary measurements. Journal of applied physiology (Bethesda, Md. : 1985). 2022; 133:893-901.

Higano, NS; Gandhi, DB; Xiao, Q; Gunatilaka, CC; Hysinger, EB; Fleck, RJ; Woods, JC; Bates, AJ. Virtual Bronchoscopy of Neonatal Airway Malacia via High-Resolution, Respiratory-gated Magnetic Resonance Imaging. American Journal of Respiratory and Critical Care Medicine. 2022; 206:e42-e43.

Hysinger, EB; Higano, NS; Critser, PJ; Woods, JC. Imaging in neonatal respiratory disease. Paediatric Respiratory Reviews. 2022; 43:44-52.

Zou, Q; Torres, LA; Fain, SB; Higano, NS; Bates, AJ; Jacob, M. Dynamic imaging using motion-compensated smoothness regularization on manifolds (MoCo-SToRM). Physics in Medicine and Biology. 2022; 67:144001.

Higano, NS; Cao, X; Guo, J; Wang, X; Kroenke, CD; Filuta, AL; Bridges, JP; Woods, JC. Fetal lung development via quantitative biomarkers from diffusion MRI and histological validation in rhesus macaques. Journal of Perinatology. 2022; 42:866-872.

Adaikalam, SA; Higano, NS; Hysinger, EB; Bates, AJ; Fleck, RJ; Schapiro, AH; House, MA; Nathan, AT; Ahlfeld, SK; Brady, JM; et al. Tracheostomy prediction model in neonatal bronchopulmonary dysplasia via lung and airway MRI. Pediatric Pulmonology. 2022; 57:1042-1050.

Adaikalam, SA; Higano, NS; Hysinger, EB; Bates, AJ; Fleck, RJ; Schapiro, AH; House, MA; Nathan, AT; Ahlfeld, SK; Brady, JM; et al. Cover Image, Volume 57, Number 4, April 2022. Pediatric pulmonology. Supplement. 2022; 57:ii.

Higano, NS; Bates, AJ; Gunatilaka, CC; Hysinger, EB; Critser, PJ; Hirsch, R; Woods, JC; Fleck, RJ. Bronchopulmonary dysplasia from chest radiographs to magnetic resonance imaging and computed tomography: adding value. Pediatric Radiology: roentgenology, nuclear medicine, ultrasonics, CT, MRI. 2022; 52:643-660.

Gunatilaka, CC; Hysinger, EB; Schuh, A; Gandhi, DB; Higano, NS; Xiao, Q; Hahn, AD; Fain, SB; Fleck, RJ; Woods, JC; et al. Neonates With Tracheomalacia Generate Auto-Positive End-Expiratory Pressure via Glottis Closure. Chest. 2021; 160:2168-2177.

Trisno, SL; Higano, NS; Kechele, D; Nasr, T; Chung, W; Zorn, AM; Woods, JC; Wells, JM; Kingma, PS. Case Report: Esophageal Bronchus in a Neonate, With Image, Histological, and Molecular Analysis. Frontiers in Pediatrics. 2021; 9:707822.

Hahn, AD; Malkus, A; Kammerman, J; Higano, N; Walkup, LL; Woods, J; Fain, SB. Effects of neonatal lung abnormalities on parenchymal R2 * estimates. Journal of Magnetic Resonance Imaging. 2021; 53:1853-1861.

Gandhi, DB; Rice, A; Gunatilaka, CC; Higano, NS; Fleck, RJ; de Alarcon, A; Hart, CK; Kuo, IC; Amin, RS; Woods, JC; et al. Quantitative Evaluation of Subglottic Stenosis Using Ultrashort Echo Time MRI in a Rabbit Model. The Laryngoscope. 2021; 131:E1971-E1979.

Higano, NS; Ruoss, JL; Woods, JC. Modern pulmonary imaging of bronchopulmonary dysplasia. Journal of Perinatology. 2021; 41:707-717.

Yang, MM; Higano, NS; Gunatilaka, CC; Hysinger, EB; Amin, RS; Woods, JC; Bates, AJ. Subglottic Stenosis Position Affects Work of Breathing. The Laryngoscope. 2021; 131:E1220-E1226.

Higano, NS; Thomen, RP; Quirk, JD; Huyck, HL; Hahn, AD; Fain, SB; Pryhuber, GS; Woods, JC. Alveolar Airspace Size in Healthy and Diseased Infant Lungs Measured via Hyperpolarized 3He Gas Diffusion Magnetic Resonance Imaging. Neonatology: foetal and neonatal research. 2021; 117:704-712.

Bates, AJ; Higano, NS; Woods, JC. Non-Bronchoscopic Assessment of the Airways. In: Goldfarb S; Piccione J, Ed. Diagnostic and Interventional Bronchoscopy in Children. Cham: Springer Nature; 2021.

Critser, PJ; Higano, NS; Lang, SM; Kingma, PS; Fleck, RJ; Hirsch, R; Taylor, MD; Woods, JC. Cardiovascular magnetic resonance imaging derived septal curvature in neonates with bronchopulmonary dysplasia associated pulmonary hypertension. Journal of Cardiovascular Magnetic Resonance. 2020; 22:50.

Gunatilaka, CC; Schuh, A; Higano, NS; Woods, JC; Bates, AJ. The effect of airway motion and breathing phase during imaging on CFD simulations of respiratory airflow. Computers in Biology and Medicine. 2020; 127:104099.

Thomen, RP; Woods, JC; Sturm, PF; Jain, V; Walkup, LL; Higano, NS; Quirk, JD; Varisco, BM. Lung microstructure in adolescent idiopathic scoliosis before and after posterior spinal fusion. Editor, Koval M. PloS one. 2020; 15:e0240265.

Gunatilaka, CC; Higano, NS; Hysinger, EB; Gandhi, DB; Fleck, RJ; Hahn, AD; Fain, SB; Woods, JC; Bates, AJ. Increased Work of Breathing due to Tracheomalacia in Neonates. Annals of the American Thoracic Society. 2020; 17:1247-1256.

Gouwens, KR; Higano, NS; Marks, KT; Stimpfl, JN; Hysinger, EB; Woods, JC; Kingma, PS. Magentic Resonance Imaging Evaluation of Regional Lung Vts in Severe Neonatal Bronchopulmonary Dysplasia. American Journal of Respiratory and Critical Care Medicine. 2020; 202:1024-1031.

Hahn, AD; Malkus, A; Kammerman, J; Higano, N; Walkup, L; Woods, J; Fain, SB. Characterization of R2∗ and tissue density in the human lung: Application to neonatal imaging in the intensive care unit. Magnetic Resonance in Medicine. 2020; 84:920-927.

Thomen, RP; Walkup, LL; Roach, DJ; Higano, N; Schapiro, A; Brody, A; Clancy, JP; Cleveland, ZI; Woods, JC. Regional Structure-Function in Cystic Fibrosis Lung Disease Using Hyperpolarized 129Xe and Ultrashort Echo Magnetic Resonance Imaging. American Journal of Respiratory and Critical Care Medicine. 2020; 202:290-292.

Hysinger, EB; Bates, AJ; Higano, NS; Benscoter, D; Fleck, RJ; Hart, CK; Burg, G; De Alarcon, A; Kingma, PS; Woods, JC. Ultrashort Echo-Time MRI for the Assessment of Tracheomalacia in Neonates. Chest. 2020; 157:595-602.

Critser, PJ; Higano, NS; Tkach, JA; Olson, ES; Spielberg, DR; Kingma, PS; Fleck, RJ; Lang, SM; Moore, RA; Taylor, MD; et al. Cardiac Magnetic Resonance Imaging Evaluation of Neonatal Bronchopulmonary Dysplasia-associated Pulmonary Hypertension. American Journal of Respiratory and Critical Care Medicine. 2020; 201:73-82.

Higano, NS; Woods, JC. Chapter 6 Advancing Imaging Modalities in Bronchopulmonary Dysplasia and Other Neonatal Chronic Lung Diseases. Updates on Neonatal Chronic Lung Disease. : Elsevier; Elsevier; 2020.