Grom / Thornton Lab

Publications

Eloseily, E; Romankevych, I; Sabit, T; Berklite, L; Ranganathan, S; Rosen, P; Henrickson, M; Huggins, J; Schulert, G; Grom, A. Hepatic Manifestations in Systemic Juvenile Idiopathic Arthritis and Macrophage Activation Syndrome. Journal of Rheumatology. 2025.

Vega-Fernandez, P; Avar-Aydin, PO; Rogers, K; Lovell, DJ; Huggins, J; Grom, A; Brunner, HI; Schulert, GS; Angeles-Han, ST; Altaye, M; Cassedy, A; Meyers, AB; Ting, TV. Validation of the Pediatric Arthritis Ultrasound Scoring System for the Elbow, Wrist, and Finger Joints in Children with Juvenile Idiopathic Arthritis. Arthritis Care and Research. 2025.

Nguyen, K; Yasin, S; Fall, N; Grom, AA; Brunner, HI; Towe, C; Schulert, GS. Utility of patient-reported outcomes for pulmonary symptoms and sleep disturbance and impairment in children with systemic juvenile idiopathic arthritis. Pediatric Rheumatology. 2025; 23(1):74.

Macaraeg, M; Baker, E; Handorf, E; Matt, M; Baker, EK; Brunner, H; Grom, AA; Henrickson, M; Huggins, J; Zhang, W; Lee, P; Marsh, R; Schulert, GS. Clinical, Immunologic, and Genetic Characteristics in Patients With Syndrome of Undifferentiated Recurrent Fevers. Arthritis & Rheumatology. 2025; 77(5):596-605.

Cook, E; Schulert, G; Grom, A; Towe, C; Burg, G; Marsh, R; Chandra, S. Experience with T Cell–Depleted Allogeneic HSCT for Refractory sJIA Associated with Lung Disease. Journal of Human Immunity. 2025; 1(CIS2025).

Matt, MG; Drozdov, D; Bendstrup, E; Glerup, M; Hauge, E-M; Masmas, T; Schneider, EC; Zeilhofer, UB; Abu-Arja, RF; Driest, KD; Chandra, S; Grom, A; Schulert, GS; Marsh, RA. Allogeneic haematopoietic stem-cell transplantation for children with refractory systemic juvenile idiopathic arthritis and associated lung disease: outcomes from an international, retrospective cohort study. The Lancet Rheumatology. 2025; 7(4):e243-e251.

Basaran, O; Sag, E; Aydın, EA; Aydın, B; Tasdemir, NK; Celikel, E; Bayındır, Y; Özdel, S; Bilginer, Y; Grom, AA; Ozen, S. Lack of HLH in FMF. Pediatric Rheumatology. 2025; 23(1):14.

Maccora, I; Brunner, HI; Cassedy, A; Altaye, M; Quinlan-Waters, M; Lovell, DJ; Grom, A; Angeles-Han, ST. Achieving Medication-Free Remission in Patients With Juvenile Dermatomyositis. ACR Open Rheumatology. 2025; 7(1):e11751.

Baldo, F; Erkens, RGA; Mizuta, M; Rogani, G; Lucioni, F; Bracaglia, C; Foell, D; Gattorno, M; Jelusic, M; Anton, J; Ruperto, N; Swart, JF; Vastert, S; Minoia, F. Current treatment in macrophage activation syndrome worldwide: a systematic literature review to inform the METAPHOR project. Rheumatology. 2025; 64(1):32-44.

Wallace, PK; Jellison, ER; Thornton, S; Kluepfel, K; Back, J; Beadnell, TC; Bebes, A; Behrends, J; Belkina, AC; Black, M; Woolard, S; Yeh, N-Y; Yuecel, R; Rajwa, B. Cyt-Geist: Current and Future Challenges in Cytometry: Reports of the CYTO 2025 Conference Workshops. Cytometry. Part A : the journal of the International Society for Analytical Cytology. 2025.

Eloseily, E; Riordan, ME; Mahmoud, I; Clark, A; Chang, M-L; Russell, A; Natter, M; Thornton, S; Canna, S; Co, DO; Deguzman, M; Kimura, Y; Schulert, GS. Baseline Clinical Features and Biomarker Profiles of the Childhood Arthritis and Rheumatology Research Alliance Systemic Juvenile Idiopathic Arthritis- Associated Lung Disease Cohort. Arthritis Care and Research. 2025.

O'connor, SK; Devarajan, P; Liu, J; Maldonado, MA; Sproles, A; Rose, J; Thornton, S; Chen, C; Huang, B; Brunner, HI. The Renal Activity Index for Lupus: Validation for Prediction of Kidney Inflammation in Adult Patients with Lupus Nephritis. Journal of Rheumatology. 2025.

Tursi, AR; Lages, CS; Quayle, K; Koenig, ZT; Loni, R; Eswar, S; Cobeña-Reyes, J; Thornton, S; Tilburgs, T; Andorf, S. Automated descriptive cell type naming in flow and mass cytometry with CytoPheno. Scientific Reports. 2025; 15(1):26750.

Cody, EM; Sproles, A; Rose, J; Huang, B; Devarajan, P; Brunner, HI; Thornton, S. Development and Validation of Multiplex Assays for Lupus Nephritis Activity Biomarkers. Kidney International Reports. 2025; 10(7):2255-2264.

Vega-Fernandez, P; Huggins, J; Angeles-Han, S; Lovell, DJ; Brunner, H; Rogers, K; Quinlan-Waters, M; Thornton, S; Cassedy, A; Ting, T. POS0295 RELATIONSHIP AMONG A PEDIATRIC-SPECIFIC ULTRASOUND SCORING SYSTEM FOR THE EVALUATION OF ARTHRITIS AND BIOLOGIC MARKERS OF INFLAMMATION. Annals of the Rheumatic Diseases. 2025; 84:556.

Maccora, I; Altaye, M; Greis, KD; Brunner, HI; Duell, A; Haffey, WD; Nguyen, T; Quinlan-Waters, M; Schulert, GS; Sproles, A; Utz, VM; Thornton, S; Angeles-Han, ST. Candidate Tear-Based Uveitis Biomarkers in Children with JIA Based on Arthritis Activity and Topical Corticosteroid Use. Ocular Immunology and Inflammation. 2025; 33(4):603-612.

Eloseily, E; Pickering, A; Dhakal, S; Ruperto, N; Brunner, HI; Grom, AA; Thornton, S. Transcriptional Profiling of Tofacitinib Treatment in Juvenile Idiopathic Arthritis: Implications for Treatment Response Prediction. Arthritis Care and Research. 2025; 77(4):513-521.

Fautrel, B; Mitrovic, S; De Matteis, A; Bindoli, S; Antón, J; Belot, A; Bracaglia, C; Constantin, T; Dagna, L; Di Bartolo, A; Wilhelmer, T-C; Wouters, C; Carmona, L; De Benedetti, F. EULAR/PReS recommendations for the diagnosis and management of Still's disease, comprising systemic juvenile idiopathic arthritis and adult-onset Still's disease. Annals of the Rheumatic Diseases. 2024; 83(12):1614-1627.

Correia Marques, M; Rubin, D; Shuldiner, EG; Datta, M; Schmitz, E; Gutierrez Cruz, G; Patt, A; Bennett, E; Grom, A; Foell, D; Woo, P; Ozen, S; Deng, Z; Ombrello, MJ. Enrichment of Rare Variants of Hemophagocytic Lymphohistiocytosis Genes in Systemic Juvenile Idiopathic Arthritis. Arthritis & Rheumatology. 2024; 76(10):1566-1572.

Lovell, DJ; Tzaribachev, N; Henrickson, M; Simonini, G; Griffin, TA; Alexeeva, E; Bohnsack, JF; Zeft, A; Horneff, G; Vehe, RK; Simon, TA; Martini, A; Brunner, HI; Ruperto, N. Safety and effectiveness of abatacept in juvenile idiopathic arthritis: results from the PRINTO/PRCSG registry. Rheumatology. 2024; 63(SI2):SI195-SI206.

Huang, Y; Sompii-Montgomery, L; Patti, J; Pickering, A; Yasin, S; Do, T; Baker, E; Gao, D; Abdul-Aziz, R; Behrens, EM; Ting, T; Grom, AA; Towe, C; Schulert, GS. Disease Course, Treatments, and Outcomes of Children With Systemic Juvenile Idiopathic Arthritis-Associated Lung Disease. Arthritis Care and Research. 2024; 76(3):328-339.

Peng, J; Dönnes, P; Ardoin, SP; Schanberg, LE; Lewandowski, L; Robinson, G; Jury, EC; Ciurtin, C. Atherosclerosis Progression in the APPLE Trial Can Be Predicted in Young People With Juvenile-Onset Systemic Lupus Erythematosus Using a Novel Lipid Metabolomic Signature. Arthritis & Rheumatology. 2024; 76(3):455-468.

Schulert, G; Vastert, SJ; Grom, AA. The 4th NextGen therapies for SJIA and MAS: part 2 phenotypes of refractory SJIA and the landscape for clinical trials in refractory SJIA. Pediatric Rheumatology. 2024; 21(Suppl 1):87.

Grom, AA; Canna, SW; Abu-Arja, RF; Sinha, R; Peixoto, L; Cannizzaro, E; Chandrakasan, S; Driest, K; Marsh, R; Neven, B; Schulert, G; Silva, JMF; Wall, D; Zeilhofer, U. Part 5: Allogeneic HSCT in refractory SJIA with lung disease; recent cases from centers in North America & Europe. Pediatric Rheumatology. 2024; 21(Suppl 1):86.

Sinha, R; De Benedetti, F; Grom, AA. Proceedings from the 4th NextGen Therapies for SJIA and MAS virtual symposium held February 13-14, 2022. Pediatric Rheumatology. 2024; 21(Suppl 1):91.

De Benedetti, F; Grom, AA; Brunner, H. The 4th NextGen therapies for SJIA and MAS: part 3 clinical trials in refractory SJIA: historic controls as an alternative to a withdrawal design study. Pediatric Rheumatology. 2024; 21(Suppl 1):150.

Erkens, RGA; Calis, JJA; Verwoerd, A; De Roock, S; Ter Haar, NM; Den Engelsman, G; Van Der Veken, LT; Ernst, RF; Van Deutekom, HWM; Pickering, A; Schulert, GS; Grom, AA; Van Loosdregt, J; Vastert, SJ. Recombinant Interleukin-1 Receptor Antagonist Is an Effective First-Line Treatment Strategy in New-Onset Systemic Juvenile Idiopathic Arthritis, Irrespective of HLA-DRB1 Background and IL1RN Variants. Arthritis & Rheumatology. 2024; 76(1):119-129.

Grom, AA. Genetics of Macrophage Activation Syndrome in Systemic Juvenile Idiopathic Arthritis. Advances in Experimental Medicine and Biology. 2024; 1448:121-126.

Vega-Fernandez, P; Rogers, K; Sproles, A; Thornton, S; Huggins, J; Lovell, DJ; Cassedy, A; Meyers, AB; Ting, TV. Diagnostic Accuracy Study of the Pediatric-Specific Ultrasound Scoring System for the Knee Joint in Children With Juvenile Idiopathic Arthritis. Arthritis Care and Research. 2024; 76(2):251-258.

Ogbu, EA; Brunner, HI; Eloseily, E; Aviel, YB; Nanda, K; Schmeling, H; Tory, H; Uziel, Y; Viola, DO; Wahezi, DM; Ruperto, N; Huang, B; Grom, A; Thornton, S. Biomarker Changes in Response to Tofacitinib Treatment in Patients With Polyarticular-Course Juvenile Idiopathic Arthritis. Arthritis Care and Research. 2024; 76(12):1723-1732.

Brunner, HI; Schulert, GS; Sproles, A; Thornton, S; Cornejo, GV; Antón, J; Cuttica, R; Henrickson, M; Foeldvari, I; Kingsbury, DJ; Lovell, DJ; Martini, A; Ruperto, N; Grom, AA. S100 proteins as potential predictive biomarkers of abatacept response in polyarticular juvenile idiopathic arthritis. Arthritis Research & Therapy. 2024; 26(1):125.

Verweyen, EL; Thakkar, K; Dhakal, S; Baker, E; Chetal, K; Schnell, D; Canna, S; Grom, AA; Salomonis, N; Schulert, GS. Population-level single-cell genomics reveals conserved gene programs in systemic juvenile idiopathic arthritis. Journal of Clinical Investigation. 2023; 133(22).

Towe, C; Grom, AA; Schulert, GS. Diagnosis and Management of the Systemic Juvenile Idiopathic Arthritis Patient with Emerging Lung Disease. Paediatric Drugs. 2023; 25(6):649-658.

Shakoory, B; Geerlinks, A; Wilejto, M; Kernan, K; Hines, M; Romano, M; Piskin, D; Ravelli, A; Sinha, R; Aletaha, D; Goldbach-Mansky, R; De Benedetti, F; Marsh, RA; Canna, SW. The 2022 EULAR/ACR points to consider at the early stages of diagnosis and management of suspected haemophagocytic lymphohistiocytosis/macrophage activation syndrome (HLH/MAS). Annals of the Rheumatic Diseases. 2023; 82(10):1271-1285.

Shakoory, B; Geerlinks, A; Wilejto, M; Kernan, K; Hines, M; Romano, M; Piskin, D; Ravelli, A; Sinha, R; Aletaha, D; Goldbach-Mansky, R; De Benedetti, F; Marsh, RA; Canna, SW. The 2022 EULAR/ACR Points to Consider at the Early Stages of Diagnosis and Management of Suspected Haemophagocytic Lymphohistiocytosis/Macrophage Activation Syndrome (HLH/MAS). Arthritis & Rheumatology. 2023; 75(10):1714-1732.

De Benedetti, F; Grom, AA; Brogan, PA; Bracaglia, C; Pardeo, M; Marucci, G; Eleftheriou, D; Papadopoulou, C; Schulert, GS; Quartier, P; Asnaghi, V; Ballabio, M; Jacqmin, P; De Min, C. Efficacy and safety of emapalumab in macrophage activation syndrome. Annals of the Rheumatic Diseases. 2023; 82(6):857-865.

De Benedetti, F; Grom, A; Brogan, P; Bracaglia, C; Pardeo, M; Marucci, G; Eleftheriou, D; Papadopoulou, C; Schulert, G; Quartier, P; Asnaghi, V; Ballabio, M; Jacqmin, P; De Min, C. OP0166 LONG-TERM FOLLOW-UP OF PATIENTS ADMINISTERED EMAPALUMAB, AN ANTI–INTERFERON-Γ MONOCLONAL ANTIBODY, TO TREAT MACROPHAGE ACTIVATION SYNDROME (MAS) SECONDARY TO SYSTEMIC JUVENILE IDIOPATHIC ARTHRITIS (SJIA) Annals of the Rheumatic Diseases. 2023; 82:110-111.

Vega-Fernandez, P; Ting, TV; Mar, DA; Schapiro, AH; Deluna, MD; Saper, VE; Grom, AA; Schulert, GS; Fairchild, RM. Lung Ultrasound in Children With Systemic Juvenile Idiopathic Arthritis-Associated Interstitial Lung Disease. Arthritis Care and Research. 2023; 75(5):983-988.

Miraldi Utz, V; Angeles-Han, ST; Mwase, N; Cassedy, A; Hennard, T; Lovell, DJ; Lopper, S; Brunner, HI; Dosunmu, EO; Grom, AA; Henrickson, M; Huggins, JL; Sisk, RA; Ting, TV; Kaufman, AH. Alternative Biologic Therapy in Children Failing Conventional TNFα Inhibitors for Refractory, Noninfectious, Chronic Anterior Uveitis. American Journal of Ophthalmology. 2022; 244:183-195.

Chen, G; Deutsch, GH; Schulert, GS; Zheng, H; Jang, S; Trapnell, B; Lee, PY; Macaubas, C; Ho, K; Schneider, C; Goldbach-Mansky, R; Khatri, P; Mellins, ED; Canna, SW. Identification of Distinct Inflammatory Programs and Biomarkers in Systemic Juvenile Idiopathic Arthritis and Related Lung Disease by Serum Proteome Analysis. Arthritis & Rheumatology. 2022; 74(7):1271-1283.

Chalhoub, NE; Wenderfer, SE; Levy, DM; Rouster-Stevens, K; Aggarwal, A; Savani, SI; Ruth, NM; Arkachaisri, T; Qiu, T; Merritt, A; Al-Mayouf, SM; Devarajan, P; Huang, B; Brunner, HI. International Consensus for the Dosing of Corticosteroids in Childhood-Onset Systemic Lupus Erythematosus With Proliferative Lupus Nephritis. Arthritis & Rheumatology. 2022; 74(2):263-273.

Chimote, AA; Mayhew, C; Thornton, S; Wetzel, C; White, AN. Implementing Research Shared (Core) Facility Billing Systems. Journal of Biomolecular Techniques. 2022; 33(4).

Back, JB; Martinez, L; Nettenstrom, L; Sheerar, D; Thornton, S. Establishing a biosafety plan for a flow cytometry shared resource laboratory. Cytometry. Part A : the journal of the International Society for Analytical Cytology. 2022; 101(5):380-386.