Development of the animal body requires precise and complex control of gene expression at specific times and places. Complete instructions on temporal and spatial control of expression of individual genes are embedded in the genome in the form of cis-regulatory elements, such as promoters, enhancers and silencers. At the cellular level, these instructions are read by transcription factors, and mammalian genomes contain over 1500 of them. Various combinations of these transcription factors exist in each cell type. A number of signaling pathways have well-defined downstream transcriptional regulatory complexes that interact with endogenous transcription factors to regulate gene expression in a cell type-specific manner. Our goal is to understand how these interactions regulate developmental processes during organogenesis of the kidney and bladder. To achieve this goal, we employ genomics, mouse genetics and molecular biology.
The Park Lab employs genomics, mouse genetics and molecular biology in their research.