Urology
Park Lab

Park Research Lab

Development of the animal body requires precise and complex control of gene expression at specific times and places. Complete instructions on temporal and spatial control of expression of individual genes are embedded in the genome in the form of cis-regulatory elements, such as promoters, enhancers and silencers. At the cellular level, these instructions are read by transcription factors, and mammalian genomes contain over 1500 of them. Various combinations of these transcription factors exist in each cell type. A number of signaling pathways have well-defined downstream transcriptional regulatory complexes that interact with endogenous transcription factors to regulate gene expression in a cell type-specific manner. Our goal is to understand how these interactions regulate developmental processes during organogenesis of the kidney and bladder. To achieve this goal, we employ genomics, mouse genetics and molecular biology.

The Park Lab employs genomics, mouse genetics and molecular biology in their research.  The Park Lab employs genomics, mouse genetics and molecular biology in their research.

Publications

Marable, SS; Chung, E; Adam, M; Potter, SS; Park, J. Hnf4a deletion in the mouse kidney phenocopies Fanconi renotubular syndrome. JCI insight. 2018; 3.

O'Brien, LL; Guo, Q; Bahrami-Samani, E; Park, J; Hasso, SM; Lee, Y; Fang, A; Kim, AD; Guo, J; Hong, TM; et al. Transcriptional regulatory control of mammalian nephron progenitors revealed by multi-factor cistromic analysis and genetic studies. PLoS Genetics. 2018; 14.

Chung, E; Deacon, P; Park, J. Notch is required for the formation of all nephron segments and primes nephron progenitors for differentiation. Development (Cambridge). 2017; 144:4530-4539.

Lo, Y; Chung, E; Li, Z; Wan, Y; Mahe, MM; Chen, M; Noah, TK; Bell, KN; Yalamanchili, HK; Klisch, TJ; et al. Transcriptional Regulation by ATOH1 and its Target SPDEF in the Intestine. CMGH Cellular and Molecular Gastroenterology and Hepatology. 2017; 3:51-71.

Chung, E; Deacon, P; Marable, S; Shin, J; Park, J. Notch signaling promotes nephrogenesis by downregulating Six2. Development (Cambridge). 2016; 143:3907-3913.

Brunskill, EW; Park, J; Chung, E; Chen, F; Magella, B; Potter, SS. Single cell dissection of early kidney development: multilineage priming. Development (Cambridge). 2014; 141:3093-3101.

Xu, J; Liu, H; Park, J; Lan, Y; Jiang, R. Osr1 acts downstream of and interacts synergistically with Six2 to maintain nephron progenitor cells during kidney organogenesis. Development (Cambridge). 2014; 141:1442-1452.

Park, J; Ma, W; O'Brien, LL; Chung, E; Guo, J; Cheng, J; Valerius, MT; McMahon, JA; Wong, WH; McMahon, AP. Six2 and Wnt regulate self-renewal and commitment of nephron progenitors through shared gene regulatory networks. Developmental Cell. 2012; 23:637-651.

Park, J; Valerius, MT; McMahon, AP. Wnt/beta-catenin signaling regulates nephron induction during mouse kidney development. Development (Cambridge). 2007; 134:2533-2539.

Carroll, TJ; Park, JS; Hayashi, S; Majumdar, A; McMahon, AP. Wnt9b plays a central role in the regulation of mesenchymal to epithelial transitions underlying organogenesis of the mammalian urogenital system. Developmental Cell. 2005; 9:283-292.

Marable, SS; Chung, E; Park, JS. Hnf4a Is Required for the Development of Cdh6-Expressing Progenitors into Proximal Tubules in the Mouse Kidney. Journal of the American Society of Nephrology : JASN. 2020; 31:2543-2558.

Xu, J; Liu, H; Lan, Y; Park, JS; Jiang, R. Genome-wide Identification of Foxf2 Target Genes in Palate Development. Journal of Dental Research. 2020; 99:463-471.

Deacon, P; Concodora, CW; Chung, E; Park, JS. β-catenin regulates the formation of multiple nephron segments in the mouse kidney. Scientific Reports. 2019; 9.

Won, KJ; Park, JS; Jeong, H. Repression of hepatocyte nuclear factor 4 alpha by AP-1 underlies dyslipidemia associated with retinoic acid. Journal of Lipid Research. 2019; 60:794-804.

Lawlor, KT; Zappia, L; Lefevre, J; Park, JS; Hamilton, NA; Oshlack, A; Little, MH; Combes, AN. Nephron progenitor commitment is a stochastic process influenced by cell migration. eLife. 2019; 8.

Modur, V; Singh, N; Mohanty, V; Chung, E; Muhammad, B; Choi, K; Chen, X; Chetal, K; Ratner, N; Salomonis, N; et al. Defective transcription elongation in a subset of cancers confers immunotherapy resistance. Nature Communications. 2018; 9.

Marable, SS; Chung, E; Adam, M; Potter, SS; Park, J. Hnf4a deletion in the mouse kidney phenocopies Fanconi renotubular syndrome. JCI insight. 2018; 3.

O'Brien, LL; Guo, Q; Bahrami-Samani, E; Park, J; Hasso, SM; Lee, Y; Fang, A; Kim, AD; Guo, J; Hong, TM; et al. Transcriptional regulatory control of mammalian nephron progenitors revealed by multi-factor cistromic analysis and genetic studies. PLoS Genetics. 2018; 14.

Chung, E; Deacon, P; Park, J. Notch is required for the formation of all nephron segments and primes nephron progenitors for differentiation. Development (Cambridge). 2017; 144:4530-4539.

Lo, Y; Chung, E; Li, Z; Wan, Y; Mahe, MM; Chen, M; Noah, TK; Bell, KN; Yalamanchili, HK; Klisch, TJ; et al. Transcriptional Regulation by ATOH1 and its Target SPDEF in the Intestine. CMGH Cellular and Molecular Gastroenterology and Hepatology. 2017; 3:51-71.

Chung, E; Deacon, P; Marable, S; Shin, J; Park, J. Notch signaling promotes nephrogenesis by downregulating Six2. Development (Cambridge). 2016; 143:3907-3913.

Contact Us

Joo-Seop Park, PhD's head shot photo.

Joo-Seop Park, PhD

Assistant Professor

joo-seop.park@cchmc.org
513-803-7871

Division of Urology
3333 Burnet Ave.
Cincinnati, OH 45229

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