The Bronchopulmonary Dysplasia (BPD) Center at Cincinnati Children’s combines multidisciplinary clinical care with translational medicine and imaging research. The center has four arms focusing on:
- Clinical care, through our multidisciplinary team of neonatologists, pulmonologists, cardiologists and radiologists
- Diagnostics, with rigorous clinical validation of cardiopulmonary and airway MRI phenotyping
- Discovery, through integration of bronchoalveolar lavage and blood samples with a map of the developing lung, animal models and novel drug interventions
- Translation, with the creation of individualized treatment strategies and tailored interventions
Our multidisciplinary team has a long history of excellent, cutting-edge clinical care. We offer new technologies not available anywhere else and a personalized care plan that is supported by our unique technologies.
Since BPD is a life-long disease, it is our goal to both improve the immediate clinical status of the patient and build a care plan with the referring medical team. Our goal is to work with our patients’ other healthcare providers on a plan that can be cooperatively implemented through the patient’s adolescence. This includes partnering with providers both within and outside of Cincinnati Children’s.
We keep in close communication with referring physicians and primary care providers to ensure the best possible care. After discharge, patients will, as is appropriate, return to our center for follow-up care, and we will continue to partner with their medical team.
The Most Advanced Imaging
Over the past few years, we have developed unique neonatal MRI capabilities that provide high-resolution, detailed images of lung parenchymal and vascular structures, regional cardiopulmonary function, and dynamic airway collapse, all during quiet breathing and without sedation or ionizing radiation. This collective information allows phenotyping of respiratory disease related to premature birth (bronchopulmonary dysplasia, BPD) and has the potential to significantly change the understanding and time course of this disease. Particularly, this provides avenues for personalized treatments via a combination of existing and new therapies.
Four phenotypic elements of BPD revealed from modern MRI.
The faculty members in the Bronchopulmonary Dysplasia Center have been leading the effort to increase understanding of this condition nationwide. Here is a sample of recent peer-reviewed articles published by our faculty:
- Higano NS, Spielberg DR, Fleck RJ, Schapiro AH, Walkup LL, Hahn AD, Tkach JA, Kingma PS, Merhar SL, Fain SB, Woods JC. Neonatal pulmonary MRI of bronchopulmonary dysplasia predicts short-term clinical outcomes. Am J Respir Crit Care Med. 2018 May 23.
- Bates AJ, Higano NS, Hysinger EB, Fleck RJ, Hahn AD, Fain SB, Kingma PS, Woods JC. Quantitative assessment of regional dynamic airway collapse in neonates via retrospectively respiratory-gated 1H ultrashort echo-time (UTE) MRI. J Magn Reson Imag. 2018.
- Higgins RD, Jobe AH, Koso-Thomas M, Bancalari E, Viscardi RM, Hartert TV, Ryan RM, Kallapur SG, Steinhorn RH, Konduri GG, Davis SD, Thebaud B, Clyman RI, Collaco JM, Martin CR, Woods JC, Finer NN, Raju TNK. Executive summary of the workshop on bronchopulmonary dysplasia. J Pediatrics. 2018;197:300-308.
- Walkup LL, Tkach JA, Higano NS, Thomen RP, Fain SB, Merhar SL, Fleck RJ, Amin RS, Woods JC. Quantitative magnetic resonance imaging of bronchopulmonary dysplasia in the NICU environment. Am J Respir Crit Care Med. 2015;92:1215-1222.