Other Solid Tumors Research Studies

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Solid Tumors Neurofibromatosis Other

ADVL1615: A Phase 1 Study of Pevonedistat (MLN4924, IND# 136078), a NEDD8 Activating Enzyme (NAE) Inhibitor, in Combination with Temozolomide and Irinotecan in Pediatric Patients with Recurrent or Refractory Solid Tumors

  • Conditions: Lymphoma Hodgkin Relapse, Adult - Lymphoma Hodgkin Relapse, Lymphoma Non Hodgkin Relapse, Adult - Lymphoma Non Hodgkin Relapse, Brain Spinal Tumors Medulloblastoma Relapse, Adult - Brain Spinal Tumors Medulloblastoma Relapse, Brain Spinal Tumor Low Grade Glioma Relapse, Adult - Brain Spinal Tumor Low Grade Glioma Relapse, Brain Spinal Tumor DIPG Relapse, Adult - Brain Spinal Tumor DIPG Relapse, Brain and Spinal Tumor Ependymoma Relapse, Adult - Brain and Spinal Tumor Ependymoma Relapse, Brain Spinal Neurofibromatosis Sarcoma MPNST Relapse, Adult - Brain Spinal Neurofibromatosis Sarcoma MPNST Relapse, Brain Spinal Other All Other, Adult - Brain Spinal Other All Other, Brain Spinal Other ATRT, Adult - Brain Spinal Other ATRT, Brain Spinal Other Craniopharyngioma, Adult - Brain Spinal Other Craniopharyngioma, Brain Spinal Other Germ Cell Tumor, Adult - Brain Spinal Other Germ Cell Tumor, Adult - Brain Spinal Other Choroid Plexus Tumor, Brain Spinal Other Choroid Plexus Tumor, Adult - Sarcoma Osteosarcoma Relapse, Sarcoma Osteosarcoma Relapse, Sarcoma Ewing Relapse, Adult - Sarcoma Ewing Relapse, Sarcoma Rhabdomyosarcoma Relapse, Adult - Sarcoma Rhabdomyosarcoma Relapse, Neuroblastoma Relapse - Refractory, Adult - Neuroblastoma Relapse - Refractory, Liver Relapse - Refractory, Adult - Liver Relapse - Refractory, Kidney Relapse - Refractory, Adult - Kidney Relapse - Refractory, Solid Tumor Retinoblastoma Relapse - Refractory, Adult - Solid Tumor Retinoblastoma Relapse - Refractory, Solid Tumor Neurofibromatosis Sarcoma MPNST Relapse - Refractory, Adult - Solid Tumor Neurofibromatosis Sarcoma MPNST Relapse - Refractory, Adult - Solid Tumor Neurofibromatosis OPG Low Grade Glioma, Solid Tumor Neurofibromatosis OPG Low Grade Glioma, Adult - Solid Tumor Neurofibromatosis Other, Solid Tumor Neurofibromatosis Other, Solid Tumor Melanoma Relapse - Refractory, Adult - Solid Tumor Melanoma Relapse - Refractory, Adult - Solid Tumor Germ Cell Tumor Relapse - Refractory, Solid Tumor Germ Cell Tumor Relapse - Refractory, Solid Tumors - All Other, Adult - Solid Tumors - All Other

OFFICIAL TITLE A Phase 1 Study of Pevonedistat (MLN4924), a Cullin Ligase Inhibitor, in Combination With Temozolomide and Irinotecan in Pediatric Patients With Recurrent or Refractory Solid Tumors BRIEF SUMMARY: This phase I trial studies the side effects and best dose of pevonedistat when giving t ...More