Other Solid Tumors Research Studies

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Neurofibromatosis Sarcoma Relapse / Refractory

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20110261-TVEC: A Phase 1, Multi-center, Open-label, Dose De-escalation Study to Evaluate the Safety and Efficacy of Talimogene Laherparepvec in Pediatric Subjects with Advanced Non Central Nervous System Tumors That are Amenable to Direct Injection

  • Conditions: Neuroblastoma Relapse - Refractory, Sarcoma Osteosarcoma Relapse, Sarcoma Ewing Relapse, Sarcoma Rhabdomyosarcoma Relapse, Brain Spinal Neurofibromatosis Sarcoma MPNST Relapse, Liver Relapse - Refractory, Kidney Relapse - Refractory, Solid Tumor Retinoblastoma Relapse - Refractory, Solid Tumor Neurofibromatosis Sarcoma MPNST Relapse - Refractory, Solid Tumor Melanoma Relapse - Refractory, Solid Tumor Germ Cell Tumor Relapse - Refractory, Solid Tumors - All Other, Adult - Brain Spinal Neurofibromatosis Sarcoma MPNST Relapse, Adult - Sarcoma Osteosarcoma Relapse, Adult - Sarcoma Ewing Relapse, Adult - Sarcoma Rhabdomyosarcoma Relapse, Adult - Neuroblastoma Relapse - Refractory, Adult - Liver Relapse - Refractory, Adult - Kidney Relapse - Refractory, Adult - Solid Tumor Retinoblastoma Relapse - Refractory, Adult - Solid Tumor Neurofibromatosis Sarcoma MPNST Relapse - Refractory, Adult - Solid Tumor Melanoma Relapse - Refractory, Adult - Solid Tumor Germ Cell Tumor Relapse - Refractory, Adult - Solid Tumors - All Other

PURPOSE: This is a phase 1 study to evaluate the safety of intralesional talimogene laherparepvec administration in pediatric subjects with advanced non-CNS tumors that are amenable to direct injection.
 DETAILED DESCRIPTION: This is a phase 1, multicenter, open-label study of talimogene ...More

ADVL1312: A Phase 1/2 Study of MK-1775 in Combination With Irinotecan in Children, Adolescents, and Young Adults With Relapsed or Refractory Solid Tumors

  • Conditions: Brain Spinal Tumors Medulloblastoma Relapse, Brain Spinal Tumor Low Grade Glioma Relapse, Brain Spinal Tumor DIPG Relapse, Brain and Spinal Tumor Ependymoma Relapse, Brain Spinal Neurofibromatosis Sarcoma MPNST Relapse, Brain Spinal Other ATRT, Brain Spinal Other Craniopharyngioma, Brain Spinal Other Germ Cell Tumor, Brain Spinal Other Choroid Plexus Tumor, Brain Spinal Other All Other, Sarcoma Ewing Relapse, Sarcoma Osteosarcoma Relapse, Sarcoma Rhabdomyosarcoma Relapse, Neuroblastoma Relapse - Refractory, Liver Relapse - Refractory, Kidney Relapse - Refractory, Solid Tumor Retinoblastoma Relapse - Refractory, Solid Tumor Neurofibromatosis Sarcoma MPNST Relapse - Refractory, Solid Tumor Melanoma Relapse - Refractory, Solid Tumor Germ Cell Tumor Relapse - Refractory, Solid Tumors - All Other, Adult - Brain Spinal Tumors Medulloblastoma Relapse, Adult - Brain Spinal Tumor Low Grade Glioma Relapse, Adult - Brain Spinal Tumor DIPG Relapse, Adult - Brain and Spinal Tumor Ependymoma Relapse, Adult - Brain Spinal Other ATRT, Adult - Brain Spinal Other Choroid Plexus Tumor, Adult - Brain Spinal Neurofibromatosis Sarcoma MPNST Relapse, Adult - Brain Spinal Other Craniopharyngioma, Adult - Brain Spinal Other All Other, Adult - Brain Spinal Other Germ Cell Tumor, Adult - Sarcoma Ewing Relapse, Adult - Sarcoma Osteosarcoma Relapse, Adult - Sarcoma Rhabdomyosarcoma Relapse, Adult - Neuroblastoma Relapse - Refractory, Adult - Liver Relapse - Refractory, Adult - Kidney Relapse - Refractory, Adult - Solid Tumor Retinoblastoma Relapse - Refractory, Adult - Solid Tumor Neurofibromatosis Sarcoma MPNST Relapse - Refractory, Adult - Solid Tumor Melanoma Relapse - Refractory, Adult - Solid Tumor Germ Cell Tumor Relapse - Refractory, Adult - Solid Tumors - All Other

This phase I/II trial studies the side effects and best dose of WEE1 inhibitor MK-1775 and irinotecan hydrochloride in treating younger patients with solid tumors that have come back or that have not responded to standard therapy. WEE1 inhibitor MK-1775 and irinotecan hydrochloride may stop the grow ...More

ADVL1322: A Phase II Study of Pazopanib (GW786034, NSC# 737754) in Children, Adolescents and Young Adults with Refractory Solid Tumors

  • Conditions: Brain Spinal Neurofibromatosis Sarcoma MPNST Relapse, Sarcoma Osteosarcoma Relapse, Sarcoma Ewing Relapse, Sarcoma Rhabdomyosarcoma Relapse, Neuroblastoma Relapse - Refractory, Liver Relapse - Refractory, Solid Tumor Neurofibromatosis Sarcoma MPNST Relapse - Refractory

PURPOSE: The purpose of this study is to find out what effects, good or bad, pazopanib (GW786034), National Service Center (NSC) # 737754, has on children, adolescents and young adults between 12 months and less than or equal to 18 years of age with relapsed or refractory rhabdomyosarcoma, no ...More

ADVL1411: A Phase 1/2 Study of BMN 673, an Oral Poly(ADP-Ribose) Polymerase Inhibitor, Plus Temozolomide in Children With Refractory or Recurrent Malignancies

  • Conditions: Brain Spinal Tumors Medulloblastoma Relapse, Brain Spinal Tumor Low Grade Glioma Relapse, Brain Spinal Tumor DIPG Relapse, Brain and Spinal Tumor Ependymoma Relapse, Brain Spinal Neurofibromatosis Sarcoma MPNST Relapse, Brain Spinal Neurofibromatosis OPG, Brain Spinal Other Craniopharyngioma, Brain Spinal Other All Other, Brain Spinal Other ATRT, Brain Spinal Other Germ Cell Tumor, Brain Spinal Other Choroid Plexus Tumor, Sarcoma Osteosarcoma Relapse, Sarcoma Ewing Relapse, Sarcoma Rhabdomyosarcoma Relapse, Neuroblastoma Relapse - Refractory, Liver Relapse - Refractory, Kidney Relapse - Refractory, Solid Tumor Retinoblastoma Relapse - Refractory, Solid Tumor Neurofibromatosis Sarcoma MPNST Relapse - Refractory, Solid Tumor Melanoma Relapse - Refractory, Solid Tumor Germ Cell Tumor Relapse - Refractory, Adult - Brain Spinal Tumors Medulloblastoma Relapse, Adult - Brain Spinal Tumor Low Grade Glioma Relapse, Adult - Brain Spinal Tumor DIPG Relapse, Adult - Brain and Spinal Tumor Ependymoma Relapse, Adult - Brain Spinal Neurofibromatosis Sarcoma MPNST Relapse, Adult - Brain Spinal Neurofibromatosis OPG, Adult - Brain Spinal Other ATRT, Adult - Brain Spinal Other Craniopharyngioma, Adult - Brain Spinal Other Germ Cell Tumor, Adult - Brain Spinal Other Choroid Plexus Tumor, Adult - Brain Spinal Other All Other, Adult - Sarcoma Ewing Relapse, Adult - Sarcoma Osteosarcoma Relapse, Adult - Sarcoma Rhabdomyosarcoma Relapse, Adult - Neuroblastoma Relapse - Refractory, Adult - Liver Relapse - Refractory, Adult - Kidney Relapse - Refractory, Adult - Solid Tumor Retinoblastoma Relapse - Refractory, Adult - Solid Tumor Neurofibromatosis Sarcoma MPNST Relapse - Refractory, Solid Tumor Neurofibromatosis OPG Low Grade Glioma, Adult - Solid Tumor Neurofibromatosis OPG Low Grade Glioma, Adult - Solid Tumor Melanoma Relapse - Refractory, Adult - Solid Tumor Germ Cell Tumor Relapse - Refractory, Adult - Solid Tumors - All Other

PURPOSE: This phase I/II trial studies the side effects and best dose of talazoparib and temozolomide and to see how well they work in treating younger patients with tumors that have not responded to previous treatment (refractory) or have come back (recurrent). Talazoparib may stop the growth of ca ...More

ADVL1414: A Phase 1 Study of Selinexor (KPT-330, IND#125052), a Selective XPO1 Inhibitor, in Recurrent and Refractory Pediatric Solid Tumors, Including CNS Tumors.

  • Conditions: Lymphoma Hodgkin Relapse, Lymphoma Non Hodgkin Relapse, Brain Spinal Tumors Medulloblastoma Relapse, Brain Spinal Tumor Low Grade Glioma Relapse, Brain Spinal Tumor DIPG Relapse, Brain and Spinal Tumor Ependymoma Relapse, Brain Spinal Neurofibromatosis Sarcoma MPNST Relapse, Brain Spinal Neurofibromatosis OPG, Brain Spinal Other Germ Cell Tumor, Brain Spinal Other Choroid Plexus Tumor, Brain Spinal Other Craniopharyngioma, Brain Spinal Other ATRT, Brain Spinal Other All Other, Sarcoma Osteosarcoma Relapse, Sarcoma Ewing Relapse, Sarcoma Rhabdomyosarcoma Relapse, Neuroblastoma Relapse - Refractory, Liver Relapse - Refractory, Kidney Relapse - Refractory, Solid Tumor Retinoblastoma Relapse - Refractory, Solid Tumor Neurofibromatosis Sarcoma MPNST Relapse - Refractory, Solid Tumor Neurofibromatosis OPG Low Grade Glioma, Solid Tumor Melanoma Relapse - Refractory, Solid Tumor Germ Cell Tumor Relapse - Refractory, Solid Tumors - All Other, Adult - Kidney Relapse - Refractory, Adult - Liver Relapse - Refractory, Adult - Lymphoma Hodgkin Relapse, Adult - Lymphoma Non Hodgkin Relapse, Adult - Brain Spinal Tumors Medulloblastoma Relapse, Adult - Brain Spinal Tumor Low Grade Glioma Relapse, Adult - Brain Spinal Tumor DIPG Relapse, Adult - Brain and Spinal Tumor Ependymoma Relapse, Adult - Sarcoma Osteosarcoma Relapse, Adult - Sarcoma Ewing Relapse, Adult - Sarcoma Rhabdomyosarcoma Relapse, Adult - Brain Spinal Neurofibromatosis Sarcoma MPNST Relapse, Adult - Brain Spinal Neurofibromatosis OPG, Adult - Brain Spinal Other ATRT, Adult - Brain Spinal Other Choroid Plexus Tumor, Adult - Brain Spinal Other Craniopharyngioma, Adult - Brain Spinal Other Germ Cell Tumor, Adult - Brain Spinal Other All Other, Adult - Neuroblastoma Relapse - Refractory, Adult - Solid Tumor Retinoblastoma Relapse - Refractory, Adult - Solid Tumor Neurofibromatosis Sarcoma MPNST Relapse - Refractory, Adult - Solid Tumor Neurofibromatosis OPG Low Grade Glioma, Adult - Solid Tumor Melanoma Relapse - Refractory, Adult - Solid Tumor Germ Cell Tumor Relapse - Refractory, Adult - Solid Tumors - All Other

PURPOSE: The investigators will conduct a phase 1 trial of Selinexor in children with recurrent or refractory solid tumors, including CNS tumors using the Rolling Six design. The aims of the trial will be to establish the maximum tolerated pediatric doses of tablet formulation; to investigate ...More

ADVL1416: A Phase 1 Study of Ramucirumab, a Human Monoclonal Antibody Against the Vascular Endothelial Growth Factor-2 (VEGFR-2) Receptor in Children With Refractory Solid Tumors, Including CNS Tumors

  • Conditions: Brain Spinal Tumors Medulloblastoma Relapse, Brain Spinal Tumor Low Grade Glioma Relapse, Brain Spinal Tumor DIPG Relapse, Brain and Spinal Tumor Ependymoma Relapse, Brain Spinal Neurofibromatosis Sarcoma MPNST Relapse, Brain Spinal Neurofibromatosis OPG, Sarcoma Ewing Relapse, Sarcoma Osteosarcoma Relapse, Sarcoma Rhabdomyosarcoma Relapse, Brain Spinal Other All Other, Brain Spinal Other ATRT, Brain Spinal Other Craniopharyngioma, Brain Spinal Other Germ Cell Tumor, Brain Spinal Other Choroid Plexus Tumor, Neuroblastoma Relapse - Refractory, Liver Relapse - Refractory, Kidney Relapse - Refractory, Solid Tumor Retinoblastoma Relapse - Refractory, Solid Tumor Neurofibromatosis Sarcoma MPNST Relapse - Refractory, Solid Tumor Neurofibromatosis OPG Low Grade Glioma, Solid Tumor Melanoma Relapse - Refractory, Solid Tumor Germ Cell Tumor Relapse - Refractory, Solid Tumors - All Other, Adult - Brain Spinal Tumors Medulloblastoma Relapse, Adult - Brain Spinal Tumor Low Grade Glioma Relapse, Adult - Brain Spinal Tumor DIPG Relapse, Adult - Brain and Spinal Tumor Ependymoma Relapse, Adult - Brain Spinal Neurofibromatosis Sarcoma MPNST Relapse, Adult - Brain Spinal Neurofibromatosis OPG, Adult - Brain Spinal Other All Other, Adult - Brain Spinal Other ATRT, Adult - Brain Spinal Other Choroid Plexus Tumor, Adult - Brain Spinal Other Craniopharyngioma, Adult - Brain Spinal Other Germ Cell Tumor, Adult - Sarcoma Osteosarcoma Relapse, Adult - Sarcoma Rhabdomyosarcoma Relapse, Adult - Sarcoma Ewing Relapse, Adult - Neuroblastoma Relapse - Refractory, Adult - Liver Relapse - Refractory, Adult - Kidney Relapse - Refractory, Adult - Solid Tumors - All Other, Adult - Solid Tumor Retinoblastoma Relapse - Refractory, Adult - Solid Tumor Neurofibromatosis Sarcoma MPNST Relapse - Refractory, Adult - Solid Tumor Neurofibromatosis OPG Low Grade Glioma, Adult - Solid Tumor Melanoma Relapse - Refractory, Adult - Solid Tumor Germ Cell Tumor Relapse - Refractory

PURPOSE: The main purpose of this study is to evaluate the safety of the study drug known as ramucirumab in children with recurrent or refractory solid tumors including central nervous system (CNS) tumors. DETAILED DESCRIPTION: Primary Outcome Measures: Maximum Tolerated Dose of Ramucirumab [ T ...More

ADVL1513: A Phase 1 Study of Entinostat, an Oral Histone Deacetylase Inhibitor, in Pediatric Patients with Recurrent or Refractory Solid Tumors, Including CNS Tumors and Lymphoma

  • Conditions: Lymphoma Hodgkin Relapse, Lymphoma Non Hodgkin Relapse, Brain Spinal Tumors Medulloblastoma Relapse, Brain Spinal Tumor DIPG Relapse, Brain Spinal Tumor Low Grade Glioma Relapse, Brain and Spinal Tumor Ependymoma Relapse, Brain Spinal Neurofibromatosis Sarcoma MPNST Relapse, Brain Spinal Neurofibromatosis OPG, Sarcoma Ewing Relapse, Sarcoma Osteosarcoma Relapse, Sarcoma Rhabdomyosarcoma Relapse, Brain Spinal Other Choroid Plexus Tumor, Brain Spinal Other Germ Cell Tumor, Brain Spinal Other ATRT, Brain Spinal Other Craniopharyngioma, Brain Spinal Other All Other, Neuroblastoma Relapse - Refractory, Liver Relapse - Refractory, Kidney Relapse - Refractory, Solid Tumor Retinoblastoma Relapse - Refractory, Solid Tumor Neurofibromatosis Sarcoma MPNST Relapse - Refractory, Solid Tumor Neurofibromatosis OPG Low Grade Glioma, Solid Tumor Melanoma Relapse - Refractory, Solid Tumor Germ Cell Tumor Relapse - Refractory, Solid Tumors - All Other, Adult - Kidney Relapse - Refractory, Adult - Liver Relapse - Refractory, Adult - Lymphoma Hodgkin Relapse, Adult - Lymphoma Non Hodgkin Relapse, Adult - Brain Spinal Tumors Medulloblastoma Relapse, Adult - Brain Spinal Tumor Low Grade Glioma Relapse, Adult - Brain Spinal Tumor DIPG Relapse, Adult - Brain and Spinal Tumor Ependymoma Relapse, Adult - Brain Spinal Neurofibromatosis Sarcoma MPNST Relapse, Adult - Brain Spinal Neurofibromatosis OPG, Adult - Brain Spinal Other ATRT, Adult - Brain Spinal Other Choroid Plexus Tumor, Adult - Brain Spinal Other Craniopharyngioma, Adult - Brain Spinal Other Germ Cell Tumor, Adult - Brain Spinal Other All Other, Adult - Sarcoma Ewing Relapse, Adult - Sarcoma Osteosarcoma Relapse, Adult - Sarcoma Rhabdomyosarcoma Relapse, Adult - Neuroblastoma Relapse - Refractory, Adult - Solid Tumor Retinoblastoma Relapse - Refractory, Adult - Solid Tumor Neurofibromatosis Sarcoma MPNST Relapse - Refractory, Adult - Solid Tumor Neurofibromatosis OPG Low Grade Glioma, Adult - Solid Tumor Melanoma Relapse - Refractory, Adult - Solid Tumor Germ Cell Tumor Relapse - Refractory, Adult - Solid Tumors - All Other

PURPOSE: This phase I trial studies the side effects and best dose of entinostat in treating pediatric patients with solid tumors that have come back or have not responded to treatment. Entinostat may block some of the enzymes needed for cell division and it may help to kill tumor cells. DETAILED D ...More

ADVL1514: A Phase 1 study of ABI-009 (NAB-RAPAMYCIN) in Pediatric Patients with Recurrent or Refractory Solid Tumors, Including CNS Tumors as a Single Agent and in Combination with Temozolomide and Irinotecan

  • Conditions: Brain Spinal Tumors Medulloblastoma Relapse, Brain Spinal Tumor Low Grade Glioma Relapse, Brain Spinal Tumor DIPG Relapse, Brain and Spinal Tumor Ependymoma Relapse, Brain Spinal Neurofibromatosis Sarcoma MPNST Relapse, Sarcoma Ewing Relapse, Sarcoma Osteosarcoma Relapse, Sarcoma Rhabdomyosarcoma Relapse, Brain Spinal Neurofibromatosis OPG, Brain Spinal Other Germ Cell Tumor, Brain Spinal Other Choroid Plexus Tumor, Brain Spinal Other Craniopharyngioma, Brain Spinal Other ATRT, Brain Spinal Other All Other, Neuroblastoma Relapse - Refractory, Liver Relapse - Refractory, Kidney Relapse - Refractory, Solid Tumors - All Other, Solid Tumor Retinoblastoma Relapse - Refractory, Solid Tumor Neurofibromatosis Sarcoma MPNST Relapse - Refractory, Solid Tumor Neurofibromatosis OPG Low Grade Glioma, Solid Tumor Melanoma Relapse - Refractory, Solid Tumor Germ Cell Tumor Relapse - Refractory

PURPOSE: This phase I trial studies the side effects and best dose of nanoparticle albumin-bound rapamycin when given together with temozolomide and irinotecan hydrochloride in treating pediatric patients with solid tumors that have come back after a period of time during which the tumor could not ...More

ADVL1515: A Phase 1 Study of LY2606368, a CHK1/2 Inhibitor, in Pediatric Patients With Recurrent or Refractory Solid Tumors, Including CNS Tumors

  • Conditions: Brain Spinal Tumors Medulloblastoma Relapse, Brain Spinal Tumor Low Grade Glioma Relapse, Brain Spinal Tumor DIPG Relapse, Brain and Spinal Tumor Ependymoma Relapse, Brain Spinal Neurofibromatosis Sarcoma MPNST Relapse, Brain Spinal Neurofibromatosis OPG, Brain Spinal Other ATRT, Brain Spinal Other Craniopharyngioma, Brain Spinal Other Germ Cell Tumor, Brain Spinal Other Choroid Plexus Tumor, Brain Spinal Other All Other, Sarcoma Ewing Relapse, Sarcoma Osteosarcoma Relapse, Sarcoma Rhabdomyosarcoma Relapse, Neuroblastoma Relapse - Refractory, Liver Relapse - Refractory, Kidney Relapse - Refractory, Solid Tumors - All Other, Solid Tumor Retinoblastoma Relapse - Refractory, Solid Tumor Neurofibromatosis Sarcoma MPNST Relapse - Refractory, Solid Tumor Neurofibromatosis OPG Low Grade Glioma, Solid Tumor Melanoma Relapse - Refractory, Solid Tumor Germ Cell Tumor Relapse - Refractory, Adult - Brain Spinal Tumors Medulloblastoma Relapse, Adult - Brain Spinal Tumor Low Grade Glioma Relapse, Adult - Brain Spinal Tumor DIPG Relapse, Adult - Brain and Spinal Tumor Ependymoma Relapse, Adult - Brain Spinal Neurofibromatosis Sarcoma MPNST Relapse, Adult - Brain Spinal Neurofibromatosis OPG, Adult - Brain Spinal Other All Other, Adult - Brain Spinal Other ATRT, Adult - Brain Spinal Other Choroid Plexus Tumor, Adult - Brain Spinal Other Craniopharyngioma, Adult - Brain Spinal Other Germ Cell Tumor, Adult - Sarcoma Ewing Relapse, Adult - Sarcoma Osteosarcoma Relapse, Adult - Sarcoma Rhabdomyosarcoma Relapse, Adult - Neuroblastoma Relapse - Refractory, Adult - Liver Relapse - Refractory, Adult - Kidney Relapse - Refractory, Adult - Solid Tumor Melanoma Relapse - Refractory, Adult - Solid Tumor Retinoblastoma Relapse - Refractory, Adult - Solid Tumor Neurofibromatosis Sarcoma MPNST Relapse - Refractory, Adult - Solid Tumor Neurofibromatosis OPG Low Grade Glioma, Adult - Solid Tumor Germ Cell Tumor Relapse - Refractory, Adult - Solid Tumors - All Other

PURPOSE: This phase I trial studies the side effects and best dose of prexasertib in treating pediatric patients with solid tumors that have come back after a period of time during which the tumor could not be detected or does not respond to treatment. Checkpoint kinase 1 inhibitor LY2606368 may sto ...More

ADVL1615: A Phase 1 Study of Pevonedistat (MLN4924, IND# 136078), a NEDD8 Activating Enzyme (NAE) Inhibitor, in Combination with Temozolomide and Irinotecan in Pediatric Patients with Recurrent or Refractory Solid Tumors

  • Conditions: Lymphoma Hodgkin Relapse, Adult - Lymphoma Hodgkin Relapse, Lymphoma Non Hodgkin Relapse, Adult - Lymphoma Non Hodgkin Relapse, Brain Spinal Tumors Medulloblastoma Relapse, Adult - Brain Spinal Tumors Medulloblastoma Relapse, Brain Spinal Tumor Low Grade Glioma Relapse, Adult - Brain Spinal Tumor Low Grade Glioma Relapse, Brain Spinal Tumor DIPG Relapse, Adult - Brain Spinal Tumor DIPG Relapse, Brain and Spinal Tumor Ependymoma Relapse, Adult - Brain and Spinal Tumor Ependymoma Relapse, Brain Spinal Neurofibromatosis Sarcoma MPNST Relapse, Adult - Brain Spinal Neurofibromatosis Sarcoma MPNST Relapse, Brain Spinal Other All Other, Adult - Brain Spinal Other All Other, Brain Spinal Other ATRT, Adult - Brain Spinal Other ATRT, Brain Spinal Other Craniopharyngioma, Adult - Brain Spinal Other Craniopharyngioma, Brain Spinal Other Germ Cell Tumor, Adult - Brain Spinal Other Germ Cell Tumor, Adult - Brain Spinal Other Choroid Plexus Tumor, Brain Spinal Other Choroid Plexus Tumor, Adult - Sarcoma Osteosarcoma Relapse, Sarcoma Osteosarcoma Relapse, Sarcoma Ewing Relapse, Adult - Sarcoma Ewing Relapse, Sarcoma Rhabdomyosarcoma Relapse, Adult - Sarcoma Rhabdomyosarcoma Relapse, Neuroblastoma Relapse - Refractory, Adult - Neuroblastoma Relapse - Refractory, Liver Relapse - Refractory, Adult - Liver Relapse - Refractory, Kidney Relapse - Refractory, Adult - Kidney Relapse - Refractory, Solid Tumor Retinoblastoma Relapse - Refractory, Adult - Solid Tumor Retinoblastoma Relapse - Refractory, Solid Tumor Neurofibromatosis Sarcoma MPNST Relapse - Refractory, Adult - Solid Tumor Neurofibromatosis Sarcoma MPNST Relapse - Refractory, Adult - Solid Tumor Neurofibromatosis OPG Low Grade Glioma, Solid Tumor Neurofibromatosis OPG Low Grade Glioma, Adult - Solid Tumor Neurofibromatosis Other, Solid Tumor Neurofibromatosis Other, Solid Tumor Melanoma Relapse - Refractory, Adult - Solid Tumor Melanoma Relapse - Refractory, Adult - Solid Tumor Germ Cell Tumor Relapse - Refractory, Solid Tumor Germ Cell Tumor Relapse - Refractory, Solid Tumors - All Other, Adult - Solid Tumors - All Other

OFFICIAL TITLE A Phase 1 Study of Pevonedistat (MLN4924), a Cullin Ligase Inhibitor, in Combination With Temozolomide and Irinotecan in Pediatric Patients With Recurrent or Refractory Solid Tumors BRIEF SUMMARY: This phase I trial studies the side effects and best dose of pevonedistat when giving t ...More