Clinical Trials / Research Studies
KB707-01: A Study Assessing KB707 for the Treatment of Locally Advanced or Metastatic Solid Tumors
Why are we doing this research?
KB707-01 is a Phase 1, open-label, multicenter, dose escalation and expansion study to evaluate the safety and tolerability of KB707 in adults with locally advanced or metastatic solid tumors who have progressed on standard of care therapy, cannot tolerate standard of care therapy, refused standard of care therapy, or for whom there is no standard of care therapy. In this study, patients will receive KB707 via direct intratumoral (IT) injection into solid tumors to assess the safety and tolerability as well preliminary efficacy of KB707 monotherapy treatment.
KB707-01: A Phase 1, Open-Label, Multi-Center, Dose Escalation and Expansion Study of KB707 in Subjects With Locally Advanced or Metastatic Solid Tumor Malignancies.
Who can participate?
Inclusion Criteria:
- Histologically confirmed diagnosis of a locally advanced or metastatic solid tumor and the individual has progressed on standard of care therapy, cannot tolerate standard of care therapy, refused standard of care therapy, or there is no standard of care therapy.
- Age 18 years or older at the time of informed consent
- Life expectancy >12 weeks
- ECOG performance status of 0 or 1
- Have at least one measurable and injectable tumor that is accessible by transcutaneous administration
Exclusion Criteria:
- Prior oncology therapy (chemotherapy, immunotherapy, biological therapy) or use of an investigational agent or an investigational device within 21 days or 5 half-lives before administration of first dose of KB707, whichever is shorter
- The subject is pregnant, nursing, or plans to become pregnant during study treatment and through three months after the last dose of KB707
- Have known history of positive human immunodeficiency virus (HIV 1/2)
Ages
18 years and older
Conditions
- Adult - Solid Tumor Melanoma Relapse - Refractory
- Adult - Sarcoma Osteosarcoma Relapse - Refractory
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