Eosinophilic Disorders

Treatments and Services

Your doctor will consider prescribing a proton pump inhibitor, a classic medicine used to treat acid or reflux-associated esophagitis. This approach is considered a first-line treatment for acid-associated esophagitis (e.g., reflux). It is now also considered a treatment option for some patients with EoE.

Corticosteroids, which control inflammation, are effective medications for treating EoE. They help control inflammation in the esophagus.

• Fluticasone comes in an inhaler, like those used for asthma. It is sprayed into the mouth and then swallowed. See this video for instructions on how to take topical steroids for EoE.
• Budesonide is a liquid that comes in a vial that is mixed with Splenda© or another mixing agent and then swallowed.

Biologics for eosinophilic asthma include mepolizumab, reslizumab, benralizumab and dupilumab. Biologics for eosinophilic granulomatosis with polyangiitis (EGPA, formerly known as Churg-Strauss syndrome) include mepolizumab. Biologics for hypereosinophilic syndrome (HES) include imatinib. Biologics for EoE include dupilumab.

We play a critical role in developing new medications and treatments, working tirelessly on each stage of the process. We already had a key role in the development of therapeutic strategies for eosinophilic disorders. Our clinical trials to study how these medicines can help children with EGIDs. Learn more about our research.

An elemental diet is achieved via the use of nutritionally complete, amino acid-containing formulas. These formulas are referred to as "elemental formulas" because the protein in the formula is in the form of amino acids rather than whole, intact protein. Amino acids are the basic building blocks of protein, and the body breaks down proteins into amino acids during the process of digestion. Allergic reactions can develop against intact or partially broken down protein, but not against amino acids.

Elemental formulas, when taken in the prescribed amount, can provide all of the calories, vitamins and minerals that a person needs. There is a range of elemental formulas offered by Abbot Nutrition, Nutricia, Nestle, and Mead Johnson Nutrition.

Food trials are used to determine what specific foods trigger a patient’s symptoms, with the goal of adding back non-triggering foods into the diet. In general, food trials consist of eating the trial food in a specified amount and frequency over a period of time. The serving size, frequency of consumption and length of the trial vary by the patient age and the trial food. To determine whether a trialed food is tolerated, disease activity is assessed at the end of the trial period by endoscopy and presenting symptoms.

A six-food elimination diet involves avoiding all foods that contain the six most commonly implicated dietary antigens in the United States, i.e. milk, soy, wheat, eggs, fish (and shellfish) and peanuts (and tree nuts), regardless of allergy testing results.

Traditional gastrointestinal endoscopy is performed under anesthesia in a procedure center or operating room.