Clinical Mass Spectrometry (led by Director Kenneth D.R. Setchell, PhD) is a section of the Division of Pathology and Laboratory Medicine of the Department of Pediatrics, Cincinnati Children’s Hospital Medical Center and the University of Cincinnati College of Medicine. The facility is a state-of-the-art analytical laboratory occupying approximately 5,000 sq. ft of space at Cincinnati Children's. Features of the facility include: 

  • Being equipped with a full range of analytical equipment (see our instrument list).
  • Operating under both clinical diagnostic and research studies under Good Laboratory Practice (GLP) principles with Standard Operating Procedures (SOPs) written for all equipment and operations.
  • Being accredited with the College of American Pathologists (CAP license #1667801) and with Clinical Laboratory Improvement Amendments certification (CLIA 88 license #36D0656333) to perform all of the clinical analytical methods and has undergone regularly internal and external audits.

The laboratory is also involved in method development and the evaluation of new drugs under clinical development. 

There is also a strong research component in the application of mass spectrometry to the field of liver disease, gastroenterology and nutrition and cancer biology that utilizes targeted and untargeted metabolomic analysis, with a strong emphasis on lipids, bile acids, sterols and steroids. In the last two years, the facility has established a strong metabolomics Core operation offering support to other investigators in the Institute and the University of Cincinnati College of Medicine.