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Attending Physician, Pediatric Intensive Care Unit (PICU)
Mihir's research focus is on understanding the role of proprotein convertase subtislsin/kenexin type 9 (PCSK9) in pediatric septic shock. PCSK9 is a regulator of lipid metabolism and inhibition of PCSK9 activity in sepsis has been associated with improved outcomes in adult sepsis. During residency, he received an intramural 'research in residency' grant for his preliminary work with Dr. Wong, on understanding the association between PCSK9 gene variants and septic shock outcomes in a large pediatric cohort of over 500 patients. He found that the association was markedly different in pediatric patients in comparison with data in adults. For this work, he was recognized by the Society of Pediatric Research at Pediatric Academic Societies 2017 and awarded the House Officer Research award. Currently, he is working on an immature murine models of sepsis to validate his clinical findings and to identify the biological pathways involved.
Pediatric critical care medicine
Sepsis; ARDS; multiple organ failure; endothelial dysfunction; lipid biology
MBBS: Kasturba Medical College, Manipal University, Manipal, India, 2012.
MPH: Mailman School of Public Health, Columbia University, New York, NY, 2014.
Residency: Pediatrics, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, 2017.
Proprotein Convertase Subtilisin/Kexin Type 9 Loss-of-Function Is Detrimental to the Juvenile Host With Septic Shock.
Atreya, MR; Whitacre, BE; Cvijanovich, NZ; Bigham, MT; Thomas, NJ; Schwarz, AJ; Weiss, SL; Fitzgerald, JC; Allen, GL; Lutfi, R; et al.
Critical Care Medicine.
Precision medicine in pediatric sepsis.
Atreya, MR; Wong, HR.
Current Opinion in Pediatrics.
Provider Perceptions of Bubble Continuous Positive Airway Pressure and Barriers to Implementation in a Level III Neonatal Unit in South India.
Atreya, MR; Lorenz, JM; Narendran, V.
Advances in Neonatal Care.
Continuum of care in pediatric sepsis: a prototypical acute care delivery model.
Vidrine, R; Atreya, MR; Stalets, EL.
Case 6: Skin Discoloration, Methemoglobinemia, and Acute Interstitial Nephritis in a 15-year-old Girl.
Atreya, MR; Al Jaberi, N; Claes, DJ; Volovelsky, O.
Pediatrics in Review.
Racial Differences in the Influence of Interpregnancy Interval on Fetal Growth.
Atreya, MR; Muglia, LJ; Greenberg, JM; DeFranco, EA.
Maternal and Child Health Journal.
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