Mihir's research focus is on understanding the role of proprotein convertase subtislsin/kenexin type 9 (PCSK9) in pediatric septic shock. PCSK9 is a regulator of lipid metabolism and inhibition of PCSK9 activity in sepsis has been associated with improved outcomes in adult sepsis. During residency, he received an intramural 'research in residency' grant for his preliminary work with Dr. Wong, on understanding the association between PCSK9 gene variants and septic shock outcomes in a large pediatric cohort of over 500 patients. He found that the association was markedly different in pediatric patients in comparison with data in adults. For this work, he was recognized by the Society of Pediatric Research at Pediatric Academic Societies 2017 and awarded the House Officer Research award. Currently, he is working on an immature murine models of sepsis to validate his clinical findings and to identify the biological pathways involved.