A photo of Paul Andreassen.

Paul R. Andreassen, PhD

  • Member, Division of Experimental Hematology & Cancer Biology
  • Professor, UC Department of Pediatrics
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About

Biography

Paul Andreassen completed his PhD in Experimental Pathology from the University of Washington (Seattle, WA) while working at the Fred Hutchinson Cancer Research Center (Seattle) and the Institut de Biologie Structurale (Grenoble, France). Dr. Andreassen then completed a research fellowship at the Dana-Farber Cancer Institute (Boston, MA) before moving to Cincinnati Children’s Hospital Medical Center in 2004.

BS: Willamette University, Salem, Oregon, 1984.

PhD: University of Washington, Seattle, Washington, 1995.

Interests

Fanconi anemia; breast cancer susceptibility; genetic variants; genome instability; DNA damage responses; replication stress; relationship of DNA repair and chromatin; mitosis; radiation biology; cell biology

Research Areas

Experimental Hematology and Cancer Biology, Cancer and Blood Diseases

Publications

Selected

Identification of new RAD51D-regulating microRNAs that also emerge as potent inhibitors of the Fanconi anemia/homologous recombination pathways. Hater, N; Iwaniuk, KM; Leifeld, C; Grüten, P; Wiek, C; Raba, K; Zhang, F; Fischer, JC; Andreassen, PR; Hanenberg, H; et al. Human Molecular Genetics. 2022; 31:4241-4254.

Selected

Active DNA damage response signaling initiates and maintains meiotic sex chromosome inactivation. Abe, H; Yeh, YH; Munakata, Y; Ishiguro, KI; Andreassen, PR; Namekawa, SH. Nature Communications. 2022; 13:7212.

Selected

Head and Neck Cancer Susceptibility and Metabolism in Fanconi Anemia. Chihanga, T; Vicente-Muñoz, S; Ruiz-Torres, S; Pal, B; Sertorio, M; Andreassen, PR; Khoury, R; Mehta, P; Davies, SM; Lane, AN; et al. Cancers. 2022; 14:2040.

Selected

Meiotic sex chromosome inactivation and the XY body: a phase separation hypothesis. Alavattam, KG; Maezawa, S; Andreassen, PR; Namekawa, SH. Cellular and Molecular Life Sciences. 2022; 79:18.

Selected

RNF8 is not required for histone-to-protamine exchange in spermiogenesis†. Abe, H; Meduri, R; Li, Z; Andreassen, PR; Namekawa, SH. Biology of Reproduction. 2021; 105:1154-1159.

Selected

Understanding BRCA2 Function as a Tumor Suppressor Based on Domain-Specific Activities in DNA Damage Responses. Andreassen, PR; Seo, J; Wiek, C; Hanenberg, H. Genes. 2021; 12:1034.

Selected

The p.Ser64Leu and p.Pro104Leu missense variants of PALB2 identified in familial pancreatic cancer patients compromise the DNA damage response. Zhang, Y; Park, JY; Zhang, F; Olson, SH; Orlow, I; Li, Y; Kurtz, RC; Ladanyi, M; Chen, J; Toland, AE; et al. Human Mutation. 2021; 42:150-163.

Selected

The Initiation of Meiotic Sex Chromosome Inactivation Sequesters DNA Damage Signaling from Autosomes in Mouse Spermatogenesis. Abe, H; Alavattam, KG; Hu, Y; Pang, Q; Andreassen, PR; Hegde, RS; Namekawa, SH. Current Biology. 2020; 30:408-420.e5.

Selected

NF1 patient missense variants predict a role for ATM in modifying neurofibroma initiation. Yu, Y; Choi, K; Wu, J; Andreassen, PR; Dexheimer, PJ; Keddache, M; Brems, H; Spinner, RJ; Cancelas, JA; Martin, LJ; et al. Acta Neuropathologica. 2020; 139:157-174.

Selected

CRISPR-Cas9 fusion to dominant-negative 53BP1 enhances HDR and inhibits NHEJ specifically at Cas9 target sites. Jayavaradhan, R; Pillis, DM; Goodman, M; Zhang, F; Zhang, Y; Andreassen, PR; Malik, P. Nature Communications. 2019; 10:2866.

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