Sheila T. Angeles-Han, MD, MSc

A photo of Sheila Angeles-Han, MD, MSc.

Physician, Division of Rheumatology

Associate Professor, UC Department of PediatricsAssistant Professor, UC Department of Ophthalmology

513-636-4676

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My Biography & Research

Biography

The field of rheumatology presents a unique challenge because of the thought processes involved in making decisions and diagnoses. During my fellowship training and as part of obtaining my master’s degree, I discovered a profound lack of high-quality research studies in pediatric uveitis. Now, I dedicate my research to improving the visual outcomes of children with chronic, noninfectious uveitis using interventions that decrease vision loss and blindness.

In the past, there were no valid measures of uveitis outcomes, which led to my development of the only questionnaire that assesses vision-related function and quality of life in children with the condition. The Effects of Youngsters’ Eyesight on QOL (EYE-Q) is now part of clinical outcome measurements used to characterize the impact of uveitis on children’s lives.

Through my research, I identify risk factors for uveitis development, specifically in children with juvenile idiopathic arthritis. I accomplish this by discovering biomarkers in tears and by using genetic associations.

I work to standardize the approach clinicians use to evaluate uveitis outcomes, including assessments of the impact of uveitis on quality of life and functioning. This information then helps improve treatment outcomes.

Throughout my career, I have received several grants from organizations like Cincinnati Children’s Hospital Medical Center, the National Institutes of Health, and other ophthalmology and rheumatology foundations. In my continuing work, I lead initiatives to improve screening, monitoring and treatment of children with juvenile idiopathic arthritis and uveitis.

Clinical Interests

Juvenile idiopathic arthritis; juvenile idiopathic arthritis-associated uveitis; chronic pediatric non-infectious uveitis

Research Interests

Uveitis; juvenile idiopathic arthritis; biomarkers; visual outcomes; quality of life

Academic Affiliation

Associate Professor, UC Department of PediatricsAssistant Professor, UC Department of Ophthalmology

Clinical Divisions

Rheumatology, Lupus

Research Divisions

Rheumatology

My Education

MD: University of Santo Tomas.

Residency: University of Illinois at Chicago, Chicago, IL.

Fellowship: Hospital for Special Surgery, New York, NY.

MS in Clinical Investigation: Weill Graduate School of Medical Sciences of Cornell University, New York, NY.

My Publications

Discontinuing adalimumab in patients with controlled juvenile idiopathic arthritis-associated uveitis (ADJUST—Adalimumab in Juvenile Idiopathic Arthritis-associated Uveitis Stopping Trial): study protocol for a randomised controlled trial. Ebert, CD; Kelly, NK; Porco, TC; Ramanan, AV; Arnold, BF; Acharya, NR; Doan, T; Gonzales, JA; von Scheven, E; Angeles-Han, ST; et al. Trials. 2020; 21.

Reply. Ringold, S; Schrandt, S; Creek, EL; Beukelman, T; Angeles-Han, ST; Lovell, DJ. Arthritis and Rheumatology. 2020; 72:1040-1041.

Improving quick and accurate diagnosis of childhood JIA-uveitis from a pediatric rheumatology perspective. Rodriguez-Smith, J; Yeh, S; Angeles-Han, ST. Expert Review of Ophthalmology. 2020; 15:101-109.

Proposal for a definition for response to treatment, inactive disease and damage for JIA associated uveitis based on the validation of a uveitis related JIA outcome measures from the Multinational Interdisciplinary Working Group for Uveitis in Childhood (MIWGUC). Foeldvari, I; Klotsche, J; Simonini, G; Edelsten, C; Angeles-Han, ST; Bangsgaard, R; de Boer, J; Brumm, G; Bou Torrent, R; Constantin, T; et al. Pediatric Rheumatology Online Journal. 2019; 17.

Update on the management of uveitis in children: an overview for the clinician. Kim, L; Li, A; Angeles-Han, S; Yeh, S; Shantha, J. Expert Review of Ophthalmology. 2019; 14:211-218.

2019 American College of Rheumatology/Arthritis Foundation Guideline for the Screening, Monitoring, and Treatment of Juvenile Idiopathic Arthritis-Associated Uveitis. Angeles-Han, ST; Ringold, S; Beukelman, T; Lovell, D; Cuello, CA; Becker, ML; Colbert, RA; Feldman, BM; Holland, GN; Ferguson, PJ; et al. Arthritis and Rheumatology. 2019; 71:864-877.

2019 American College of Rheumatology/Arthritis Foundation Guideline for the Screening, Monitoring, and Treatment of Juvenile Idiopathic Arthritis-Associated Uveitis. Angeles-Han, ST; Ringold, S; Beukelman, T; Lovell, D; Cuello, CA; Becker, ML; Colbert, RA; Feldman, BM; Holland, GN; Ferguson, PJ; et al. Arthritis Care and Research. 2019; 71:703-716.

2019 American College of Rheumatology/Arthritis Foundation Guideline for the Treatment of Juvenile Idiopathic Arthritis: Therapeutic Approaches for Non-Systemic Polyarthritis, Sacroiliitis, and Enthesitis. Ringold, S; Angeles-Han, ST; Beukelman, T; Lovell, D; Cuello, CA; Becker, ML; Colbert, RA; Feldman, BM; Ferguson, PJ; Gewanter, H; et al. Arthritis Care and Research. 2019; 71:717-734.

2019 American College of Rheumatology/Arthritis Foundation Guideline for the Treatment of Juvenile Idiopathic Arthritis: Therapeutic Approaches for Non-Systemic Polyarthritis, Sacroiliitis, and Enthesitis. Ringold, S; Angeles-Han, ST; Beukelman, T; Lovell, D; Cuello, CA; Becker, ML; Colbert, RA; Feldman, BM; Ferguson, PJ; Gewanter, H; et al. Arthritis and Rheumatology. 2019; 71:846-863.

Childhood Arthritis and Rheumatology Research Alliance Consensus Treatment Plans for Juvenile Idiopathic Arthritis-Associated and Idiopathic Chronic Anterior Uveitis. Angeles-Han, ST; Lo, MS; Henderson, LA; Lerman, MA; Abramson, L; Coopers, AM; Parsa, MF; Zemel, LS; Ronis, T; Beukelman, T; et al. Arthritis Care and Research. 2019; 71:482-491.