Artem Barski, PhD

Biography & Affiliation Education Publications

Director, Epigenomics Data Analysis Core

Associate Professor, UC Department of Pediatrics

artem.barski@cchmc.org

513-636-1851

Visit the Barski Lab

Biography & Affiliation

Biography

Artem Barski, PhD, is interested in epigenomics and transcriptional regulation of gene expression. His PhD at the University of Southern California was focused on transcriptional regulation in osteoblasts. During his post-doctoral training in Keji Zhao lab at NIH, Dr. Barski took part in the development of ChIP-Seq, a revolutionary method that combines ChIP with the next-generation sequencing. ChIP-Seq allows genome-wide mapping of chromatin modifications and transcription factor binding sites with resolution and sensitivity far exceeding older methods. Since his arrival to Cincinnati Children’s Hospital Medical Center in 2011, Dr. Barski is working on epigenomics of immunological memory. His laboratory is also developing both wet lab and computational approaches to the study of epigenomics and runs Cincinnati Children's Epigenomics Data Analysis Core.

Dr. Barski has publications in prestigious journals including Cell, Nature Structural and Molecular Biology Genome Biology and others. He is a recipient of NHLBI Career Transition Award (K22) and NIH Director’s New Innovator Award (DP2).

Research Interests

Epigenetics; epigenomics; immunology; T cell memory

Academic Affiliation

Associate Professor, UC Department of Pediatrics

Departments

Allergy and Immunology, Human Genetics

Education

BS/MS: Moscow State University, Department of Chemistry, Moscow, Russia, 2000.

PhD: University of Southern California, Los Angeles, CA, 2006.

Fellowship: National Institutes of Health (NIH), National Heart Lung, and Blood Institute (NHLBI), Bethesda, MD, 2011.

Publications

Selected Publication

CWL-Airflow: a lightweight pipeline manager supporting Common Workflow Language. Kotliar, M; Kartashov, AV; Barski, A. GigaScience. 2019; 8.

Genetic, Inflammatory, and Epithelial Cell Differentiation Factors Control Expression of Human Calpain-14. Miller, DE; Forney, C; Rochman, M; Cranert, S; Habel, J; Rymer, J; Lynch, A; Schroeder, C; Lee, J; Sauder, A; et al. G3-Genes Genomes Genetics. 2019; 9:g3.200901.2018-g3.200901.2018.

Attenuated chromatin compartmentalization in meiosis and its maturation in sperm development. Alavattam, KG; Maezawa, S; Sakashita, A; Khoury, H; Barski, A; Kaplan, N; Namekawa, SH. Nature Structural and Molecular Biology. 2019; 26:175-184.

A rapidly evolved domain, the SCML2 DNA-binding repeats, contributes to chromatin binding of mouse SCML2. Maezawa, S; Alavattam, KG; Tatara, M; Nagai, R; Barski, A; Namekawa, SH. Biology of Reproduction. 2019; 100:409-419.

Microbiota-sensitive epigenetic signature predicts inflammation in Crohn's disease. Kelly, D; Kotliar, M; Woo, V; Jagannathan, S; Whitt, J; Moncivaiz, J; Aronow, BJ; Dubinsky, MC; Hyams, JS; Markowitz, JF; et al. JCI insight. 2018; 3.

SCML2 promotes heterochromatin organization in late spermatogenesis. Maezawa, S; Hasegawa, K; Alavattam, KG; Funakoshi, M; Sato, T; Barski, A; Namekawa, SH. Journal of Cell Science. 2018; 131:jcs217125-jcs217125.

Reuse of public, genome-wide, murine eosinophil expression data for hypotheses development. Grace, JO; Malik, A; Reichman, H; Munitz, A; Barski, A; Fulkerson, PC. Journal of Leukocyte Biology. 2018; 104:185-193.

Polycomb protein SCML2 facilitates H3K27me3 to establish bivalent domains in the male germline. Maezawa, S; Hasegawa, K; Yukawa, M; Kubo, N; Sakashita, A; Alavattam, KG; Sin, H; Kartashov, AV; Sasaki, H; Barski, A; et al. Proceedings of the National Academy of Sciences of USA. 2018; 115:4957-4962.

Transcription factors operate across disease loci, with EBNA2 implicated in autoimmunity. Harley, JB; Chen, X; Pujato, M; Miller, D; Maddox, A; Forney, C; Magnusen, AF; Lynch, A; Chetal, K; Yukawa, M; et al. Nature Genetics. 2018; 50:699-707.

TSLP signaling in CD4(+) T cells programs a pathogenic T helper 2 cell state. Rochman, Y; Dienger-Stambaugh, K; Richgels, PK; Lewkowich, IP; Kartashov, AV; Barski, A; Hershey, GK K; Leonard, WJ; Singh, H. Science Signaling. 2018; 11:eaam8858-eaam8858.