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Artem Barski, PhD

Director, Epigenomics Data Analysis Core

Academic Affiliations

Associate Professor, UC Department of Pediatrics

Phone 513-636-1851

Email artem.barski@cchmc.org

Research Interests
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Epigenetics; epigenomics; immunology; T cell memory

Visit the Barski Lab.

Biography
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Artem Barski, PhD, is interested in epigenomics and transcriptional regulation of gene expression. His PhD at the University of Southern California was focused on transcriptional regulation in osteoblasts. During his post-doctoral training in Keji Zhao lab at NIH, Dr. Barski took part in the development of ChIP-Seq, a revolutionary method that combines ChIP with the next-generation sequencing. ChIP-Seq allows genome-wide mapping of chromatin modifications and transcription factor binding sites with resolution and sensitivity far exceeding older methods. Since his arrival to Cincinnati Children’s Hospital Medical Center in 2011, Dr. Barski is working on epigenomics of immunological memory. His laboratory is also developing both wet lab and computational approaches to the study of epigenomics and runs Cincinnati Children's Epigenomics Data Analysis Core.

Dr. Barski has publications in prestigious journals including Cell, Nature Structural and Molecular Biology Genome Biology and others. He is a recipient of NHLBI Career Transition Award (K22) and NIH Director’s New Innovator Award (DP2).

Education and Training
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BS/MS: Moscow State University, Department of Chemistry, Moscow, Russia, 2000.

PhD: University of Southern California, Los Angeles, CA, 2006.

Fellowship: National Institutes of Health (NIH), National Heart Lung, and Blood Institute (NHLBI), Bethesda, MD, 2011.

Publications
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View PubMed Publications

Barski A, Cuddapah S, Kartashov AV, Liu C, Imamichi H, Yang W, Peng W, Lane HC, Zhao K. Rapid Recall Ability of Memory T cells is Encoded in their Epigenome. Sci Rep. 2017 Jan 5;7:39785. 

Kartashov AV, Barski A. BioWardrobe: an integrated platform for analysis of epigenomics and transcriptomics data. Genome Biol. 2015 Dec 7;16(1):158.

Sin H-S, Kartashov AV, Hasegawa K, Barski A, Namekawa SH. Poised chromatin and bivalent domains facilitate the mitosis-to-meiosis transition in the male germline. BMC Biol. 2015;13:53.

Rochman Y, Yukawa M, Kartashov AV, Barski A. Functional characterization of human T cell hyporesponsiveness induced by CTLA4-Ig. PLoS One. 2015;10(4):e0122198.

Hasegawa K, Sin H-S, Maezawa S, Broering TJ, Kartashov AV, Alavattam KG, Ichijima Y, Zhang F, Bacon WC, Greis KD, Andreassen PR, Barski A, Namekawa S. SCML2 Establishes the Male Germline Epigenome through Regulation of Histone H2A Ubiquitination. Dev Cell. 2015;(5):574–88.

Rochman Y, Yukawa M, Kartashov AV, Barski A. Functional characterization of human T cell hyporesponsiveness induced by CTLA4-Ig. PLoS One. 2015;10(4):e0122198. 

Barski A, Chepelev I, Liko D, Cuddapah S, Fleming AB, Birch J, Cui K, White RJ, Zhao K. Pol II and its associated epigenetic marks are present at Pol III-transcribed noncoding RNA genes. Nat Struct Mol Biol. 2010 May;17(5):629-34.

Barski A, Jothi R, Cuddapah S, Cui K, Roh TY, Schones DE, Zhao K. Chromatin poises miRNA- and protein-coding genes for expression. Genome Res. 2009 Oct;19(10):1742-51

Barski A, Zhao K. Genomic location analysis by ChIP-Seq. J Cell Biochem. 2009 May 1;107(1):11-8.

Barski A, Cuddapah S, Cui K, Roh TY, Schones DE, Wang Z, Wei G, Chepelev I, Zhao K. High-resolution profiling of histone methylations in the human genome. Cell. 2007 May 18;129(4):823-37.

Barski A, Cuddapah S, Cui K, Roh T-Y, Schones DE, Wang Z, et al. High-resolution profiling of histone methylations in the human genome. Cell. 2007 May 18;129(4):823–37.

Grants
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Direct Epigenetic Reprogramming of T Cells. Principal Investigator. National Institute of General Medical Sciences/National Institutes of Health New Innovator Award. Sep 2015-Sep 2020.

Epigenetic Mechanisms of Humoral Immune Deficiency in Kabuki Syndrome. Co-principal Investigator. Center for Pediatric Genomics. Jan 2016-Dec 2017.

Epigenomics Data Analysis Core Translational T1 grant. Principal Investigator. Center for Clinical and Translational Science and Technology. Jul 2015–Jun 2017.

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