Allergy and Immunology
Allergy and Immunology Research
The Division of Allergy and Immunology at Cincinnati Children’s strives to provide the best treatment of allergic and immunologic disorders and conducts leading research focused on elucidating the causes, mechanisms and most effective treatment of allergic and immunological diseases.
Allergy and Immunology Research
Bench to Bedside
Our research spans fundamental studies, translational investigations, genetic and genomic analyses, big data analyses (informatics) and clinical trials. Novel models of immunological diseases, developed and/or fine-tuned by divisional researchers, provide unprecedented systems to investigate key inflammatory steps involved in allergic and immunological disease and to enhance our understanding of adaptive and innate immunity, including analyses of individuals, with a focus on mast cells, eosinophils, macrophages and lymphocytes.
Bench to Bedside
Innovation
Our integrative laboratories, such as the Rothenberg Lab, are led by nationally recognized researchers and employ state-of-the-art model systems for genetic, biochemical, immunological and physiological analysis.
Innovation
Our division is dedicated to educating the next generation of leaders in allergy and immunology clinical practice and research. We have competitive clinical and research fellowship and postdoctorate programs and mentor students of several graduate programs (Molecular and Developmental Biology, Immunobiology, Molecular Genetics, Biochemistry and Microbiology).
Our Mission
To improve the health of children with allergic and immune conditions through innovative research, outstanding clinical care and education of the current and next generation of leaders in healthcare and research.
Fundamental Studies
We focus on uncovering the molecular mechanisms (steps) of inflammation, primarily those involved in allergic and other immune-mediated disorders.
Translational Investigation
We concentrate on discovering key processes in the initiation and propagation of allergic and other immune-mediated responses in the lung (asthma), skin (eczema), upper respiratory tract (allergic rhinitis) and gastrointestinal tract (especially eosinophilic gastrointestinal disorders, inflammatory bowel disease and food allergy) as well as systemically (anaphylaxis). Molecular pathways involved in macrophage activation syndrome (perforin mutations), hypereosinophilic syndrome (IL-5 and activated tyrosine kinases), asthma (T helper cytokines) and food allergy (IL-9, mast cells and their progenitors) are focus areas.
Clinical Trials
We focus on uncovering clinical, genetic and therapeutic principles concerning asthma, eosinophilic disorders (e.g., eosinophilic esophagitis and hypereosinophilic syndrome), macrophage activation syndrome and food allergy. Innovative clinical trials, based on fundamental and translational laboratory findings, are highly prioritized.
Our Clinic
Research Collaborations
Research Achievements
Learn more about our most significant findings and view grant funding and division statistics in this year's Research Annual Report.
Learn More
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