To improve the health of children with allergic and immune conditions through innovative research, outstanding clinical care and education of the current and next generation of leaders in healthcare and research.
We focus on uncovering the molecular mechanisms (steps) of inflammation, primarily those involved in allergic and other immune-mediated disorders.
We concentrate on discovering key processes in the initiation and propagation of allergic and other immune-mediated responses in the lung (asthma), skin (eczema), upper respiratory tract (allergic rhinitis) and gastrointestinal tract (especially eosinophilic gastrointestinal disorders, inflammatory bowel disease and food allergy) as well as systemically (anaphylaxis). Molecular pathways involved in macrophage activation syndrome (perforin mutations), hypereosinophilic syndrome (IL-5 and activated tyrosine kinases), asthma (T helper cytokines) and food allergy (IL-9, mast cells and their progenitors) are focus areas.
We focus on uncovering clinical, genetic and therapeutic principles concerning asthma, eosinophilic disorders (e.g., eosinophilic esophagitis and hypereosinophilic syndrome), macrophage activation syndrome and food allergy. Innovative clinical trials, based on fundamental and translational laboratory findings, are highly prioritized.