Institutes, Divisions & Centers
Allergy and Immunology

Allergy and Immunology Research


Our Mission

To improve the health of children with allergic and immune conditions through innovative research, outstanding clinical care and education of the current and next generation of leaders in healthcare and research.

Fundamental Studies

We focus on uncovering the molecular mechanisms (steps) of inflammation, primarily those involved in allergic and other immune-mediated disorders.

Translational Investigation

We concentrate on discovering key processes in the initiation and propagation of allergic and other immune-mediated responses in the lung (asthma), skin (eczema), upper respiratory tract (allergic rhinitis) and gastrointestinal tract (especially eosinophilic gastrointestinal disordersinflammatory bowel disease and food allergy) as well as systemically (anaphylaxis). Molecular pathways involved in macrophage activation syndrome (perforin mutations), hypereosinophilic syndrome (IL-5 and activated tyrosine kinases), asthma (T helper cytokines) and food allergy (IL-9, mast cells and their progenitors) are focus areas. 

Clinical Trials

We focus on uncovering clinical, genetic and therapeutic principles concerning asthma, eosinophilic disorders (e.g., eosinophilic esophagitis and hypereosinophilic syndrome), macrophage activation syndrome and food allergy. Innovative clinical trials, based on fundamental and translational laboratory findings, are highly prioritized.

Our Clinic

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Learn more about our clinic. We offer comprehensive care for children with allergic and immunologic disorders as well as opportunities for clinical research studies.  Read More

Research Collaborations

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Our investigators conduct studies in collaboration with outstanding researchers locally, nationally and internationally. Read More

Research Achievements

2022 Research Annual Report.

Learn more about our most significant findings and view grant funding and division statistics in this year's Research Annual Report.

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National Organization for Rare Disorders (NORD) Rare Disease Center of Excellence
Cincinnati Children's is proud to be a National Organization for Rare Disorders (NORD) Rare Disease Center of Excellence, where we are part of an innovative network seeking to expand access, advance care, and promote research for people with rare diseases in the U.S.