Research Highlights Prior to 2016

Show All

Allergic diseases and internalizing behaviors in early childhood

Nuclear factor κB1/RelA mediates inflammation in human lung epithelial cells at atmospheric oxygen levels

IL-25 and CD4(+) T(H)2 cells enhance type 2 innate lymphoid cell-derived IL-13 production, which promotes IgE-mediated experimental food allergy

LRRC31 is induced by IL-13 and regulates kallikrein expression and barrier function in the esophageal epithelium

Interleukin-4 receptor α signaling in myeloid cells controls collagen fibril assembly in skin repair

Utility of frozen section analysis for fungal organisms in soft tissue wound debridement margin determination

Induction of interleukin-9-producing mucosal mast cells promotes susceptibility to IgE-mediated experimental food allergy

Loss of IL-4Rα-mediated PI3K signaling accelerates the progression of IgE/mast  cell-mediated reactions

Resistin-like molecule α in allergen-induced pulmonary vascular remodeling

Liver microRNA-21 is overexpressed in non-alcoholic steatohepatitis and contributes to the disease in experimental models by inhibiting PPARα expression

BioWardrobe: an integrated platform for analysis of epigenomics and transcriptomics data

Transcription factor repertoire of homeostatic eosinophilopoiesis

IL-33 signaling protects from murine oxazolone colitis by supporting intestinal epithelial function

Defects of B-cell terminal differentiation in patients with type-1 Kabuki syndrome

Poised chromatin and bivalent domains facilitate the mitosis-to-meiosis transition in the male germline

Pediatric Eosinophilic Esophagitis Symptom Scores (PEESS v2.0) identify histologic and molecular correlates of the key clinical features of disease

Factor XIII transglutaminase supports the resolution of mucosal damage in experimental colitis

Live cell evaluation of granzyme delivery and death receptor signaling in tumor cells targeted by human natural killer cells

In vitro model for studying esophageal epithelial differentiation and allergic inflammatory responses identifies keratin involvement in eosinophilic esophagitis

Clinical features of pediatric hereditary angioedema

TNF-related apoptosis-inducing ligand (TRAIL) regulates midline-1, thymic stromal lymphopoietin, inflammation, and remodeling in experimental eosinophilic esophagitis

Functional characterization of human T cell hyporesponsiveness induced by CTLA4-Ig

Identification of a negative regulatory role for spi-C in the murine B cell lineage

Allergen sensitization profiles in a population-based cohort of children hospitalized for asthma

Collaborative interactions between type 2 Innate lymphoid cells and antigen-specific CD4+ Th2 cells exacerbate murine allergic airway diseases with prominent eosinophilia

Serum inflammatory markers after rupture retinal laser injury in mice

Differential control of CD4(+) T-cell subsets by the PD-1/PD-L1 axis in a mouse model of allergic asthma

Hospital admission associates with higher total IgE level in pediatric patients with asthma

SCML2 establishes the male germline epigenome through regulation of histone H2A ubiquitination

Differential control of CD4+ T-cell subsets by the PD-1/PD-L1 axis in a mouse model of allergic asthma

Value of an additional review for eosinophil quantification in esophageal biopsies

Allergen sensitization profiles in a population-based cohort of children hospitalized for asthma

Clinical features of pediatric hereditary angioedema

Resistin-like molecule alpha in allergen-induced pulmonary vascular remodeling

IL-1β in eosinophil-mediated small intestinal homeostasis and IgA production

Investigating mast cell secretory granules; from biosynthesis to exocytosis.

Generation of eosinophils from cryopreserved murine bone marrow cells.

Perforin gene transfer into hematopoietic stem cells improves immune dysregulation in murine models of perforin deficiency.

Phenome-wide association study (PheWAS) in EMR-linked pediatric cohorts, genetically links PLCL1 to speech language development and IL5-IL13 to eosinophilic esophagitis.

Neurotrophic tyrosine kinase receptor 1 is a direct transcriptional and epigenetic target of IL-13 involved in allergic inflammation.

Transcriptome analysis of proton pump inhibitor-responsive esophageal eosinophilia reveals proton pump inhibitor-reversible allergic inflammation.

Twin and family studies reveal strong environmental and weaker genetic cues explaining heritability of eosinophilic esophagitis.

Histologic eosinophilic gastritis is a systemic disorder associated with blood and extra gastric eosinophilia, TH2 immunity, and a unique gastric transcriptome.

Mepolizumab treatment in patients with severe eosinophilic asthma.

Combined immune deficiency in a patient with a novel NFKB2 mutation.

Intravenous anti-IL-13 mAb QAX576 for the treatment of eosinophilic esophagitis.

IL-5 triggers a cooperative cytokine network that promotes eosinophil precursor maturation.

Management of asthma in school-aged children and adolescents.

New developments in the treatment of pediatric allergic rhinitis and conjunctivitis.

Roles and regulation of gastrointestinal eosinophils in immunity and disease.

Genome-wide association analysis of eosinophilic esophagitis provides insight into the tissue specificity of this allergic disease.

Biliary repair and carcinogenesis are mediated by IL-33-dependent cholangiocyte proliferation.

Analysis and expansion of the eosinophilic esophagitis transcriptome by RNA sequencing.

Murine models of eosinophilic leukemia: a model of FIP1L1-PDGFRα initiated chronic eosinophilic leukemia/systemic mastocytosis.

Real-time detection of CTL function reveals distinct patterns of caspase activation mediated by Fas versus granzyme B.

Utility of neutrophil Fcγ receptor I (CD64) index as a biomarker for mucosal inflammation in pediatric Crohn's disease.

The ATP-dependent chromatin remodeling enzyme Fun30 represses transcription by sliding promoter-proximal nucleosomes.

Cryptococcus gattii infection dampens Th1 and Th17 responses by attenuating dendritic cell function and pulmonary chemokine expression in the immunocompetent hosts.

Increased prevalence of eosinophilic gastrointestinal disorders in pediatric PTEN hamartoma tumor syndromes.

Carbonic anhydrase IV is expressed on IL-5-activated murine eosinophils.

Rab5 Is a novel regulator of mast cell secretory granules: impact on size, cargo, and exocytosis.

Differential eosinophil and mast cell regulation: mast cell viability and accumulation in inflammatory tissue are independent of proton-sensing receptor GPR65.

Efficacy, dose reduction, and resistance to high-dose fluticasone in patients with eosinophilic esophagitis.

Dendritic cell fate is determined by BCL11A.

Food-specific serum immunoglobulin E measurements in children presenting with food allergy.

Mendelian inheritance of elevated serum tryptase associated with atopy and connective tissue abnormalities.

 

Demethylation of the human eotaxin-3 gene promoter leads to the elevated expression of eotaxin-3.  

Increased prevalence of eosinophilic gastrointestinal disorders (EGID) in pediatric PTEN hamartoma tumor syndromes (PHTS).

 Desmoglein-1 regulates esophageal epithelial barrier function and immune responses in eosinophilic esophagitis.

Correlation of increased PARP14 and CCL26 expression in biopsies from children with eosinophilic esophagitis.

Paired immunoglobulin-like receptor A is an intrinsic, self-limiting suppressor of IL-5-induced eosinophil development.

Myxomycete (slime mold) spores: unrecognized aeroallergens? 

IL-33 markedly activates murine eosinophils by an NFkappaB-dependent mechanism differentially dependent upon an IL-4-driven autoinflammatory loop.

Molecular diagnosis of eosinophilic esophagitis by gene expression profiling.

CD14+CD33+ myeloid cell-CCL11-eosinophil signature in ulcerative colitis. 

Interleukin-25 (IL-25) promotes efficient protective immunity against Trichinella spiralis infection by enhancing the antigen-specific IL-9 response.

Rank-based genome-wide analysis reveals the association of ryanodine receptor-2 gene variants with childhood asthma among human populations. 

The ATP-dependent Chromatin Remodeling Enzyme Fun30 Represses Transcription by Sliding Promoter Proximal Nucleosomes.

Proton Channel HVCN1 is Required for Effector Functions of Mouse Eosinophils.

Mechanism of Siglec-8-mediated Cell Death in IL-5-activated Eosinophils: Role for Reactive Oxygen Species-enhanced MEK/ERK Activation.

Intestinal CCL11 and Eosinophilic Inflammation is Regulated by Myeloid Cell-Specific RelA/p65 in Mice.

 

Eosinophil Adoptive Transfer System to Directly Evaluate Pulmonary Eosinophil Trafficking In Vivo.

Elevated Granzyme B in Cytotoxic Lymphocytes is a Signature of Immune Activation in Hemophagocytic Lymphohistiocytosis.

Targeted Ablation of miR-21 Decreases Murine Eosinophil Progenitor Cell Growth.

PedsQL™ Eosinophilic Esophagitis Module: Feasibility, Reliability and Validity.

Inequalities in Neighborhood Child Asthma Admission Rates and Underlying Community Characteristics in One US County.

 Chymase Mediated Intestinal Epithelial Permeability is Regulated by Protease Activating Receptor (PAR)-2/ Matrix Metalloproteinase (MMP)-2-dependent Mechanism.

miR-223 Deficiency Increases Eosinophil Progenitor Proliferation.

The E3 Ubiquitin Ligase Midline 1 Promotes Allergen and Rhinovirus-induced Asthma by Inhibiting Protein Phosphatase 2A Activity.

RNF8 Regulates Active Epigenetic Modifications and Escape Gene Activation from Inactive Sex Chromosomes in Post-meiotic Spermatids.

Long-term Safety of Mepolizumab for the Treatment of Hypereosinophilic Syndromes.

The Role of TRB3 in Mast Cells Sensitized with Monomeric IgE.

Development of the Pediatric Quality of Life InventoryTM Eosinophilic Esophagitis Module items: Qualitative Methods.

Behavioral Feeding Problems and Parenting Stress in Eosinophilic Gastrointestinal Disorders in Children.

In Vivo Regulation of TGF-β by R-Ras2 Revealed through Loss of the RasGAP Protein NF1.

Trefoil Factor 2 Negatively Regulates Type 1 Immunity Against Toxoplasma Gondii.

The Greater Cincinnati Pediatric Clinic Repository: A Novel Framework for Childhood Asthma and Allergy Research.

The Murine CCR3 Receptor Regulates Both Eosinophilia and Hyperresponsiveness in IgE-mediated Allergic Conjunctivitis.

Toll-like Receptor 7 is Required for Effective Adaptive Immune Responses that Prevent Persistent Virus Infection.

Evidence That Formation of Vimentin:Mitogen-activated Protein Kinase (MAPK) Complex Mediates Mast Cell Activation following Fc{epsilon}RI/CC Chemokine Receptor 1 Cross-talk.

Comparative Dietary Therapy Effectiveness in Remission of Pediatric Eosinophilic Esophagitis.

Induction and Suppression of Allergic Diarrhea and Systemic Anaphylaxis in a Murine Model of Food Allergy

Pharmacokinetics, Tissue Distribution and Immunomodulatory Effect of Intralipid Formulation of Nystatin in Mice.

Mouse Sensitization as an Independent Risk Factor for Asthma Morbidity.

MicroRNA Signature in Patients with Eosinophilic Esophagitis, Reversibility with Glucocorticoids, and Assessment as Disease Biomarkers.

Behavioral Functioning and Treatment Adherence in Pediatric Eosinophilic Gastrointestinal Disorders.

MiR-375 is Downregulated in Epithelial Cells After IL-13 Stimulation and Regulates an IL-13-induced Epithelial Transcriptome.

Identification of Anti-Retinal Antibodies in Patients with Age-Related Macular Degeneration.

Intestinal Mast Cell Levels Control Severity of Oral Antigen-Induced Anaphylaxis in Mice.

Esophageal Functional Impairments in Experimental Eosinophilic Esophagitis.

Resistin-Like Molecule Alpha Regulates IL-13-Induced Chemokine Production but not Allergen-Induced Airway Responses.

Reslizumab in Children and Adolescents with Eosinophilic Esophagitis: Results of a Double-Blind, Randomized, Placebo-Controlled Trial.

The Pan-B Cell Marker CD22 Is Expressed on Gastrointestinal Eosinophils and Negatively Regulates Tissue Eosinophilia.

Development of a Validated Patient-Reported Symptom Metric for Pediatric Eosinophilic Esophagitis: Qualitative Methods.

Treatment Adherence in Pediatric Eosinophilic Gastrointestinal Disorders.

Serum autoantibody biomarkers for age-related macular degeneration and possible regulators of neovascularization.

IL-13 Receptor {alpha}1 Differentially Regulates Aeroallergen-Induced Lung Responses.

MicroRNA-21 Limits In Vivo Immune Response-Mediated Activation of the IL-12/IFN-{gamma} Pathway, Th1 Polarization, and the Severity of Delayed-Type Hypersensitivity.

An Antibody Against IL-5 Reduces Numbers of Esophageal Intraepithelial Eosinophils in Children with Eosinophilic Esophagitis.

Hypomorphic mutations in PRF1, MUNC13-4, and STXBP2 are associated with adult-onset familial hemophagocytic lymphohistiocytosis.

Severe allergic reactions to thiol-based cytoprotective agents mesna and amifostine in a child with a supratentorial primitive neuroectodermal tumor.

An Antibody Against IL-5 Reduces Numbers of Esophageal Intraepithelial Eosinophils in Children With Eosinophilic Esophagitis.

Alanyl-glutamine promotes intestinal epithelial cell homeostasis in vitro and in a murine model of weanling undernutrition

Quality of life in paediatric eosinophilic oesophagitis: what is important to patients?

Long-term outcomes in pediatric-onset eosinophilia.

Perforin is a critical physiologic regulator of T-cell activation.

Colonic eosinophilic inflammation in experimental colitis is mediated by Ly6C(high) CCR2(+) inflammatory monocyte/macrophage-derived CCL11.

Agonist activation of F-Actin-mediated eosinophil shape change and mediator release is dependent on Rac2.

Allergen-induced expression of IL-25 and IL-25 receptor in atopic asthmatic airways and late-phase cutaneous responses.

Murine guanylate cyclase C regulates colonic injury and inflammation.

Colonic eosinophilic inflammation in experimental colitis is mediated by Ly6C(high) CCR2(+) inflammatory monocyte/macrophage-derived CCL11.

Gene expression profiling of peripheral blood mononuclear cells from children with active hemophagocytic lymphohistiocytosis.

TGF-β limits IL-33 production and promotes the resolution of colitis through regulation of macrophage function.

Advances in mechanisms of asthma, allergy, and immunology in 2010.

Differences in candidate gene association between European ancestry and African American asthmatic children.



Epigenetic regulation of the IL-13-induced human eotaxin-3 gene by CREB-binding protein-mediated histone 3 acetylation.



Gene expression profiling of peripheral blood mononuclear cells from children with active hemophagocytic lymphohistiocytosis.

Interleukin-13 (IL-13)/IL-13 receptor alpha1 (IL-13Ralpha1) signaling regulates intestinal epithelial cystic fibrosis transmembrane conductance regulator channel-dependent Cl- secretion.

Comparison of effects of alcaftadine and olopatadine on conjunctival epithelium and eosinophil recruitment in a murine model of allergic conjunctivitis.

Increased susceptibility of 129SvEvBrd mice to IgE-Mast cell mediated anaphylaxis.

T-helper cell type 2 (Th2) memory T cell-potentiating cytokine IL-25 has the potential to promote angiogenesis in asthma.

A striking local esophageal cytokine expression profile in eosinophilic esophagitis.

Guidelines for the diagnosis and management of food allergy in the United States: summary of the NIAID-sponsored expert panel report.

T-helper cell type 2 (Th2) memory T cell-potentiating cytokine IL-25 has the potential to promote angiogenesis in asthma.

A striking local esophageal cytokine expression profile in eosinophilic esophagitis.

Guidelines for the diagnosis and management of food allergy in the United States: summary of the NIAID-sponsored expert panel report.

New Cell Type May Help Explain Why Some People Have Dangerous Food Allergies

Yui-Hsi Wang, PhD and his colleagues report their discovery of a new cell type that appears to drive life-threatening food allergies and may help explain why some people get severe allergic reactions and others do not.

News Story

Read More

Type 1 Kabuki Syndrome Evidences B-cell Terminal Differentiation Defects

Kabuki syndrome is a multisystem developmental disorder.  Andrew W. Lindsley, MD, PhD recently characterized the humoral immune defects found in patients with Kabuki syndrome with mutations in a protein that modifies histones, lysine methyltransferase 2D (KMT2D). Autosomal dominant KMT2D mutations were associated with dysregulation of terminal B-cell differentiation, leading to humoral immune deficiency and, in some cases, autoimmunity. These data suggest that patients with KS should undergo serial clinical immune evaluations. Read More