Jocelyn M. Biagini, PhD

Associate Professor, UC Department of Pediatrics

jocelyn.biagini@cchmc.org

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Our long-term goals are to improve the health of children by conducting research that advances the field of asthma and allergic disease research by investigating the interplay of genetics with environmental exposures.

About

Biography

As a molecular epidemiologist, I am engaged in researching pediatric allergic diseases. My special interests include asthma and food allergy, allergic disease progression, and the genomic and environmental contributions to allergic diseases in children. I was drawn to these research areas after growing up with seasonal allergies and asthma, and by my love of pediatric research.

In the Biagini Lab, our long-term goals are to improve the health of children by conducting research that advances the field of asthma and allergic disease research by investigating the interplay of genetics with environmental exposures. We are also studying the mechanisms underlying the progression of disease from food allergy to asthma and the biology underlying severe asthma in children.

We recently published the Pediatric Asthma Risk Score (PARS), which is the first continuous risk score for asthma in children. It relies on factors that are routinely collected in the assessment of a child being evaluated for allergy, asthma or both. It is superior to the traditional Asthma Predictive Index (API) with an 11% increase in sensitivity due to improved prediction in children with mild-to-moderate asthma risk.

I am an elected member to the American Academy of Asthma, Allergy and Immunology and a member of the editorial board for the Journal of Asthma. I began my career in 2001 and joined the Cincinnati Children’s team in 2008.

Research Areas

Asthma

Publications

Selected

A Pediatric Asthma Risk Score to better predict asthma development in young children. Biagini Myers, JM; Schauberger, E; He, H; Martin, LJ; Kroner, J; Hill, GM; Ryan, PH; LeMasters, GK; Bernstein, DI; Lockey, JE; Arshad, SH; Kurukulaaratchy, R; Hershey, GK K. Journal of Allergy and Clinical Immunology. 2019; 143:1803-1810.e2.

Joint genotype and ancestry analysis identify novel loci associated with atopic dermatitis in African American population. Gautam, Y; Satish, L; Ramirez, S; Grashel, B; Biagini, JM; Martin, LJ; Rothenberg, ME; Khurana Hershey, GK; Mersha, TB. Human Genetics and Genomics Advances. 2024; 5:100350.

Progressive accumulation of hyperinflammatory NKG2Dlow NK cells in early childhood severe atopic dermatitis. Ochayon, DE; DeVore, SB; Chang, WC; Krishnamurthy, D; Seelamneni, H; Grashel, B; Spagna, D; Andorf, S; Martin, LJ; Biagini, JM; Waggoner, SN; Khurana Hershey, GK. Science Immunology. 2024; 9:eadd3085.

Regulation of MYC by CARD14 in human epithelium is a determinant of epidermal homeostasis and disease. DeVore, SB; Schuetz, M; Alvey, L; Lujan, H; Ochayon, DE; Williams, L; Chang, WC; Filuta, A; Ruff, B; Kothari, A; Keles, S; Milner, JD; Supp, DM; Khurana Hershey, GK. Cell Reports. 2024; 43:114589.

Filaggrin loss-of-function variants are associated with atopic dermatitis phenotypes in a diverse, early-life prospective cohort. Virolainen, SJ; Satish, L; Biagini, JM; Chaib, H; Chang, WC; Dexheimer, PJ; Dixon, MR; Dunn, K; Fletcher, D; Forney, C; Shook, M; Weirauch, MT; Khurana Hershey, GK; Kottyan, LC. JCI insight. 2024; 9:e178258.

Birth outcomes in relation to neighborhood food access and individual food insecurity during pregnancy in the Environmental Influences on Child Health Outcomes (ECHO)-wide cohort study. Aris, IM; Lin, PI D; Wu, AJ; Dabelea, D; Lester, BM; Wright, RJ; Karagas, MR; Kerver, JM; Dunlop, AL; Joseph, CL; Hipwell, A; Keenan, K; Karr, C; Tylavsky, F. American Journal of Clinical Nutrition. 2024; 119:1216-1226.

What allergists/immunologists can do to limit the effects of air pollution on asthma and allergies. Sherenian, M; Biagini, JM; Ryan, P; Khurana Hershey, GK. Annals of Allergy, Asthma, and Immunology. 2024; 132:421-422.

The key roles of thrombin and fibrinogen in human infant and mice atopic dermatitis models. Filuta, AL; Amezcua, P; Ruff, BP; Biagini, JM; Kroner, J; He, H; Brandt, EB; Martin, LJ; Palumbo, JS; Khurana Hershey, GK; Sherenian, MG. Allergy: European Journal of Allergy and Clinical Immunology. 2024; 79:239-242.

Temporal relationships between Staphylococcus aureus colonization, filaggrin expression, and pediatric atopic dermatitis. Dahal, A; Chang, WC; Almasri, C; Johansson, E; Hurd, M; Velasquez, V; Grashel, B; Spagna, D; Jenkins, S; Morgan, D; Satish, L; Martin, LJ; Biagini, JM; Khurana Hershey, GK. Allergy: European Journal of Allergy and Clinical Immunology. 2024; 79:104-115.

Performance of the Pediatric Asthma Risk Score across Diverse Populations. Biagini, JM; Martin, LJ; He, H; Bacharier, LB; Gebretsadik, T; Hartert, TV; Jackson, DJ; Kim, H; Miller, RL; Rivera-Spoljaric, K; Johnson, CC; Wright, AL; Gern, JE; Khurana Hershey, GK. 2023; 2:EVIDoa2300026.