A photo of Adam Carle.

Adam C. Carle, MA, PhD

  • Associate Professor, UC Department of Pediatrics



Adam Carle, MA, PhD, is a clinically and quantitatively trained investigator who uses advanced statistical methods to study health disparities among adults and children, especially children with special health care needs.

Dr. Carle uses latent variable models like item response theory, confirmatory factor analysis, structural equation modeling, and multilevel models to examine health disparities across traditionally underserved and underrepresented groups (e.g., US minorities). He seeks to better understand individual and contextual variables in comparative effectiveness research, health disparities, and public policy for children at individual, local, state, and national levels.

Dr. Carle received his PhD in 2003 from Arizona State University. Following his doctoral degree, Dr. Carle completed a a two-year post-doctoral appointment at the US Census Bureau. He spent three years as an assistant professor of psychology at the University of North Florida before joining Cincinnati Children’s Hospital Medical Center.

PhD: Arizona State University; Quantitative Methods and Clinical Emphases, 2003.

Post Doctoral Training: US Census Bureau, 2003-2005.


Structural equation modeling; measurement theory; generalized multilevel modeling; complex survey methods; propensity scores; understanding individual and contextual level influences on children’s health and health disparities; children with special health care needs

Research Areas

Quality Improvement


Using percentiles in the interpretation of Patient-Reported Outcomes Measurement Information System scores: Guidelines for autism. Schuchard, J; Kaplan-Kahn, EA; Carle, AC; Holmes, LG; Law, K; Miller, JS; Parish-Morris, J; Forrest, CB. Autism Research. 2022; 15:2336-2345.

Interpreting Patient-Reported Outcome Scores: Pediatric Inflammatory Bowel Disease as a Use Case. Schuchard, J; Carle, AC; Kappelman, MD; Tucker, CA; Forrest, CB. Ambulatory Pediatrics. 2022; 22:1520-1528.

Testing an Automated Approach to Identify Variation in Outcomes among Children with Type 1 Diabetes across Multiple Sites. Addison, J; Razzaghi, H; Bailey, C; Dickinson, K; Corathers, SD; Hartley, DM; Utidjian, L; Carle, AC; Rhodes, ET; Alonso, GT; et al. Pediatric Quality and Safety. 2022; 7.

Types of Tobacco Products Used by Caregivers of Newborns in the Primary Care Setting. Gittelman, M; Southworth, H; Carle, AC; Anzeljc, S; Qian, X; Wervey Arnold, M; Mahabee-Gittens, EM. Clinical Pediatrics. 2022; 61:535-541.

A Medication Adherence Promotion System to Reduce Late Kidney Allograft Rejection: A Quality Improvement Study. Hooper, DK; Varnell, CD; Rich, K; Carle, A; Huber, J; Mostajabi, F; Dahale, D; Pai, AL H; Goebel, J; Modi, AC. American Journal of Kidney Diseases. 2022; 79:335-346.

Use of Patient-Reported Outcomes Measurement Information System Pediatric Measures as Clinical Trial Endpoints: Experience from a Multicenter Pragmatic Trial in Children with Crohn's Disease. Miller, TL; Schuchard, J; Carle, AC; Forrest, CB; Kappelman, MD; Adler, J; Ammoury, RF; Bass, D; Bass, J; Benkov, K; et al. Journal of Pediatrics. 2022; 242:86-92.e3.

The Mental and Physical Health of Mothers of Children with Special Health Care Needs in the United States. Hagerman, TK; McKernan, GP; Carle, AC; Yu, JA; Stover, AD; Houtrow, AJ. Maternal and Child Health Journal. 2022; 26:500-510.

Randomized Behavioral Sleep Clinical Trial to Improve Outcomes in Children With Down Syndrome. Esbensen, AJ; Hoffman, EK; Beebe, DW; Byars, K; Carle, AC; Epstein, JN; Johnson, C. American Journal on Intellectual and Developmental Disabilities. 2022; 127:149-164.

Evaluating working memory outcome measures for children with Down syndrome. Schworer, EK; Esbensen, AJ; Fidler, DJ; Beebe, DW; Carle, A; Wiley, S. Journal of Intellectual Disability Research. 2022; 66:195-211.

Phase I study of ribociclib and everolimus in children with newly diagnosed DIPG and high-grade glioma: A CONNECT pediatric neuro-oncology consortium report. Dewire, M; Lazow, M; Campagne, O; Leach, J; Fuller, C; Senthil Kumar, S; Stanek, J; De Blank, P; Hummel, TR; Pillay-Smiley, N; et al. Neuro-Oncology Advances. 2022; 4.