Jamie K. Capal, MD
- Member, Division of Neurology
- Director, Moving to Adult Care Clinic, Division of Developmental and Behavioral Pediatrics
- Co-Director, Vinaya Rett Syndrome and Related Spectrum Disorders Clinic
- Director, Tuberous Sclerosis Complex-Associated Neuropsychiatric Disorders (TAND) Clinic
- Professor, UC Department of Pediatrics
- jamie.capal@cchmc.org
- Board Certified
About
Biography
As a child neurologist with subspecialty training in neurodevelopmental disabilities, I am passionate about providing comprehensive, multidisciplinary care for children and adults with neurodevelopmental and neurobehavioral disorders. My clinical and research interests focus on rare neurodevelopmental conditions, and I am actively involved in the Tuberous Sclerosis Complex Center of Excellence and the Vinaya Rett Syndrome and Related Spectrum Disorders Clinic Center of Excellence. I also direct the Moving to Adult Care Clinic through the Division of Developmental and Behavioral Pediatrics, helping patients and families navigate important transitions in care.
What truly inspires me in my work is the opportunity to care for, work with, and learn from my patients and their families. Individuals with neurodevelopmental conditions deserve a medical home and someone to walk with them through both hardship and joy. My goal is to be that partner, helping families navigate the complexities of the healthcare system and ensuring they feel supported every step of the way.
Mentorship is also an important part of my practice. I strive to guide residents and trainees in developing both understanding and compassion for individuals with neurodevelopmental disabilities, with the hope of improving care across all medical specialties. My research is closely tied to my clinical work, and I have been fortunate to participate in clinical trials for conditions such as Angelman syndrome, Rett syndrome, tuberous sclerosis complex, and Fragile X syndrome. I am always looking for ways to develop preventative and disease-modifying treatments that can make a meaningful difference in my patients’ lives.
Outside of work, I love spending time with my husband and children. We enjoy traveling, baking, building Legos, running, and reading together—and we’re big fans of Great Wolf Lodge.
BA: Biology with honors, Ithaca College, Ithaca, NY, 2002.
MD: Albany Medical College, Albany, NY, 2002.
Mentored Research Training: Semester of research during junior year at Ithaca College in the neurophysiology laboratory of Jean Hardwick, PhD. Evaluated the effect of leukotrienes on parasympathetic postganglionic cardiac neurons in guinea pigs. August 2001–May 2001.
Mentored Research Training: Senior honors research at Ithaca College in the developmental biology laboratory of Marc Servetnick, PhD. Investigated the upstream promoter regions of the human eye-specific genes six 3 and six 6. 2001-2002.
Residency: Pediatrics, Cincinnati Children’s Hospital Medical Center, Cincinnati, OH, 2006-2008.
Resident/Fellow: Pediatric Neurology and Neurodevelopmental Disabilities, Cincinnati Children’s Hospital Medical Center, Cincinnati, OH, 2008-2012.
Interests
Neurodevelopmental disabilities; tuberous sclerosis complex; Rett syndrome; transitioning to adult care
Services and Specialties
Interests
Tuberous sclerosis complex; Rett syndrome; Angelman syndrome
Research Areas
Insurance Information
Cincinnati Children's strives to accept a wide variety of health plans. Please contact your health insurance carrier to verify coverage for your specific benefit plan.
Publications
ReNeu: A Pivotal, Phase IIb Trial of Mirdametinib in Adults and Children With Symptomatic Neurofibromatosis Type 1-Associated Plexiform Neurofibroma. Journal of Clinical Oncology. 2025; 43:716-729.
Accumulated seizure burden predicts neurodevelopmental outcome at 36 months of age in patients with tuberous sclerosis complex. Epilepsia. 2025; 66:117-133.
Preventative treatment of tuberous sclerosis complex with sirolimus: Phase I safety and efficacy results. 2024; 2:106-119.
Abnormality of Early White Matter Development in Tuberous Sclerosis Complex and Autism Spectrum Disorder: Longitudinal Analysis of Diffusion Tensor Imaging Measures. Journal of Child Neurology. 2024; 39:178-189.
Autism and Epilepsy. Pediatric Clinics of North America. 2024; 71:241-252.
Female Excellence and Leadership in Pediatrics Subspecialties (FLEXPeds): Creating a Network for Women Across Academic Pediatrics. The Journal of Pediatrics. 2023; 263:113512.
Understanding the impact of tuberous sclerosis complex: development and validation of the TSC-PROM. BMC Medicine. 2023; 21:298.
International consensus recommendations for the identification and treatment of tuberous sclerosis complex-associated neuropsychiatric disorders (TAND). Journal of Neurodevelopmental Disorders. 2023; 15:32.
Development and Feasibility of the Self-Report Quantified Tuberous Sclerosis Complex-Associated Neuropsychiatric Disorders Checklist (TAND-SQ). Pediatric Neurology. 2023; 147:101-123.
Epilepsy Severity Is Associated With Head Circumference and Growth Rate in Infants With Tuberous Sclerosis Complex. Pediatric Neurology. 2023; 144:26-32.
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