Photo of Timothy Chlon

Timothy M. Chlon, PhD


  • Member, Division of Experimental Hematology and Cancer
  • Assistant Professor, UC Department of Pediatrics

About

BSc: University of Notre Dame, Notre Dame, IN, 2007.

PhD: Northwestern University, Chicago, IL, 2012.

Postdoctoral Fellow: Cincinnati Children’s Hospital Medical Center, Cincinnati, OH, 2012-2020.

Interests

Inherited susceptibility to myelodysplastic syndrome, myeloid leukemia, and bone marrow failure; ribosome biogenesis and snoRNA processing

Research Areas

Publications

Prevalence of cytopenia(s) and somatic variants in patients with DDX41 mutant germline predisposition syndrome. Kusne, Y; Badar, T; Lasho, T; Marando, L; Mangaonkar, AA; Finke, C; Foran, JM; Al-Kali, A; Palmer, J; Arana Yi, C; Litzow, MR; Chlon, T; Ferrer, A; Patnaik, MM. British Journal of Haematology. 2025; 206:1109-1120.

Germline DDX41 mutations in myeloid neoplasms: the current clinical and molecular understanding. Kida, J; Chlon, TM. Current Opinion in Hematology. 2025; 32:67-76.

The Most Common Somatic DDX41 Mutation (p.R525H) Causes Loss of an Essential Function and Is Selected Against in Human iPSC and Leukemia Models. Kida, J; Fricker, M; Stepanchick, E; Chlon, T. Blood. 2024; 144:4089.

Clinical Characteristics of Myeloproliferative Neoplasms in Patients with DDX41 MT Germline Predisposition Syndrome. Kusne, Y; Badar, T; Lasho, TL; Marando, L; Mangaonkar, AA; Finke, C; Foran, JM; Al-Kali, A; Alkhateeb, HB; Gangat, N; Tefferi, A; Chlon, T; Ferrer, A; Patnaik, MM. Blood. 2024; 144:3183.

Prevalence and Clinical Features of Non-Myeloid Neoplasms in Patients with DDX41 Mutant Germline Predisposition Syndrome. Kusne, Y; Badar, T; Lasho, TL; Marando, L; Mangaonkar, AA; Finke, C; Foran, JM; Al-Kali, A; Alkhateeb, HB; Gangat, N; Litzow, MR; Chlon, T; Ferrer, A; Patnaik, MM. Blood. 2024; 144:440.

Absence of PNH-clones in DDX41mutant-GPS aids in their distinction from acquired BM failure syndromes. Kusne, Y; Badar, T; Lasho, T; Ferrer, A; Mangaonkar, AA; Finke, C; Marando, L; Foran, JM; Al-Kali, A; Alkhateeb, HB; Chlon, T; Patnaik, MM. Leukemia Research: clinical and laboratory studies. 2024; 145:107561.

DDX41 haploinsufficiency causes inefficient hematopoiesis under stress and cooperates with p53 mutations to cause hematologic malignancy. Stepanchick, E; Wilson, A; Sulentic, AM; Choi, K; Hueneman, K; Starczynowski, DT; Chlon, TM. Leukemia. 2024; 38:1787-1798.

Clinical and Molecular Spectrum of Somatic Mosaic States in DDX41 mutant Germline Predisposition Syndromes. Badar, T; Lasho, TL; Kusne, Y; Marando, L; Mangaonkar, AA; Finke, CM; Foran, JM; Al-Kali, A; Alkhateeb, H; Gangat, N; Litzow, MR; Chlon, T; Ferrer, A; Patnaik, MM. Blood. 2023; 142:4618.

Genetic Complementation Studies Reveal That Many Disease-Associated DDX41 Variants Do Not Cause Loss of Protein Function. Chlon, T; Stepanchick, E; Finke, CM; Lasho, TL; Badar, T; Ferrer, A; Patnaik, MM. Blood. 2023; 142:4104.

Clinical and molecular correlates of somatic and germline DDX41 variants in patients and families with myeloid neoplasms. Badar, T; Nanaa, A; Foran, JM; Viswanatha, D; Al-Kali, A; Lasho, T; Finke, C; Alkhateeb, HB; He, R; Gangat, N; Ongie, LJ; Chlon, T; Ferrer, A; Patnaik, MM. Haematologica: the hematology journal. 2023; 108:3033-3043.