Timothy Chlon.

Timothy M. Chlon, PhD

  • Member, Division of Experimental Hematology and Cancer
  • Instructor, UC Department of Pediatrics

About

BSc: University of Notre Dame, Notre Dame, IN, 2007.

PhD: Northwestern University, Chicago, IL, 2012.

Postdoctoral Fellow: Cincinnati Children’s Hospital Medical Center, Cincinnati, OH, 2012-2020.

Interests

Inherited susceptibility to myelodysplastic syndrome, myeloid leukemia, and bone marrow failure; ribosome biogenesis and snoRNA processing

Research Areas

Experimental Hematology and Cancer Biology

Publications

Germline and Somatic Defects in DDX41 and its Impact on Myeloid Neoplasms. Badar, T; Chlon, T. Current Hematologic Malignancy Reports. 2022.

The deubiquitinase USP15 modulates cellular redox and is a therapeutic target in acute myeloid leukemia. Niederkorn, M; Ishikawa, C; M. Hueneman, K; Bartram, J; Stepanchick, E; R. Bennett, J; E. Culver-Cochran, A; Bolanos, LC; Uible, E; Choi, K; et al. Leukemia. 2022; 36:438-451.

Germline DDX41 mutations cause ineffective hematopoiesis and myelodysplasia. Chlon, TM; Stepanchick, E; Hershberger, CE; Daniels, NJ; Hueneman, KM; Kuenzi Davis, A; Choi, K; Zheng, Y; Gurnari, C; Haferlach, T; et al. Cell Stem Cell. 2021; 28:1966-1981.e6.

Inherited DNA Repair Defects Disrupt the Structure and Function of Human Skin. Ruiz-Torres, S; Brusadelli, MG; Witte, DP; Wikenheiser-Brokamp, KA; Sauter, S; Nelson, AS; Sertorio, M; Chlon, TM; Lane, A; Mehta, PA; et al. Cell Stem Cell. 2021; 28:424-435.e6.

Chronic immune response dysregulation in MDS pathogenesis. Barreyro, L; Chlon, TM; Starczynowski, DT. Blood. 2018; 132:1553-1560.