Timothy M. Chlon, PhD
- Member, Division of Experimental Hematology and Cancer
- Assistant Professor, UC Department of Pediatrics
About
BSc: University of Notre Dame, Notre Dame, IN, 2007.
PhD: Northwestern University, Chicago, IL, 2012.
Postdoctoral Fellow: Cincinnati Children’s Hospital Medical Center, Cincinnati, OH, 2012-2020.
Interests
Inherited susceptibility to myelodysplastic syndrome, myeloid leukemia, and bone marrow failure; ribosome biogenesis and snoRNA processing
Research Areas
Experimental Hematology and Cancer Biology
Publications
Germline and Somatic Defects in DDX41 and its Impact on Myeloid Neoplasms. Current Hematologic Malignancy Reports. 2022; 17:113-120.
The deubiquitinase USP15 modulates cellular redox and is a therapeutic target in acute myeloid leukemia. Leukemia. 2022; 36:438-451.
Germline DDX41 mutations cause ineffective hematopoiesis and myelodysplasia. Cell Stem Cell. 2021; 28:1966-1981.e6.
Inherited DNA Repair Defects Disrupt the Structure and Function of Human Skin. Cell Stem Cell. 2021; 28:424-435.e6.
Chronic immune response dysregulation in MDS pathogenesis. Blood. 2018; 132:1553-1560.
From the Blog
Minor Cell Population Plays Major Role in Triggering a Silent Subset of Inherited MDS Cases
Timothy M. Chlon, PhD, Daniel T. Starczynowski, PhD9/1/2021
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