A photo of Zackary Cleveland.

Zackary I. Cleveland, PhD

  • Associate Director, Center for Pulmonary Imaging Research
  • Associate Professor, UC Department of Pediatrics
  • UC Department of Biomedical Engineering

About

Biography

Although hyperpolarized gases have been used to investigate regional pulmonary structure and function since the late 1990, the technology was not widely disseminated, because it relied on the rare and expensive stable isotope 3He. Dr. Cleveland helped pioneer the use of more readily available 129Xe, paving the way for clinical hyperpolarized gas MRI. Dr. Cleveland also helped expand the limits of preclinical MRI by demonstrating the feasibility of high resolution HP 129Xe imaging in rats and mice and by demonstrating the the first, in vivo molecular imaging applications of HP gases.

PhD: Department of Chemistry, Colorado State University, Fort Collins, CO.

Postdoctoral Fellowship: Department of Radiology, Duke University Medical Center, Durham, NC.

Services and Specialties

Cystic Fibrosis Center

Interests

Hyperpolarized gases; pulmonary imaging; translational studies; preclinical MRI

Research Areas

Pulmonary Medicine, Imaging, Fibrosis

Publications

Improving hyperpolarized 129 Xe ADC mapping in pediatric and adult lungs with uncertainty propagation. Bdaiwi, AS; Niedbalski, PJ; Hossain, MM; Willmering, MM; Walkup, LL; Wang, H; Thomen, RP; Ruppert, K; Woods, JC; Cleveland, ZI. NMR in Biomedicine. 2022; 35.

Hyperpolarized 129Xenon MRI Ventilation Defect Quantification via Thresholding and Linear Binning in Multiple Pulmonary Diseases. Roach, DJ; Willmering, MM; Plummer, JW; Walkup, LL; Zhang, Y; Hossain, MM; Cleveland, ZI; Woods, JC. Academic Radiology. 2022; 29 Suppl 2:S145-S155.

Protocols for multi-site trials using hyperpolarized 129 Xe MRI for imaging of ventilation, alveolar-airspace size, and gas exchange: A position paper from the 129 Xe MRI clinical trials consortium. Niedbalski, PJ; Hall, CS; Castro, M; Eddy, RL; Rayment, JH; Svenningsen, S; Parraga, G; Zanette, B; Santyr, GE; Thomen, RP; et al. Magnetic Resonance in Medicine. 2021; 86:2966-2986.

Removal of off-resonance xenon gas artifacts in pulmonary gas-transfer MRI. Willmering, MM; Cleveland, ZI; Walkup, LL; Woods, JC. Magnetic Resonance in Medicine. 2021; 86:907-915.

129Xe MRI as a measure of clinical disease severity for pediatric asthma. Lin, NY; Roach, DJ; Willmering, MM; Walkup, LL; Hossain, MM; Desirazu, P; Cleveland, ZI; Guilbert, TW; Woods, JC. Journal of Allergy and Clinical Immunology. 2021; 147:2146-2153.e1.

Preclinical MRI to Quantify Pulmonary Disease Severity and Trajectories in Poorly Characterized Mouse Models: A Pedagogical Example Using Data from Novel Transgenic Models of Lung Fibrosis. Stecker, IR; Freeman, MS; Sitaraman, S; Hall, CS; Niedbalski, PJ; Hendricks, AJ; Martin, EP; Weaver, TE; Cleveland, ZI. Journal of Magnetic Resonance Open. 2021; 6-7.

Sensitive structural and functional measurements and 1-year pulmonary outcomes in pediatric cystic fibrosis. Willmering, MM; Roach, DJ; Kramer, EL; Walkup, LL; Cleveland, ZI; Woods, JC. Journal of Cystic Fibrosis. 2021; 20:533-539.

Validating in vivo hyperpolarized 129 Xe diffusion MRI and diffusion morphometry in the mouse lung. Niedbalski, PJ; Cochran, AS; Freeman, MS; Guo, J; Fugate, EM; Davis, CB; Dahlke, J; Quirk, JD; Varisco, BM; Woods, JC; et al. Magnetic Resonance in Medicine. 2021; 85:2160-2173.

Improved preclinical hyperpolarized 129 Xe ventilation imaging with constant flip angle 3D radial golden means acquisition and keyhole reconstruction. Niedbalski, PJ; Cleveland, ZI. NMR in Biomedicine. 2021; 34.

A semi-empirical model to optimize continuous-flow hyperpolarized 129Xe production under practical cryogenic-accumulation conditions. Plummer, JW; Emami, K; Dummer, A; Woods, JC; Walkup, LL; Cleveland, ZI. Journal of Magnetic Resonance. 2020; 320.