Zackary I. Cleveland, PhD

Associate Director, Center for Pulmonary Imaging Research
Associate Professor, UC Department of Pediatrics
UC Department of Biomedical Engineering

zackary.cleveland@cchmc.org

About

Biography

Although hyperpolarized gases have been used to investigate regional pulmonary structure and function since the late 1990, the technology was not widely disseminated, because it relied on the rare and expensive stable isotope 3He. Dr. Cleveland helped pioneer the use of more readily available 129Xe, paving the way for clinical hyperpolarized gas MRI. Dr. Cleveland also helped expand the limits of preclinical MRI by demonstrating the feasibility of high resolution HP 129Xe imaging in rats and mice and by demonstrating the the first, in vivo molecular imaging applications of HP gases.

Services and Specialties

Interests

Hyperpolarized gases; pulmonary imaging; translational studies; preclinical MRI

Research Areas

Publications

Pulmonary 129 Xe Ventilation MRI Predicts Severe Exacerbations in People With CF. Matheson, AM; Bdaiwi, AS; Willmering, M; DiFrancesco, MW; Cleveland, ZI; Woods, JC. American Journal of Respiratory and Critical Care Medicine. 2025; 211:a7088.

Quantifying spatial and dynamic lung abnormalities with 3D PREFUL FLORET UTE imaging: A feasibility study. Klimeš, F; Plummer, JW; Willmering, MM; Matheson, AM; Bdaiwi, AS; Gutberlet, M; Voskrebenzev, A; Wernz, MM; Wacker, F; Woods, J; Cleveland, ZI; Walkup, LL; Vogel-Claussen, J. Magnetic Resonance in Medicine. 2025; 93:1984-1998.

Same-Day Repeatability and 28-Day Reproducibility of Xenon MRI Ventilation in Children With Cystic Fibrosis in a Multi-Site Trial. Walkup, LL; Roach, DJ; Plummer, JW; Willmering, MM; Zanette, B; Santyr, G; Fain, SB; Rock, MJ; Mata, J; Froh, D; Stanojevic, S; Cleveland, ZI; Ratjen, F; Woods, JC. Journal of Magnetic Resonance Imaging. 2025; 61:1664-1674.

Quantifying Spatial Distribution of Ventilation Defects in Multiple Pulmonary Diseases With Hyperpolarized 129Xenon MRI. Bdaiwi, AS; Willmering, MM; Woods, JC; Walkup, LL; Cleveland, ZI. Journal of Magnetic Resonance Imaging. 2025; 61:1860-1873.

129Xe Image Processing Pipeline: An open-source, graphical user interface application for the analysis of hyperpolarized 129Xe MRI. Bdaiwi, AS; Willmering, MM; Plummer, JW; Hussain, R; Roach, DJ; Parra-Robles, J; Niedbalski, PJ; Woods, JC; Walkup, LL; Cleveland, ZI. Magnetic Resonance in Medicine. 2025; 93:1220-1237.

A thermally polarized, dissolved-phase 129Xe phantom for quality-control and multisite comparisons of gas-exchange imaging. Willmering, MM; Albert, BJ; Plummer, JW; Greer, J; Walkup, LL; Lindquist, DM; Cleveland, ZI. Journal of Magnetic Resonance. 2025; 371:107829.

Improved Diffusion-Weighted Hyperpolarized 129Xe Lung MRI with Patch-Based Higher-Order, Singular Value Decomposition Denoising. Soderlund, SA; Bdaiwi, AS; Plummer, JW; Woods, JC; Walkup, LL; Cleveland, ZI. Academic Radiology. 2024; 31:5289-5299.

Hyperpolarized 129Xe Lung MRI and Spectroscopy in Mechanically Ventilated Mice. Costa, ML; Plummer, JW; Bdaiwi, AS; Albert, BJ; Fugate, EM; Niedbalski, PJ; Lindquist, DM; Cleveland, ZI. Jove-Journal of Visualized Experiments. 2024.

A decay-modeled compressed sensing reconstruction approach for non-Cartesian hyperpolarized 129Xe MRI. Plummer, JW; Hussain, R; Bdaiwi, AS; Soderlund, SA; Hoyos, X; Lanier, JM; Garrison, WJ; Parra-Robles, J; Willmering, MM; Niedbalski, PJ; Cleveland, ZI; Walkup, LL. Magnetic Resonance in Medicine. 2024; 92:1363-1375.

846 Plasma proteomics identifies changes in disease-associated pathways in subjects with CF bronchiectasis after elexacaftor/tezacaftor/ivacaftor initiation. Skala, E; Banerjee, R; Siefert, M; Dusa, C; Stevens, C; Hils, B; Bdaiwi, A; Hayes, D; Cleveland, Z; Ziady, A. Journal of Cystic Fibrosis. 2024; 23:s490.