Zackary I. Cleveland, PhD

Biography & Affiliation Education Publications

Member, Division of Pulmonary Medicine

Associate Professor, UC Department of PediatricsUC Department of Biomedical Engineering

Biography & Affiliation

Biography

Although hyperpolarized gases have been used to investigate regional pulmonary structure and function since the late 1990, the technology was not widely disseminated, because it relied on the rare and expensive stable isotope 3He. Dr. Cleveland helped pioneer the use of more readily available 129Xe, paving the way for clinical hyperpolarized gas MRI. Dr. Cleveland also helped expand the limits of preclinical MRI by demonstrating the feasibility of high resolution HP 129Xe imaging in rats and mice and by demonstrating the the first, in vivo molecular imaging applications of HP gases.

Research Interests

Hyperpolarized gases; pulmonary imaging; translational studies; preclinical MRI

Academic Affiliation

Associate Professor, UC Department of PediatricsUC Department of Biomedical Engineering

Departments

Pulmonary Medicine, Imaging, Fibrosis

Education

PhD: Department of Chemistry, Colorado State University, Fort Collins, CO.

Postdoctoral Fellowship: Department of Radiology, Duke University Medical Center, Durham, NC.

Publications

Cyst Ventilation Heterogeneity and Alveolar Airspace Dilation as Early Disease Markers in Lymphangioleiomyomatosis. Walkup, LL; Roach, DJ; Hall, CS; Gupta, N; Thomen, RP; Cleveland, ZI; McCormack, FX; Woods, JC. Annals of the American Thoracic Society. 2019; 16:1008-1016.

Mapping and correcting hyperpolarized magnetization decay with radial keyhole imaging. Niedbalski, PJ; Willmering, MM; Robertson, SH; Freeman, MS; Loew, W; Giaquinto, RO; Ireland, C; Pratt, RG; Dumoulin, CL; Woods, JC; et al. Magnetic Resonance in Medicine. 2019; 82:367-376.

Longitudinal free-breathing MRI measurement of murine lung physiology in a progressive model of lung fibrosis. Guo, J; Hardie, WD; Cleveland, ZI; Davidson, C; Xu, X; Madala, SK; Woods, JC. Journal of applied physiology (Bethesda, Md. : 1985). 2019; 126:1138-1149.

Evidence of Normal Alveolar Size in Pediatric Generalized Lymphatic Anomaly. Walkup, LL; Towe, CT; Bdaiwi, A; Merrow, AC; Hammill, AM; Cleveland, ZI; Woods, JC. American Journal of Respiratory and Critical Care Medicine. 2018; 198:1573-1574.

Murine pulmonary imaging at 7T: T-2* and T-1 with anisotropic UTE. Guo, J; Cao, X; Cleveland, ZI; Woods, JC. Magnetic Resonance in Medicine. 2018; 79:2254-2264.

Enhanced Efficiency of C-13 Dynamic Nuclear Polarization by Superparamagnetic Iron Oxide Nanoparticle Doping. Niedbalski, P; Parish, CR; Wang, Q; Hayati, Z; Song, L; Cleveland, ZI; Lumata, L. The Journal of Physical Chemistry Part C: Nanomaterials and Interfaces. 2017; 121:19505-19511.

Magnetic resonance imaging of disease progression and resolution in a transgenic mouse model of pulmonary fibrosis. Cleveland, ZI; Zhou, YM; Akinyi, TG; Dunn, RS; Davidson, CR; Guo, J; Woods, JC; Hardie, WD. American Journal of Physiology: Lung Cellular and Molecular Physiology. 2017; 312:L488-L499.

Hyperpolarized Xe-129 for investigation of mild cystic fibrosis lung disease in pediatric patients. Thomen, RP; Walkup, LL; Roach, DJ; Cleveland, ZI; Clancy, JP; Woods, JC. Journal of Cystic Fibrosis. 2017; 16:275-282.

Feasibility, tolerability and safety of pediatric hyperpolarized Xe-129 magnetic resonance imaging in healthy volunteers and children with cystic fibrosis. Walkup, LL; Thomen, RP; Akinyi, TG; Watters, E; Ruppert, K; Clancy, JP; Woods, JC; Cleveland, ZI. Pediatric Radiology: roentgenology, nuclear medicine, ultrasonics, CT, MRI. 2016; 46:1651-1662.