Zackary I. Cleveland, PhD

A photo of Zackary Cleveland.

Member, Division of Pulmonary Medicine

Associate Professor, UC Department of PediatricsUC Department of Biomedical Engineering

513-803-7186

Biography & Affiliation

Biography

Although hyperpolarized gases have been used to investigate regional pulmonary structure and function since the late 1990, the technology was not widely disseminated, because it relied on the rare and expensive stable isotope 3He. Dr. Cleveland helped pioneer the use of more readily available 129Xe, paving the way for clinical hyperpolarized gas MRI. Dr. Cleveland also helped expand the limits of preclinical MRI by demonstrating the feasibility of high resolution HP 129Xe imaging in rats and mice and by demonstrating the the first, in vivo molecular imaging applications of HP gases.

Research Interests

Hyperpolarized gases; pulmonary imaging; translational studies; preclinical MRI

Academic Affiliation

Associate Professor, UC Department of PediatricsUC Department of Biomedical Engineering

Research Divisions

Pulmonary Medicine, Imaging, Fibrosis

Education

PhD: Department of Chemistry, Colorado State University, Fort Collins, CO.

Postdoctoral Fellowship: Department of Radiology, Duke University Medical Center, Durham, NC.

Publications

A semi-empirical model to optimize continuous-flow hyperpolarized 129Xe production under practical cryogenic-accumulation conditions. Plummer, JW; Emami, K; Dummer, A; Woods, JC; Walkup, LL; Cleveland, ZI. Journal of Magnetic Resonance. 2020; 320:106845-106845.

Mapping cardiopulmonary dynamics within the microvasculature of the lungs using dissolved 129Xe MRI. Niedbalski, PJ; Bier, EA; Wang, Z; Willmering, MM; Driehuys, B; Cleveland, ZI. Journal of applied physiology (Bethesda, Md. : 1985). 2020; 129:218-229.

Regional structure-function in cystic fibrosis lung disease using hyperpolarized 129xe and ultrashort echo magnetic resonance imaging. Thomen, RP; Walkup, LL; Roach, DJ; Higano, N; Schapiro, A; Brody, A; Clancy, JP; Cleveland, ZI; Woods, JC. American Journal of Respiratory and Critical Care Medicine. 2020; 202:290-292.

Improved pulmonary 129Xe ventilation imaging via 3D-spiral UTE MRI. Willmering, MM; Niedbalski, PJ; Wang, H; Walkup, LL; Robison, RK; Pipe, JG; Cleveland, ZI; Woods, JC. Magnetic Resonance in Medicine. 2020; 84:312-320.

Preclinical hyperpolarized 129Xe MRI: ventilation and T2* mapping in mouse lungs at 7 T using multi-echo flyback UTE. Niedbalski, PJ; Cochran, AS; Akinyi, TG; Thomen, RP; Fugate, EM; Lindquist, DM; Pratt, RG; Cleveland, ZI. NMR in Biomedicine. 2020; 33.

Cyst Ventilation Heterogeneity and Alveolar Airspace Dilation as Early Disease Markers in Lymphangioleiomyomatosis. Walkup, LL; Roach, DJ; Hall, CS; Gupta, N; Thomen, RP; Cleveland, ZI; McCormack, FX; Woods, JC. Annals of the American Thoracic Society. 2019; 16:1008-1016.

Mapping and correcting hyperpolarized magnetization decay with radial keyhole imaging. Niedbalski, PJ; Willmering, MM; Robertson, SH; Freeman, MS; Loew, W; Giaquinto, RO; Ireland, C; Pratt, RG; Dumoulin, CL; Woods, JC; et al. Magnetic Resonance in Medicine. 2019; 82:367-376.

Longitudinal free-breathing MRI measurement of murine lung physiology in a progressive model of lung fibrosis. Guo, J; Hardie, WD; Cleveland, ZI; Davidson, C; Xu, X; Madala, SK; Woods, JC. Journal of applied physiology (Bethesda, Md. : 1985). 2019; 126:1138-1149.

Evidence of Normal Alveolar Size in Pediatric Generalized Lymphatic Anomaly. Walkup, LL; Towe, CT; Bdaiwi, A; Merrow, AC; Hammill, AM; Cleveland, ZI; Woods, JC. American Journal of Respiratory and Critical Care Medicine. 2018; 198:1573-1574.

Murine pulmonary imaging at 7T: T-2* and T-1 with anisotropic UTE. Guo, J; Cao, X; Cleveland, ZI; Woods, JC. Magnetic Resonance in Medicine. 2018; 79:2254-2264.