My Biography & Research

Biography

Dr. Gandhi was the first to report the hemodynamic and metabolic effects of a powerful endogenous peptide endothelin in the liver, and increase in its activity during liver injury. Subsequently, his group showed that endothelin receptor antagonism arrests and reverses liver fibrosis/cirrhosis. His laboratory also developed a novel mouse model of hepatic stellate cell depletion and showed that stellate cells play a critical role in acute liver injury and liver’s immunological tolerance. Recently, Dr. Gandhi edited a book entitled “Stellate Cells in Health and Disease” (Elsevier/Academic Press) that covers the entire spectrum of stellate cell biology known to date with contribution from leading experts in stellate cell and liver research.

Another major research program in Dr. Gandhi’s laboratory demonstrated that augmenter of liver regeneration (ALR) protein is a critical intracellular survival factor for hepatocytes, and that secreted ALR exerts important biological effects on nonparenchymal cells. His laboratory developed a novel liver-specific ALR-knockout and heterozygous (ALR+/-) mice. This research has shown, for the first time, that by its mitochondrial function and regulation of lipid and energy metabolism, ALR plays a major role in steatohepatitis. It is apparent that the ALR-deficient mice will be a valuable tool to investigate mechanisms of alcoholic and nonalcoholic steatohepatitis that progress to end-stage liver diseases.

Research Interests

Mechanisms of liver injury, immunological tolerance and steatohepatitis

Academic Affiliation

Professor, UC Department of Surgery

Divisions

Gastroenterology GI, Gastroenterology, Fibrosis

My Education

MSc: Biochemistry, Nagpur University, India.

PhD: Biochemistry, Nagpur University, India.

My Publications

Augmenter of liver regeneration protein deficiency promotes hepatic steatosis by inducing oxidative stress and microRNA-540 expression. Kumar, S; Rani, R; Karns, R; Gandhi, CR. The FASEB journal : official publication of the Federation of American Societies for Experimental Biology. 2019; 33:3825-3840.

The Forkhead box F1 transcription factor inhibits collagen deposition and accumulation of myofibroblasts during liver fibrosis. Flood, HM; Bolte, C; Dasgupta, N; Sharma, A; Zhang, Y; Gandhi, CR; Kalin, TV; Kalinichenko, VV. Biology Open. 2019; 8:bio039800-bio039800.

Mechanisms of concanavalin A-induced cytokine synthesis by hepatic stellate cells: Distinct roles of interferon regulatory factor-1 in liver injury. Rani, R; Kumar, S; Sharma, A; Mohanty, SK; Donnelly, B; Tiao, GM; Gandhi, CR. The Journal of biological chemistry. 2018; 293:18466-18476.

"CHOP "ing intestinal stem cells on way to cholestatic liver injury. Sharma, A; Gandhi, CR. Hepatology. 2018; 67:1216-1218.

"Thinking " vs. "Talking ": Differential Autocrine Inflammatory Networks in Isolated Primary Hepatic Stellate Cells and Hepatocytes under Hypoxic Stress. Vodovotz, Y; Simmons, RL; Gandhi, CR; Barclay, D; Jefferson, BS; Huang, C; Namas, R; el-Dehaibi, F; Mi, Q; Billiar, TR; et al. Frontiers in Physiology. 2017; 8.

Hepatic stellate cell activation and pro-fibrogenic signals. Gandhi, CR. Journal of Hepatology. 2017; 67:1104-1105.

Hepatology Snapshot: Hepatic stellate cell activation and pro-fibrogenic signals. Gandhi, CR. Journal of Hepatology. 2017; 67:1104-1105.

Stellate Cells Orchestrate Concanavalin A-Induced Acute Liver Damage. Rani, R; Tandon, A; Wang, J; Kumar, S; Gandhi, CR. The American journal of pathology. 2017; 187:2008-2019.

Augmenter of Liver Regeneration: A Fundamental Life Protein. Nalesnik, MA; Gandhi, CR; Starzl, TE. Hepatology. 2017; 66:266-270.

Toll-Like Receptor 4-Independent Carbon Tetrachloride-Induced Fibrosis and Lipopolysaccharide-Induced Acute Liver Injury in Mice Role of Hepatic Stellate Cells. Kumar, S; Wang, J; Shanmukhappa, SK; Gandhi, CR. The American journal of pathology. 2017; 187:1356-1367.