A photo of Christina Gross.

Christina Gross, PhD


  • Neuroscientist, Division of Neurology
  • Associate Professor, UC Department of Pediatrics

About

Biography

To me, research is a joy and a passion, not just “a job.” I began my research career in 1999 because I wanted to learn more about how the brain works. To me, the brain is the most fascinating organ in the body, and I wanted to understand how we think, learn and feel. Later, I became more interested in how these mechanisms are disturbed in brain disorders.

It struck me that most brain disorders do not have good treatment options yet. Therefore, while I am still very interested in the basic brain mechanisms, I am now more dedicated to bridging the gap between brain disorders and treatments.

The overarching purpose of my research is to identify and understand pathological molecular mechanisms which contribute to autism and epilepsy. My lab works to discover how these mechanisms affect neuronal and brain function. Our ultimate goal is using this knowledge to identify molecular biomarkers and develop therapeutic strategies.

In more recent years, parts of my lab have tried to identify potential novel brain treatments. We discovered that a PI3K isoform-selective inhibitor ameliorates disease-relevant phenotypes in mouse models for two different neurodevelopmental brain disorders. We also discovered that a specific microRNA regulates neuronal hyperexcitability in mouse models of epilepsy.

My work has been funded by the National Institutes of Health (NIH) and other organizations, such as the Brain and Behavior Research Foundation, the American Epilepsy Society, and the Fragile X Syndrome Research and Treatment (FRAXA) Research Foundation.

Publications

PARVing the Way to Cap Translation for Seizure Control. Gross, C. Epilepsy Currents. 2021; 21:360-362.

GABAA Alpha 2,3 Modulation Improves Select Phenotypes in a Mouse Model of Fragile X Syndrome. Schaefer, TL; Ashworth, AA; Tiwari, D; Tomasek, MP; Parkins, EV; White, AR; Snider, A; Davenport, MH; Grainger, LM; Becker, RA; et al. Frontiers in Psychiatry. 2021; 12.

The PI3-Kinase p110β Isoform Controls Severity of Cocaine-Induced Sequelae and Alters the Striatal Transcriptome. Shapiro, LP; Pitts, EG; Li, DC; Barbee, BR; Hinton, EA; Bassell, GJ; Gross, C; Gourley, SL. Biological Psychiatry. 2021; 89:959-969.

mTOR-driven neural circuit changes initiate an epileptogenic cascade. LaSarge, CL; Pun, RY K; Gu, Z; Riccetti, MR; Namboodiri, DV; Tiwari, D; Gross, C; Danzer, SC. Progress in Neurobiology. 2021; 200.

Myeloid EP2 Receptors in Status Epilepticus-Peripheral But Not Negligible. Gross, C. Epilepsy Currents. 2021; 21:194-196.

Fil-lamin-ing in the Gap in Cortical Dysplasia. Gross, C. Epilepsy Currents. 2021; 21:51-53.

The potassium channel Kv4.2 regulates dendritic spine morphology, electroencephalographic characteristics and seizure susceptibility in mice. Tiwari, D; Schaefer, TL; Schroeder-Carter, LM; Krzeski, JC; Bunk, AT; Parkins, EV; Snider, A; Danzer, R; Williams, MT; Vorhees, CV; et al. Neurodegeneration : a journal for neurodegenerative disorders, neuroprotection, and neuroregeneration. 2020; 334.

PI3K isoform-selective inhibition in neuron-specific PTEN-deficient mice rescues molecular defects and reduces epilepsy-associated phenotypes. White, AR; Tiwari, D; MacLeod, MC; Danzer, SC; Gross, C. Neurobiology of Disease. 2020; 144.

Violet-light suppression of thermogenesis by opsin 5 hypothalamic neurons. Zhang, KX; D'Souza, S; Upton, BA; Kernodle, S; Vemaraju, S; Nayak, G; Gaitonde, KD; Holt, AL; Linne, CD; Smith, AN; et al. Nature: New biology. 2020; 585:420-425.

AMPK-Regulated Astrocytic Lactate Shuttle Plays a Non-Cell-Autonomous Role in Neuronal Survival. Muraleedharan, R; Gawali, MV; Tiwari, D; Sukumaran, A; Oatman, N; Anderson, J; Nardini, D; Bhuiyan, MA N; Tkac, I; Ward, AL; et al. Cell Reports. 2020; 32.

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