A photo of Christina Gross.

Neuroscientist, Division of Neurology

Associate Professor, UC Department of Pediatrics

513-636-3493

Biography & Affiliation

Biography

To me, research is a joy and a passion, not just “a job.” I began my research career in 1999 because I wanted to learn more about how the brain works. To me, the brain is the most fascinating organ in the body, and I wanted to understand how we think, learn and feel. Later, I became more interested in how these mechanisms are disturbed in brain disorders.

It struck me that most brain disorders do not have good treatment options yet. Therefore, while I am still very interested in the basic brain mechanisms, I am now more dedicated to bridging the gap between brain disorders and treatments.

The overarching purpose of my research is to identify and understand pathological molecular mechanisms which contribute to autism and epilepsy. My lab works to discover how these mechanisms affect neuronal and brain function. Our ultimate goal is using this knowledge to identify molecular biomarkers and develop therapeutic strategies.

In more recent years, parts of my lab have tried to identify potential novel brain treatments. We discovered that a PI3K isoform-selective inhibitor ameliorates disease-relevant phenotypes in mouse models for two different neurodevelopmental brain disorders. We also discovered that a specific microRNA regulates neuronal hyperexcitability in mouse models of epilepsy.

My work has been funded by the National Institutes of Health (NIH) and other organizations, such as the Brain and Behavior Research Foundation, the American Epilepsy Society, and the Fragile X Syndrome Research and Treatment (FRAXA) Research Foundation.

Research Interests

Molecular neuroscience, fragile X syndrome

Academic Affiliation

Associate Professor, UC Department of Pediatrics

Research Divisions

Neurology



Blog Posts

Education

Diploma in Biochemistry: Ruhr University Bochum, Germany, 2000.

PhD: Free University of Berlin, Germany, 2004.

Publications

The potassium channel Kv4.2 regulates dendritic spine morphology, electroencephalographic characteristics and seizure susceptibility in mice. Tiwari, D; Schaefer, TL; Schroeder-Carter, LM; Krzeski, JC; Bunk, AT; Parkins, EV; Snider, A; Danzer, R; Williams, MT; Vorhees, CV; et al. Experimental Neurology. 2020; 334:113437-113437.

PI3K isoform-selective inhibition in neuron-specific PTEN-deficient mice rescues molecular defects and reduces epilepsy-associated phenotypes. White, AR; Tiwari, D; MacLeod, MC; Danzer, SC; Gross, C. Neurobiology of Disease. 2020; 144:105026-105026.

Violet-light suppression of thermogenesis by opsin 5 hypothalamic neurons. Zhang, KX; D'Souza, S; Upton, BA; Kernodle, S; Vemaraju, S; Nayak, G; Gaitonde, KD; Holt, AL; Linne, CD; Smith, AN; et al. Nature. 2020; 585:420-425.

AMPK-Regulated Astrocytic Lactate Shuttle Plays a Non-Cell-Autonomous Role in Neuronal Survival. Muraleedharan, R; Gawali, MV; Tiwari, D; Sukumaran, A; Oatman, N; Anderson, J; Nardini, D; Bhuiyan, MA N; Tkac, I; Ward, AL; et al. Cell Reports. 2020; 32:108092-108092.

KCa3.1 Impairment Is Not Just a Slow Afterthought in Epilepsy. Gross, C. Epilepsy Currents. 2020; 20:211-213.

Sustainable Brain Activity and no End in Sight—What’s in It for Status Epilepticus?. Gross, C. Epilepsy Currents. 2020; 20:113-115.

Neuroprotective roles of neurotrophic factors in depression. Gross, C; Seroogy, KB. Neuroprotection in Autism, Schizophrenia and Alzheimer's disease. : Elsevier; Elsevier; 2020.

Human genetics and neuropathology suggest a link between miR-218 and amyotrophic lateral sclerosis pathophysiology. Reichenstein, I; Eitan, C; Diaz-Garcia, S; Haim, G; Magen, I; Siany, A; Hoye, ML; Rivkin, N; Olender, T; Toth, B; et al. Science Translational Medicine. 2019; 11:eaav5264-eaav5264.

MicroRNA inhibition upregulates hippocampal A-type potassium current and reduces seizure frequency in a mouse model of epilepsy. Tiwari, D; Brager, DH; Rymer, JK; Bunk, AT; White, AR; Elsayed, NA; Krzeski, JC; Snider, A; Carter, LM S; Danzer, SC; et al. Neurobiology of Disease. 2019; 130:104508-104508.

Peripheral Amyloid Precursor Protein Derivative Expression in Fragile X Syndrome. McLane, RD; Schmitt, LM; Pedapati, EV; Shaffer, RC; Dominick, KC; Horn, PS; Gross, C; Erickson, CA. Frontiers in Integrative Neuroscience. 2019; 13.