A photo of Sonata Jodele.

Sonata Jodele, MD


  • Member, Division of Bone Marrow Transplantation and Immune Deficiency
  • Professor, UC Department of Pediatrics

About

Biography

I am an internationally recognized expert in every aspect of transplant-associated thrombotic microangiopathy (TMA), working on both clinical and research applications. My work was instrumental in linking TMA pathophysiology to the complement pathway, which demonstrated the relationship of the disease to specific clinical and genetic factors. Then, I established a new paradigm for therapy with inhibition of the complement pathway.

My ongoing research aims to develop new and better therapies for TMA. Currently, I lead multi-disciplinary international collaborative groups and research projects with clinicians and scientists from Germany, Switzerland, Italy and Japan. I also serve as a clinical consultant for physicians throughout the world regarding care of complex patients with TMA.

In previous work, I led the first prospective TMA biomarker and genetic predisposition studies. My efforts resulted in practical applications for clinical care, as well as comprehensive diagnostic laboratory panels now offered for patients worldwide. I also proposed new diagnostic algorithms and risk stratification data for TMA to help guide timely therapy initiation.

Additionally, I piloted ground-breaking complement blocking therapeutic agents for hematopoietic stem cell transplantation (HSCT) recipients living with severe TMA while also describing unique drug pharmacokinetics in this patient population. As a result of this work, the first prospective early intervention clinical study opened at four major United States pediatric healthcare centers. The study evaluates eculizumab for stem cell transplant recipients with high risk TMA.

My continuing research is supported by the National Institutes of Health (NIH) as well as institutional and industry-sponsored grants.

Publications

Selected

Complement blockade for TA-TMA: lessons learned from a large pediatric cohort treated with eculizumab. Jodele, S; Dandoy, CE; Lane, A; Laskin, BL; Laskin, B; Teusink-Cross, A; Myers, KC; Wallace, G; Nelson, AS; Nelson, A; et al. Blood. 2020; 135:1049-1057.

Selected

Interferon-complement loop in transplant-associated thrombotic microangiopathy. Jodele, S; Medvedovic, M; Luebbering, N; Chen, J; Dandoy, CE; Laskin, BL; Davies, SM. Blood Advances. 2020; 4:1166-1177.

Selected

High-dose Carboplatin/Etoposide/Melphalan increases risk of thrombotic microangiopathy and organ injury after autologous stem cell transplantation in patients with neuroblastoma. Jodele, S; Dandoy, CE; Myers, K; Wallace, G; Lane, A; Teusink-Cross, A; Weiss, B; Davies, SM. Bone Marrow Transplantation. 2018; 53:1311-1318.

Selected

Terminal Complement Blockade after Hematopoietic Stem Cell Transplantation Is Safe without Meningococcal Vaccination. Jodele, S; Dandoy, CE; Danziger-Isakov, L; Myers, KC; El-Bietar, J; Nelson, A; Wallace, G; Teusink-Cross, A; Davies, SM. Biology of Blood and Marrow Transplantation. 2016; 22:1337-1340.

Selected

New approaches in the diagnosis, pathophysiology, and treatment of pediatric hematopoietic stem cell transplantation-associated thrombotic microangiopathy. Jodele, S; Dandoy, CE; Myers, KC; El-Bietar, J; Nelson, A; Wallace, G; Laskin, BL. Transfusion and Apheresis Science. 2016; 54:181-190.

Selected

Variable Eculizumab Clearance Requires Pharmacodynamic Monitoring to Optimize Therapy for Thrombotic Microangiopathy after Hematopoietic Stem Cell Transplantation. Jodele, S; Fukuda, T; Mizuno, K; Vinks, AA; Laskin, BL; Goebel, J; Dixon, BP; Chima, RS; Hirsch, R; Teusink, A; et al. Biology of Blood and Marrow Transplantation. 2016; 22:307-315.

Selected

Diagnostic and risk criteria for HSCT-associated thrombotic microangiopathy: a study in children and young adults. Jodele, S; Davies, SM; Lane, A; Khoury, J; Dandoy, C; Goebel, J; Myers, K; Grimley, M; Bleesing, J; El-Bietar, J; et al. Blood. 2014; 124:645-653.

Selected

Eculizumab therapy in children with severe hematopoietic stem cell transplantation-associated thrombotic microangiopathy. Jodele, S; Fukuda, T; Vinks, A; Mizuno, K; Laskin, BL; Goebel, J; Dixon, BP; Teusink, A; Pluthero, FG; Lu, L; et al. Biology of Blood and Marrow Transplantation. 2014; 20:518-525.

Selected

Abnormalities in the alternative pathway of complement in children with hematopoietic stem cell transplant-associated thrombotic microangiopathy. Jodele, S; Licht, C; Goebel, J; Dixon, BP; Zhang, K; Sivakumaran, TA; Davies, SM; Pluthero, FG; Lu, L; Laskin, BL. Blood. 2013; 122:2003-2007.

Role of the lectin pathway of complement in hematopoietic stem cell transplantation-associated endothelial injury and thrombotic microangiopathy. Gavriilaki, E; Ho, VT; Schwaeble, W; Dudler, T; Daha, M; Fujita, T; Jodele, S. Experimental Hematology and Oncology. 2021; 10.

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