A photo of Andrew Lautz.

Attending Physician, Pediatric Intensive Care Unit (PICU)

Assistant Professor, UC Department of Pediatrics

513-636-4259

Board Certified

My Biography & Research

Biography

Septic shock results from a dysregulated response to infection and often leads to life-threatening organ dysfunction. Since septic shock has a rate of mortality in children, in part linked to cardiac dysfunction, it is essential to research myocardial dysfunction in sepsis to develop targeted treatment and improve outcomes.

Sepsis-associated myocardial dysfunction is common in children with septic shock. However, the genetic and physiological features that influence children to develop sepsis-associated myocardial dysfunction are not well defined and current therapy for myocardial dysfunction only consists of supportive care.

Our research program is based on the bedside-to-bench method to solve clinically driven problems. In our laboratory, my team and I apply translational research methods to study the essential systems by which serum factors and cellular responses drive myocardial dysfunction in sepsis using both in vitro and in vivo modeling. Ultimately, we hope to bring results back to the bedside and reduce mortality in pediatric septic shock. Clinically, I specialize in pediatric critical care medicine. I feel fortunate to care for children when they are at their sickest and help lead families and patients through critical illness. My daily clinical experiences in the intensive care unit strongly motivate my research, which aims to improve the survival of children with septic shock.

I received the Child Health Research Career Development Award (CHRCDA) program K12 from 2017 to 2019 for my research in modeling the developmental effects of myocardial dysfunction in sepsis. My research has been published in multiple journals, including Critical Care Medicine, American Journal of Respiratory and Critical Care Medicine, Critical Care Explorations, Academic Emergency Medicine, Hospital Pediatrics and Pediatrics.

Clinical Interests

Pediatric critical care; septic shock; cardiac arrest

Research Interests

Myocardial dysfunction in pediatric critical illness

Academic Affiliation

Assistant Professor, UC Department of Pediatrics

Clinical Divisions

Pediatric Intensive Care Unit PICU

Research Divisions

Critical Care

My Education

MD: Vanderbilt University School of Medicine, Nashville, TN, 2010.

Residency: Pediatrics, The Children's Hospital of Philadelphia, Philadelphia, PA, 2010-2013.

Chief Residency: Pediatrics, The Children's Hospital of Philadelphia, Philadelphia, PA, 2013-2014.

Fellowship: Pediatric Critical Care Medicine, The Children's Hospital of Philadelphia, Philadelphia, PA, 2014-2017.

Certification: Pediatrics, American Board of Pediatrics, 2013; Pediatric Critical Care Medicine, American Board of Pediatrics, 2018.

My Publications

Identification of the Physiologically Difficult Airway in the Pediatric Emergency Department. Dean, PN; Hoehn, EF; Geis, GL; Frey, ME; Cabrera-Thurman, MK; Kerrey, BT; Zhang, Y; Stalets, EL; Zackoff, MW; Maxwell, AR; et al. Academic Emergency Medicine. 2020; 27:1241-1248.

Peri-Intubation Cardiac Arrest in the Pediatric Emergency Department: A Novel System of Care. Hoehn, EF; Dean, P; Lautz, AJ; Frey, M; Cabrera-Thurman, MK; Geis, GL; Stalets, E; Zackoff, M; Pham, T; Maxwell, A; et al. Pediatric Quality and Safety. 2020; 5:e365-e365.

Myocardial Dysfunction Is Independently Associated With Mortality in Pediatric Septic Shock. Lautz, AJ; Wong, HR; Ryan, TD; Statile, CJ. Critical Care Explorations. 2020; 2:e0231-e0231.

Age-Dependent Myocardial Dysfunction in Critically Ill Patients: Role of Mitochondrial Dysfunction. Lautz, AJ; Zingarelli, B. International Journal of Molecular Sciences. 2019; 20:3523-3523.

Hemodynamic-Directed Cardiopulmonary Resuscitation Improves Neurologic Outcomes and Mitochondrial Function in the Heart and Brain. Lautz, AJ; Morgan, RW; Karlsson, M; Mavroudis, CD; Ko, TS; Licht, DJ; Nadkarni, VM; Berg, RA; Sutton, RM; Kilbaugh, TJ. Critical Care Medicine. 2019; 47:e241-e249.

Effect of the Procalcitonin Assay on Antibiotic Use in Critically Ill Children. Ross, RK; Keele, L; Kubis, S; Lautz, AJ; Dziorny, AC; Denson, AR; O'Connor, KA; Chilutti, MR; Weiss, SL; Gerber, JS. Journal of the Pediatric Infectious Diseases Society. 2018; 7:e43-e46.

Pulmonary Vasodilator Therapy in Shock-associated Cardiac Arrest. Morgan, RW; Sutton, RM; Karlsson, M; Lautz, AJ; Mavroudis, CD; Landis, WP; Lin, Y; Jeong, S; Craig, N; Nadkarni, VM; et al. American Journal of Respiratory and Critical Care Medicine. 2018; 197:905-912.

Focused Training for the Handover of Critical Patient Information During Simulated Pediatric Emergencies. Lautz, AJ; Martin, KC; Nishisaki, A; Bonafide, CP; Hales, RL; Hunt, EA; Nadkarni, VM; Sutton, RM; Boyer, DL. Hospital Pediatrics. 2018; 8:227-231.

Value of Procalcitonin Measurement for Early Evidence of Severe Bacterial Infections in the Pediatric Intensive Care Unit. Lautz, AJ; Dziorny, AC; Denson, AR; O'Connor, KA; Chilutti, MR; Ross, RK; Gerber, JS; Weiss, SL. The Journal of Pediatrics. 2016; 179:74-81.e2.