A photo of Diana Lindquist.

Associate Professor, UC Department of PediatricsUC Department of Radiology

513-636-9268

513-636-0434

My Biography & Research

Biography

Preclinical imaging provides an important translational bridge between the basic science lab and the clinic. Imaging findings in human patients can drive basic science experiments, and basic science can help explain imaging findings. My work is centered on this bridge, as I am primarily interested in preclinical imaging, but in the context of unmet needs in human imaging.

I have utilized preclinical imaging to answer a variety of questions in psychiatry, oncology and nephrology, among others, since my graduate work. My early research involved examining the brain and investigating the effects of antipsychotic medications on brain composition and neurochemistry. Eventually, I transitioned to examining liver metabolism using proton, sodium, phosphorus and carbon imaging or spectroscopy with the aim of using these magnetic resonance methods to quantify liver fibrosis and stage liver disease.

In addition to pursuing my own research, I serve as the director of the In Vivo Microimaging Laboratory. I support several researchers who use imaging in their investigations of various diseases, including multiple sclerosis, neurofibromatosis, cardiac dysfunction, kidney and liver disease and genetic disorders.

Clinical Interests

Magnetic resonance spectroscopy of drug effects; magnetic resonance spectroscopy of metabolic disease; multinuclear magnetic resonance spectroscopy; pulse sequence design

Academic Affiliation

Associate Professor, UC Department of PediatricsUC Department of Radiology

Divisions

Radiology, Radiology, Imaging, Fibrosis

My Education

BS: University of New Mexico, Albuquerque, NM, 1989.

MA: Brandeis University, Waltham, MA, 1991.

PhD: University of Arkansas-Little Rock, Little Rock, AR, 1998.

My Publications

Characterization of a novel rat model of X-linked hydrocephalus by CRISPR-mediated mutation in L1cam. Emmert, AS; Vuong, SM; Shula, C; Lindquist, D; Yuan, W; Hu, Y; Mangano, FT; Goto, J. Journal of Neurosurgery. 2020; 132:945-958.

Impaired neural differentiation and glymphatic CSF flow in the Ccdc39 rat model of neonatal hydrocephalus: Genetic interaction with L1cam. Emmert, AS; Iwasawa, E; Shula, C; Schultz, P; Lindquist, D; Dunn, RS; Fugate, EM; Hu, Y; Mangano, FT; Goto, J. DMM Disease Models and Mechanisms. 2019; 12:dmm040972-dmm040972.

Correction of glycogen synthase kinase 3β in myotonic dystrophy 1 reduces the mutant RNA and improves postnatal survival of DMSXL mice. Wang, M; Weng, W; Stock, L; Lindquist, D; Martinez, A; Gourdon, G; Timchenko, N; Snape, M; Timchenko, L. Molecular and Cellular Biology. 2019; 39.

Omega-3 fatty acid deficiency impairs frontostriatal recruitment following repeated amphetamine treatment in rats: A 7 Tesla in vivo phMRI study. McNamara, RK; Schurdak, JD; Asch, RH; Lindquist, DM. Nutritional Neuroscience (Informa). 2019; 22:587-595.

Role of polyunsaturated fatty acids in human brain structure and function across the lifespan: An update on neuroimaging findings. McNamara, RK; Asch, RH; Lindquist, DM; Krikorian, R. Prostaglandins, Leukotrienes and Essential Fatty Acids. 2018; 136:23-34.

Deficits in Docosahexaenoic Acid Accrual during Adolescence Reduce Rat Forebrain White Matter Microstructural Integrity: An in vivo Diffusion Tensor Imaging Study. McNamara, RK; Schurdak, JD; Asch, RH; Peters, BD; Lindquist, DM. Developmental Neuroscience. 2018; 40:84-92.

Glutamate homeostasis in the adult rat prefrontal cortex is altered by cortical docosahexaenoic acid accrual during adolescence: An &ITin vivo&(ITH)-H- 1 MRS study. McNamara, RK; Asch, RH; Schurdak, JD; Lindquist, DM. Psychiatry Research: Neuroimaging. 2017; 270:39-45.

Effects of dietary-induced alterations in rat brain docosahexaenoic acid accrual on phospholipid metabolism and mitochondrial bioenergetics: An in vivo P-31 MRS study. Lindquist, DM; Asch, RH; Schurdak, JD; McNamara, RK. Journal of Psychiatric Research. 2017; 95:143-146.

Loss of SLC25A46 causes neurodegeneration by affecting mitochondrial dynamics and energy production in mice. Li, Z; Peng, Y; Hufnagel, RB; Hu, Y; Zhao, C; Queme, LF; Khuchua, Z; Driver, AM; Dong, F; Lu, QR; et al. Human Molecular Genetics. 2017; 26:3776-3791.

Intravenous miR-144 inhibits tumor growth in diethylnitrosamine-induced hepatocellular carcinoma in mice. He, Q; Wang, F; Honda, T; Lindquist, DM; Dillman, JR; Timchenko, NA; Redington, AN. Tumor Biology: from basic science to clinical application. 2017; 39:1010428317737729-8.