A photo of Diana Lindquist.

Diana M. Lindquist, PhD

  • Associate Professor, UC Department of Pediatrics
  • UC Department of Radiology

About

Biography

Preclinical imaging provides an important translational bridge between the basic science lab and the clinic. Imaging findings in human patients can drive basic science experiments, and basic science can help explain imaging findings. My work is centered on this bridge, as I am primarily interested in preclinical imaging, but in the context of unmet needs in human imaging.

I have utilized preclinical imaging to answer a variety of questions in psychiatry, oncology and nephrology, among others, since my graduate work. My early research involved examining the brain and investigating the effects of antipsychotic medications on brain composition and neurochemistry. Eventually, I transitioned to examining liver metabolism using proton, sodium, phosphorus and carbon imaging or spectroscopy with the aim of using these magnetic resonance methods to quantify liver fibrosis and stage liver disease.

In addition to pursuing my own research, I serve as the director of the In Vivo Microimaging Laboratory. I support several researchers who use imaging in their investigations of various diseases, including multiple sclerosis, neurofibromatosis, cardiac dysfunction, kidney and liver disease and genetic disorders.

BS: University of New Mexico, Albuquerque, NM, 1989.

MA: Brandeis University, Waltham, MA, 1991.

PhD: University of Arkansas-Little Rock, Little Rock, AR, 1998.

Interests

Magnetic resonance spectroscopy of drug effects; magnetic resonance spectroscopy of metabolic disease; multinuclear magnetic resonance spectroscopy; pulse sequence design

Services and Specialties

Radiology

Research Areas

Radiology, Imaging, Fibrosis

Publications

Editorial for "Hepatic Iron Quantification Using a Free-Breathing 3D Radial Gradient Echo Technique and Validation with a 2D Biopsy-Calibrated R2* Relaxometry Method ". Lindquist, DM; Dillman, JR; Tkach, JA. Journal of Magnetic Resonance Imaging. 2022; 55:1417-1418.

Creatine transporter deficiency impairs stress adaptation and brain energetics homeostasis. Chen, HR; Zhang-Brotzge, X; Morozov, YM; Li, Y; Wang, S; Zhang, HH; Kuan, IS; Fugate, EM; Mao, H; Sun, YY; et al. JCI insight. 2021; 6.

MRI Measures of Murine Liver Fibrosis. Lindquist, DM; Fugate, EM; Wang, J; Sharma, A; Gandhi, CR; Dillman, JR. Journal of Magnetic Resonance Imaging. 2021; 54:739-749.

An image registration framework to estimate 3D myocardial strains from cine cardiac MRI in mice. Keshavarzian, M; Fugate, E; Chavan, S; Chu, V; Arif, M; Lindquist, D; Sadayappan, S; Avazmohammadi, R. . 2021.

Magnetic resonance spectroscopy in the rodent brain: Experts' consensus recommendations. Lanz, B; Abaei, A; Braissant, O; Choi, IY; Cudalbu, C; Henry, PG; Gruetter, R; Kara, F; Kantarci, K; Lee, P; et al. NMR in Biomedicine. 2021.

Ablation of polyamine catabolic enzymes provokes Purkinje cell damage, neuroinflammation, and severe ataxia. Zahedi, K; Brooks, M; Barone, S; Rahmati, N; Murray Stewart, T; Dunworth, M; Destefano-Shields, C; Dasgupta, N; Davidson, S; Lindquist, DM; et al. Journal of Neuroinflammation. 2020; 17.

Preclinical hyperpolarized 129 Xe MRI: ventilation and T2 * mapping in mouse lungs at 7 T using multi-echo flyback UTE. Niedbalski, PJ; Cochran, AS; Akinyi, TG; Thomen, RP; Fugate, EM; Lindquist, DM; Pratt, RG; Cleveland, ZI. NMR in Biomedicine. 2020; 33.

Characterization of a novel rat model of X-linked hydrocephalus by CRISPR-mediated mutation in L1cam. Emmert, AS; Vuong, SM; Shula, C; Lindquist, D; Yuan, W; Hu, Y; Mangano, FT; Goto, J. Journal of Neurosurgery. 2020; 132:945-958.

Impaired neural differentiation and glymphatic CSF flow in the Ccdc39 rat model of neonatal hydrocephalus: genetic interaction with L1cam. Emmert, AS; Iwasawa, E; Shula, C; Schultz, P; Lindquist, D; Dunn, RS; Fugate, EM; Hu, Y; Mangano, FT; Goto, J. DMM Disease Models and Mechanisms. 2019; 12.

Correction of Glycogen Synthase Kinase 3β in Myotonic Dystrophy 1 Reduces the Mutant RNA and Improves Postnatal Survival of DMSXL Mice. Wang, M; Weng, W; Stock, L; Lindquist, D; Martinez, A; Gourdon, G; Timchenko, N; Snape, M; Timchenko, L. Molecular and Cellular Biology. 2019; 39.