Pluripotent stem cell biology; disease modeling with human iPSCs; hPSC-derived organoids
Implementing Research Shared (Core) Facility Billing Systems. Journal of Biomolecular Techniques. 2022; 33.
Aggregation of cryopreserved mid-hindgut endoderm for more reliable and reproducible hPSC-derived small intestinal organoid generation. Stem Cell Reports. 2022; 17:1889-1902.
Human iPSC-derived hepatocyte system models cholestasis with tight junction protein 2 deficiency. 2022; 4.
High-Throughput Functional Analysis of CFTR and Other Apically Localized Proteins in iPSC-Derived Human Intestinal Organoids. Cells. 2021; 10.
Modeling Human Bile Acid Transport and Synthesis in Stem Cell-Derived Hepatocytes with a Patient-Specific Mutation. Stem Cell Reports. 2021; 16:309-323.
Comparative analysis of human microglial models for studies of HIV replication and pathogenesis. Retrovirology. 2020; 17.
Intravenous infusion of iPSC-derived neural precursor cells increases acid β-glucosidase function in the brain and lessens the neuronopathic phenotype in a mouse model of Gaucher disease. Human Molecular Genetics. 2019; 28:3406-3421.
Modeling Steatohepatitis in Humans with Pluripotent Stem Cell-Derived Organoids. Cell Metabolism. 2019; 30:374-384.e6.
Noncoding deletions reveal a gene that is critical for intestinal function. Nature. 2019; 571:107-111.
Constitutive STAT5 activation regulates Paneth and Paneth-like cells to control Clostridium difficile colitis. Life Science Alliance. 2019; 2.
Christopher N. Mayhew, PhD7/28/2022