A photo of Christopher N. Mayhew.

Director, Pluripotent Stem Cell Facility

Assistant Professor, UC Department of Pediatrics

513-636-3744

Biography & Affiliation

Research Interests

Pluripotent stem cell biology; disease modeling with human iPSCs; hPSC-derived organoids

Academic Affiliation

Assistant Professor, UC Department of Pediatrics

Department

Developmental Biology

Education

PhD: University of Wolverhampton, Wolverhampton, UK, 2000.

Publications

Peng Y et al. Intravenous infusion of iPSC-derived neural precursor cells increases acid β-glucosidase function in the brain and lessens the neuronopathic phenotype in a mouse model of Gaucher disease. Hum Mol Genet. 2019.

Oz-Levi D et al. Noncoding deletions reveal a gene that is critical for intestinal function. Nature. 2019 Jul;571(7763):107-111.

Ouchi R et al. Modeling Steatohepatitis In Humans With Pluripotent Stem Cell-Derived Organoids. Cell Metab. 2019 Aug 6;30(2):374-384.

Liu R et al. Constitutive STAT5 activation regulates Paneth and Paneth-like cells to control Clostridium difficile colitis. Life Sci Alliance. 2019;2(2).

Kimura M et al. Digitalized Human Organoid for Wireless Phenotyping. iScience. 2018;4:294-301.

Daily K et al. Molecular, phenotypic, and sample-associated data to describe pluripotent stem cell lines and derivatives. Sci Data. 2017;4:170030.

Asai A et al. Paracrine signals regulate human liver organoid maturation from induced pluripotent stem cells. Development. 2017 Mar 15;144(6):1056-1064.

Salomonis N et al. Integrated Genomic Analysis of Diverse Induced Pluripotent Stem Cells from the Progenitor Cell Biology Consortium. Stem Cell Reports. 2016;7(1):110-25.

Ulm A et al. Cultivate primary nasal epithelial cells from nasal mucosa samples of children and reprogram into induced pluripotent stem cells. J Vis Exp. 2016;109.

Chlon TM et al. Overcoming Pluripotent Stem Cell Dependence on the Repair of Endogenous DNA Damage. Stem Cell Reports. 2016;6(1):44-54.