Christopher N. Mayhew, PhD

Large-scale and innervated functional human gut tissues for transplantation via transient spheroid confinement. Poling, HM; Noël, T; Singh, A; Fisher, GW; Thorner, K; Chaturvedi, P; Nattamai, K; Srivastava, K; Batie, MR; Hausfeld, T; Takebe, T; Wells, JM; Helmrath, MA; Mahe, MM. Nature Biomedical Engineering. 2026; 10(10):2077-2093.

Frequency of ZFHX3-Mediated Spinocerebellar Ataxia 4 in a US Undiagnosed Ataxia Cohort. Chen, A; Avadhani, U; Ngo, K; Corona, RI; Neto, GDVC; Figueroa, KP; Perlman, S; Pulst, SM; Nelson, SF; Wong, D; Fogel, BL. Movement Disorders. 2026; 41(9):2476-2489.

Patient-specific midbrain organoids with CRISPR correction recapitulate neuronopathic Gaucher disease phenotypes and enable evaluation of novel therapies. Lin, Y; Liou, B; Fannin, V; Adler, S; Mayhew, CN; Hammonds, JE; Hu, Y-C; Tchieu, J; Zhang, W; Zhao, X; Kaynak, A; Qi, X; Feldman, RA; Sun, Y. eLife. 2026; 15.

DNASE1L3 Deficiency With Novel Missense Variant: Enzymatic and Plasma Fragmentomic Evidence of Pathogenicity and Partial Response to JAK Blockade. Leon Tenorio, AA; Sugio, T; Cheng, J; Bonner, DE; Esfahani, MS; Kasinathan, S; Hsu, JJ; Moyer, A; Pimentel Vera, L; Carter, J; Wheeler, MT; Bernstein, JA; Alizadeh, A; Gomez-Ospina, N. ACR Open Rheumatology. 2026; 8(2):e70184.

SUN-056 The National Biorepository and Resource for Pituitary Neuroendocrine Tumor Translational Research (BioPitNeT) Zavros, Y; Little, AS; Santagata, S; Wells, JM; Mayhew, C; Kim, AH; Zada, G; Chakrabarti, J; Eschbacher, JM; Yuen, KCJ; Pandey, R; Mochel, JP; Allenspach, K; Jordan, G. Journal of the Endocrine Society. 2025; 9(Supplement_1):bvaf149.1641.

Integrating collecting systems in human kidney organoids through fusion of distal nephron to ureteric bud. Shi, M; Crouse, B; Sundaram, N; Pode Shakked, N; Thorner, K; King, NM; Dutta, P; Ester, L; Zhang, W; Govindarajah, V; Mayhew, CN; Helmrath, MA; Bonventre, JV; Mccracken, KW. Cell Stem Cell. 2025; 32(7):1055-1070.e8.

Human pluripotent stem cell-derived organoids repair damaged bowel in vivo. Poling, HM; Sundaram, N; Fisher, GW; Singh, A; Shiley, JR; Nattamai, K; Govindarajah, V; Cortez, AR; Krutko, MO; Ménoret, S; Mayhew, CN; Takebe, T; Mahe, MM; Helmrath, MA. Cell Stem Cell. 2024; 31(10):1513-1523.e7.

Protocol for establishing inducible CRISPR interference system for multiple-gene silencing in human pluripotent stem cells. Matsui, S; Shiley, JR; Granitto, M; Ludwig, K; Buckley, M; Koigi, S; Mirizio, G; Hu, Y-C; Mayhew, CN; Iwafuchi, M. STAR Protocols. 2024; 5(3):103221.

Protocol for establishing inducible CRISPRd system for blocking transcription factor-binding sites in human pluripotent stem cells. Matsui, S; Shiley, JR; Buckley, M; Lim, H-W; Hu, Y-C; Mayhew, CN; Iwafuchi, M. STAR Protocols. 2024; 5(3):103233.

Pioneer and PRDM transcription factors coordinate bivalent epigenetic states to safeguard cell fate. Matsui, S; Granitto, M; Buckley, M; Ludwig, K; Koigi, S; Shiley, J; Zacharias, WJ; Mayhew, CN; Lim, H-W; Iwafuchi, M. Molecular Cell. 2024; 84(3):476-489.e10.