Christopher N. Mayhew, PhD

iPSC-derived neural precursor cells engineering GBA1 recovers acid β-glucosidase deficiency and diminishes α-synuclein and neuropathology. Peng, Y; Liou, B; Lin, Y; Mayhew, CN; Fleming, SM; Sun, Y. Molecular Therapy-Methods & Clinical Development. 2023; 29:185-201.

A review of protocols for brain organoids and applications for disease modeling. Mayhew, CN; Singhania, R. STAR Protocols. 2023; 4:101860.

Implementing Research Shared (Core) Facility Billing Systems. Chimote, AA; Mayhew, C; Thornton, S; Wetzel, C; White, AN. Journal of biomolecular techniques : JBT. 2022; 33:3fc1f5fe.1a877626.

Aggregation of cryopreserved mid-hindgut endoderm for more reliable and reproducible hPSC-derived small intestinal organoid generation. Pitstick, AL; Poling, HM; Sundaram, N; Lewis, PL; Kechele, DO; Sanchez, JG; Scott, MA; Broda, TR; Helmrath, MA; Wells, JM; et al. Stem Cell Reports. 2022; 17:1889-1902.

Human iPSC-derived hepatocyte system models cholestasis with tight junction protein 2 deficiency. Li, CZ; Ogawa, H; Ng, SS; Chen, X; Kishimoto, E; Sakabe, K; Fukami, A; Hu, YC; Mayhew, CN; Hellmann, J; et al. JHEP Reports. 2022; 4:100446.

High-Throughput Functional Analysis of CFTR and Other Apically Localized Proteins in iPSC-Derived Human Intestinal Organoids. Xia, S; Bozóky, Z; Di Paola, M; Laselva, O; Ahmadi, S; Jiang, JX; Pitstick, AL; Jiang, C; Rotin, D; Mayhew, CN; et al. Cells. 2021; 10:3419.

Modeling Human Bile Acid Transport and Synthesis in Stem Cell-Derived Hepatocytes with a Patient-Specific Mutation. Hayashi, H; Osaka, S; Sakabe, K; Fukami, A; Kishimoto, E; Aihara, E; Sabu, Y; Mizutani, A; Kusuhara, H; Naritaka, N; et al. Stem Cell Reports. 2021; 16:309-323.

Comparative analysis of human microglial models for studies of HIV replication and pathogenesis. Rai, MA; Hammonds, J; Pujato, M; Mayhew, C; Roskin, K; Spearman, P. Retrovirology. 2020; 17:35.

Comparative analysis of human microglial models for studies of HIV replication and pathogenesis. Rai, MA; Hammonds, J; Pujato, M; Mayhew, C; Roskin, K; Spearman, P. Retrovirology. 2020; 17:35.

Intravenous infusion of iPSC-derived neural precursor cells increases acid β-glucosidase function in the brain and lessens the neuronopathic phenotype in a mouse model of Gaucher disease. Peng, Y; Liou, B; Inskeep, V; Blackwood, R; Mayhew, CN; Grabowski, GA; Sun, Y. Human Molecular Genetics. 2019; 28:3406-3421.