A photo of Christopher N. Mayhew.

Director, Pluripotent Stem Cell Facility

Assistant Professor, UC Department of Pediatrics


Biography & Affiliation

Research Interests

Pluripotent stem cell biology; disease modeling with human iPSCs; hPSC-derived organoids

Academic Affiliation

Assistant Professor, UC Department of Pediatrics

Research Divisions

Developmental Biology


PhD: University of Wolverhampton, Wolverhampton, UK, 2000.


Modeling Human Bile Acid Transport and Synthesis in Stem Cell-Derived Hepatocytes with a Patient-Specific Mutation. Hayashi, H; Osaka, S; Sakabe, K; Fukami, A; Kishimoto, E; Aihara, E; Sabu, Y; Mizutani, A; Kusuhara, H; Naritaka, N; et al. Stem Cell Reports. 2021; 16:309-323.

Comparative analysis of human microglial models for studies of HIV replication and pathogenesis. Rai, MA; Hammonds, J; Pujato, M; Mayhew, C; Roskin, K; Spearman, P. Retrovirology. 2020; 17.

Intravenous infusion of iPSC-derived neural precursor cells increases acid β-glucosidase function in the brain and lessens the neuronopathic phenotype in a mouse model of Gaucher disease. Peng, Y; Liou, B; Inskeep, V; Blackwood, R; Mayhew, CN; Grabowski, GA; Sun, Y. Human Molecular Genetics. 2019; 28:3406-3421.

Modeling Steatohepatitis in Humans with Pluripotent Stem Cell-Derived Organoids. Ouchi, R; Togo, S; Kimura, M; Shinozawa, T; Koido, M; Koike, H; Thompson, W; Karns, RA; Mayhew, CN; McGrath, PS; et al. Cell Metabolism. 2019; 30:374-384.e6.

Noncoding deletions reveal a gene that is critical for intestinal function. Oz-Levi, D; Olender, T; Bar-Joseph, I; Zhu, Y; Marek-Yagel, D; Barozzi, I; Osterwalder, M; Alkelai, A; Ruzzo, EK; Han, Y; et al. Nature: New biology. 2019; 571:107-111.

Constitutive STAT5 activation regulates Paneth and Paneth-like cells to control Clostridium difficile colitis. Liu, R; Moriggl, R; Zhang, D; Li, H; Karns, R; Ruan, H; Niu, H; Mayhew, C; Watson, C; Bangar, H; et al. Life Science Alliance. 2019; 2.

Induction of CD44 Variant Isoforms is an Early Epithelial Response to Helicobacter pylori Infection. Chakrabarti, J; Steele, N; Holokai, L; Broda, T; Biesiada, J; Pitstick, A; Mayhew, C; Medvedovic, M; Wells, J; Zavros, Y. FASEB Journal. 2019; 33:869.28-869.28.

Digitalized Human Organoid for Wireless Phenotyping. Kimura, M; Azuma, M; Zhang, R; Thompson, W; Mayhew, CN; Takebe, T. iScience. 2018; 4:294-301.

Molecular, phenotypic, and sample-associated data to describe pluripotent stem cell lines and derivatives. Daily, K; Sui, SJ H; Schriml, LM; Dexheimer, PJ; Salomonis, N; Schroll, R; Bush, S; Keddache, M; Mayhew, C; Lotia, S; et al. Scientific data. 2017; 4.

Paracrine signals regulate human liver organoid maturation from induced pluripotent stem cells. Asai, A; Aihara, E; Watson, C; Mourya, R; Mizuochi, T; Shivakumar, P; Phelan, K; Mayhew, C; Helmrath, M; Takebe, T; et al. Development (Cambridge). 2017; 144:1056-1064.