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A photo of Christopher N. Mayhew.

Director, Pluripotent Stem Cell Facility

Assistant Professor, UC Department of Pediatrics


Biography & Affiliation

Research Interests

Pluripotent stem cell biology; disease modeling with human iPSCs; hPSC-derived organoids

Academic Affiliation

Assistant Professor, UC Department of Pediatrics


Developmental Biology


PhD: University of Wolverhampton, Wolverhampton, UK, 2000.


Modeling Steatohepatitis in Humans with Pluripotent Stem Cell-Derived Organoids. Ouchi, R; Togo, S; Kimura, M; Shinozawa, T; Koido, M; Koike, H; Thompson, W; Karns, RA; Mayhew, CN; McGrath, PS; et al. Cell Metabolism. 2019; 30:374-384.e6.

Noncoding deletions reveal a gene that is critical for intestinal function. Oz-Levi, D; Olender, T; Bar-Joseph, I; Zhu, Y; Marek-Yagel, D; Barozzi, I; Osterwalder, M; Alkelai, A; Ruzzo, EK; Han, Y; et al. Nature. 2019; 571:107-111.

Constitutive STAT5 activation regulates Paneth and Paneth-like cells to control Clostridium difficile colitis. Liu, R; Moriggl, R; Zhang, D; Li, H; Karns, R; Ruan, H; Niu, H; Mayhew, C; Watson, C; Bangar, H; et al. Life Science Alliance. 2019; 2:e201900296-e201900296.

Digitalized Human Organoid for Wireless Phenotyping. Kimura, M; Azuma, M; Zhang, R; Thompson, W; Mayhew, CN; Takebe, T. iScience. 2018; 4:294-301.

Molecular, phenotypic, and sample-associated data to describe pluripotent stem cell lines and derivatives. Daily, K; Sui, SJ H; Schriml, LM; Dexheimer, PJ; Salomonis, N; Schroll, R; Bush, S; Keddache, M; Mayhew, C; Lotia, S; et al. Scientific Data. 2017; 4.

Paracrine signals regulate human liver organoid maturation from induced pluripotent stem cells. Asai, A; Aihara, E; Watson, C; Mourya, R; Mizuochi, T; Shivakumar, P; Phelan, K; Mayhew, C; Helmrath, M; Takebe, T; et al. Development (Cambridge). 2017; 144:1056-1064.

Integrated Genomic Analysis of Diverse Induced Pluripotent Stem Cells from the Progenitor Cell Biology Consortium. Salomonis, N; Dexheimer, PJ; Omberg, L; Schroll, R; Bush, S; Huo, J; Schriml, L; Sui, SH; Keddache, M; Mayhew, C; et al. Stem Cell Reports. 2016; 7:110-125.

Cultivate Primary Nasal Epithelial Cells from Children and Reprogram into Induced Pluripotent Stem Cells. Ulm, A; Mayhew, CN; Debley, J; Hershey, GK K; Ji, H. Jove-Journal of Visualized Experiments. 2016; 2016.

Overcoming Pluripotent Stem Cell Dependence on the Repair of Endogenous DNA Damage. Chlon, TM; Ruiz-Torres, S; Maag, L; Mayhew, CN; Wikenheiser-Brokamp, KA; Davies, SM; Mehta, P; Myers, KC; Wells, JM; Wells, SI. Stem Cell Reports. 2016; 6:44-54.