A photo of Christopher N. Mayhew.

Christopher N. Mayhew, PhD

  • Director, Pluripotent Stem Cell Facility
  • Assistant Professor, UC Department of Pediatrics


PhD: University of Wolverhampton, Wolverhampton, UK, 2000.


Pluripotent stem cell biology; disease modeling with human iPSCs; hPSC-derived organoids

Research Areas

Developmental Biology


Implementing Research Shared (Core) Facility Billing Systems. Chimote, AA; Mayhew, C; Thornton, S; Wetzel, C; White, AN. Journal of Biomolecular Techniques. 2022; 33.

Aggregation of cryopreserved mid-hindgut endoderm for more reliable and reproducible hPSC-derived small intestinal organoid generation. Pitstick, AL; Poling, HM; Sundaram, N; Lewis, PL; Kechele, DO; Sanchez, JG; Scott, MA; Broda, TR; Helmrath, MA; Wells, JM; et al. Stem Cell Reports. 2022; 17:1889-1902.

Human iPSC-derived hepatocyte system models cholestasis with tight junction protein 2 deficiency. Li, CZ; Ogawa, H; Ng, SS; Chen, X; Kishimoto, E; Sakabe, K; Fukami, A; Hu, YC; Mayhew, CN; Hellmann, J; et al. 2022; 4.

High-Throughput Functional Analysis of CFTR and Other Apically Localized Proteins in iPSC-Derived Human Intestinal Organoids. Xia, S; Bozóky, Z; Di Paola, M; Laselva, O; Ahmadi, S; Jiang, JX; Pitstick, AL; Jiang, C; Rotin, D; Mayhew, CN; et al. Cells. 2021; 10.

Modeling Human Bile Acid Transport and Synthesis in Stem Cell-Derived Hepatocytes with a Patient-Specific Mutation. Hayashi, H; Osaka, S; Sakabe, K; Fukami, A; Kishimoto, E; Aihara, E; Sabu, Y; Mizutani, A; Kusuhara, H; Naritaka, N; et al. Stem Cell Reports. 2021; 16:309-323.

Comparative analysis of human microglial models for studies of HIV replication and pathogenesis. Rai, MA; Hammonds, J; Pujato, M; Mayhew, C; Roskin, K; Spearman, P. Retrovirology. 2020; 17.

Intravenous infusion of iPSC-derived neural precursor cells increases acid β-glucosidase function in the brain and lessens the neuronopathic phenotype in a mouse model of Gaucher disease. Peng, Y; Liou, B; Inskeep, V; Blackwood, R; Mayhew, CN; Grabowski, GA; Sun, Y. Human Molecular Genetics. 2019; 28:3406-3421.

Modeling Steatohepatitis in Humans with Pluripotent Stem Cell-Derived Organoids. Ouchi, R; Togo, S; Kimura, M; Shinozawa, T; Koido, M; Koike, H; Thompson, W; Karns, RA; Mayhew, CN; McGrath, PS; et al. Cell Metabolism. 2019; 30:374-384.e6.

Noncoding deletions reveal a gene that is critical for intestinal function. Oz-Levi, D; Olender, T; Bar-Joseph, I; Zhu, Y; Marek-Yagel, D; Barozzi, I; Osterwalder, M; Alkelai, A; Ruzzo, EK; Han, Y; et al. Nature. 2019; 571:107-111.

Constitutive STAT5 activation regulates Paneth and Paneth-like cells to control Clostridium difficile colitis. Liu, R; Moriggl, R; Zhang, D; Li, H; Karns, R; Ruan, H; Niu, H; Mayhew, C; Watson, C; Bangar, H; et al. Life Science Alliance. 2019; 2.

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