A photo of James Mulloy.

Co-Leader, Hematological Malignancy Program

Professor, UC Department of Pediatrics

513-517-7028

513-636-3768

Biography & Affiliation

Biography

I’ve always been interested in cancer and immunity. My research interests include hematologic malignancies, animal models and the pathophysiology of leukemia.

My work aims to understand leukemia biology and to identify effective treatments for this disease. I have developed numerous mouse models of human leukemia and identified various signaling pathways that can be targeted for additional research. I’m also an environmental activist working to address climate change.

I have more than 28 years’ experience and began working at Cincinnati Children’s in 2003. My research has been published in various respected journals, including Cancer Cell, Stem Cells, Blood, Leukemia, Science Translational Medicine and Experimental Hematology.

Academic Affiliation

Professor, UC Department of Pediatrics

Research Divisions

Experimental Hematology and Cancer Biology, Cancer and Blood Diseases

Education

BA: St. Anselm College, Manchester, NH, 1986.

MS: Rutgers University-University of Medicine and Dentistry, New Brunswick, NJ, 1989.

PhD: Rutgers University-University of Medicine and Dentistry, New Brunswick, NJ, 1992.

Publications

Therapeutic targeting of the E3 ubiquitin ligase SKP2 in T-ALL. Rodriguez, S; Abundis, C; Boccalatte, F; Mehrotra, P; Chiang, MY; Yui, MA; Wang, L; Zhang, H; Zollman, A; Bonfim-Silva, R; et al. Leukemia. 2020; 34:1241-1252.

Asymmetrically Segregated Mitochondria Provide Cellular Memory of Hematopoietic Stem Cell Replicative History and Drive HSC Attrition. Hinge, A; He, J; Bartram, J; Javier, J; Xu, J; Fjellman, E; Sesaki, H; Li, T; Yu, J; Wunderlich, M; et al. Cell Stem Cell. 2020; 26:420-430.e6.

Rapid desensitization of humanized mice with anti-human FcεRIα monoclonal antibodies. Khodoun, MV; Morris, SC; Angerman, E; Potter, C; Schuman, R; Wunderlich, M; Maciag, JJ; Locker, KC S; Mulloy, JC; Herr, AB; et al. Journal of Allergy and Clinical Immunology. 2020; 145:907-921.e3.

Improved chemotherapy modeling with RAG-based immune deficient mice. Wunderlich, M; Manning, N; Sexton, C; Sabulski, A; Byerly, L; O'Brien, E; Perentesis, JP; Mizukawa, B; Mulloy, JC. PLoS ONE. 2019; 14:e0225532-e0225532.

Overcoming adaptive therapy resistance in AML by targeting immune response pathways. Melgar, K; Walker, MM; Jones, LM; Bolanos, LC; Hueneman, K; Wunderlich, M; Jiang, J; Wilson, KM; Zhang, X; Sutter, P; et al. Science Translational Medicine. 2019; 11:eaaw8828-eaaw8828.

Epigenetic Regulator Genes Direct the Fate of Multipotent Progenitor Cell of Origin in Lineage Switched MLL-AF4 Leukaemia. Tirtakusuma, R; Milne, P; Ptasinska, A; Meyer, C; Nakjang, S; Komkov, A; Williamson, D; Cauchy, P; Assi, S; Blair, H; et al. 2019.

Small-Molecule Targeting of Oncogenic FTO Demethylase in Acute Myeloid Leukemia. Huang, Y; Su, R; Sheng, Y; Dong, L; Dong, Z; Xu, H; Ni, T; Zhang, ZS; Zhang, T; Li, C; et al. Cancer Cell. 2019; 35:677-691.e10.

Alternative translation initiation generates the N-terminal truncated form of RUNX1 that retains hematopoietic activity. Goyama, S; Schibler, J; Mulloy, JC. Experimental Hematology. 2019; 72:27-35.

Improved multilineage human hematopoietic reconstitution and function in NSGS mice. Wunderlich, M; Chou, F; Sexton, C; Presicce, P; Chougnet, CA; Aliberti, J; Mulloy, JC. PLoS ONE. 2018; 13:e0209034-e0209034.

Comparative utility of NRG and NRGS mice for the study of normal hematopoiesis, leukemogenesis, and therapeutic response. Barve, A; Casson, L; Krem, M; Wunderlich, M; Mulloy, JC; Beverly, LJ. Experimental Hematology. 2018; 67:18-31.