A photo of James Mulloy.

Co-Leader, Hematological Malignancy Program

Professor, UC Department of Pediatrics

513-636-1844

513-636-3768

Biography & Affiliation

Academic Affiliation

Professor, UC Department of Pediatrics

Divisions

Experimental Hematology and Cancer Biology, Cancer and Blood Diseases

Education

BA: St. Anselm College, Manchester, NH, 1986.

MS: Rutgers University-University of Medicine and Dentistry, New Brunswick, NJ, 1989.

PhD: Rutgers University-University of Medicine and Dentistry, New Brunswick, NJ, 1992.

Publications

Therapeutic targeting of the E3 ubiquitin ligase SKP2 in T-ALL. Rodriguez, S; Abundis, C; Boccalatte, F; Mehrotra, P; Chiang, MY; Yui, MA; Wang, L; Zhang, H; Zollman, A; Bonfim-Silva, R; et al. Leukemia. 2020; 34:1241-1252.

Asymmetrically Segregated Mitochondria Provide Cellular Memory of Hematopoietic Stem Cell Replicative History and Drive HSC Attrition. Hinge, A; He, J; Bartram, J; Javier, J; Xu, J; Fjellman, E; Sesaki, H; Li, T; Yu, J; Wunderlich, M; et al. Cell Stem Cell. 2020; 26:420-430.e6.

Rapid desensitization of humanized mice with anti-human FcεRIα monoclonal antibodies. Khodoun, MV; Morris, SC; Angerman, E; Potter, C; Schuman, R; Wunderlich, M; Maciag, JJ; Locker, KC S; Mulloy, JC; Herr, AB; et al. Journal of Allergy and Clinical Immunology. 2020; 145:907-921.e3.

Improved chemotherapy modeling with RAG-based immune deficient mice. Wunderlich, M; Manning, N; Sexton, C; Sabulski, A; Byerly, L; O'Brien, E; Perentesis, JP; Mizukawa, B; Mulloy, JC. PLoS ONE. 2019; 14:e0225532-e0225532.

Overcoming adaptive therapy resistance in AML by targeting immune response pathways. Melgar, K; Walker, MM; Jones, LM; Bolanos, LC; Hueneman, K; Wunderlich, M; Jiang, J; Wilson, KM; Zhang, X; Sutter, P; et al. Science Translational Medicine. 2019; 11:eaaw8828-eaaw8828.

Epigenetic Regulator Genes Direct the Fate of Multipotent Progenitor Cell of Origin in Lineage Switched MLL-AF4 Leukaemia. Tirtakusuma, R; Milne, P; Ptasinska, A; Meyer, C; Nakjang, S; Komkov, A; Williamson, D; Cauchy, P; Assi, S; Blair, H; et al. 2019.

Small-Molecule Targeting of Oncogenic FTO Demethylase in Acute Myeloid Leukemia. Huang, Y; Su, R; Sheng, Y; Dong, L; Dong, Z; Xu, H; Ni, T; Zhang, ZS; Zhang, T; Li, C; et al. Cancer Cell. 2019; 35:677-691.e10.

Alternative translation initiation generates the N-terminal truncated form of RUNX1 that retains hematopoietic activity. Goyama, S; Schibler, J; Mulloy, JC. Experimental Hematology. 2019; 72:27-35.

Improved multilineage human hematopoietic reconstitution and function in NSGS mice. Wunderlich, M; Chou, F; Sexton, C; Presicce, P; Chougnet, CA; Aliberti, J; Mulloy, JC. PLoS ONE. 2018; 13:e0209034-e0209034.

Comparative utility of NRG and NRGS mice for the study of normal hematopoiesis, leukemogenesis, and therapeutic response. Barve, A; Casson, L; Krem, M; Wunderlich, M; Mulloy, JC; Beverly, LJ. Experimental Hematology. 2018; 67:18-31.