A photo of Maxime M. Mahe.

Adjunct Assistant Professor, UC Department of Surgery


My Biography & Research


Prior to joining Cincinnati Children's Hospital Medical Center, Dr. Mahe performed his PhD research at the National Institute of Health and Medical Research in the Division of Neuropathies of the Enteric Nervous System and Digestive Diseases, in Nantes, France. His work emphasizes on understanding interactions between the enteric nervous system and intestinal epithelial cells.

In 2012, Dr. Mahe moved to Cincinnati Children's Hospital Medical Center to focus on the study of intestinal stem cells in the laboratory of Dr. Michael Helmrath. Since, he has been involved in collaborative studies aiming at understanding stem cell fate and gastrointestinal epithelial biology including the generation of functional human small intestine.

In 2015, Dr. Mahe became an instructor in the Division of Pediatric General and Thoracic Surgery at Cincinnati Children's within the UC Department of Pediatrics. In 2017, he was recruited as an assistant professor at Inserm, France to establish a research program on the effects of the enteric nervous system on intestinal development using innovative approaches. Dr. Mahe is currently an adjunct assistant professor in the Division of Pediatric General and Thoracic Surgery at Cincinnati Children's Hospital Medical Center.

Research Interests

Intestinal stem cells; pluripotent stem cells; neurogastroenterology; enteric nervous system; epithelial biology

Academic Affiliation

Adjunct Assistant Professor, UC Department of Surgery


Surgery - General and Thoracic, General and Thoracic Surgery

My Education

BS: University of Nantes, Nantes, France, 2006.

MS: University of Nantes, Nantes, France, 2008.

PHD: INSERM U913, Nantes, France, 2012.

Postdoctoral Fellowship: Cincinnati Children's Hospital Medical Center, Cincinnati, OH, 2015.

My Publications

Mahe MM. Engineering a second brain in a dish. Brain Res. 2018 Aug 15;1693(Pt B):165-168.

Poling HM, Wu D, Brown N, Baker M, Hausfeld TA, Huynh N, Chaffron S, Dunn JCY, Hogan SP, Wells JM, Helmrath MA, Mahe MM. Mechanically induced development and maturation of human intestinal organoids in vivo. Nat Biomed Eng. 2018 Jun;2(6):429-442.

Workman MJ*, Mahe MM*, Trisno S, Poling HM, Watson CL, Sundaram N, Chang CF, Schiesser J, Aubert P, Stanley EG, Elefanty AG, Miyaoka Y, Mandegar MA, Conklin BR, Neunlist M, Brugmann SA, Helmrath MA, Wells JM. Engineered human pluripotent-stem-cell-derived intestinal tissues with a functional enteric nervous system. Nat Med. 2017 Jan;23(1):49-59. (*Equal contributors)

Watson CL*, Mahe MM*, Múnera J, Howell JC, Sundaram N, Poling HM, Schweitzer JI, Vallance JE, Mayhew CN, Sun Y, Grabowski G, Finkbeiner SR, Spence JR, Shroyer NF, Wells JM, Helmrath MA. An in vivo model of human small intestine using pluripotent stem cells. Nat Med. 2014 Nov;20(11):1310-4. (*Equal contributors) 

Mahe MM, Sundaram N, Watson CL, Shroyer NF, Helmrath MA. Establishment of human epithelial enteroids and colonoids from whole tissue and biopsy. J Vis Exp. 2015 Mar 6;(97).