Maxime M. Mahe, PhD

Adjunct Assistant Professor, UC Department of Surgery

maxime.mahe@cchmc.org

About

Biography

Prior to joining Cincinnati Children's, I performed my PhD research at the National Institute of Health and Medical Research in the Division of Neuropathies of the Enteric Nervous System and Digestive Diseases, in Nantes, France. My work emphasizes on understanding interactions between the enteric nervous system and intestinal epithelial cells.

In 2012, I moved to Cincinnati Children's to focus on the study of intestinal stem cells in the laboratory of Dr. Michael Helmrath. Since, I have been involved in collaborative studies aiming at understanding stem cell fate and gastrointestinal epithelial biology including the generation of functional human small intestine.

In 2015, I became an instructor in the Division of Pediatric General and Thoracic Surgery at Cincinnati Children's within the UC Department of Pediatrics. In 2017, I was recruited as an assistant professor at Inserm, France to establish a research program on the effects of the enteric nervous system on intestinal development using innovative approaches. I am currently an adjunct assistant professor in the Division of Pediatric General and Thoracic Surgery at Cincinnati Children's.

Services and Specialties

General and Thoracic Surgery

Interests

Intestinal stem cells; pluripotent stem cells; neurogastroenterology; enteric nervous system; epithelial biology

Research Areas

Publications

Differentiating Enteric Glial Cells Within Intestinal Organoids Derived from Human Pluripotent Stem Cells. Vales, S; Bonneau, L; Mahe, MM. Methods in Molecular Biology. 2026; 2971:67-80.

Generation of Intestinal and Colonic Organoids Derived From Human Pluripotent Stem Cells. Bonneau, L; Brossard, L; Noël, T; Perreaux, V; Bachir, L; Khan, A; Vales, S; Mahe, MM. Biology of the Cell. 2025; 117(12):e70044.

Unraveling enteroendocrine cell lineage dynamics and associated gene regulatory networks during intestinal development. Jiménez, S; Blot, F; Meunier, A; Kapoor, R; Schreiber, V; Giethlen, C; Ghimire, S; Mahe, MM; Molina, N; De Arcangelis, A; Gradwohl, G. Biology Open. 2025; 14(10).

HUMESS: integrating quantitative transcriptomic analysis and metabolic modeling to unveil condition-specific gene signatures. Paré, L; Bordron, P; David, L; Mahé, M; Bihouée, A; Eveillard, D. Bioinformatics. 2025; 41(8).

Coordinated differentiation of human intestinal organoids with functional enteric neurons and vasculature. Childs, CJ; Poling, HM; Chen, K; Tsai, Y-H; Wu, A; Vallie, A; Eiken, MK; Huang, S; Sweet, CW; Schreiner, R; Helmrath, MA; Walton, KD; Rafii, S; Spence, JR. Cell Stem Cell. 2025; 32(4):640-651.e9.

Human pluripotent stem cell-derived organoids repair damaged bowel in vivo. Poling, HM; Sundaram, N; Fisher, GW; Singh, A; Shiley, JR; Nattamai, K; Govindarajah, V; Cortez, AR; Krutko, MO; Ménoret, S; Mayhew, CN; Takebe, T; Mahe, MM; Helmrath, MA. Cell Stem Cell. 2024; 31(10):1513-1523.e7.

Mechanical stimulation promotes human intestinal villus morphogenesis in vivo. Poling, HM; Brown, N; Wells, JM; Barrile, R; Helmrath, MA; Mahe, MM. Biophys Rev (Melville). 2024; 5(3):032102.

Gut-liver interaction study on an all-polydimethylsiloxane microfluidic device integrating intestinal paracellular permeability assay. Kida, R; Rajendran, A; Tsugane, M; Duclos-Vallée, J-C; Mahe, MM; Bensalem, S; Suzuki, H; Le Pioufle, B. Talanta Open. 2024; 9:100289.

Community metabolic modeling of host-microbiota interactions through multi-objective optimization. Lambert, A; Budinich, M; Mahé, M; Chaffron, S; Eveillard, D. iScience. 2024; 27(6):110092.

Development of functional resident macrophages in human pluripotent stem cell-derived colonic organoids and human fetal colon. Múnera, JO; Kechele, DO; Bouffi, C; Qu, N; Jing, R; Maity, P; Enriquez, JR; Han, L; Campbell, I; Mahe, MM; Hu, Y-C; Takebe, T; Helmrath, MA; Wells, JM. Cell Stem Cell. 2023; 30(11):1434-1451.e9.