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Maxime M. Mahe, PhD

Academic Affiliations

Instructor, UC Department of Pediatrics

Phone 513-602-6899

Email maxime.mahe@cchmc.org

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Research Interests

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Intestinal stem cells; pluripotent stem cells; neurogastroenterology; enteric nervous system; epithelial biology

Biography

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Prior to joining Cincinnati Children's Hospital Medical Center, Dr. Mahe performed his PhD research at the National Institute of Health and Medical Research in the Division of Neuropathies of the Enteric Nervous System and Digestive Diseases, in Nantes, France. His work emphasizes on understanding interactions between the enteric nervous system and intestinal epithelial cells.

In 2012, Dr. Mahe moved to Cincinnati Children's to focus on the study of intestinal stem cells in the laboratory of Dr. Michael Helmrath. Since, he has been involved in collaborative studies aiming at understanding stem cell fate and gastrointestinal epithelial biology including the generation of functional human small intestine.

Since 2015, Dr. Mahe is an instructor in the Division of Pediatric General and Thoracic Surgery at Cincinnati Children's within the UC Department of Pediatrics.

His research goals are to study human enteric nervous system regulation of intestinal growth and its impact on gastrointestinal dysfunctions.

Education and Training

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BS: University of Nantes, Nantes, France, 2006.

MS: University of Nantes, Nantes, France, 2008.

PHD: INSERM U913, Nantes, France, 2012.

Postdoctoral Fellowship: Cincinnati Children's Hospital Medical Center, Cincinnati, OH, 2015.

Publications

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View PubMed Publications

Mahe MM, Sundaram N, Watson CL, Shroyer NF, Helmrath MA. Establishment of human epithelial enteroids and colonoids from whole tissue and biopsy. J Vis Exp. 2015 Mar 6.

Watson CL, Mahe MM*, Múnera J, Howell JC, Sundaram N, Poling HM, Schweitzer JI, Vallance JE, Mayhew CN, Sun Y, Grabowski G, Finkbeiner SR, Spence JR, Shroyer NF, Wells JM, Helmrath MA. An in vivo model of human small intestine using pluripotent stem cells. Nat Med. 2014 Nov;20(11):1310-4. *Equal contributors

Mahe MM, Aihara E, Schumacher MA, Zavros Y, Montrose MH, Helmrath MA, Sato T, Shroyer NF. Establishment of gastrointestinal epithelial organoids. Curr Protoc Mouse Biol. 2013 Dec 19;3:217-240.

Neunlist M, Van Landeghem L, Mahé MM, Derkinderen P, des Varannes SB, Rolli-Derkinderen M. The digestive neuronal-glial-epithelial unit: a new actor in gut health and disease. Nat Rev Gastroenterol Hepatol. 2013 Feb;10(2):90-100.

Abdo H, Mahé MM, Derkinderen P, Bach-Ngohou K, Neunlist M, Lardeux B. The omega-6 fatty acid derivative 15-deoxy-Δ¹²,¹⁴-prostaglandin J2 is involved in neuroprotection by enteric glial cells against oxidative stress. J Physiol. 2012 Jun 1;590(Pt 11):2739-50.

Bach-Ngohou K, Mahé MM*, Aubert P, Abdo H, Boni S, Bourreille A, Denis MG, Lardeux B, Neunlist M, Masson D. Enteric glia modulate epithelial cell proliferation and differentiation through 15-deoxy-12,14-prostaglandin J2. J Physiol. 2010 Jul 15;588(Pt 14):2533-44. *Equal contributors

Grants

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Effects of the enteric nervous system on the intestinal epithelial barrier. Principal Investigator. DHC Pilot & Feasibility Grant. Digestive Health Center: Bench to Bedside Research in Pediatric Digestive Disease. Jun 2015-May 2016. P30 DK078392.

Role of the human enteric nervous system on intestinal growth. Principal Investigator. AGA - Athena Troxel Blackburn Research Scholar Award in Neuroenteric Disease. Oct 2015-Sep 2018.