Maxime M. Mahe, PhD

Biography & Affiliation Education Publications

Adjunct Assistant Professor, UC Department of Surgery

Biography & Affiliation

Biography

Prior to joining Cincinnati Children's Hospital Medical Center, Dr. Mahe performed his PhD research at the National Institute of Health and Medical Research in the Division of Neuropathies of the Enteric Nervous System and Digestive Diseases, in Nantes, France. His work emphasizes on understanding interactions between the enteric nervous system and intestinal epithelial cells.

In 2012, Dr. Mahe moved to Cincinnati Children's Hospital Medical Center to focus on the study of intestinal stem cells in the laboratory of Dr. Michael Helmrath. Since, he has been involved in collaborative studies aiming at understanding stem cell fate and gastrointestinal epithelial biology including the generation of functional human small intestine.

In 2015, Dr. Mahe became an instructor in the Division of Pediatric General and Thoracic Surgery at Cincinnati Children's within the UC Department of Pediatrics. In 2017, he was recruited as an assistant professor at Inserm, France to establish a research program on the effects of the enteric nervous system on intestinal development using innovative approaches. Dr. Mahe is currently an adjunct assistant professor in the Division of Pediatric General and Thoracic Surgery at Cincinnati Children's Hospital Medical Center.

Research Interests

Intestinal stem cells; pluripotent stem cells; neurogastroenterology; enteric nervous system; epithelial biology

Academic Affiliation

Adjunct Assistant Professor, UC Department of Surgery

Department

General and Thoracic Surgery

Education

BS: University of Nantes, Nantes, France, 2006.

MS: University of Nantes, Nantes, France, 2008.

PHD: INSERM U913, Nantes, France, 2012.

Postdoctoral Fellowship: Cincinnati Children's Hospital Medical Center, Cincinnati, OH, 2015.

Publications

From human pluripotent stem cells to custom-made intestinal organoids. Flatres, C; Loffet, E; Neunlist, M; Mahe, MM. médecine/sciences. 2019; 35:549-555.

An Organoid-Based Preclinical Model of Human Gastric Cancer. Steele, NG; Chakrabarti, J; Wang, J; Biesiada, J; Holokai, L; Chang, J; Nowacki, LM; Hawkins, J; Mahe, M; Sundaram, N; et al. CMGH Cellular and Molecular Gastroenterology and Hepatology. 2019; 7:161-184.

Transplantation of human intestinal organoids into the mouse mesentery: A more physiologic and anatomic engraftment site. Cortez, AR; Poling, HM; Brown, NE; Singh, A; Mahe, MM; Helmrath, MA. Surgery. 2018; 164:643-650.

Engineering a second brain in a dish. Mahe, MM. Brain Research. 2018; 1693:165-168.

Mechanically induced development and maturation of human intestinal organoids in vivo. Poling, HM; Wu, D; Brown, N; Baker, M; Hausfeld, TA; Huynh, N; Chaffron, S; Dunn, JC Y; Hogan, SP; Wells, JM; et al. Nature Biomedical Engineering. 2018; 2:429-442.

CD44 variant isoform 9 emerges in response to injury and contributes to the regeneration of the gastric epithelium. Bertaux-Skeirik, N; Wunderlich, M; Teal, E; Chakrabarti, J; Biesiada, J; Mahe, M; Sundaram, N; Gabre, J; Hawkins, J; Jian, G; et al. The Journal of pathology and bacteriology. 2017; 242:463-475.

Differentiation of Human Pluripotent Stem Cells into Colonic Organoids via Transient Activation of BMP Signaling. Munera, JO; Sundaram, N; Rankin, SA; Hill, D; Watson, C; Mahe, M; Vallance, JE; Shroyer, NF; Sinagoga, KL; Zarzoso-Lacoste, A; et al. Cell Stem Cell. 2017; 21:51-64.e6.

Canonical Wnt Signaling Ameliorates Aging of Intestinal Stem Cells. Nalapareddy, K; Nattamai, KJ; Kumar, RS; Karns, R; Wikenheiser-Brokamp, KA; Sampson, LL; Mahe, MM; Sundaram, N; Yacyshyn, M; Yacyshyn, B; et al. Cell Reports. 2017; 18:2608-2621.

Engineered human pluripotent-stem-cell-derived intestinal tissues with a functional enteric nervous system. Workman, MJ; Mahe, MM; Trisno, S; Poling, HM; Watson, CL; Sundaram, N; Chang, C; Schiesser, J; Aubert, P; Stanley, EG; et al. Nature Medicine. 2017; 23:49-59.

Transcriptional Regulation by ATOH1 and its Target SPDEF in the Intestine. Lo, YH; Chung, E; Li, Z; Wan, YW; Mahe, MM; Chen, MS; Noah, TK; Bell, KN; Yalamanchili, HK; Klisch, TJ; et al. CMGH Cellular and Molecular Gastroenterology and Hepatology. 2017; 3:51-71.