A photo of Melinda Mahabee-Gittens.

E. Melinda Mahabee-Gittens, MD, PhD


  • Professor, UC Department of Pediatrics

About

Biography

My primary research goal is to prevent and reduce tobacco smoke exposure (TSE) in children. I am a clinical researcher and pediatrician with subspecialty training in pediatric emergency medicine. I am the first investigator to translate evidence-based pediatric TSE reduction and parental tobacco cessation interventions into the busy Pediatric Emergency Department (PED) and Urgent Care (UC) settings. This seminal work with over 3,000 children and parents involved overcoming many barriers through the incorporation of complex screening, intervention and sample collection protocols. This included the development of clinical decision support tools within Epic to help fit research procedures seamlessly into the clinical workflow. This work has provided important answers on how to intervene with parents during their child’s healthcare visit.

My team’s research has focused on youth tobacco prevention (K23CA117864 and R03CA142099); TSE reduction in children and parental tobacco cessation interventions (K22CA163747, R21CA184337 and R01HD083354); and the collection and analysis of child biological samples, environmental samples and national secondary data to assess the effects of secondhand smoke exposure (SHSe), thirdhand smoke exposure (THSe) and pollution, and electronic cigarette aerosol exposure on children (R01ES027815, R01ES030743, and R21ES032161).

My team’s work demonstrates that the PED/UC setting is a unique, untapped and opportune setting in which to conduct tobacco-related research for several reasons. First, many low-income children and their parents utilize PED/UCs as a source of primary care. These parents have a high prevalence of smoking, and even when parents are nonsmokers, many of their children live in multiunit housing or other homes which are highly polluted with THS. Second, there are natural delays during the PED/UC visit when clinical testing and observation occurs; thus, the PED/UC visit is an excellent time to conduct research. Third, parents find the conduct of this research acceptable and endorse that tobacco screening and counseling should be done during the PED/UC visit. Finally, this work demonstrates that children with TSE are more likely to have respiratory symptoms and illnesses and increased severity of clinical illness.

Unfortunately, we have also found that 30% of children of smokers under the age of 5 years have TSE levels equal to that of active smokers, and 2- to 4-year-olds have the highest levels of hand nicotine (a measure of THSe) — over seven times higher than nonsmoking adults living with smokers. Thus, I believe that it is imperative that tobacco-related investigations continue in this setting so that children can be protected from preventable TSE-related illnesses. The findings from this research will disentangle which environmental sources contribute to THSe levels so that policy and remediation strategies can be developed to decrease the cumulative effects of tobacco smoke. This research will result in a new understanding of the clinical effects of SHSe and THSe on children and will improve and expand existing preventive measures.

My awards and appointments include the:

  • Preventive Medicine Alumni Award, the State University of New York Health Science Center at Brooklyn (2017)
  • Leonard P. Rome Award, Ohio (2019)
  • American Academy of Pediatrics (AAP) award to Smoke Free Families program team (2019)
  • Appointed to the Fellows Program of the Society for Research on Nicotine & Tobacco (SRNT) in recognition of outstanding contributions to the field of nicotine and tobacco research and of service to SRNT (2020)

My research is funded by the National Institutes of Health: R01HD083354, R01ES027815, R01ES030743, and R21ES032161.

Publications

Collecting Hand Wipe Samples to Assess Thirdhand Smoke Exposure. Mahabee-Gittens, EM; Quintana, PJ E; Hoh, E; Merianos, AL; Stone, L; Lopez-Galvez, N; Matt, GE. Frontiers in Public Health. 2021; 9.

Assessment of Exclusive, Dual, and Polytobacco E-Cigarette Use and COVID-19 Outcomes Among College Students. Merianos, AL; Russell, AM; Mahabee-Gittens, EM; Barry, AE; Yang, M; Lin, HC. American Journal of Health Promotion. 2021.

Altered microbiomes in thirdhand smoke-exposed children and their home environments. Kelley, ST; Liu, W; Quintana, PJ E; Hoh, E; Dodder, NG; Mahabee-Gittens, EM; Padilla, S; Ogden, S; Frenzel, S; Sisk-Hackworth, L; et al. Pediatric Research. 2021; 90:1153-1160.

Tobacco smoke exposure and fractional exhaled nitric oxide levels among U.S. adolescents. Merianos, AL; Jandarov, RA; Cataletto, M; Mahabee-Gittens, EM. Nitric Oxide - Biology and Chemistry. 2021; 117:53-59.

Comparison of Levels of Three Tobacco Smoke Exposure Biomarkers in Children of Smokers. Melinda Mahabee-Gittens, E; Matt, GE; Ding, L; Merianos, AL. International Journal of Environmental Research and Public Health. 2021; 18.

Differential associations of hand nicotine and urinary cotinine with children's exposure to tobacco smoke and clinical outcomes. Mahabee-Gittens, EM; Merianos, AL; Jandarov, RA; Quintana, PJ E; Hoh, E; Matt, GE. Environmental Research. 2021; 202.

Tobacco smoke exposure and inadequate sleep among U.S. school-aged children. Merianos, AL; Mahabee-Gittens, EM; Choi, K. Sleep Medicine. 2021; 86:99-105.

Examination of the '5-2-1-0' Recommendations in Racially Diverse Young Children Exposed to Tobacco Smoke. Mahabee-Gittens, EM; Ding, L; Merianos, AL; Khoury, JC; Gordon, JS. American Journal of Health Promotion. 2021; 35:966-972.

E-cigarette and marijuana use and the attainment of obesity prevention guidelines among U.S. adolescents. Jacobs, W; Nabors, L; Mahabee-Gittens, ME; Merianos, AL. Preventive Medicine Reports. 2021; 23.

Assessment of Severe COVID-19 Outcomes Using Measures of Smoking Status and Smoking Intensity. Mahabee-Gittens, EM; Mendy, A; Merianos, AL. International Journal of Environmental Research and Public Health. 2021; 18.

From the Blog


Many Children Still Exposed to Tobacco Smoke Pollution Even in ‘Smoke-Free’ Homes
Community Health

Many Children Still Exposed to Tobacco Smoke Pollution Even in ‘Smoke-Free’ Homes

E. Melinda Mahabee-Gittens, MD, PhD2/7/2022

Third-Hand Smoke: How Children Pick Up Surprising Levels of Nicotine Exposure
Asthma and Allergy

Third-Hand Smoke: How Children Pick Up Surprising Levels of Nicotine Exposure

E. Melinda Mahabee-Gittens, MD, PhD6/29/2019

Study Highlights Potential Dangers of Thirdhand Smoke in Kids
BlogResearch and DiscoveriesResearch and Discoveries

Study Highlights Potential Dangers of Thirdhand Smoke in Kids

By Melinda Mahabee-Gittens, MD4/26/2017

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